Medicine

The molecular landscape of glioma in patients with Neurofibromatosis 1

Nature Medicine - 10 December 2018 - 12:00am

The molecular landscape of glioma in patients with Neurofibromatosis 1

The molecular landscape of glioma in patients with Neurofibromatosis 1, Published online: 10 December 2018; doi:10.1038/s41591-018-0263-8

An integrated analysis of glioma samples from patients with neurofibromatosis 1 annotates their mutational, epigenetic, transcriptional, and immunological features and uncovers similitudes with a subset of sporadic gliomas.
Categories: Medicine

The microbiome influence

Nature Medicine - 6 December 2018 - 12:00am

The microbiome influence

The microbiome influence, Published online: 06 December 2018; doi:10.1038/s41591-018-0285-2

The microbiome influence
Categories: Medicine

Metformin action through the microbiome and bile acids

Nature Medicine - 6 December 2018 - 12:00am

Metformin action through the microbiome and bile acids

Metformin action through the microbiome and bile acids, Published online: 06 December 2018; doi:10.1038/s41591-018-0273-6

Metformin functions through a gut microbiome–bile acid–farnesoid X receptor axis to lower glucose in type 2 diabetes, revealing a new therapeutic target in this disease.
Categories: Medicine

Treatments that made headlines in 2018

Nature Medicine - 6 December 2018 - 12:00am

Treatments that made headlines in 2018

Treatments that made headlines in 2018, Published online: 06 December 2018; doi:10.1038/s41591-018-0292-3

In 2018, drugs for rare conditions such as beta-thalassemia and forms of amyloidosis made it onto the approval mainstage in addition to drugs for more common diseases such as cancer. The gene-editing technology CRISPR slowly made strides into the therapeutic realm, while drugs for Alzheimer’s disease continued to falter, leaving a wide gap that is still in need of filling.
Categories: Medicine

Single cell dissection of plasma cell heterogeneity in symptomatic and asymptomatic myeloma

Nature Medicine - 6 December 2018 - 12:00am

Single cell dissection of plasma cell heterogeneity in symptomatic and asymptomatic myeloma

Single cell dissection of plasma cell heterogeneity in symptomatic and asymptomatic myeloma, Published online: 06 December 2018; doi:10.1038/s41591-018-0269-2

Single cell dissection of plasma cell heterogeneity in myeloma patients reveals new insights into disease that may inform early diagnosis and clinical management.
Categories: Medicine

Monitoring yellow fever

Nature Medicine - 6 December 2018 - 12:00am

Monitoring yellow fever

Monitoring yellow fever, Published online: 06 December 2018; doi:10.1038/s41591-018-0280-7

Monitoring yellow fever
Categories: Medicine

Understanding genetic disease with electronic records

Nature Medicine - 6 December 2018 - 12:00am

Understanding genetic disease with electronic records

Understanding genetic disease with electronic records, Published online: 06 December 2018; doi:10.1038/s41591-018-0283-4

Understanding genetic disease with electronic records
Categories: Medicine

Diversifying clinical trials

Nature Medicine - 6 December 2018 - 12:00am

Diversifying clinical trials

Diversifying clinical trials, Published online: 06 December 2018; doi:10.1038/s41591-018-0303-4

Diversifying clinical trials
Categories: Medicine

In utero correction of a genetic disorder

Nature Medicine - 6 December 2018 - 12:00am

In utero correction of a genetic disorder

In utero correction of a genetic disorder, Published online: 06 December 2018; doi:10.1038/s41591-018-0288-z

In utero correction of a genetic disorder
Categories: Medicine

Most precise ‘surgery’ of cell carried out on neurons

Nature Medicine - 4 December 2018 - 12:00am

Most precise ‘surgery’ of cell carried out on neurons

Most precise ‘surgery’ of cell carried out on neurons, Published online: 04 December 2018; doi:10.1038/d41591-018-00002-5

New tweezer technology plucks out single organelles and could help in study of Parkinson’s
Categories: Medicine

Low and variable tumor reactivity of the intratumoral TCR repertoire in human cancers

Nature Medicine - 3 December 2018 - 12:00am

Low and variable tumor reactivity of the intratumoral TCR repertoire in human cancers

Low and variable tumor reactivity of the intratumoral TCR repertoire in human cancers, Published online: 03 December 2018; doi:10.1038/s41591-018-0266-5

Intratumoral T cells that are capable of recognizing adjacent tumor tissue antigens can be exceedingly rare.
Categories: Medicine

UK Biobank debuts as a powerful resource for genomic research

Nature Medicine - 3 December 2018 - 12:00am

UK Biobank debuts as a powerful resource for genomic research

UK Biobank debuts as a powerful resource for genomic research, Published online: 03 December 2018; doi:10.1038/s41591-018-0276-3

