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The immunological anatomy of the skin

Nature Rev. Imm. - 17 hours 5 min ago

The immunological anatomy of the skin

The immunological anatomy of the skin, Published online: 14 November 2018; doi:10.1038/s41577-018-0084-5

This Review considers the unique anatomy of the cutaneous immune system. The authors explain how both protective and pathological immune responses are shaped in the skin, its associated appendages (such as hair follicles and sweat glands) and skin-associated lymphoid tissues.

A dragon that prefers a quiet life at home

Nature - 17 hours 5 min ago

A dragon that prefers a quiet life at home

A dragon that prefers a quiet life at home, Published online: 14 November 2018; doi:10.1038/d41586-018-07400-2

The 70-kilogram lizards have little to fear, yet they seldom explore outside their natal valleys.

Daily briefing: Hints of a microbiome in the brain

Nature - 13 November 2018 - 12:00am

Daily briefing: Hints of a microbiome in the brain

Daily briefing: Hints of a microbiome in the brain, Published online: 13 November 2018; doi:10.1038/d41586-018-07416-8

Gut bacteria might also live in our brain, new technique that turns mice transparent and mental-health first aid in the lab.

Author Correction: Rock fluidization during peak-ring formation of large impact structures

Nature - 13 November 2018 - 12:00am

Author Correction: Rock fluidization during peak-ring formation of large impact structures

Author Correction: Rock fluidization during peak-ring formation of large impact structures, Published online: 13 November 2018; doi:10.1038/s41586-018-0748-0

Author Correction: Rock fluidization during peak-ring formation of large impact structures

mTOR signalling and cellular metabolism are mutual determinants in cancer

Nature Rev. Cancer - 13 November 2018 - 12:00am

mTOR signalling and cellular metabolism are mutual determinants in cancer

mTOR signalling and cellular metabolism are mutual determinants in cancer, Published online: 13 November 2018; doi:10.1038/s41568-018-0074-8

This Review discusses the interdependencies of mTOR signalling and metabolism pathways in cancer and how metabolic reprogramming in response to changes in mTOR signalling and vice versa can sustain tumorigenicity. The authors highlight therapeutic opportunities when targeting metabolism and mTOR.
Categories: Cancer

Tame or inflame: gut reactions to pro- and antibiotics

Nature Rev. Imm. - 13 November 2018 - 12:00am

Tame or inflame: gut reactions to pro- and antibiotics

Tame or inflame: gut reactions to pro- and antibiotics, Published online: 13 November 2018; doi:10.1038/s41577-018-0093-4

The gut microbiota and intestinal immune cells profoundly affect each other, an interaction that can be manipulated with antibiotics and probiotics.

‘Oriental’ archaeology society reconsiders its name

Nature - 13 November 2018 - 12:00am

‘Oriental’ archaeology society reconsiders its name

‘Oriental’ archaeology society reconsiders its name, Published online: 13 November 2018; doi:10.1038/d41586-018-07396-9

Members of the American Schools of Oriental Research are pushing to update wording they consider outdated and racist.

How Facebook and Twitter could be the next disruptive force in clinical trials

Nature - 13 November 2018 - 12:00am

How Facebook and Twitter could be the next disruptive force in clinical trials

How Facebook and Twitter could be the next disruptive force in clinical trials, Published online: 13 November 2018; doi:10.1038/d41586-018-07351-8

Participants in medical research are more empowered than ever to influence the design and outcomes of experiments. Now, researchers are trying to keep up.

Osamu Shimomura (1928–2018)

Nature - 13 November 2018 - 12:00am

Osamu Shimomura (1928–2018)

Osamu Shimomura (1928–2018), Published online: 13 November 2018; doi:10.1038/d41586-018-07401-1

Chemist who illuminated bioluminescence.

