Medicine

Antisense therapies pose a regulatory conundrum

Nature Medicine - 7 June 2019 - 12:00am

Nature Medicine, Published online: 07 June 2019; doi:10.1038/d41591-019-00014-9

A wave of customized medicines is coming, but are drug agencies ready?
Categories: Medicine

Rapid neonatal diagnosis

Nature Medicine - 6 June 2019 - 12:00am

Nature Medicine, Published online: 06 June 2019; doi:10.1038/s41591-019-0487-2

Rapid neonatal diagnosis
Categories: Medicine

Finding diversity in the microbiome

Nature Medicine - 6 June 2019 - 12:00am

Nature Medicine, Published online: 06 June 2019; doi:10.1038/s41591-019-0494-3

The National Institutes of Health Human Microbiome Project is coming to a close, offering an opportunity to reflect on its legacy and the urgent need to understand the microbiome of underrepresented populations.
Categories: Medicine

Combining checkpoint inhibition and targeted therapy in melanoma

Nature Medicine - 6 June 2019 - 12:00am

Nature Medicine, Published online: 06 June 2019; doi:10.1038/s41591-019-0482-7

The combination of BRAF and MEK inhibition and anti-PD-1 is tolerable and has promising efficacy, which warrants further investigation into its use as melanoma therapy.
Categories: Medicine

A chance encounter changes everything

Nature Medicine - 6 June 2019 - 12:00am

Nature Medicine, Published online: 06 June 2019; doi:10.1038/s41591-019-0418-2

Vijay Sankaran is a practicing pediatric hematologist and researcher at Boston Children’s Hospital, the Dana-Farber Cancer Institute and the Broad Institute of MIT and Harvard. His laboratory uses insights from human genetics to study blood cell production in health and disease.
Categories: Medicine

Defining the path of a physician–scientist

Nature Medicine - 6 June 2019 - 12:00am

Nature Medicine, Published online: 06 June 2019; doi:10.1038/s41591-019-0466-7

Karishma Kaushik’s research at University of Pune focuses on chronic wound infections, from probing the complex wound infection microenvironment to enabling personalized therapeutic approaches. She is a recipient of the Ramalingaswami Re-entry Fellowship, a program funded by the Government of India to support the research of early-career scientists and their return to the country from abroad.
Categories: Medicine

Translating thoughts into speech

Nature Medicine - 6 June 2019 - 12:00am

Nature Medicine, Published online: 06 June 2019; doi:10.1038/s41591-019-0488-1

Translating thoughts into speech
Categories: Medicine

Combined BRAF and MEK inhibition with PD-1 blockade immunotherapy in <i>BRAF</i>-mutant melanoma

Nature Medicine - 6 June 2019 - 12:00am

Nature Medicine, Published online: 06 June 2019; doi:10.1038/s41591-019-0476-5

Triple therapy combining BRAF and MEK inhibitors with immune checkpoint blockade may benefit a subset of patients with BRAFV600-mutated metastatic melanoma.
Categories: Medicine

Preventing HIV transmission

Nature Medicine - 6 June 2019 - 12:00am

Nature Medicine, Published online: 06 June 2019; doi:10.1038/s41591-019-0490-7

Preventing HIV transmission
Categories: Medicine

Spinal cord repair: advances in biology and technology

Nature Medicine - 3 June 2019 - 12:00am

Nature Medicine, Published online: 03 June 2019; doi:10.1038/s41591-019-0475-6

Advances in cellular regeneration and technical approaches to spinal cord repair are on the verge of being translated into clinical trials.
Categories: Medicine

Deep learning can predict microsatellite instability directly from histology in gastrointestinal cancer

Nature Medicine - 3 June 2019 - 12:00am

Nature Medicine, Published online: 03 June 2019; doi:10.1038/s41591-019-0462-y

A deep residual learning framework identifies microsatellite instability in histology slides from patients with cancer and can be used to guide immunotherapy.
Categories: Medicine

<i>CCR5</i>-∆32 is deleterious in the homozygous state in humans

Nature Medicine - 3 June 2019 - 12:00am

Nature Medicine, Published online: 03 June 2019; doi:10.1038/s41591-019-0459-6

Individuals homozygous for the CCR5-∆32 allele have a 21% increase in mortality rate in the UK Biobank cohort. In light of the CRISPR-baby scandal, this work highlights the need for understanding the unintended consequences of introducing mutations in humans.
Categories: Medicine

Principles of and strategies for germline gene therapy

Nature Medicine - 3 June 2019 - 12:00am

Nature Medicine, Published online: 03 June 2019; doi:10.1038/s41591-019-0473-8

Germline gene therapy has the potential to prevent inheritance of monogenic disorders but must first be optimized for accuracy.
Categories: Medicine

Identification of rare-disease genes using blood transcriptome sequencing and large control cohorts

Nature Medicine - 3 June 2019 - 12:00am

Nature Medicine, Published online: 03 June 2019; doi:10.1038/s41591-019-0457-8

A diagnostic tool based on blood RNA-seq is shown to identify causal genes and variants linked to clinical phenotypes in individuals with rare diseases for which whole-exome genetic sequencing was uninformative.
Categories: Medicine

Novel correlates of protection against pandemic H1N1 influenza A virus infection

Nature Medicine - 3 June 2019 - 12:00am

Nature Medicine, Published online: 03 June 2019; doi:10.1038/s41591-019-0463-x

Study of influenza virus transmission in humans provides evidence that hemagglutinin stalk-specific antibodies correlate with protection from infection.
Categories: Medicine

The hidden cost of genetic resistance to HIV-1

Nature Medicine - 3 June 2019 - 12:00am

Nature Medicine, Published online: 03 June 2019; doi:10.1038/s41591-019-0481-8

Assessment of more than 400,000 people over the age of 40 demonstrates that homozygosity for a CCR5 variant that prevents HIV-1 infection comes at the cost of increased rates of mortality.
Categories: Medicine

In support of mitochondrial replacement therapy

Nature Medicine - 3 June 2019 - 12:00am

Nature Medicine, Published online: 03 June 2019; doi:10.1038/s41591-019-0477-4

In support of mitochondrial replacement therapy
Categories: Medicine

<i>Tailored treatment for ALS poised to move ahead </i>

Nature Medicine - 30 May 2019 - 12:00am

Nature Medicine, Published online: 30 May 2019; doi:10.1038/d41591-019-00013-w

For a young woman with a rare disease, researchers are pushing the boundaries of personalized medicine
Categories: Medicine

The vaginal microbiome and preterm birth

Nature Medicine - 29 May 2019 - 12:00am

Nature Medicine, Published online: 29 May 2019; doi:10.1038/s41591-019-0450-2

As part of the second phase of Human Microbiome Project, the Multi-Omic Microbiome Study: Pregnancy Initiative presents a community resource to help better understand how microbiome and host profiles change throughout pregnancy as well as to identify new opportunities for assessment of the risk of preterm birth.
Categories: Medicine

Gestational shaping of the maternal vaginal microbiome

Nature Medicine - 29 May 2019 - 12:00am

Nature Medicine, Published online: 29 May 2019; doi:10.1038/s41591-019-0483-6

The diversity of the vaginal microbiome is linked to ethnicity, preterm birth and transitions to a healthier profile upon pregnancy.
Categories: Medicine

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