Medicine

Fetal gene therapy for neurodegenerative disease of infants

Nature Medicine - 16 July 2018 - 12:00am

Fetal gene therapy for neurodegenerative disease of infants

Fetal gene therapy for neurodegenerative disease of infants, Published online: 16 July 2018; doi:10.1038/s41591-018-0106-7

In utero GBA gene therapy extends lifespan and provides long-lasting phenotypic amelioration in a mouse model of neuronopathic Gaucher disease. Fetal ultrasound-guided in utero gene vector delivery is also achieved in the non-human primate brain.
Categories: Medicine

Author Correction: Nociceptor sensory neurons suppress neutrophil and γδ T cell responses in bacterial lung infections and lethal pneumonia

Nature Medicine - 16 July 2018 - 12:00am

Author Correction: Nociceptor sensory neurons suppress neutrophil and γδ T cell responses in bacterial lung infections and lethal pneumonia

Author Correction: Nociceptor sensory neurons suppress neutrophil and γδ T cell responses in bacterial lung infections and lethal pneumonia, Published online: 16 July 2018; doi:10.1038/s41591-018-0093-8

Author Correction: Nociceptor sensory neurons suppress neutrophil and γδ T cell responses in bacterial lung infections and lethal pneumonia
Categories: Medicine

A pig model of Huntington’s disease

Nature Medicine - 9 July 2018 - 12:00am

A pig model of Huntington’s disease

A pig model of Huntington’s disease, Published online: 09 July 2018; doi:10.1038/s41591-018-0119-2

A pig model of Huntington’s disease
Categories: Medicine

A path to efficient gene editing

Nature Medicine - 9 July 2018 - 12:00am

A path to efficient gene editing

A path to efficient gene editing, Published online: 09 July 2018; doi:10.1038/s41591-018-0110-y

Signaling by the tumor-suppressor protein p53 antagonizes CRISPR–Cas9 gene editing of human pluripotent stem cells and immortalized human retinal pigment epithelial cells.
Categories: Medicine

Microbiome metabolomics reveals new drivers of human liver steatosis

Nature Medicine - 9 July 2018 - 12:00am

Microbiome metabolomics reveals new drivers of human liver steatosis

Microbiome metabolomics reveals new drivers of human liver steatosis, Published online: 09 July 2018; doi:10.1038/s41591-018-0126-3

An integrative multiomics approach in nondiabetic obese women identifies phenylacetate as a microbial metabolite contributing to the accumulation of lipids in the liver and hence to nonalcoholic steatohepatitis.
Categories: Medicine

Predicting progression to AML

Nature Medicine - 9 July 2018 - 12:00am

Predicting progression to AML

Predicting progression to AML, Published online: 09 July 2018; doi:10.1038/s41591-018-0114-7

The number, identity, and burden of mutations in clonal hematopoiesis are associated with the risk and timing of progression to acute myeloid leukemia.
Categories: Medicine

Author Correction: What models eat

Nature Medicine - 9 July 2018 - 12:00am

Author Correction: What models eat

Author Correction: What models eat, Published online: 09 July 2018; doi:10.1038/s41591-018-0133-4

Author Correction: What models eat
Categories: Medicine

Somatic mutations precede acute myeloid leukemia years before diagnosis

Nature Medicine - 9 July 2018 - 12:00am

Somatic mutations precede acute myeloid leukemia years before diagnosis

Somatic mutations precede acute myeloid leukemia years before diagnosis, Published online: 09 July 2018; doi:10.1038/s41591-018-0081-z

Somatic mutations detected years before diagnosis increase the odds of development of acute myeloid leukemia in women.
Categories: Medicine

Understanding genetic disease with electronic medical records

Nature Medicine - 9 July 2018 - 12:00am

Understanding genetic disease with electronic medical records

Understanding genetic disease with electronic medical records, Published online: 09 July 2018; doi:10.1038/s41591-018-0121-8

Understanding genetic disease with electronic medical records
Categories: Medicine

Senolytics improve physical function and increase lifespan in old age

Nature Medicine - 9 July 2018 - 12:00am

Senolytics improve physical function and increase lifespan in old age

Senolytics improve physical function and increase lifespan in old age, Published online: 09 July 2018; doi:10.1038/s41591-018-0092-9

Transfer of senescent cells into naive, young mice can induce physical dysfunction, and a senolytic can reverse this dysfunction and potently increase lifespan in aged mice.
Categories: Medicine

