Medicine

Rapid HIV RNA rebound after antiretroviral treatment interruption in persons durably suppressed in Fiebig I acute HIV infection

Nature Medicine - 11 June 2018 - 12:00am

Rapid HIV RNA rebound after antiretroviral treatment interruption in persons durably suppressed in Fiebig I acute HIV infection

Rapid HIV RNA rebound after antiretroviral treatment interruption in persons durably suppressed in Fiebig I acute HIV infection, Published online: 11 June 2018; doi:10.1038/s41591-018-0026-6

Initiation of antiretroviral therapy in the first 2 weeks of HIV infection fails to prevent resurgence of virus after stopping treatment, indicating early establishment of a resilient viral reservoir.
Categories: Medicine

An inhibitor of oxidative phosphorylation exploits cancer vulnerability

Nature Medicine - 11 June 2018 - 12:00am

An inhibitor of oxidative phosphorylation exploits cancer vulnerability

An inhibitor of oxidative phosphorylation exploits cancer vulnerability, Published online: 11 June 2018; doi:10.1038/s41591-018-0052-4

A new inhibitor targeting the mitochondrial complex I shows antitumor activity in preclinical models of acute myeloid leukemia and glioblastoma relying on oxidative phosphorylation.
Categories: Medicine

Reducing diabetes risk at an early age

Nature Medicine - 6 June 2018 - 12:00am

Reducing diabetes risk at an early age

Reducing diabetes risk at an early age, Published online: 06 June 2018; doi:10.1038/s41591-018-0067-x

A large retrospective study involving 62,565 Danish men shows that those who have been overweight in childhood have a lower risk of having type 2 diabetes in adulthood if they had remission of overweight before 13 years of age.
Categories: Medicine

Tracing clear cell renal carcinoma evolution

Nature Medicine - 6 June 2018 - 12:00am

Tracing clear cell renal carcinoma evolution

Tracing clear cell renal carcinoma evolution, Published online: 06 June 2018; doi:10.1038/s41591-018-0074-y

Tracing clear cell renal carcinoma evolution
Categories: Medicine

Potential and ethics

Nature Medicine - 6 June 2018 - 12:00am

Potential and ethics

Potential and ethics, Published online: 06 June 2018; doi:10.1038/s41591-018-0072-0

With the ongoing demand for assisted reproduction, the need and ability to study the fundamentals of human reproduction at a cellular level have never been greater. At this juncture, we join other Nature Research Journals in formalizing our ethical guidelines for papers in this growing field.
Categories: Medicine

About time

Nature Medicine - 6 June 2018 - 12:00am

About time

About time, Published online: 06 June 2018; doi:10.1038/s41591-018-0069-8

Chronotherapy looks beyond to treating more than just cancer
Categories: Medicine

Training neuropathology

Nature Medicine - 6 June 2018 - 12:00am

Training neuropathology

Training neuropathology, Published online: 06 June 2018; doi:10.1038/s41591-018-0076-9

Training neuropathology
Categories: Medicine

Zika virus shedding in semen

Nature Medicine - 6 June 2018 - 12:00am

Zika virus shedding in semen

Zika virus shedding in semen, Published online: 06 June 2018; doi:10.1038/s41591-018-0075-x

Zika virus shedding in semen
Categories: Medicine

Metastatic cancers promote cachexia through ZIP14 upregulation in skeletal muscle

Nature Medicine - 6 June 2018 - 12:00am

Metastatic cancers promote cachexia through ZIP14 upregulation in skeletal muscle

Metastatic cancers promote cachexia through ZIP14 upregulation in skeletal muscle, Published online: 06 June 2018; doi:10.1038/s41591-018-0054-2

Accumulation of zinc in muscle cells resulting from transcriptional upregulation of metal transporter ZIP14 causes muscle atrophy and promotes cachexia in metastatic cancer.
Categories: Medicine

Intersection of schizophrenia genetics and placental complications

Nature Medicine - 6 June 2018 - 12:00am

Intersection of schizophrenia genetics and placental complications

Intersection of schizophrenia genetics and placental complications, Published online: 06 June 2018; doi:10.1038/s41591-018-0066-y

Genetic risk scores in schizophrenia are influenced by pregnancy complications that compromise the placenta, enhancing association of genes involved in metabolism and cellular stress with schizophrenia risk.
Categories: Medicine

Clinical activity and molecular correlates of response to atezolizumab alone or in combination with bevacizumab versus sunitinib in renal cell carcinoma

Nature Medicine - 4 June 2018 - 12:00am

Clinical activity and molecular correlates of response to atezolizumab alone or in combination with bevacizumab versus sunitinib in renal cell carcinoma

