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Reduced mitochondrial fusion and Huntingtin levels contribute to impaired dendritic maturation and behavioral deficits in <i>Fmr1</i>-mutant mice

Nature Neuroscience - 18 February 2019 - 12:00am

Reduced mitochondrial fusion and Huntingtin levels contribute to impaired dendritic maturation and behavioral deficits in Fmr1-mutant mice

Reduced mitochondrial fusion and Huntingtin levels contribute to impaired dendritic maturation and behavioral deficits in <i>Fmr1</i>-mutant mice, Published online: 18 February 2019; doi:10.1038/s41593-019-0338-y

Shen et al. show that FMRP promotes mitochondrial fusion through HTT. FMRP loss caused fragmented mitochondria and oxidative stress in immature neurons, and enhancing mitochondrial fusion rescued neuronal and behavioral deficits in Fmr1-mutant mice.
Categories: Neuroscience

Antarctic voyage will explore ocean hidden under ice for 100,000 years

Nature - 15 February 2019 - 12:00am

Antarctic voyage will explore ocean hidden under ice for 100,000 years

Antarctic voyage will explore ocean hidden under ice for 100,000 years, Published online: 15 February 2019; doi:10.1038/d41586-019-00588-x

Scientists on board German research icebreaker Polarstern hope to observe underwater ecosystem changing in real-time.

Hungary’s scientists outraged by government budget grab

Nature - 15 February 2019 - 12:00am

Hungary’s scientists outraged by government budget grab

Hungary’s scientists outraged by government budget grab, Published online: 15 February 2019; doi:10.1038/d41586-019-00586-z

Innovation ministry’s decision to issue grant call using money meant for Hungarian Academy of Sciences’ operations sparks protests.

Daily briefing: How one academic couple solved the two-body problem

Nature - 15 February 2019 - 12:00am

Daily briefing: How one academic couple solved the two-body problem

Daily briefing: How one academic couple solved the two-body problem, Published online: 15 February 2019; doi:10.1038/d41586-019-00603-1

Juggling two careers and a child, how broken sleep promotes cardiovascular disease, and why we’re about to see a lot more gravitational waves.

Cytokine-mediated communication: a quantitative appraisal of immune complexity

Nature Rev. Imm. - 15 February 2019 - 12:00am

Cytokine-mediated communication: a quantitative appraisal of immune complexity

Cytokine-mediated communication: a quantitative appraisal of immune complexity, Published online: 15 February 2019; doi:10.1038/s41577-019-0131-x

Recent advances in systems immunology are beginning to elucidate the quantitative rules that govern cytokine-mediated cell-to-cell communication. This Review describes how combining theoretical analysis with experimental validation can lead to a better understanding of cytokine-mediated communication between cells of the immune system.

Rare trial of open peer review allays common concerns

Nature - 15 February 2019 - 12:00am

Rare trial of open peer review allays common concerns

Rare trial of open peer review allays common concerns, Published online: 15 February 2019; doi:10.1038/d41586-019-00500-7

Study suggests that making reviewers’ reports freely readable doesn’t compromise peer-review process.

The vaporized rock and extreme heat at a huge landslide’s heart

Nature - 15 February 2019 - 12:00am

The vaporized rock and extreme heat at a huge landslide’s heart

The vaporized rock and extreme heat at a huge landslide’s heart, Published online: 15 February 2019; doi:10.1038/d41586-019-00536-9

An entire mountainside came crashing down after a devastating earthquake in China’s Sichuan Province.

Indian payment-for-papers proposal rattles scientists

Nature - 15 February 2019 - 12:00am

Indian payment-for-papers proposal rattles scientists

Indian payment-for-papers proposal rattles scientists, Published online: 15 February 2019; doi:10.1038/d41586-019-00514-1

Researchers say the policy could intensify existing issues with research quality and misconduct.

Gravitational-wave observatory LIGO set to double its detecting power

Nature - 15 February 2019 - 12:00am

Gravitational-wave observatory LIGO set to double its detecting power

Gravitational-wave observatory LIGO set to double its detecting power, Published online: 15 February 2019; doi:10.1038/d41586-019-00573-4

A planned $35-million upgrade could enable LIGO to spot one black-hole merger per day by the mid-2020s.

