Medicine

Single-cell profiling of breast cancer T cells reveals a tissue-resident memory subset associated with improved prognosis

Nature Medicine - 25 June 2018 - 12:00am

Single-cell profiling of breast cancer T cells reveals a tissue-resident memory subset associated with improved prognosis

Single-cell profiling of breast cancer T cells reveals a tissue-resident memory subset associated with improved prognosis, Published online: 25 June 2018; doi:10.1038/s41591-018-0078-7

Extensive, high-dimensional characterization of T cells in breast cancer reveals activated TRM population and a gene signature associated with improved prognosis.
Categories: Medicine

Genetic deficiency of indoleamine 2,3-dioxygenase promotes gut microbiota-mediated metabolic health

Nature Medicine - 25 June 2018 - 12:00am

Genetic deficiency of indoleamine 2,3-dioxygenase promotes gut microbiota-mediated metabolic health

Genetic deficiency of indoleamine 2,3-dioxygenase promotes gut microbiota-mediated metabolic health, Published online: 25 June 2018; doi:10.1038/s41591-018-0060-4

Indoleamine 2,3-dioxygenase normally suppresses inflammation, but knockout of its gene is metabolically beneficial as its depletion reshapes the gut microbiota.
Categories: Medicine

A natural killer–dendritic cell axis defines checkpoint therapy–responsive tumor microenvironments

Nature Medicine - 25 June 2018 - 12:00am

A natural killer–dendritic cell axis defines checkpoint therapy–responsive tumor microenvironments

A natural killer–dendritic cell axis defines checkpoint therapy–responsive tumor microenvironments, Published online: 25 June 2018; doi:10.1038/s41591-018-0085-8

Cross-talk between innate immune cells helps to enhance the antitumor T cell response during checkpoint blockade therapy.
Categories: Medicine

A human anti-IL-2 antibody that potentiates regulatory T cells by a structure-based mechanism

Nature Medicine - 25 June 2018 - 12:00am

A human anti-IL-2 antibody that potentiates regulatory T cells by a structure-based mechanism

A human anti-IL-2 antibody that potentiates regulatory T cells by a structure-based mechanism, Published online: 25 June 2018; doi:10.1038/s41591-018-0070-2

A human anti-IL-2 antibody that selectively expands regulatory T cells is developed in this study for clinical applications aiming to mitigate autoimmune and inflammatory disorders and to promote transplant tolerance.
Categories: Medicine

F508del-CFTR is not corrected by thymosin α1

Nature Medicine - 25 June 2018 - 12:00am

F508del-CFTR is not corrected by thymosin α1

F508del-CFTR is not corrected by thymosin α1, Published online: 25 June 2018; doi:10.1038/s41591-018-0079-6

F508del-CFTR is not corrected by thymosin α1
Categories: Medicine

Molecular phenomics and metagenomics of hepatic steatosis in non-diabetic obese women

Nature Medicine - 25 June 2018 - 12:00am

Molecular phenomics and metagenomics of hepatic steatosis in non-diabetic obese women

Molecular phenomics and metagenomics of hepatic steatosis in non-diabetic obese women, Published online: 25 June 2018; doi:10.1038/s41591-018-0061-3

Metabolic activity of specific human gut microorganisms contributes to liver steatosis in obese women.
Categories: Medicine

Reply to ‘F508del-CFTR is not corrected by thymosin α1’

Nature Medicine - 25 June 2018 - 12:00am

Reply to ‘F508del-CFTR is not corrected by thymosin α1’

Reply to ‘F508del-CFTR is not corrected by thymosin α1’, Published online: 25 June 2018; doi:10.1038/s41591-018-0080-0

Reply to ‘F508del-CFTR is not corrected by thymosin α1’
Categories: Medicine

Global characterization of T cells in non-small-cell lung cancer by single-cell sequencing

Nature Medicine - 25 June 2018 - 12:00am

Global characterization of T cells in non-small-cell lung cancer by single-cell sequencing

Global characterization of T cells in non-small-cell lung cancer by single-cell sequencing, Published online: 25 June 2018; doi:10.1038/s41591-018-0045-3

Deep single-cell RNA sequencing of tumor-infiltrating T cells in non-small-cell lung cancer identifies features associated with functional states and clinical outcome
Categories: Medicine

Author Correction: Thymosin α1 represents a potential potent single-molecule-based therapy for cystic fibrosis

Nature Medicine - 22 June 2018 - 12:00am

Author Correction: Thymosin α1 represents a potential potent single-molecule-based therapy for cystic fibrosis

Author Correction: Thymosin α1 represents a potential potent single-molecule-based therapy for cystic fibrosis, Published online: 22 June 2018; doi:10.1038/s41591-018-0100-0

Author Correction: Thymosin α1 represents a potential potent single-molecule-based therapy for cystic fibrosis
Categories: Medicine

Publisher Correction: Thymosin α1 represents a potential potent single-molecule-based therapy for cystic fibrosis

Nature Medicine - 22 June 2018 - 12:00am

Publisher Correction: Thymosin α1 represents a potential potent single-molecule-based therapy for cystic fibrosis

Publisher Correction: Thymosin α1 represents a potential potent single-molecule-based therapy for cystic fibrosis, Published online: 22 June 2018; doi:10.1038/s41591-018-0099-2

Publisher Correction: Thymosin α1 represents a potential potent single-molecule-based therapy for cystic fibrosis
Categories: Medicine

Publisher Correction: Stimulation of entorhinal cortex–dentate gyrus circuitry is antidepressive

