Medicine

Molecular profiling in precision medicine oncology

Nature Medicine - 29 April 2019 - 12:00am

Molecular profiling in precision medicine oncology

Molecular profiling in precision medicine oncology, Published online: 29 April 2019; doi:10.1038/s41591-019-0442-2

Three innovative precision medicine studies show the utility of evidence beyond that from tumor DNA sequencing to guide therapy in patients with cancer.
Categories: Medicine

A signature of circulating inflammatory proteins and development of end-stage renal disease in diabetes

Nature Medicine - 22 April 2019 - 12:00am

A signature of circulating inflammatory proteins and development of end-stage renal disease in diabetes

A signature of circulating inflammatory proteins and development of end-stage renal disease in diabetes, Published online: 22 April 2019; doi:10.1038/s41591-019-0415-5

A robust signature of circulating inflammatory proteins is causally associated with 10-year risk of progression to end-stage renal disease in diabetic patients
Categories: Medicine

Immunogenic neoantigens derived from gene fusions stimulate T cell responses

Nature Medicine - 22 April 2019 - 12:00am

Immunogenic neoantigens derived from gene fusions stimulate T cell responses

Immunogenic neoantigens derived from gene fusions stimulate T cell responses, Published online: 22 April 2019; doi:10.1038/s41591-019-0434-2

Fusion proteins in cancers with low mutational burden represent functional neoantigens that elicit T cell activation and mediate responses to immunotherapy.
Categories: Medicine

An organoid platform for ovarian cancer captures intra- and interpatient heterogeneity

Nature Medicine - 22 April 2019 - 12:00am

An organoid platform for ovarian cancer captures intra- and interpatient heterogeneity

An organoid platform for ovarian cancer captures intra- and interpatient heterogeneity, Published online: 22 April 2019; doi:10.1038/s41591-019-0422-6

A biobank of ovarian cancer organoids recapitulates the histopathological and molecular hallmarks of patient tumors and provides a resource for preclinical research.
Categories: Medicine

Utility of ctDNA to support patient selection for early phase clinical trials: the TARGET study

Nature Medicine - 22 April 2019 - 12:00am

Utility of ctDNA to support patient selection for early phase clinical trials: the TARGET study

Utility of ctDNA to support patient selection for early phase clinical trials: the TARGET study, Published online: 22 April 2019; doi:10.1038/s41591-019-0380-z

Sequencing of circulating tumor DNA from cancer patients is a cost-efficient approach with turnaround time compatible with clinical practice to inform treatment decision-making in a phase 1 trial setting
Categories: Medicine

Molecular profiling of cancer patients enables personalized combination therapy: the I-PREDICT study

Nature Medicine - 22 April 2019 - 12:00am

Molecular profiling of cancer patients enables personalized combination therapy: the I-PREDICT study

Molecular profiling of cancer patients enables personalized combination therapy: the I-PREDICT study, Published online: 22 April 2019; doi:10.1038/s41591-019-0407-5

A prospective clinical study of cancer patients (I-PREDICT) demonstrated the feasibility of matching genomic alterations found in tumors to combined drug treatments.
Categories: Medicine

A safe and potent anti-CD19 CAR T cell therapy

Nature Medicine - 22 April 2019 - 12:00am

A safe and potent anti-CD19 CAR T cell therapy

A safe and potent anti-CD19 CAR T cell therapy, Published online: 22 April 2019; doi:10.1038/s41591-019-0421-7

A new anti-CD19 CAR T cell therapy induces potent antitumor responses without causing severe cytokine-release syndrome or neurotoxicity in patients with lymphoma.
Categories: Medicine

Genomic and transcriptomic profiling expands precision cancer medicine: the WINTHER trial

Nature Medicine - 22 April 2019 - 12:00am

Genomic and transcriptomic profiling expands precision cancer medicine: the WINTHER trial

Genomic and transcriptomic profiling expands precision cancer medicine: the WINTHER trial, Published online: 22 April 2019; doi:10.1038/s41591-019-0424-4

Prospective analysis of transcriptomic and genomic alterations increases the proportion of patients with solid cancer who are eligible for receiving matched therapies and shows promise in improving clinical outcomes.
Categories: Medicine

Author Correction: Immune and genomic correlates of response to anti-PD-1 immunotherapy in glioblastoma

Nature Medicine - 17 April 2019 - 12:00am

Author Correction: Immune and genomic correlates of response to anti-PD-1 immunotherapy in glioblastoma

Author Correction: Immune and genomic correlates of response to anti-PD-1 immunotherapy in glioblastoma, Published online: 17 April 2019; doi:10.1038/s41591-019-0449-8