US science agencies set for budget boost in deal to avert government shutdown

Nature - 14 February 2019 - 12:00am

US science agencies set for budget boost in deal to avert government shutdown

US science agencies set for budget boost in deal to avert government shutdown, Published online: 14 February 2019; doi:10.1038/d41586-019-00590-3

NASA, the National Science Foundation and the Environmental Protection Agency are among the agencies whose funding would increase.

Author Correction: Predictable and precise template-free CRISPR editing of pathogenic variants

Nature - 14 February 2019 - 12:00am

Author Correction: Predictable and precise template-free CRISPR editing of pathogenic variants

Author Correction: Predictable and precise template-free CRISPR editing of pathogenic variants, Published online: 14 February 2019; doi:10.1038/s41586-019-0938-4

Author Correction: Predictable and precise template-free CRISPR editing of pathogenic variants

Daily briefing: <i>Nature </i>editors review Ladybird books

Nature - 14 February 2019 - 12:00am

Daily briefing: Nature editors review Ladybird books

Daily briefing: <i>Nature </i>editors review Ladybird books, Published online: 14 February 2019; doi:10.1038/d41586-019-00592-1

Britain’s top boffins write pocket-sized guides, final farewell to Opportunity and one scientist’s quest to learn why he didn’t get tenure.

Principal investigators are people, too

Nature - 14 February 2019 - 12:00am

Principal investigators are people, too

Principal investigators are people, too, Published online: 14 February 2019; doi:10.1038/d41586-019-00413-5

Recognizing that fact could help researchers in their journey through their graduate studies, says one second-year PhD student.

One couple, two cities: How to handle an international career move

Nature - 14 February 2019 - 12:00am

One couple, two cities: How to handle an international career move

One couple, two cities: How to handle an international career move, Published online: 14 February 2019; doi:10.1038/d41586-019-00582-3

Mette Bendixen and Lars Iversen found a creative solution to their ‘two-body problem’.

Electrical resistivity across a nematic quantum critical point

Nature - 13 February 2019 - 12:00am

Electrical resistivity across a nematic quantum critical point

Electrical resistivity across a nematic quantum critical point, Published online: 13 February 2019; doi:10.1038/s41586-019-0923-y

The pattern of electrical resistivity in an unconventional superconductor at high magnetic fields and low temperatures across the nematic quantum critical point reveals two classic signatures of quantum criticality.

Investors bet billions on health-care start-ups with paltry publication records

Nature - 13 February 2019 - 12:00am

Investors bet billions on health-care start-ups with paltry publication records

Investors bet billions on health-care start-ups with paltry publication records, Published online: 13 February 2019; doi:10.1038/d41586-019-00564-5

Firms can achieve fêted ‘unicorn’ valuations without publishing much peer-reviewed science.

Daily briefing: Data sharing is like “a love letter to your future self”

Nature - 13 February 2019 - 12:00am

Daily briefing: Data sharing is like “a love letter to your future self”

Daily briefing: Data sharing is like “a love letter to your future self”, Published online: 13 February 2019; doi:10.1038/d41586-019-00583-2

Learn how to apply the FAIR principles of data sharing to your research, discover the latest high-altitude pseudosatellites and gain a new perspective on ancient Maya bones.

High frequency of shared clonotypes in human B cell receptor repertoires

Nature - 13 February 2019 - 12:00am

High frequency of shared clonotypes in human B cell receptor repertoires

High frequency of shared clonotypes in human B cell receptor repertoires, Published online: 13 February 2019; doi:10.1038/s41586-019-0934-8

Many clonotypes in human B cell repertoires are shared, including between adult and umbilical cord blood repertoires, which indicates that this similarity is not driven only by exposure to common antigens.

Large teams develop and small teams disrupt science and technology

Nature - 13 February 2019 - 12:00am

Large teams develop and small teams disrupt science and technology

Large teams develop and small teams disrupt science and technology, Published online: 13 February 2019; doi:10.1038/s41586-019-0941-9

Analyses of the output produced by large versus small teams of researchers and innovators demonstrate that their work differs systematically in the extent to which it disrupts or develops existing science and technology.

Deep learning and process understanding for data-driven Earth system science

Nature - 13 February 2019 - 12:00am

Deep learning and process understanding for data-driven Earth system science

Deep learning and process understanding for data-driven Earth system science, Published online: 13 February 2019; doi:10.1038/s41586-019-0912-1

Complex Earth system challenges can be addressed by incorporating spatial and temporal context into machine learning, especially via deep learning, and further by combining with physical models into hybrid models.

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