Why diversity helps to produce stronger research

Nature - 13 November 2018 - 12:00am

Why diversity helps to produce stronger research

Why diversity helps to produce stronger research, Published online: 13 November 2018; doi:10.1038/d41586-018-07415-9

Teams should comprise all gender identities to spark the most innovative endeavours, say researchers.

China’s crackdown on genetics breaches could deter data sharing

Nature - 13 November 2018 - 12:00am

China’s crackdown on genetics breaches could deter data sharing

China’s crackdown on genetics breaches could deter data sharing , Published online: 13 November 2018; doi:10.1038/d41586-018-07222-2

Several big biomedical companies have been caught out and punished.

Ethics at the cutting edge, beastly movers and shakers, and teeth as time machines: Books in brief.

Nature - 13 November 2018 - 12:00am

Ethics at the cutting edge, beastly movers and shakers, and teeth as time machines: Books in brief.

Ethics at the cutting edge, beastly movers and shakers, and teeth as time machines: Books in brief., Published online: 13 November 2018; doi:10.1038/d41586-018-07354-5

Barbara Kiser reviews five of the week’s best science picks.

Be open about drug failures to speed up research

Nature - 13 November 2018 - 12:00am

Be open about drug failures to speed up research

Be open about drug failures to speed up research, Published online: 13 November 2018; doi:10.1038/d41586-018-07352-7

Access to evidence from disappointing drug-development programmes advances the whole scientific process, explain Enrica Alteri and Lorenzo Guizzaro.

US elections signal a welcome change for science

Nature - 13 November 2018 - 12:00am

US elections signal a welcome change for science

US elections signal a welcome change for science, Published online: 13 November 2018; doi:10.1038/d41586-018-07409-7

Science-based policies should benefit from midterm-election results in the United States.

If you can’t build well, then build nothing at all

Nature - 13 November 2018 - 12:00am

If you can’t build well, then build nothing at all

If you can’t build well, then build nothing at all, Published online: 13 November 2018; doi:10.1038/d41586-018-07348-3

Scientists must call out — not merely greenwash — infrastructure building that will ruin environments, lives and economies, urges William Laurance.

North and South Korea team up to tackle TB and malaria

Nature - 13 November 2018 - 12:00am

North and South Korea team up to tackle TB and malaria

North and South Korea team up to tackle TB and malaria, Published online: 13 November 2018; doi:10.1038/d41586-018-07393-y

The agreement is the first joint public-health initiative since the country’s leaders met for historic talks in September.

Italy’s olive crisis intensifies as deadly tree disease spreads

Nature - 13 November 2018 - 12:00am

Italy’s olive crisis intensifies as deadly tree disease spreads

Italy’s olive crisis intensifies as deadly tree disease spreads, Published online: 13 November 2018; doi:10.1038/d41586-018-07389-8

Containment measures meant to stop a rampant bacterium have been frequently delayed.

How a simple ‘thank you’ could improve clinical trials

Nature - 13 November 2018 - 12:00am

How a simple ‘thank you’ could improve clinical trials

How a simple ‘thank you’ could improve clinical trials, Published online: 13 November 2018; doi:10.1038/d41586-018-07410-0

Everyone would benefit if researchers did more to make participants feel part of a study.

Plump mice help to unravel the tangled ties between obesity and cancer

Nature - 12 November 2018 - 12:00am

Plump mice help to unravel the tangled ties between obesity and cancer

Plump mice help to unravel the tangled ties between obesity and cancer , Published online: 12 November 2018; doi:10.1038/d41586-018-07390-1

Obesity raises the risk of certain tumours, but might also amplify the effects of some cancer therapies.

Statistical ‘rock star’ wins coveted international prize

Nature - 12 November 2018 - 12:00am

Statistical ‘rock star’ wins coveted international prize

Statistical ‘rock star’ wins coveted international prize, Published online: 12 November 2018; doi:10.1038/d41586-018-07395-w

Bradley Efron, at Stanford University, has won the US$80,000 International Prize in Statistics for his 1970s work on a method for inferring uncertainty in data.

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