Medicine

Author Correction: Regional variation limits applications of healthy gut microbiome reference ranges and disease models

Nature Medicine - 24 September 2018 - 12:00am

Author Correction: Regional variation limits applications of healthy gut microbiome reference ranges and disease models

Author Correction: Regional variation limits applications of healthy gut microbiome reference ranges and disease models, Published online: 24 September 2018; doi:10.1038/s41591-018-0219-z

Author Correction: Regional variation limits applications of healthy gut microbiome reference ranges and disease models
Categories: Medicine

MitoTALEN reduces mutant mtDNA load and restores tRNA<sup>Ala</sup> levels in a mouse model of heteroplasmic mtDNA mutation

Nature Medicine - 24 September 2018 - 12:00am

MitoTALEN reduces mutant mtDNA load and restores tRNAAla levels in a mouse model of heteroplasmic mtDNA mutation

MitoTALEN reduces mutant mtDNA load and restores tRNA<sup>Ala</sup> levels in a mouse model of heteroplasmic mtDNA mutation, Published online: 24 September 2018; doi:10.1038/s41591-018-0166-8

Mitochondrial-targeted TALENs reduce mutation burden and correct biochemical defects in a mouse model of mitochondrial disease.
Categories: Medicine

Transcriptional addiction in cancer cells is mediated by YAP/TAZ through BRD4

Nature Medicine - 17 September 2018 - 12:00am

Transcriptional addiction in cancer cells is mediated by YAP/TAZ through BRD4

Transcriptional addiction in cancer cells is mediated by YAP/TAZ through BRD4, Published online: 17 September 2018; doi:10.1038/s41591-018-0158-8

Interdependence between YAP/TAZ and BRD4 drives transcriptional addiction in cancer cells and determines sensitivity to BET inhibition.
Categories: Medicine

Classification and mutation prediction from non–small cell lung cancer histopathology images using deep learning

Nature Medicine - 17 September 2018 - 12:00am

Classification and mutation prediction from non–small cell lung cancer histopathology images using deep learning

Classification and mutation prediction from non–small cell lung cancer histopathology images using deep learning, Published online: 17 September 2018; doi:10.1038/s41591-018-0177-5

A convolutional neural network model using feature extraction and machine-learning techniques provides a tool for classification of lung cancer histopathology images and predicting mutational status of driver oncogenes
Categories: Medicine

<i>BRAF</i> somatic mutation contributes to intrinsic epileptogenicity in pediatric brain tumors

Nature Medicine - 17 September 2018 - 12:00am

BRAF somatic mutation contributes to intrinsic epileptogenicity in pediatric brain tumors

<i>BRAF</i> somatic mutation contributes to intrinsic epileptogenicity in pediatric brain tumors, Published online: 17 September 2018; doi:10.1038/s41591-018-0172-x

In pediatric brain tumors that are accompanied by epileptic seizures, the BRAF somatic mutation V600E contributes to intrinsic epileptic properties in neurons, which can be suppressed by vemurafenib in mice.
Categories: Medicine

Revising salt consumption

Nature Medicine - 7 September 2018 - 12:00am

Revising salt consumption

Revising salt consumption, Published online: 07 September 2018; doi:10.1038/s41591-018-0193-5

Revising salt consumption
Categories: Medicine

Modeling tumors and their T cell killers

Nature Medicine - 7 September 2018 - 12:00am

Modeling tumors and their T cell killers

Modeling tumors and their T cell killers, Published online: 07 September 2018; doi:10.1038/s41591-018-0189-1

Modeling tumors and their T cell killers
Categories: Medicine

Right data for right patient—a precisionFDA NCI–CPTAC Multi-omics Mislabeling Challenge

Nature Medicine - 7 September 2018 - 12:00am

Right data for right patient—a precisionFDA NCI–CPTAC Multi-omics Mislabeling Challenge

Right data for right patient—a precisionFDA NCI–CPTAC Multi-omics Mislabeling Challenge, Published online: 07 September 2018; doi:10.1038/s41591-018-0180-x

To address a critical roadblock that can occur in translational and clinical research, the National Cancer Institute and the Food and Drug Administration, in coordination with the DREAM Challenges, are launching the first computational challenge using multi-omics datasets to detect and correct specimen mislabeling.
Categories: Medicine

An option for treatment of multidrug-resistant HIV

Nature Medicine - 7 September 2018 - 12:00am

An option for treatment of multidrug-resistant HIV

An option for treatment of multidrug-resistant HIV, Published online: 07 September 2018; doi:10.1038/s41591-018-0191-7

An option for treatment of multidrug-resistant HIV
Categories: Medicine

Preconception cold–induced epigenetic inheritance

Nature Medicine - 7 September 2018 - 12:00am

Preconception cold–induced epigenetic inheritance

Preconception cold–induced epigenetic inheritance, Published online: 07 September 2018; doi:10.1038/s41591-018-0187-3