Clinical activity and molecular correlates of response to atezolizumab alone or in combination with bevacizumab versus sunitinib in renal cell carcinoma, Published online: 04 June 2018; doi:10.1038/s41591-018-0053-3

An exploratory randomized controlled clinical trial of renal cell carcinoma identifies molecular patterns distinguishing responders to immune checkpoint blockade alone or combined with angiogenesis inhibitor versus angiogenesis inhibitor alone.
Categories: Medicine

Targeting the cancer mutanome of breast cancer

Nature Medicine - 4 June 2018 - 12:00am

Targeting the cancer mutanome of breast cancer

Targeting the cancer mutanome of breast cancer, Published online: 04 June 2018; doi:10.1038/s41591-018-0065-z

A metastatic hormone receptor–positive breast cancer, usually resistant to immunotherapy, is successfully treated with tumor-infiltrating lymphocytes enriched for neoantigen reactivity, underscoring the broad potential of this immunotherapeutic approach.
Categories: Medicine

Therapeutic and protective efficacy of a dengue antibody against Zika infection in rhesus monkeys

Nature Medicine - 4 June 2018 - 12:00am

Therapeutic and protective efficacy of a dengue antibody against Zika infection in rhesus monkeys

Therapeutic and protective efficacy of a dengue antibody against Zika infection in rhesus monkeys, Published online: 04 June 2018; doi:10.1038/s41591-018-0056-0

A single monoclonal antibody is therapeutic and has prophylactic activity against Zika virus in monkeys.
Categories: Medicine

Wang et al. reply

Nature Medicine - 4 June 2018 - 12:00am

Wang et al. reply

Wang et al. reply, Published online: 04 June 2018; doi:10.1038/s41591-018-0063-1

Wang et al. reply
Categories: Medicine

Epitope-based vaccine design yields fusion peptide-directed antibodies that neutralize diverse strains of HIV-1

Nature Medicine - 4 June 2018 - 12:00am

Epitope-based vaccine design yields fusion peptide-directed antibodies that neutralize diverse strains of HIV-1

Epitope-based vaccine design yields fusion peptide-directed antibodies that neutralize diverse strains of HIV-1, Published online: 04 June 2018; doi:10.1038/s41591-018-0042-6

An alternative HIV vaccine design facilitates generation of HIV-1-antibodies, with promising neutralization breadth in rodents and nonhuman primates.
Categories: Medicine

Myeloid cell contributions to cardiovascular health and disease

Nature Medicine - 4 June 2018 - 12:00am

Myeloid cell contributions to cardiovascular health and disease

Myeloid cell contributions to cardiovascular health and disease, Published online: 04 June 2018; doi:10.1038/s41591-018-0064-0

The precise link between macrophages and cardiovascular disease is emerging from mouse studies and clinical trials, providing new therapeutic avenues.
Categories: Medicine

Immune recognition of somatic mutations leading to complete durable regression in metastatic breast cancer

Nature Medicine - 4 June 2018 - 12:00am

Immune recognition of somatic mutations leading to complete durable regression in metastatic breast cancer

Immune recognition of somatic mutations leading to complete durable regression in metastatic breast cancer, Published online: 04 June 2018; doi:10.1038/s41591-018-0040-8

Adoptive T cell therapy induced complete and durable remission in a patient with refractory metastatic breast cancer, providing proof of principle for this approach in breast cancer therapy.
Categories: Medicine

Inactivating hepatic follistatin alleviates hyperglycemia

Nature Medicine - 4 June 2018 - 12:00am

Inactivating hepatic follistatin alleviates hyperglycemia

Inactivating hepatic follistatin alleviates hyperglycemia, Published online: 04 June 2018; doi:10.1038/s41591-018-0048-0

Follistatin acts as a hepatokine to induce insulin resistance and can be targeted to improve diabetes in mice.
Categories: Medicine

Modeling cytokine release syndrome

Nature Medicine - 28 May 2018 - 12:00am

Modeling cytokine release syndrome

Modeling cytokine release syndrome, Published online: 28 May 2018; doi:10.1038/s41591-018-0068-9

Complete leukemic responses to chimeric antigen receptor–modified T cells are invariably accompanied by severe toxicity. Recently developed animal models allow mechanistic dissection and prevention of toxicity without loss of therapeutic benefit.
Categories: Medicine

Convergence of placenta biology and genetic risk for schizophrenia

Nature Medicine - 28 May 2018 - 12:00am

Convergence of placenta biology and genetic risk for schizophrenia

Convergence of placenta biology and genetic risk for schizophrenia, Published online: 28 May 2018; doi:10.1038/s41591-018-0021-y

Early-life complications modulate the association of genomic risk and schizophrenia.
Categories: Medicine

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