Medicine

Publisher Correction: Inactivating hepatic follistatin alleviates hyperglycemia

Nature Medicine - 15 August 2018 - 12:00am

Publisher Correction: Inactivating hepatic follistatin alleviates hyperglycemia

Publisher Correction: Inactivating hepatic follistatin alleviates hyperglycemia, Published online: 15 August 2018; doi:10.1038/s41591-018-0129-0

Publisher Correction: Inactivating hepatic follistatin alleviates hyperglycemia
Categories: Medicine

Automated deep-neural-network surveillance of cranial images for acute neurologic events

Nature Medicine - 13 August 2018 - 12:00am

Automated deep-neural-network surveillance of cranial images for acute neurologic events

Automated deep-neural-network surveillance of cranial images for acute neurologic events, Published online: 13 August 2018; doi:10.1038/s41591-018-0147-y

A deep-learning algorithm is developed to provide rapid and accurate diagnosis of clinical 3D head CT-scan images to triage and prioritize urgent neurological events, thus potentially accelerating time to diagnosis and care in clinical settings.
Categories: Medicine

Clinically applicable deep learning for diagnosis and referral in retinal disease

Nature Medicine - 13 August 2018 - 12:00am

Clinically applicable deep learning for diagnosis and referral in retinal disease

Clinically applicable deep learning for diagnosis and referral in retinal disease, Published online: 13 August 2018; doi:10.1038/s41591-018-0107-6

A novel deep learning architecture performs device-independent tissue segmentation of clinical 3D retinal images followed by separate diagnostic classification that meets or exceeds human expert clinical diagnoses of retinal disease.
Categories: Medicine

Author Correction: Mutations in the SWI/SNF complex induce a targetable dependence on oxidative phosphorylation in lung cancer

Nature Medicine - 13 August 2018 - 12:00am

Author Correction: Mutations in the SWI/SNF complex induce a targetable dependence on oxidative phosphorylation in lung cancer

Author Correction: Mutations in the SWI/SNF complex induce a targetable dependence on oxidative phosphorylation in lung cancer, Published online: 13 August 2018; doi:10.1038/s41591-018-0173-9

Author Correction: Mutations in the SWI/SNF complex induce a targetable dependence on oxidative phosphorylation in lung cancer
Categories: Medicine

Sequestration of T cells in bone marrow in the setting of glioblastoma and other intracranial tumors

Nature Medicine - 13 August 2018 - 12:00am

Sequestration of T cells in bone marrow in the setting of glioblastoma and other intracranial tumors

Sequestration of T cells in bone marrow in the setting of glioblastoma and other intracranial tumors, Published online: 13 August 2018; doi:10.1038/s41591-018-0135-2

Patients with glioblastoma experience lymphopenia and sequestration of T cells in the bone marrow, which is recapitulated in mice with brain tumors, where the reversible nature of this effect is demonstrated by an approach that enables the efficacy of other immunotherapeutics.
Categories: Medicine

Author Correction: Metformin reverses established lung fibrosis in a bleomycin model

Nature Medicine - 13 August 2018 - 12:00am

Author Correction: Metformin reverses established lung fibrosis in a bleomycin model

Author Correction: Metformin reverses established lung fibrosis in a bleomycin model, Published online: 13 August 2018; doi:10.1038/s41591-018-0170-z

Author Correction: Metformin reverses established lung fibrosis in a bleomycin model
Categories: Medicine

Publisher Correction: Global characterization of T cells in non-small-cell lung cancer by single-cell sequencing

Nature Medicine - 9 August 2018 - 12:00am

Publisher Correction: Global characterization of T cells in non-small-cell lung cancer by single-cell sequencing

Publisher Correction: Global characterization of T cells in non-small-cell lung cancer by single-cell sequencing, Published online: 09 August 2018; doi:10.1038/s41591-018-0167-7

Publisher Correction: Global characterization of T cells in non-small-cell lung cancer by single-cell sequencing
Categories: Medicine

Author Correction: Targeting wild-type <i>KRAS</i>-amplified gastroesophageal cancer through combined MEK and SHP2 inhibition

Nature Medicine - 9 August 2018 - 12:00am

Author Correction: Targeting wild-type KRAS-amplified gastroesophageal cancer through combined MEK and SHP2 inhibition

Author Correction: Targeting wild-type <i>KRAS</i>-amplified gastroesophageal cancer through combined MEK and SHP2 inhibition, Published online: 09 August 2018; doi:10.1038/s41591-018-0168-6

Author Correction: Targeting wild-type KRAS-amplified gastroesophageal cancer through combined MEK and SHP2 inhibition
Categories: Medicine

Publisher Correction: Global characterization of T cells in non-small-cell lung cancer by single-cell sequencing

Nature Medicine - 9 August 2018 - 12:00am

Publisher Correction: Global characterization of T cells in non-small-cell lung cancer by single-cell sequencing

Publisher Correction: Global characterization of T cells in non-small-cell lung cancer by single-cell sequencing, Published online: 09 August 2018; doi:10.1038/s41591-018-0169-5

Publisher Correction: Global characterization of T cells in non-small-cell lung cancer by single-cell sequencing
Categories: Medicine