Preconception cold–induced alterations of sperm DNA methylation result in offspring with altered brown adipose tissue and improved adaptation to overnutrition and hypothermia.
Categories: Medicine

Restoring sight with native cell reprogramming

Nature Medicine - 7 September 2018 - 12:00am

Restoring sight with native cell reprogramming

Restoring sight with native cell reprogramming, Published online: 07 September 2018; doi:10.1038/s41591-018-0192-6

Restoring sight with native cell reprogramming
Categories: Medicine

Clarifying access to data

Nature Medicine - 7 September 2018 - 12:00am

Clarifying access to data

Clarifying access to data, Published online: 07 September 2018; doi:10.1038/s41591-018-0188-2

To facilitate access to and improve the discoverability of the data in our papers, Nature Medicine is making the data availability statement in our papers more prominent and its language more transparent.
Categories: Medicine

Wound, heal thyself

Nature Medicine - 7 September 2018 - 12:00am

Wound, heal thyself

Wound, heal thyself, Published online: 07 September 2018; doi:10.1038/s41591-018-0179-3

An in vivo cellular reprogramming strategy to generate epithelial cells from wound mesenchymal cells promotes healing and provides a new avenue for the treatment of nonhealing wounds.
Categories: Medicine

Modulating NAD<sup>+</sup> metabolism to prevent acute kidney injury

Nature Medicine - 3 September 2018 - 12:00am

Modulating NAD+ metabolism to prevent acute kidney injury

Modulating NAD<sup>+</sup> metabolism to prevent acute kidney injury, Published online: 03 September 2018; doi:10.1038/s41591-018-0181-9

Impaired de novo NAD+ biosynthesis predisposes to acute kidney injury, and augmenting NAD+ metabolism with oral nicotinamide supplementation may prevent acute kidney injury.
Categories: Medicine

A role for chromatin regulatory dynamics in breast cancer evolution

Nature Medicine - 3 September 2018 - 12:00am

A role for chromatin regulatory dynamics in breast cancer evolution

A role for chromatin regulatory dynamics in breast cancer evolution, Published online: 03 September 2018; doi:10.1038/s41591-018-0182-8

Enhancer profiling of breast tumors reveals that chromatin regulatory elements contribute to the clonal fitness landscape, treatment resistance and phenotypic divergence.
Categories: Medicine

New machine-learning technologies for computer-aided diagnosis

Nature Medicine - 3 September 2018 - 12:00am

New machine-learning technologies for computer-aided diagnosis

New machine-learning technologies for computer-aided diagnosis, Published online: 03 September 2018; doi:10.1038/s41591-018-0178-4

Machine learning can be used for computer-aided diagnosis of acute neurological events and retinal disease and can be incorporated into conventional clinical workflows to improve health outcomes.
Categories: Medicine

Route of immunization defines multiple mechanisms of vaccine-mediated protection against SIV

Nature Medicine - 3 September 2018 - 12:00am

Route of immunization defines multiple mechanisms of vaccine-mediated protection against SIV

Route of immunization defines multiple mechanisms of vaccine-mediated protection against SIV, Published online: 03 September 2018; doi:10.1038/s41591-018-0161-0

Distinct routes of immunization elicit different antibody isotypes and functions associated with protection against SIV infection that converge on phagocytosis as a candidate protective mechanism of independent SIV vaccines.
Categories: Medicine

Regional variation limits applications of healthy gut microbiome reference ranges and disease models

Nature Medicine - 27 August 2018 - 12:00am

Regional variation limits applications of healthy gut microbiome reference ranges and disease models

Regional variation limits applications of healthy gut microbiome reference ranges and disease models, Published online: 27 August 2018; doi:10.1038/s41591-018-0164-x

The definition of a 'healthy' microbiome is impacted by geographic regional variations.
Categories: Medicine

Metformin reduces liver glucose production by inhibition of fructose-1-6-bisphosphatase

Nature Medicine - 27 August 2018 - 12:00am

Metformin reduces liver glucose production by inhibition of fructose-1-6-bisphosphatase

Metformin reduces liver glucose production by inhibition of fructose-1-6-bisphosphatase, Published online: 27 August 2018; doi:10.1038/s41591-018-0159-7

The antidiabetic action of metformin raises heptocyte intracellular AMP levels, causing allosteric inhibition of fructose-1,6-bisphosphatase and thus reductions in gluconeogenesis.
Categories: Medicine

Depicting the composition of gut microbiota in a population with varied ethnic origins but shared geography

Nature Medicine - 27 August 2018 - 12:00am

Depicting the composition of gut microbiota in a population with varied ethnic origins but shared geography

Depicting the composition of gut microbiota in a population with varied ethnic origins but shared geography, Published online: 27 August 2018; doi:10.1038/s41591-018-0160-1

Stool microbiota composition correlates with the ethnic backgrounds of people living in the same city, suggesting that geographical location and ethnicity have distinct effects on microbiota.
Categories: Medicine

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