Medicine

Immune and genomic correlates of response to anti-PD-1 immunotherapy in glioblastoma

Nature Medicine - 11 February 2019 - 12:00am

Immune and genomic correlates of response to anti-PD-1 immunotherapy in glioblastoma

Immune and genomic correlates of response to anti-PD-1 immunotherapy in glioblastoma, Published online: 11 February 2019; doi:10.1038/s41591-019-0349-y

Genomic, transcriptomic, and microenvironmental analyses of samples from patients with glioblastoma treated with nivolumab or pembrolizumab identifies features associated with treatment response that may help in refining patient stratification.
Categories: Medicine

Neoadjuvant anti-PD-1 immunotherapy promotes a survival benefit with intratumoral and systemic immune responses in recurrent glioblastoma

Nature Medicine - 11 February 2019 - 12:00am

Neoadjuvant anti-PD-1 immunotherapy promotes a survival benefit with intratumoral and systemic immune responses in recurrent glioblastoma

Neoadjuvant anti-PD-1 immunotherapy promotes a survival benefit with intratumoral and systemic immune responses in recurrent glioblastoma, Published online: 11 February 2019; doi:10.1038/s41591-018-0337-7

Neoadjuvant pembrolizumab promotes a survival benefit with intratumoral and systemic immune responses in patients with recurrent glioblastoma.
Categories: Medicine

Evaluation and accurate diagnoses of pediatric diseases using artificial intelligence

Nature Medicine - 11 February 2019 - 12:00am

Evaluation and accurate diagnoses of pediatric diseases using artificial intelligence

Evaluation and accurate diagnoses of pediatric diseases using artificial intelligence, Published online: 11 February 2019; doi:10.1038/s41591-018-0335-9

A natural language processing system can support physicians in diagnostic assessments by extracting clinical information from electronic medical records to accurately predict diagnosis in pediatric patients.
Categories: Medicine

Neoadjuvant nivolumab modifies the tumor immune microenvironment in resectable glioblastoma

Nature Medicine - 11 February 2019 - 12:00am

Neoadjuvant nivolumab modifies the tumor immune microenvironment in resectable glioblastoma

Neoadjuvant nivolumab modifies the tumor immune microenvironment in resectable glioblastoma, Published online: 11 February 2019; doi:10.1038/s41591-018-0339-5

Neoadjuvant nivolumab treatment in patients with glioblastoma induces intratumoral immune activation and underscores the need for rationale-based combination approaches for improving clinical responses.
Categories: Medicine

Evidence mounts for a role for immune cells in the brain

Nature Medicine - 7 February 2019 - 12:00am

Evidence mounts for a role for immune cells in the brain

Evidence mounts for a role for immune cells in the brain, Published online: 07 February 2019; doi:10.1038/d41591-019-00007-8

Immune cells that flood the brain may help reduce damage from stroke and multiple sclerosis.
Categories: Medicine

Author Correction: Metformin inhibits gluconeogenesis via a redox-dependent mechanism in vivo

Nature Medicine - 7 February 2019 - 12:00am

Author Correction: Metformin inhibits gluconeogenesis via a redox-dependent mechanism in vivo

Author Correction: Metformin inhibits gluconeogenesis via a redox-dependent mechanism in vivo, Published online: 07 February 2019; doi:10.1038/s41591-018-0220-6

Author Correction: Metformin inhibits gluconeogenesis via a redox-dependent mechanism in vivo
Categories: Medicine

Positive selection

Nature Medicine - 6 February 2019 - 12:00am

Positive selection

Positive selection, Published online: 06 February 2019; doi:10.1038/s41591-019-0351-4

Careful sorting of probiotics may finally pave the way for an FDA approval.
Categories: Medicine

No guts, no research glory

Nature Medicine - 6 February 2019 - 12:00am

No guts, no research glory

No guts, no research glory, Published online: 06 February 2019; doi:10.1038/s41591-019-0342-5

Eran Elinav is an immunologist at the Weizmann Institute of Science in Rehovot, Israel. He has earned many distinctions, including being named a Howard Hughes Medical Institute and Bill and Melinda Gates Foundation research scholar in 2017.
Categories: Medicine

Exome sequencing for chronic kidney disease diagnosis

Nature Medicine - 6 February 2019 - 12:00am

Exome sequencing for chronic kidney disease diagnosis

Exome sequencing for chronic kidney disease diagnosis, Published online: 06 February 2019; doi:10.1038/s41591-019-0361-2

Exome sequencing for chronic kidney disease diagnosis
Categories: Medicine

Precision epidemiology for infectious disease control

Nature Medicine - 6 February 2019 - 12:00am

Precision epidemiology for infectious disease control

Precision epidemiology for infectious disease control, Published online: 06 February 2019; doi:10.1038/s41591-019-0345-2

The emerging field of precision epidemiology allows the personalized diagnosis, tracking and treatment of infectious diseases.
Categories: Medicine

