Medicine

Modeling vaccination rollouts, SARS-CoV-2 variants and the requirement for non-pharmaceutical interventions in Italy

Nature Medicine - 16 April 2021 - 12:00am

Nature Medicine, Published online: 16 April 2021; doi:10.1038/s41591-021-01334-5

Integration of variables to account for different speeds of vaccination rollouts and transmission dynamics of new SARS-CoV-2 strains into the SIDARTHE-V model suggests that maintaining non-pharmaceutical interventions during the COVID-19 vaccination campaign in Italy is essential for minimizing mortality in Italy into 2022.
Categories: Medicine

Author Correction: Tomorrow’s biggest microbial threats

Nature Medicine - 15 April 2021 - 12:00am

Nature Medicine, Published online: 15 April 2021; doi:10.1038/s41591-021-01341-6

Author Correction: Tomorrow’s biggest microbial threats
Categories: Medicine

Gene therapy needs a long-term approach

Nature Medicine - 15 April 2021 - 12:00am

Nature Medicine, Published online: 15 April 2021; doi:10.1038/s41591-021-01333-6

Gene-therapy trials are on the rise, but more needs to be done to understand the long-term risks associated with this type of treatment.
Categories: Medicine

Comprehensive large-scale nucleic acid–testing strategies support China’s sustained containment of COVID-19

Nature Medicine - 15 April 2021 - 12:00am

Nature Medicine, Published online: 15 April 2021; doi:10.1038/s41591-021-01308-7

Comprehensive large-scale nucleic acid–testing strategies support China’s sustained containment of COVID-19
Categories: Medicine

Is presymptomatic ALS perivascular?

Nature Medicine - 15 April 2021 - 12:00am

Nature Medicine, Published online: 15 April 2021; doi:10.1038/s41591-021-01311-y

Increased activity in perivascular fibroblasts could precede motor-neuron degeneration and be a predictor of shorter survival in amyotrophic lateral sclerosis.
Categories: Medicine

The STEP 1 trial for weight loss: a step change in treating obesity?

Nature Medicine - 15 April 2021 - 12:00am

Nature Medicine, Published online: 15 April 2021; doi:10.1038/s41591-021-01319-4

A new trial shows that adding the glucagon‐like peptide 1 analog semaglutide to diet and exercise leads to weight loss.
Categories: Medicine

Open letter to international funders of science and development in Africa

Nature Medicine - 15 April 2021 - 12:00am

Nature Medicine, Published online: 15 April 2021; doi:10.1038/s41591-021-01307-8

Open letter to international funders of science and development in Africa
Categories: Medicine

“I had to be with bodyguards with guns”—attacks on scientists during the pandemic

Nature Medicine - 15 April 2021 - 12:00am

Nature Medicine, Published online: 15 April 2021; doi:10.1038/s41591-021-01314-9

Public-health researchers are more visible than ever before. But for some, this has led to abuse and attacks that threaten to silence them.
Categories: Medicine

Triage-driven diagnosis of Barrett’s esophagus for early detection of esophageal adenocarcinoma using deep learning

Nature Medicine - 15 April 2021 - 12:00am

Nature Medicine, Published online: 15 April 2021; doi:10.1038/s41591-021-01287-9

A clinician-in-the-loop deep learning system streamlines the workflow of pathologists for detection of Barrett’s esophagus and retains the diagnostic accuracy of full manual review.
Categories: Medicine

Black scientists gather to form communities and boost diversity in science

Nature Medicine - 12 April 2021 - 12:00am

Nature Medicine, Published online: 12 April 2021; doi:10.1038/s41591-021-01315-8

Black scientists have been historically underrepresented in academia and science. A 2018 study of the National Center for Education Statistics found that only 6% of faculty in the USA were Black. Systemic racism and other issues that translate into a lack of diversity in research often cause unwelcoming environments for Black scientists. Last fall, sparked by the Black Lives Matter movement and triggered by the #BlackBirdersWeek virtual event, several scientific communities took to social media to create ‘#BlackIn...’ movements. Over the course of a week, organizers offered virtual talks, workshops and social events highlighting Black scientists in their fields. We spoke with the founders of four of these ‘#BlackIn...’ movements to learn how they are empowering the Black scientific community to start conversations about being Black in science, and to discuss strategies for continuing to diversify scientific research.
Categories: Medicine