Author Correction: Immune and genomic correlates of response to anti-PD-1 immunotherapy in glioblastoma
Categories: Medicine

Systemic clinical tumor regressions and potentiation of PD1 blockade with in situ vaccination

Nature Medicine - 8 April 2019 - 12:00am

Systemic clinical tumor regressions and potentiation of PD1 blockade with in situ vaccination

Systemic clinical tumor regressions and potentiation of PD1 blockade with in situ vaccination, Published online: 08 April 2019; doi:10.1038/s41591-019-0410-x

In situ vaccine recruits and activates cross-presenting dendritic cells and augments PD1 blockade efficacy in patients with indolent non-Hodgkin’s lymphoma.
Categories: Medicine

Enlighten e-cigarettes

Nature Medicine - 4 April 2019 - 12:00am

Enlighten e-cigarettes

Enlighten e-cigarettes, Published online: 04 April 2019; doi:10.1038/s41591-019-0431-5

The use of electronic cigarettes is on the rise, but we need more evidence about their risks as well as their value in curbing tobacco use. Ultimately, we need to design better, smarter vaping tools for smoking cessation.
Categories: Medicine

The breast milk microbiome

Nature Medicine - 4 April 2019 - 12:00am

The breast milk microbiome

The breast milk microbiome, Published online: 04 April 2019; doi:10.1038/s41591-019-0427-1

The breast milk microbiome
Categories: Medicine

Training the physician of the future

Nature Medicine - 4 April 2019 - 12:00am

Training the physician of the future

Training the physician of the future, Published online: 04 April 2019; doi:10.1038/s41591-019-0354-1

Radical changes are afoot in medical schools.
Categories: Medicine

Seasonal manifestations of sickle cell disease activity

Nature Medicine - 4 April 2019 - 12:00am

Seasonal manifestations of sickle cell disease activity

Seasonal manifestations of sickle cell disease activity, Published online: 04 April 2019; doi:10.1038/s41591-019-0409-3

Seasonal manifestations of sickle cell disease activity
Categories: Medicine

Modeling kidney disease with organoids

Nature Medicine - 4 April 2019 - 12:00am

Modeling kidney disease with organoids

Modeling kidney disease with organoids, Published online: 04 April 2019; doi:10.1038/s41591-019-0428-0

Modeling kidney disease with organoids
Categories: Medicine

Maternal infection linked to psychiatric disorders

Nature Medicine - 4 April 2019 - 12:00am

Maternal infection linked to psychiatric disorders

Maternal infection linked to psychiatric disorders, Published online: 04 April 2019; doi:10.1038/s41591-019-0430-6

Maternal infection linked to psychiatric disorders
Categories: Medicine

Lymph removal not tied to positive outcomes

Nature Medicine - 4 April 2019 - 12:00am

Lymph removal not tied to positive outcomes

Lymph removal not tied to positive outcomes, Published online: 04 April 2019; doi:10.1038/s41591-019-0426-2

Lymph removal not tied to positive outcomes
Categories: Medicine

Charting a path from ‘bench to bedside’

Nature Medicine - 4 April 2019 - 12:00am

Charting a path from ‘bench to bedside’

Charting a path from ‘bench to bedside’, Published online: 04 April 2019; doi:10.1038/s41591-019-0394-6

Lars Zender is professor and chairman of internal medicine at University Hospital Tubingen in Germany. He has received many awards, including the Gottfried Wilhelm Leibniz Prize of the German Research Foundation.
Categories: Medicine

Author Correction: Patient-derived induced pluripotent stem cells in cancer research and precision oncology

Nature Medicine - 3 April 2019 - 12:00am

Author Correction: Patient-derived induced pluripotent stem cells in cancer research and precision oncology

Author Correction: Patient-derived induced pluripotent stem cells in cancer research and precision oncology, Published online: 03 April 2019; doi:10.1038/s41591-019-0435-1

Author Correction: Patient-derived induced pluripotent stem cells in cancer research and precision oncology
Categories: Medicine

Platelet GPIbα is a mediator and potential interventional target for NASH and subsequent liver cancer

Nature Medicine - 1 April 2019 - 12:00am

Platelet GPIbα is a mediator and potential interventional target for NASH and subsequent liver cancer

Platelet GPIbα is a mediator and potential interventional target for NASH and subsequent liver cancer, Published online: 01 April 2019; doi:10.1038/s41591-019-0379-5

Blockade of intrahepatic accumulation and function of platelets represents a potential approach to treat non-alcoholic steatohepatitis (NASH) and prevent subsequent progression to hepatocellular carcinoma
Categories: Medicine

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