Nature Medicine - 22 June 2018 - 12:00am

Publisher Correction: Stimulation of entorhinal cortex–dentate gyrus circuitry is antidepressive

Publisher Correction: Stimulation of entorhinal cortex–dentate gyrus circuitry is antidepressive, Published online: 22 June 2018; doi:10.1038/s41591-018-0084-9

Publisher Correction: Stimulation of entorhinal cortex–dentate gyrus circuitry is antidepressive
Categories: Medicine

Author Correction: STAT3 labels a subpopulation of reactive astrocytes required for brain metastasis

Nature Medicine - 19 June 2018 - 12:00am

Author Correction: STAT3 labels a subpopulation of reactive astrocytes required for brain metastasis

Author Correction: STAT3 labels a subpopulation of reactive astrocytes required for brain metastasis, Published online: 19 June 2018; doi:10.1038/s41591-018-0108-5

Author Correction: STAT3 labels a subpopulation of reactive astrocytes required for brain metastasis
Categories: Medicine

Low-frequency cortical activity is a neuromodulatory target that tracks recovery after stroke

Nature Medicine - 18 June 2018 - 12:00am

Low-frequency cortical activity is a neuromodulatory target that tracks recovery after stroke

Low-frequency cortical activity is a neuromodulatory target that tracks recovery after stroke, Published online: 18 June 2018; doi:10.1038/s41591-018-0058-y

Recovery of skilled motor function in rodents after stroke correlates with the restoration of low-frequency quasi-oscillatory activity in the motor cortex, and neuromodulatory electrical stimulation targeting this activity can further accelerate recovery.
Categories: Medicine

Publisher Correction: Targeting hepatic glutaminase activity to ameliorate hyperglycemia

Nature Medicine - 12 June 2018 - 12:00am

Publisher Correction: Targeting hepatic glutaminase activity to ameliorate hyperglycemia

Publisher Correction: Targeting hepatic glutaminase activity to ameliorate hyperglycemia, Published online: 12 June 2018; doi:10.1038/s41591-018-0047-1

Publisher Correction: Targeting hepatic glutaminase activity to ameliorate hyperglycemia
Categories: Medicine

p53 inhibits CRISPR–Cas9 engineering in human pluripotent stem cells

Nature Medicine - 11 June 2018 - 12:00am

p53 inhibits CRISPR–Cas9 engineering in human pluripotent stem cells

p53 inhibits CRISPR–Cas9 engineering in human pluripotent stem cells, Published online: 11 June 2018; doi:10.1038/s41591-018-0050-6

CRISPR–Cas9-induced DNA damage triggers p53 to limit the efficiency of gene editing in human pluripotent cells.
Categories: Medicine

Suppression of detyrosinated microtubules improves cardiomyocyte function in human heart failure

Nature Medicine - 11 June 2018 - 12:00am

Suppression of detyrosinated microtubules improves cardiomyocyte function in human heart failure

Suppression of detyrosinated microtubules improves cardiomyocyte function in human heart failure, Published online: 11 June 2018; doi:10.1038/s41591-018-0046-2

Post-translational modification of microtubules by detyrosination is prevalent in failing human cardiomyocytes and inhibits cardiomyocyte contraction, suggesting a new therapeutic strategy for improving heart function.
Categories: Medicine

STAT3 labels a subpopulation of reactive astrocytes required for brain metastasis

Nature Medicine - 11 June 2018 - 12:00am

STAT3 labels a subpopulation of reactive astrocytes required for brain metastasis

STAT3 labels a subpopulation of reactive astrocytes required for brain metastasis, Published online: 11 June 2018; doi:10.1038/s41591-018-0044-4

Reactive astrocytes expressing STAT3 support the metastatic growth of tumor cells colonizing the brain and can be pharmacologically targeted to improve the clinical management of patients with secondary brain tumors.
Categories: Medicine

CRISPR–Cas9 genome editing induces a p53-mediated DNA damage response

Nature Medicine - 11 June 2018 - 12:00am

CRISPR–Cas9 genome editing induces a p53-mediated DNA damage response

CRISPR–Cas9 genome editing induces a p53-mediated DNA damage response, Published online: 11 June 2018; doi:10.1038/s41591-018-0049-z

CRISPR–Cas9-induced DNA damage triggers p53 to limit the efficiency of gene editing in immortalized human retinal pigment epithelial cells.
Categories: Medicine

Block of A1 astrocyte conversion by microglia is neuroprotective in models of Parkinson’s disease

Nature Medicine - 11 June 2018 - 12:00am

Block of A1 astrocyte conversion by microglia is neuroprotective in models of Parkinson’s disease

Block of A1 astrocyte conversion by microglia is neuroprotective in models of Parkinson’s disease, Published online: 11 June 2018; doi:10.1038/s41591-018-0051-5

Agonism of microglial glucagon-like peptide-1 receptor (GLP1R) using a brain-penetrant peptide prevents the generation of neurotoxic astrocytes and ameliorates disease progression in two rodent models of Parkinson’s disease.
Categories: Medicine

The human heart contains distinct macrophage subsets with divergent origins and functions

Nature Medicine - 11 June 2018 - 12:00am

The human heart contains distinct macrophage subsets with divergent origins and functions

The human heart contains distinct macrophage subsets with divergent origins and functions, Published online: 11 June 2018; doi:10.1038/s41591-018-0059-x

Study of macrophage heterogeneity in human hearts reveals a subset of inflammatory macrophages that is associated with cardiac dysfunction in patients with heart failure.
Categories: Medicine

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