Medicine

Publisher Correction: Targeting hepatic glutaminase activity to ameliorate hyperglycemia

Nature Medicine - 12 June 2018 - 12:00am

Publisher Correction: Targeting hepatic glutaminase activity to ameliorate hyperglycemia

Publisher Correction: Targeting hepatic glutaminase activity to ameliorate hyperglycemia, Published online: 12 June 2018; doi:10.1038/s41591-018-0047-1

Publisher Correction: Targeting hepatic glutaminase activity to ameliorate hyperglycemia
Categories: Medicine

p53 inhibits CRISPR–Cas9 engineering in human pluripotent stem cells

Nature Medicine - 11 June 2018 - 12:00am

p53 inhibits CRISPR–Cas9 engineering in human pluripotent stem cells

p53 inhibits CRISPR–Cas9 engineering in human pluripotent stem cells, Published online: 11 June 2018; doi:10.1038/s41591-018-0050-6

CRISPR–Cas9-induced DNA damage triggers p53 to limit the efficiency of gene editing in human pluripotent cells.
Categories: Medicine

Suppression of detyrosinated microtubules improves cardiomyocyte function in human heart failure

Nature Medicine - 11 June 2018 - 12:00am

Suppression of detyrosinated microtubules improves cardiomyocyte function in human heart failure

Suppression of detyrosinated microtubules improves cardiomyocyte function in human heart failure, Published online: 11 June 2018; doi:10.1038/s41591-018-0046-2

Post-translational modification of microtubules by detyrosination is prevalent in failing human cardiomyocytes and inhibits cardiomyocyte contraction, suggesting a new therapeutic strategy for improving heart function.
Categories: Medicine

STAT3 labels a subpopulation of reactive astrocytes required for brain metastasis

Nature Medicine - 11 June 2018 - 12:00am

STAT3 labels a subpopulation of reactive astrocytes required for brain metastasis

STAT3 labels a subpopulation of reactive astrocytes required for brain metastasis, Published online: 11 June 2018; doi:10.1038/s41591-018-0044-4

Reactive astrocytes expressing STAT3 support the metastatic growth of tumor cells colonizing the brain and can be pharmacologically targeted to improve the clinical management of patients with secondary brain tumors.
Categories: Medicine

CRISPR–Cas9 genome editing induces a p53-mediated DNA damage response

Nature Medicine - 11 June 2018 - 12:00am

CRISPR–Cas9 genome editing induces a p53-mediated DNA damage response

CRISPR–Cas9 genome editing induces a p53-mediated DNA damage response, Published online: 11 June 2018; doi:10.1038/s41591-018-0049-z

CRISPR–Cas9-induced DNA damage triggers p53 to limit the efficiency of gene editing in immortalized human retinal pigment epithelial cells.
Categories: Medicine

Block of A1 astrocyte conversion by microglia is neuroprotective in models of Parkinson’s disease

Nature Medicine - 11 June 2018 - 12:00am

Block of A1 astrocyte conversion by microglia is neuroprotective in models of Parkinson’s disease

Block of A1 astrocyte conversion by microglia is neuroprotective in models of Parkinson’s disease, Published online: 11 June 2018; doi:10.1038/s41591-018-0051-5

Agonism of microglial glucagon-like peptide-1 receptor (GLP1R) using a brain-penetrant peptide prevents the generation of neurotoxic astrocytes and ameliorates disease progression in two rodent models of Parkinson’s disease.
Categories: Medicine

The human heart contains distinct macrophage subsets with divergent origins and functions

Nature Medicine - 11 June 2018 - 12:00am

The human heart contains distinct macrophage subsets with divergent origins and functions

The human heart contains distinct macrophage subsets with divergent origins and functions, Published online: 11 June 2018; doi:10.1038/s41591-018-0059-x

Study of macrophage heterogeneity in human hearts reveals a subset of inflammatory macrophages that is associated with cardiac dysfunction in patients with heart failure.
Categories: Medicine

Rapid HIV RNA rebound after antiretroviral treatment interruption in persons durably suppressed in Fiebig I acute HIV infection

Nature Medicine - 11 June 2018 - 12:00am

Rapid HIV RNA rebound after antiretroviral treatment interruption in persons durably suppressed in Fiebig I acute HIV infection

Rapid HIV RNA rebound after antiretroviral treatment interruption in persons durably suppressed in Fiebig I acute HIV infection, Published online: 11 June 2018; doi:10.1038/s41591-018-0026-6

Initiation of antiretroviral therapy in the first 2 weeks of HIV infection fails to prevent resurgence of virus after stopping treatment, indicating early establishment of a resilient viral reservoir.
Categories: Medicine

An inhibitor of oxidative phosphorylation exploits cancer vulnerability

Nature Medicine - 11 June 2018 - 12:00am

An inhibitor of oxidative phosphorylation exploits cancer vulnerability

An inhibitor of oxidative phosphorylation exploits cancer vulnerability, Published online: 11 June 2018; doi:10.1038/s41591-018-0052-4