Vaccine development for emerging infectious diseases

Nature Medicine - 12 April 2021 - 12:00am

Nature Medicine, Published online: 12 April 2021; doi:10.1038/s41591-021-01301-0

Examination of the vaccine strategies and technical platforms used for the COVID-19 pandemic in the context of those used for previous emerging and reemerging infectious diseases and pandemics can offer critical lessons to prepare for future public health emergencies.
Categories: Medicine

Integration of genomic sequencing into the response to the Ebola virus outbreak in Nord Kivu, Democratic Republic of the Congo

Nature Medicine - 12 April 2021 - 12:00am

Nature Medicine, Published online: 12 April 2021; doi:10.1038/s41591-021-01302-z

Phylogeographic analysis of 792 Ebola virus genomes from the 2018 oubreak in the Democratic Republic of the Congo integrated into an end-to-end surveillance program demonstrates the feasibility of using genomic sequencing data to inform the public health epidemic response in near-real time.
Categories: Medicine

Actionable druggable genome-wide Mendelian randomization identifies repurposing opportunities for COVID-19

Nature Medicine - 9 April 2021 - 12:00am

Nature Medicine, Published online: 09 April 2021; doi:10.1038/s41591-021-01310-z

Large-scale Mendelian randomization and colocalization analyses using gene expression and soluble protein data for 1,263 actionable druggable genes, which encode protein targets for approved drugs or drugs in clinical development, identify IFNAR2 and ACE2 as the most promising therapeutic targets for early management of COVID-19.
Categories: Medicine

Africa needs more genome sequencing to tackle new variants of SARS-CoV-2

Nature Medicine - 7 April 2021 - 12:00am

Nature Medicine, Published online: 07 April 2021; doi:10.1038/s41591-021-01327-4

Africa needs more genome sequencing to tackle new variants of SARS-CoV-2
Categories: Medicine

How medical AI devices are evaluated: limitations and recommendations from an analysis of FDA approvals

Nature Medicine - 5 April 2021 - 12:00am

Nature Medicine, Published online: 05 April 2021; doi:10.1038/s41591-021-01312-x

A comprehensive overview of medical AI devices approved by the US Food and Drug Administration sheds new light on limitations of the evaluation process that can mask vulnerabilities of devices when they are deployed on patients.
Categories: Medicine

The need for a new strategy for Ebola vaccination

Nature Medicine - 5 April 2021 - 12:00am

Nature Medicine, Published online: 05 April 2021; doi:10.1038/s41591-021-01313-w

News of two new outbreaks of Ebola virus disease in the Democratic Republic of the Congo and Republic of Guinea, on the backdrop of the COVID-19 pandemic, signals the need for a change of direction in vaccination strategies in the area.
Categories: Medicine

Immunotherapy and targeted-therapy combinations mark a new era of kidney cancer treatment

Nature Medicine - 5 April 2021 - 12:00am

Nature Medicine, Published online: 05 April 2021; doi:10.1038/s41591-021-01320-x

Results from the latest phase 3 clinical trial testing combinations of immunotherapy and tyrosine-kinase inhibitors for advanced kidney cancer improve standard first-line treatment options for patients.
Categories: Medicine

Changing climate and the COVID-19 pandemic: more than just heads or tails

Nature Medicine - 5 April 2021 - 12:00am

Nature Medicine, Published online: 05 April 2021; doi:10.1038/s41591-021-01303-y

Climate change can both facilitate zoonotic spillovers and have an effect on transmission chains. These effects, alongside human behavior and awareness, need to be integrated in pandemic forecasting models.
Categories: Medicine

Integrative microbiomics in bronchiectasis exacerbations

Nature Medicine - 5 April 2021 - 12:00am

Nature Medicine, Published online: 05 April 2021; doi:10.1038/s41591-021-01289-7

Integrated analysis of bacterial, fungal and microbial communities in the airways of patients with bronchiectasis demonstrates that interaction networks, rather than the relative abundance of any single microbial species, are associated with exacerbation risk.
Categories: Medicine

A framework for microbiome science in public health

Nature Medicine - 5 April 2021 - 12:00am

Nature Medicine, Published online: 05 April 2021; doi:10.1038/s41591-021-01258-0

Microbiome science is fast advancing and its careful integration into public health is detailed in this Perspective.
Categories: Medicine

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