Medicine

Meta-analysis of fecal metagenomes reveals global microbial signatures that are specific for colorectal cancer

Nature Medicine - 1 April 2019 - 12:00am

Meta-analysis of fecal metagenomes reveals global microbial signatures that are specific for colorectal cancer

Meta-analysis of fecal metagenomes reveals global microbial signatures that are specific for colorectal cancer, Published online: 01 April 2019; doi:10.1038/s41591-019-0406-6

Cross-study analysis defines fecal microbial species associated with colorectal cancer.
Categories: Medicine

Intracellular MLCK1 diversion reverses barrier loss to restore mucosal homeostasis

Nature Medicine - 1 April 2019 - 12:00am

Intracellular MLCK1 diversion reverses barrier loss to restore mucosal homeostasis

Intracellular MLCK1 diversion reverses barrier loss to restore mucosal homeostasis, Published online: 01 April 2019; doi:10.1038/s41591-019-0393-7

A small molecule that restores the integrity of the intestinal barrier provides a novel therapeutic strategy for inflammatory bowel diseases.
Categories: Medicine

A new approach for inflammatory bowel disease therapy

Nature Medicine - 1 April 2019 - 12:00am

A new approach for inflammatory bowel disease therapy

A new approach for inflammatory bowel disease therapy, Published online: 01 April 2019; doi:10.1038/s41591-019-0416-4

A new drug restores a compromised intestinal barrier and ameliorates colitis in mice by modulating paracellular permeability through a newly discovered mechanism.
Categories: Medicine

Metagenomic analysis of colorectal cancer datasets identifies cross-cohort microbial diagnostic signatures and a link with choline degradation

Nature Medicine - 1 April 2019 - 12:00am

Metagenomic analysis of colorectal cancer datasets identifies cross-cohort microbial diagnostic signatures and a link with choline degradation

Metagenomic analysis of colorectal cancer datasets identifies cross-cohort microbial diagnostic signatures and a link with choline degradation, Published online: 01 April 2019; doi:10.1038/s41591-019-0405-7

Multicohort analysis identifies microbial signatures of colorectal cancer in fecal microbiomes.
Categories: Medicine

Broadly neutralizing anti-HIV-1 monoclonal antibodies in the clinic

Nature Medicine - 1 April 2019 - 12:00am

Broadly neutralizing anti-HIV-1 monoclonal antibodies in the clinic

Broadly neutralizing anti-HIV-1 monoclonal antibodies in the clinic, Published online: 01 April 2019; doi:10.1038/s41591-019-0412-8

Broadly neutralizing antibodies have the potential to clear HIV and prevent further infection, as shown in emerging clinical studies.
Categories: Medicine

Publisher Correction: Spreading the search

Nature Medicine - 1 April 2019 - 12:00am

Publisher Correction: Spreading the search

Publisher Correction: Spreading the search, Published online: 01 April 2019; doi:10.1038/s41591-019-0438-y

Publisher Correction: Spreading the search
Categories: Medicine

Publisher Correction: Protective autophagy elicited by RAF→MEK→ERK inhibition suggests a treatment strategy for RAS-driven cancers

Nature Medicine - 27 March 2019 - 12:00am

Publisher Correction: Protective autophagy elicited by RAF→MEK→ERK inhibition suggests a treatment strategy for RAS-driven cancers

Publisher Correction: Protective autophagy elicited by RAF→MEK→ERK inhibition suggests a treatment strategy for RAS-driven cancers, Published online: 27 March 2019; doi:10.1038/s41591-019-0433-3

Publisher Correction: Protective autophagy elicited by RAF→MEK→ERK inhibition suggests a treatment strategy for RAS-driven cancers
Categories: Medicine

A fresh look at adult neurogenesis

Nature Medicine - 25 March 2019 - 12:00am

A fresh look at adult neurogenesis

A fresh look at adult neurogenesis, Published online: 25 March 2019; doi:10.1038/s41591-019-0408-4

Improved protocols for the visualization of immature neurons in the human brain provide evidence for generation of neurons in the adult hippocampus and uncover reduced neurogenesis in Alzheimer’s disease.
Categories: Medicine

Distinct phenotype of CD4<sup>+</sup> T cells driving celiac disease identified in multiple autoimmune conditions

Nature Medicine - 25 March 2019 - 12:00am

Distinct phenotype of CD4+ T cells driving celiac disease identified in multiple autoimmune conditions

Distinct phenotype of CD4<sup>+</sup> T cells driving celiac disease identified in multiple autoimmune conditions, Published online: 25 March 2019; doi:10.1038/s41591-019-0403-9

Mass cytometry identifies a unique phenotype enriched in CD4+ T cells isolated from autoimmune disease patients.
Categories: Medicine

Divergent effects of lipids on stroke

Nature Medicine - 25 March 2019 - 12:00am

Divergent effects of lipids on stroke

Divergent effects of lipids on stroke, Published online: 25 March 2019; doi:10.1038/s41591-019-0413-7

A large study provides causal evidence of the opposing effects of plasma low-density lipoprotein (LDL) levels on ischemic and hemorrhagic stroke in a Chinese population and suggests there is a a net benefit associated with LDL lowering.
Categories: Medicine

Immune signature drives leukemia escape and relapse after hematopoietic cell transplantation

Nature Medicine - 25 March 2019 - 12:00am

Immune signature drives leukemia escape and relapse after hematopoietic cell transplantation