A new inhibitor targeting the mitochondrial complex I shows antitumor activity in preclinical models of acute myeloid leukemia and glioblastoma relying on oxidative phosphorylation.
Categories: Medicine

Reducing diabetes risk at an early age

Nature Medicine - 6 June 2018 - 12:00am

Reducing diabetes risk at an early age

Reducing diabetes risk at an early age, Published online: 06 June 2018; doi:10.1038/s41591-018-0067-x

A large retrospective study involving 62,565 Danish men shows that those who have been overweight in childhood have a lower risk of having type 2 diabetes in adulthood if they had remission of overweight before 13 years of age.
Categories: Medicine

Tracing clear cell renal carcinoma evolution

Nature Medicine - 6 June 2018 - 12:00am

Tracing clear cell renal carcinoma evolution

Tracing clear cell renal carcinoma evolution, Published online: 06 June 2018; doi:10.1038/s41591-018-0074-y

Tracing clear cell renal carcinoma evolution
Categories: Medicine

Potential and ethics

Nature Medicine - 6 June 2018 - 12:00am

Potential and ethics

Potential and ethics, Published online: 06 June 2018; doi:10.1038/s41591-018-0072-0

With the ongoing demand for assisted reproduction, the need and ability to study the fundamentals of human reproduction at a cellular level have never been greater. At this juncture, we join other Nature Research Journals in formalizing our ethical guidelines for papers in this growing field.
Categories: Medicine

About time

Nature Medicine - 6 June 2018 - 12:00am

About time

About time, Published online: 06 June 2018; doi:10.1038/s41591-018-0069-8

Chronotherapy looks beyond to treating more than just cancer
Categories: Medicine

Training neuropathology

Nature Medicine - 6 June 2018 - 12:00am

Training neuropathology

Training neuropathology, Published online: 06 June 2018; doi:10.1038/s41591-018-0076-9

Training neuropathology
Categories: Medicine

Zika virus shedding in semen

Nature Medicine - 6 June 2018 - 12:00am

Zika virus shedding in semen

Zika virus shedding in semen, Published online: 06 June 2018; doi:10.1038/s41591-018-0075-x

Zika virus shedding in semen
Categories: Medicine

Metastatic cancers promote cachexia through ZIP14 upregulation in skeletal muscle

Nature Medicine - 6 June 2018 - 12:00am

Metastatic cancers promote cachexia through ZIP14 upregulation in skeletal muscle

Metastatic cancers promote cachexia through ZIP14 upregulation in skeletal muscle, Published online: 06 June 2018; doi:10.1038/s41591-018-0054-2

Accumulation of zinc in muscle cells resulting from transcriptional upregulation of metal transporter ZIP14 causes muscle atrophy and promotes cachexia in metastatic cancer.
Categories: Medicine

Intersection of schizophrenia genetics and placental complications

Nature Medicine - 6 June 2018 - 12:00am

Intersection of schizophrenia genetics and placental complications

Intersection of schizophrenia genetics and placental complications, Published online: 06 June 2018; doi:10.1038/s41591-018-0066-y

Genetic risk scores in schizophrenia are influenced by pregnancy complications that compromise the placenta, enhancing association of genes involved in metabolism and cellular stress with schizophrenia risk.
Categories: Medicine

Clinical activity and molecular correlates of response to atezolizumab alone or in combination with bevacizumab versus sunitinib in renal cell carcinoma

Nature Medicine - 4 June 2018 - 12:00am

Clinical activity and molecular correlates of response to atezolizumab alone or in combination with bevacizumab versus sunitinib in renal cell carcinoma

Clinical activity and molecular correlates of response to atezolizumab alone or in combination with bevacizumab versus sunitinib in renal cell carcinoma, Published online: 04 June 2018; doi:10.1038/s41591-018-0053-3

An exploratory randomized controlled clinical trial of renal cell carcinoma identifies molecular patterns distinguishing responders to immune checkpoint blockade alone or combined with angiogenesis inhibitor versus angiogenesis inhibitor alone.
Categories: Medicine

Targeting the cancer mutanome of breast cancer

Nature Medicine - 4 June 2018 - 12:00am

Targeting the cancer mutanome of breast cancer

Targeting the cancer mutanome of breast cancer, Published online: 04 June 2018; doi:10.1038/s41591-018-0065-z

A metastatic hormone receptor–positive breast cancer, usually resistant to immunotherapy, is successfully treated with tumor-infiltrating lymphocytes enriched for neoantigen reactivity, underscoring the broad potential of this immunotherapeutic approach.
Categories: Medicine

Therapeutic and protective efficacy of a dengue antibody against Zika infection in rhesus monkeys

Nature Medicine - 4 June 2018 - 12:00am

Therapeutic and protective efficacy of a dengue antibody against Zika infection in rhesus monkeys

Therapeutic and protective efficacy of a dengue antibody against Zika infection in rhesus monkeys, Published online: 04 June 2018; doi:10.1038/s41591-018-0056-0

A single monoclonal antibody is therapeutic and has prophylactic activity against Zika virus in monkeys.
Categories: Medicine

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