Medicine

Elevated prenatal anti-Müllerian hormone reprograms the fetus and induces polycystic ovary syndrome in adulthood

Nature Medicine - 14 May 2018 - 12:00am

Elevated prenatal anti-Müllerian hormone reprograms the fetus and induces polycystic ovary syndrome in adulthood

Elevated prenatal anti-Müllerian hormone reprograms the fetus and induces polycystic ovary syndrome in adulthood, Published online: 14 May 2018; doi:10.1038/s41591-018-0035-5

Excess anti-Müllerian hormone during pregnancy results in polycystic ovary syndrome-like phenotypes in female offspring, possibly explaining its pathogenesis as well as suggesting a possible therapy.
Categories: Medicine

Sleeper cells

Nature Medicine - 7 May 2018 - 12:00am

Sleeper cells

Sleeper cells, Published online: 07 May 2018; doi:10.1038/s41591-018-0039-1

New studies question how HIV persists in the body
Categories: Medicine

CAR T cells for childhood diffuse midline gliomas

Nature Medicine - 7 May 2018 - 12:00am

CAR T cells for childhood diffuse midline gliomas

CAR T cells for childhood diffuse midline gliomas, Published online: 07 May 2018; doi:10.1038/s41591-018-0031-9

Anti-GD2 chimeric antigen receptor (CAR)-modified T cells may be a new and innovative approach for the treatment of pediatric H3-K27M-mutant diffuse midline gliomas.
Categories: Medicine

Adrenergic nerve degeneration in bone marrow drives aging of the hematopoietic stem cell niche

Nature Medicine - 7 May 2018 - 12:00am

Adrenergic nerve degeneration in bone marrow drives aging of the hematopoietic stem cell niche

Adrenergic nerve degeneration in bone marrow drives aging of the hematopoietic stem cell niche, Published online: 07 May 2018; doi:10.1038/s41591-018-0030-x

Loss of sympathetic nerve innervention of the bone marrow contributes to the aging of hematopoietic stem cells, which can be rejuvenated using an adrenergic receptor agonist.
Categories: Medicine

Targeting metabolism to treat psoriasis

Nature Medicine - 7 May 2018 - 12:00am

Targeting metabolism to treat psoriasis

Targeting metabolism to treat psoriasis, Published online: 07 May 2018; doi:10.1038/s41591-018-0027-5

A crucial role for glucose metabolism has been identified in wound repair and in the pathogenesis of chronic inflammatory skin diseases, indicating that targeting metabolism is an approach for treating psoriasis.
Categories: Medicine

MC4R agonism promotes durable weight loss in patients with leptin receptor deficiency

Nature Medicine - 7 May 2018 - 12:00am

MC4R agonism promotes durable weight loss in patients with leptin receptor deficiency

MC4R agonism promotes durable weight loss in patients with leptin receptor deficiency, Published online: 07 May 2018; doi:10.1038/s41591-018-0015-9

Treatment with setmelanotide, a new-generation MC4R agonist, provides durable weight loss in hyperphagic, leptin receptor–deficient patients, suggesting a pharmacological avenue to treat patients with various MC4R pathway defects.
Categories: Medicine

Redefining <i>Medicine</i>

Nature Medicine - 7 May 2018 - 12:00am

Redefining Medicine

Redefining <i>Medicine</i>, Published online: 07 May 2018; doi:10.1038/s41591-018-0037-3

For more than two decades, Nature Medicine has been the prime venue for publication of outstanding work in the translational space. Now the journal’s scope is evolving to embrace the clinical research that meets the challenges and complexities of contemporary medicine.
Categories: Medicine

ARID1A deficiency promotes mutability and potentiates therapeutic antitumor immunity unleashed by immune checkpoint blockade

Nature Medicine - 7 May 2018 - 12:00am

ARID1A deficiency promotes mutability and potentiates therapeutic antitumor immunity unleashed by immune checkpoint blockade

ARID1A deficiency promotes mutability and potentiates therapeutic antitumor immunity unleashed by immune checkpoint blockade, Published online: 07 May 2018; doi:10.1038/s41591-018-0012-z

Loss of mismatch-repair protein ARID1A in cancer correlates with high mutation load & checkpoint blockade response, complementing MSI-based prognosis.
Categories: Medicine

The best Cas scenario

Nature Medicine - 7 May 2018 - 12:00am

The best Cas scenario

The best Cas scenario, Published online: 07 May 2018; doi:10.1038/s41591-018-0038-2

Finding poetry in gene editing and ways to improve it
Categories: Medicine

<i>PM20D1</i> is a quantitative trait locus associated with Alzheimer’s disease

Nature Medicine - 7 May 2018 - 12:00am

PM20D1 is a quantitative trait locus associated with Alzheimer’s disease

<i>PM20D1</i> is a quantitative trait locus associated with Alzheimer’s disease, Published online: 07 May 2018; doi:10.1038/s41591-018-0013-y

Expression of PM20D1 is regulated by long-range chromatin interactions with an Alzheimer’s disease risk haplotype, and PM20D1 overexpression reduces AD-like pathology and cognitive impairment in a rodent model.
Categories: Medicine

Carboplatin in <i>BRCA1/2</i>-mutated and triple-negative breast cancer BRCAness subgroups: the TNT Trial

Nature Medicine - 30 April 2018 - 12:00am

Carboplatin in BRCA1/2-mutated and triple-negative breast cancer BRCAness subgroups: the TNT Trial

Carboplatin in <i>BRCA1/2</i>-mutated and triple-negative breast cancer BRCAness subgroups: the TNT Trial, Published online: 30 April 2018; doi:10.1038/s41591-018-0009-7

The phase 3 TNT Trial in subjects with triple-negative breast cancer supports the superiority of carboplatin over docetaxel in BRCA1/2-mutated tumors and a greater response to taxanes in the nonbasal subtype.
Categories: Medicine

Determinants of response and resistance to CD19 chimeric antigen receptor (CAR) T cell therapy of chronic lymphocytic leukemia

Nature Medicine - 30 April 2018 - 12:00am

Determinants of response and resistance to CD19 chimeric antigen receptor (CAR) T cell therapy of chronic lymphocytic leukemia

Determinants of response and resistance to CD19 chimeric antigen receptor (CAR) T cell therapy of chronic lymphocytic leukemia, Published online: 30 April 2018; doi:10.1038/s41591-018-0010-1

An IL-6/STAT3 signature and memory CD8 T cell subset in preinfusion chimeric antigen receptor–expressing T cells associate with response in patients with high-risk chronic lymphocytic leukemia.
Categories: Medicine

Molecular subtypes of diffuse large B cell lymphoma are associated with distinct pathogenic mechanisms and outcomes

Nature Medicine - 30 April 2018 - 12:00am

Molecular subtypes of diffuse large B cell lymphoma are associated with distinct pathogenic mechanisms and outcomes

Molecular subtypes of diffuse large B cell lymphoma are associated with distinct pathogenic mechanisms and outcomes, Published online: 30 April 2018; doi:10.1038/s41591-018-0016-8

Comprehensive integration of mutational and structural alterations in clinically-annotated DLBCL patient samples provides a novel molecular classification of the disease.
Categories: Medicine

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