Metformin reverses established lung fibrosis in a bleomycin model

Nature Medicine - 2 July 2018 - 12:00am

Metformin reverses established lung fibrosis in a bleomycin model

Metformin reverses established lung fibrosis in a bleomycin model, Published online: 02 July 2018; doi:10.1038/s41591-018-0087-6

Metformin reverses established lung fibrosis in a bleomycin model in mice.
Categories: Medicine

Author Correction: High-dimensional single-cell analysis predicts response to anti-PD-1 immunotherapy

Nature Medicine - 2 July 2018 - 12:00am

Author Correction: High-dimensional single-cell analysis predicts response to anti-PD-1 immunotherapy

Author Correction: High-dimensional single-cell analysis predicts response to anti-PD-1 immunotherapy, Published online: 02 July 2018; doi:10.1038/s41591-018-0094-7

Author Correction: High-dimensional single-cell analysis predicts response to anti-PD-1 immunotherapy
Categories: Medicine

Miscarriage and stillbirth following maternal Zika virus infection in nonhuman primates

Nature Medicine - 2 July 2018 - 12:00am

Miscarriage and stillbirth following maternal Zika virus infection in nonhuman primates

Miscarriage and stillbirth following maternal Zika virus infection in nonhuman primates, Published online: 02 July 2018; doi:10.1038/s41591-018-0088-5

Zika virus infection during pregnancy is associated with an increased rate of fetal loss in nonhuman primates, as reported in this multicenter analysis.
Categories: Medicine

DPP8/DPP9 inhibitor-induced pyroptosis for treatment of acute myeloid leukemia

Nature Medicine - 2 July 2018 - 12:00am

DPP8/DPP9 inhibitor-induced pyroptosis for treatment of acute myeloid leukemia

DPP8/DPP9 inhibitor-induced pyroptosis for treatment of acute myeloid leukemia, Published online: 02 July 2018; doi:10.1038/s41591-018-0082-y

Small-molecule inhibitors of the serine dipeptidases DPP8 and DPP9 block AML progression by promoting CARD8-dependent pyroptosis of leukemic myeloid cells.
Categories: Medicine

Functional diversity and cooperativity between subclonal populations of pediatric glioblastoma and diffuse intrinsic pontine glioma cells

Nature Medicine - 2 July 2018 - 12:00am

Functional diversity and cooperativity between subclonal populations of pediatric glioblastoma and diffuse intrinsic pontine glioma cells

Functional diversity and cooperativity between subclonal populations of pediatric glioblastoma and diffuse intrinsic pontine glioma cells, Published online: 02 July 2018; doi:10.1038/s41591-018-0086-7

Genomic and functional analysis of intratumor heterogeneity in pediatric glioma uncovers early clonal divergence and stable spontaneous cooperation between subclonal populations throughout tumor evolution.
Categories: Medicine

Mechanisms of NAFLD development and therapeutic strategies

Nature Medicine - 2 July 2018 - 12:00am

Mechanisms of NAFLD development and therapeutic strategies

Mechanisms of NAFLD development and therapeutic strategies, Published online: 02 July 2018; doi:10.1038/s41591-018-0104-9

Understanding of pathogenic mechanisms and clinical features of NAFLD is driving progress in therapeutic strategies now in clinical trials.
Categories: Medicine

Author Correction: Molecular subtypes of diffuse large B cell lymphoma are associated with distinct pathogenic mechanisms and outcomes

Nature Medicine - 28 June 2018 - 12:00am

Author Correction: Molecular subtypes of diffuse large B cell lymphoma are associated with distinct pathogenic mechanisms and outcomes

Author Correction: Molecular subtypes of diffuse large B cell lymphoma are associated with distinct pathogenic mechanisms and outcomes, Published online: 28 June 2018; doi:10.1038/s41591-018-0097-4

Author Correction: Molecular subtypes of diffuse large B cell lymphoma are associated with distinct pathogenic mechanisms and outcomes
Categories: Medicine

Publisher Correction: Molecular subtypes of diffuse large B cell lymphoma are associated with distinct pathogenic mechanisms and outcomes

Nature Medicine - 28 June 2018 - 12:00am

Publisher Correction: Molecular subtypes of diffuse large B cell lymphoma are associated with distinct pathogenic mechanisms and outcomes

Publisher Correction: Molecular subtypes of diffuse large B cell lymphoma are associated with distinct pathogenic mechanisms and outcomes, Published online: 28 June 2018; doi:10.1038/s41591-018-0098-3

Publisher Correction: Molecular subtypes of diffuse large B cell lymphoma are associated with distinct pathogenic mechanisms and outcomes
Categories: Medicine

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