Immune signature drives leukemia escape and relapse after hematopoietic cell transplantation, Published online: 25 March 2019; doi:10.1038/s41591-019-0400-z

Post-transplantation relapse in acute myeloid leukemia patients without genomic loss of HLA is driven by transcriptional alterations in antigen presentation and T cell costimulation genes.
Categories: Medicine

Adult hippocampal neurogenesis is abundant in neurologically healthy subjects and drops sharply in patients with Alzheimer’s disease

Nature Medicine - 25 March 2019 - 12:00am

Adult hippocampal neurogenesis is abundant in neurologically healthy subjects and drops sharply in patients with Alzheimer’s disease

Adult hippocampal neurogenesis is abundant in neurologically healthy subjects and drops sharply in patients with Alzheimer’s disease, Published online: 25 March 2019; doi:10.1038/s41591-019-0375-9

Newborn neurons are continuously incorporated into the healthy adult human hippocampus up to the ninth decade of life. However, robust adult hippocampal neurogenesis sharply declines during the progression of Alzheimer’s disease.
Categories: Medicine

Highly efficient therapeutic gene editing of human hematopoietic stem cells

Nature Medicine - 25 March 2019 - 12:00am

Highly efficient therapeutic gene editing of human hematopoietic stem cells

Highly efficient therapeutic gene editing of human hematopoietic stem cells, Published online: 25 March 2019; doi:10.1038/s41591-019-0401-y

Optimized conditions for ribonucleoprotein delivery of Cas9–sgRNA complexes enables precise and efficient gene editing to restore fetal hemoglobin expression in sickle cell disease patient-derived HSCs
Categories: Medicine

Author Correction: Adrenergic nerve degeneration in bone marrow drives aging of the hematopoietic stem cell niche

Nature Medicine - 22 March 2019 - 12:00am

Author Correction: Adrenergic nerve degeneration in bone marrow drives aging of the hematopoietic stem cell niche

Author Correction: Adrenergic nerve degeneration in bone marrow drives aging of the hematopoietic stem cell niche, Published online: 22 March 2019; doi:10.1038/s41591-019-0425-3

Author Correction: Adrenergic nerve degeneration in bone marrow drives aging of the hematopoietic stem cell niche
Categories: Medicine

<i>The promise of real-world data</i>

Nature Medicine - 20 March 2019 - 12:00am

The promise of real-world data

<i>The promise of real-world data</i>, Published online: 20 March 2019; doi:10.1038/d41591-019-00010-z

We discussed with five scientists what the sources and roles of real-world evidence are, how we can use such data in clinical trials and how these data can be converted into useful information that can impact patient management and regulatory decisions in oncology.
Categories: Medicine

The repertoire of maternal anti-viral antibodies in human newborns

Nature Medicine - 18 March 2019 - 12:00am

The repertoire of maternal anti-viral antibodies in human newborns

The repertoire of maternal anti-viral antibodies in human newborns, Published online: 18 March 2019; doi:10.1038/s41591-019-0392-8

A longitudinal survey of maternal antiviral antibodies in newborns provides a blueprint for understanding infectious disease susceptibility and vaccine development, and inform vaccine scheduling in newborn children.
Categories: Medicine

Transplant success reignites interest in reprogramming cells against HIV

Nature Medicine - 14 March 2019 - 12:00am

Transplant success reignites interest in reprogramming cells against HIV

Transplant success reignites interest in reprogramming cells against HIV, Published online: 14 March 2019; doi:10.1038/d41591-019-00011-y

Editing cells to lack the CCR5 receptor may prove more feasible for more people.
Categories: Medicine

Causal associations of blood lipids with risk of ischemic stroke and intracerebral hemorrhage in Chinese adults

Nature Medicine - 11 March 2019 - 12:00am

Causal associations of blood lipids with risk of ischemic stroke and intracerebral hemorrhage in Chinese adults

Causal associations of blood lipids with risk of ischemic stroke and intracerebral hemorrhage in Chinese adults, Published online: 11 March 2019; doi:10.1038/s41591-019-0366-x

In a nested case-control study from the China Kadoorie Biobank, lowering blood low-density lipoprotein cholesterol levels confers lower risk for ischemic stroke but elevated risk for intracerebral hemorrhage, which was confirmed by genetic Mendelian randomization analyses.
Categories: Medicine

Altered neuronal migratory trajectories in human cerebral organoids derived from individuals with neuronal heterotopia

Nature Medicine - 11 March 2019 - 12:00am

Altered neuronal migratory trajectories in human cerebral organoids derived from individuals with neuronal heterotopia

Altered neuronal migratory trajectories in human cerebral organoids derived from individuals with neuronal heterotopia, Published online: 11 March 2019; doi:10.1038/s41591-019-0371-0

iPSC-derived brain organoids from patients with neurodevelopmental disease reveal dysfunction in neural progenitors underlying impaired migration of developing neurons in periventricular heterotopia.
Categories: Medicine

Publisher Correction: Microbial network disturbances in relapsing refractory Crohn’s disease

Nature Medicine - 7 March 2019 - 12:00am

Publisher Correction: Microbial network disturbances in relapsing refractory Crohn’s disease

Publisher Correction: Microbial network disturbances in relapsing refractory Crohn’s disease, Published online: 07 March 2019; doi:10.1038/s41591-019-0411-9

Publisher Correction: Microbial network disturbances in relapsing refractory Crohn’s disease
Categories: Medicine

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