Analysis of the UK Biobank genetic and phenotypic data demonstrate the power of including a large population and detailed phenotyping in a prospective study to identify genetic and lifestyle factors related to health and disease.
Categories: Medicine

Identification of evolutionarily conserved gene networks mediating neurodegenerative dementia

Nature Medicine - 3 December 2018 - 12:00am

Identification of evolutionarily conserved gene networks mediating neurodegenerative dementia

Identification of evolutionarily conserved gene networks mediating neurodegenerative dementia, Published online: 03 December 2018; doi:10.1038/s41591-018-0223-3

Evolutionarily conserved gene modules mediate neurodegenerative dementia in a variety of mouse models and in postmortem brain tissue from patients.
Categories: Medicine

Myelodysplastic syndrome progression to acute myeloid leukemia at the stem cell level

Nature Medicine - 3 December 2018 - 12:00am

Myelodysplastic syndrome progression to acute myeloid leukemia at the stem cell level

Myelodysplastic syndrome progression to acute myeloid leukemia at the stem cell level, Published online: 03 December 2018; doi:10.1038/s41591-018-0267-4

High-resolution sequencing of longitudinal patient samples reveals subclonal mutational diversity in the stem cell compartment driving parallel evolution patterns in acute myeloid leukemia progression.
Categories: Medicine

Wiskott–Aldrich syndrome protein (WASP) is a tumor suppressor in T cell lymphoma

Nature Medicine - 3 December 2018 - 12:00am

Wiskott–Aldrich syndrome protein (WASP) is a tumor suppressor in T cell lymphoma

Wiskott–Aldrich syndrome protein (WASP) is a tumor suppressor in T cell lymphoma, Published online: 03 December 2018; doi:10.1038/s41591-018-0262-9

WASP is a novel tumor-suppressor gene in ALK-driven anaplastic large cell lymphoma through modulation of CDC42 and MAPK signaling and provides a rationale for combination therapy.
Categories: Medicine

Genetic characterization of amyloid-β and tau network spread

Nature Medicine - 3 December 2018 - 12:00am

Genetic characterization of amyloid-β and tau network spread

Genetic characterization of amyloid-β and tau network spread , Published online: 03 December 2018; doi:10.1038/s41591-018-0277-2

Protein-specific and shared genetic pathways influence the spread of amyloid-β and tau pathology. Hence, distinct gene expression profiles may induce regional vulnerability of the human cortex to the specific proteinopathies of Alzheimer’s disease.
Categories: Medicine

Ultraviolet radiation–induced DNA damage is prognostic for outcome in melanoma

Nature Medicine - 3 December 2018 - 12:00am

Ultraviolet radiation–induced DNA damage is prognostic for outcome in melanoma

Ultraviolet radiation–induced DNA damage is prognostic for outcome in melanoma, Published online: 03 December 2018; doi:10.1038/s41591-018-0265-6

Mutational signatures in melanoma are associated with prognostic features in patients and suggest distinct disease etiologies associated with the influence of different wavelengths of ultraviolet radiation.
Categories: Medicine

Implicating or exonerating the gut microbiome in blood-borne infection

Nature Medicine - 3 December 2018 - 12:00am

Implicating or exonerating the gut microbiome in blood-borne infection

Implicating or exonerating the gut microbiome in blood-borne infection, Published online: 03 December 2018; doi:10.1038/s41591-018-0270-9

StrainSifter is a tool that is able to identify the relatedness of a blood-borne infection to the gut microbiome using single-nucleotide variant data.
Categories: Medicine

Author Correction: Fecal microbiota transplantation for refractory immune checkpoint inhibitor-associated colitis

Nature Medicine - 27 November 2018 - 12:00am

Author Correction: Fecal microbiota transplantation for refractory immune checkpoint inhibitor-associated colitis

Author Correction: Fecal microbiota transplantation for refractory immune checkpoint inhibitor-associated colitis, Published online: 27 November 2018; doi:10.1038/s41591-018-0305-2

Author Correction: Fecal microbiota transplantation for refractory immune checkpoint inhibitor-associated colitis
Categories: Medicine

A CD4<sup>+</sup> T cell population expanded in lupus blood provides B cell help through interleukin-10 and succinate

Nature Medicine - 26 November 2018 - 12:00am

A CD4+ T cell population expanded in lupus blood provides B cell help through interleukin-10 and succinate

A CD4<sup>+</sup> T cell population expanded in lupus blood provides B cell help through interleukin-10 and succinate, Published online: 26 November 2018; doi:10.1038/s41591-018-0254-9

A new population of T helper cells employs unique signals to support autoreactive B cells in patients with systemic lupus erythematosus.
Categories: Medicine

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