A framework for responsibility

Nature Medicine - 6 February 2019 - 12:00am

A framework for responsibility

A framework for responsibility, Published online: 06 February 2019; doi:10.1038/s41591-019-0352-3

As the world reckons with the news of the first use of genome editing in the human germline, researchers, clinicians, ethicists and policy makers must work across international boundaries to outline a transparent path forward for the responsible translation of this technology in the future.
Categories: Medicine

Transmission of Aβ seeds

Nature Medicine - 6 February 2019 - 12:00am

Transmission of Aβ seeds

Transmission of Aβ seeds, Published online: 06 February 2019; doi:10.1038/s41591-019-0364-z

Transmission of Aβ seeds
Categories: Medicine

Detecting opioid overdoses with smartphones

Nature Medicine - 6 February 2019 - 12:00am

Detecting opioid overdoses with smartphones

Detecting opioid overdoses with smartphones, Published online: 06 February 2019; doi:10.1038/s41591-019-0362-1

Detecting opioid overdoses with smartphones
Categories: Medicine

Biomarkers for Alzheimer’s disease beyond amyloid and tau

Nature Medicine - 6 February 2019 - 12:00am

Biomarkers for Alzheimer’s disease beyond amyloid and tau

Biomarkers for Alzheimer’s disease beyond amyloid and tau, Published online: 06 February 2019; doi:10.1038/s41591-019-0348-z

Two new biomarkers for Alzheimer’s disease include one in the blood that relates to neurodegeneration and another that reflects blood–brain barrier dysfunction and is identifiable in cerebrospinal fluid analysis.
Categories: Medicine

New video tool peers deeply into growing embryos

Nature Medicine - 5 February 2019 - 12:00am

New video tool peers deeply into growing embryos

New video tool peers deeply into growing embryos, Published online: 05 February 2019; doi:10.1038/d41591-019-00006-9

The approach can detect heartbeat changes earlier than the human eye.
Categories: Medicine

Gene pattern predicts sickness from dengue virus

Nature Medicine - 5 February 2019 - 12:00am

Gene pattern predicts sickness from dengue virus

Gene pattern predicts sickness from dengue virus, Published online: 05 February 2019; doi:10.1038/d41591-019-00005-w

Measuring the activity of 20 genes offers clues of how severe the disease will be in a given patient.
Categories: Medicine

Gene therapy for retinal dystrophy

Nature Medicine - 4 February 2019 - 12:00am

Gene therapy for retinal dystrophy

Gene therapy for retinal dystrophy, Published online: 04 February 2019; doi:10.1038/s41591-019-0346-1

Counteracting splice defects in the CEP290 gene using RNA antisense oligonucleotides or Cas9-mediated gene editing is a therapeutic strategy for Leber congenital amaurosis type 10—a severe untreatable retinal dystrophy leading to childhood blindness.
Categories: Medicine

Publisher Correction: ApoE attenuates unresolvable inflammation by complex formation with activated C1q

Nature Medicine - 4 February 2019 - 12:00am

Publisher Correction: ApoE attenuates unresolvable inflammation by complex formation with activated C1q

Publisher Correction: ApoE attenuates unresolvable inflammation by complex formation with activated C1q, Published online: 04 February 2019; doi:10.1038/s41591-019-0378-6

Publisher Correction: ApoE attenuates unresolvable inflammation by complex formation with activated C1q
Categories: Medicine

Publisher Correction: The molecular landscape of pediatric acute myeloid leukemia reveals recurrent structural alterations and age-specific mutational interactions

Nature Medicine - 31 January 2019 - 12:00am

Publisher Correction: The molecular landscape of pediatric acute myeloid leukemia reveals recurrent structural alterations and age-specific mutational interactions

Publisher Correction: The molecular landscape of pediatric acute myeloid leukemia reveals recurrent structural alterations and age-specific mutational interactions, Published online: 31 January 2019; doi:10.1038/s41591-019-0369-7

Publisher Correction: The molecular landscape of pediatric acute myeloid leukemia reveals recurrent structural alterations and age-specific mutational interactions
Categories: Medicine

Publisher Correction: Cannabinoid CB<sub>1</sub> receptors in the amygdalar cholecystokinin glutamatergic afferents to nucleus accumbens modulate depressive-like behavior

Nature Medicine - 30 January 2019 - 12:00am

Publisher Correction: Cannabinoid CB1 receptors in the amygdalar cholecystokinin glutamatergic afferents to nucleus accumbens modulate depressive-like behavior

Publisher Correction: Cannabinoid CB<sub>1</sub> receptors in the amygdalar cholecystokinin glutamatergic afferents to nucleus accumbens modulate depressive-like behavior, Published online: 30 January 2019; doi:10.1038/s41591-019-0372-z

Publisher Correction: Cannabinoid CB1 receptors in the amygdalar cholecystokinin glutamatergic afferents to nucleus accumbens modulate depressive-like behavior
Categories: Medicine

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