Author Correction: Cold-induced epigenetic programming of the sperm enhances brown adipose tissue activity in the offspring

Nature Medicine - 7 August 2018 - 12:00am

Author Correction: Cold-induced epigenetic programming of the sperm enhances brown adipose tissue activity in the offspring

Author Correction: Cold-induced epigenetic programming of the sperm enhances brown adipose tissue activity in the offspring, Published online: 07 August 2018; doi:10.1038/s41591-018-0162-z

Author Correction: Cold-induced epigenetic programming of the sperm enhances brown adipose tissue activity in the offspring
Categories: Medicine

Publisher Correction: Cold-induced epigenetic programming of the sperm enhances brown adipose tissue activity in the offspring

Nature Medicine - 7 August 2018 - 12:00am

Publisher Correction: Cold-induced epigenetic programming of the sperm enhances brown adipose tissue activity in the offspring

Publisher Correction: Cold-induced epigenetic programming of the sperm enhances brown adipose tissue activity in the offspring, Published online: 07 August 2018; doi:10.1038/s41591-018-0163-y

Publisher Correction: Cold-induced epigenetic programming of the sperm enhances brown adipose tissue activity in the offspring
Categories: Medicine

Early antiretroviral therapy limits SIV reservoir establishment to delay or prevent post-treatment viral rebound

Nature Medicine - 6 August 2018 - 12:00am

Early antiretroviral therapy limits SIV reservoir establishment to delay or prevent post-treatment viral rebound

Early antiretroviral therapy limits SIV reservoir establishment to delay or prevent post-treatment viral rebound, Published online: 06 August 2018; doi:10.1038/s41591-018-0130-7

Early and prolonged administration of antiretroviral therapy to SIV-infected and post-exposure-vaccinated rhesus macaques was associated with absence or delay of detectable virus after therapy interruption.
Categories: Medicine

Predicting preterm birth

Nature Medicine - 6 August 2018 - 12:00am

Predicting preterm birth

Predicting preterm birth, Published online: 06 August 2018; doi:10.1038/s41591-018-0154-z

Predicting preterm birth
Categories: Medicine

Learning from bacterial competition in the host to develop antimicrobials

Nature Medicine - 6 August 2018 - 12:00am

Learning from bacterial competition in the host to develop antimicrobials

Learning from bacterial competition in the host to develop antimicrobials, Published online: 06 August 2018; doi:10.1038/s41591-018-0145-0

The delicate balance of microbial communities is maintained by competitive mechanisms that provide an avenue for new antimicrobial development.
Categories: Medicine

An antiviral for smallpox

Nature Medicine - 6 August 2018 - 12:00am

An antiviral for smallpox

An antiviral for smallpox, Published online: 06 August 2018; doi:10.1038/s41591-018-0152-1

An antiviral for smallpox
Categories: Medicine

Cellular origin of human cardiac macrophage populations

Nature Medicine - 6 August 2018 - 12:00am

Cellular origin of human cardiac macrophage populations

Cellular origin of human cardiac macrophage populations, Published online: 06 August 2018; doi:10.1038/s41591-018-0143-2

The human heart contains two macrophage populations with distinct self-maintenance and inflammatory functions. A shift in the balance between these macrophage populations correlates with left-ventricle remodeling and systolic function in patients with heart failure.
Categories: Medicine

Keep off-target effects in focus

Nature Medicine - 6 August 2018 - 12:00am

Keep off-target effects in focus

Keep off-target effects in focus, Published online: 06 August 2018; doi:10.1038/s41591-018-0150-3

Concerns about potential unintended DNA changes that might accidentally arise from CRISPR gene editing have emerged to varying degrees with the advent of the technology. As new therapies move from bench to bedside, scientists need to redouble their efforts to document the spectrum of these off-target effects while also acknowledging the reality that a certain degree of risk is embedded in many promising and successful medical therapies.
Categories: Medicine

Cell therapy for spinal cord injury

Nature Medicine - 6 August 2018 - 12:00am

Cell therapy for spinal cord injury

Cell therapy for spinal cord injury, Published online: 06 August 2018; doi:10.1038/s41591-018-0155-y

Cell therapy for spinal cord injury
Categories: Medicine

Blood-based tumor mutational burden as a predictor of clinical benefit in non-small-cell lung cancer patients treated with atezolizumab

Nature Medicine - 6 August 2018 - 12:00am

Blood-based tumor mutational burden as a predictor of clinical benefit in non-small-cell lung cancer patients treated with atezolizumab

Blood-based tumor mutational burden as a predictor of clinical benefit in non-small-cell lung cancer patients treated with atezolizumab, Published online: 06 August 2018; doi:10.1038/s41591-018-0134-3

A blood-based DNA sequencing assay to infer tumor mutational burden in the absence of tumor biopsy predicts response to PD-L1 blockade in patients with non-small-cell lung cancer.
Categories: Medicine

Discovery cycle

Nature Medicine - 1 August 2018 - 12:00am

Discovery cycle

Discovery cycle, Published online: 01 August 2018; doi:10.1038/s41591-018-0149-9

Period-tracking apps offer new insights on women’s health.
Categories: Medicine

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