Medicine

Tumor-educated B cells selectively promote breast cancer lymph node metastasis by HSPA4-targeting IgG

Nature Medicine - 14 January 2019 - 12:00am

Tumor-educated B cells selectively promote breast cancer lymph node metastasis by HSPA4-targeting IgG

Tumor-educated B cells selectively promote breast cancer lymph node metastasis by HSPA4-targeting IgG, Published online: 14 January 2019; doi:10.1038/s41591-018-0309-y

B cells facilitate breast cancer metastasis to lymph nodes through production of antibodies targeting a protein on the surface of cancer cells that stimulates tumor dissemination.
Categories: Medicine

Biomimetic 3D-printed scaffolds for spinal cord injury repair

Nature Medicine - 14 January 2019 - 12:00am

Biomimetic 3D-printed scaffolds for spinal cord injury repair

Biomimetic 3D-printed scaffolds for spinal cord injury repair, Published online: 14 January 2019; doi:10.1038/s41591-018-0296-z

Fast scalable 3D bioprinting generates biocompatible and biomimetic scaffolds to precisely fit the geometries of spinal cord lesions, promote axonal regeneration, and support stem cell grafts to promote recovery from spinal cord injury in rodents.
Categories: Medicine

Translation control of the immune checkpoint in cancer and its therapeutic targeting

Nature Medicine - 14 January 2019 - 12:00am

Translation control of the immune checkpoint in cancer and its therapeutic targeting

Translation control of the immune checkpoint in cancer and its therapeutic targeting, Published online: 14 January 2019; doi:10.1038/s41591-018-0321-2

Oncogene cooperation enhances PD-L1 translation to promote immune evasion and metastasis in a novel model of liver cancer.
Categories: Medicine

Full dairy ahead!

Nature Medicine - 7 January 2019 - 12:00am

Full dairy ahead!

Full dairy ahead!, Published online: 07 January 2019; doi:10.1038/s41591-018-0331-0

Full dairy ahead!
Categories: Medicine

Braving the new world of artificial intelligence

Nature Medicine - 7 January 2019 - 12:00am

Braving the new world of artificial intelligence

Braving the new world of artificial intelligence, Published online: 07 January 2019; doi:10.1038/s41591-018-0317-y

Kee Yuan Ngiam is the group chief technology officer at National University Health System, Singapore, and assistant professor at the School of Medicine of the National University of Singapore. His research focuses on the effects of using artificial intelligence in healthcare. He is the 2018 recipient of Singapore’s National Health IT Excellence Award, which recognizes individuals who advanced healthcare through innovation.
Categories: Medicine

High-performance medicine: the convergence of human and artificial intelligence

Nature Medicine - 7 January 2019 - 12:00am

High-performance medicine: the convergence of human and artificial intelligence

High-performance medicine: the convergence of human and artificial intelligence, Published online: 07 January 2019; doi:10.1038/s41591-018-0300-7

Artificial intelligence is beginning to be applied in the medical setting and has potential to improve workflows and errors, impacting patients and clinicians alike.
Categories: Medicine

<i>Medicine</i> in the digital age

Nature Medicine - 7 January 2019 - 12:00am

Medicine in the digital age

<i>Medicine</i> in the digital age, Published online: 07 January 2019; doi:10.1038/s41591-018-0322-1

As Nature Medicine celebrates its 25th anniversary, we bring you a special Focus on Digital Medicine that highlights the new technologies transforming medicine and healthcare, as well as the related regulatory challenges ahead.
Categories: Medicine

Identifying facial phenotypes of genetic disorders using deep learning

Nature Medicine - 7 January 2019 - 12:00am

Identifying facial phenotypes of genetic disorders using deep learning

Identifying facial phenotypes of genetic disorders using deep learning, Published online: 07 January 2019; doi:10.1038/s41591-018-0279-0

A deep-learning algorithm, trained on over 17,000 real-world patient facial images, achieves high accuracy in identifying rare genetic disorders.
Categories: Medicine

Combination therapy

Nature Medicine - 7 January 2019 - 12:00am

Combination therapy

Combination therapy, Published online: 07 January 2019; doi:10.1038/s41591-018-0328-8

Combination therapy
Categories: Medicine

Guidelines for reinforcement learning in healthcare

Nature Medicine - 7 January 2019 - 12:00am

Guidelines for reinforcement learning in healthcare

Guidelines for reinforcement learning in healthcare, Published online: 07 January 2019; doi:10.1038/s41591-018-0310-5

In this Comment, we provide guidelines for reinforcement learning for decisions about patient treatment that we hope will accelerate the rate at which observational cohorts can inform healthcare practice in a safe, risk-conscious manner.
Categories: Medicine

Artificial intelligence for the electrocardiogram

Nature Medicine - 7 January 2019 - 12:00am

Artificial intelligence for the electrocardiogram

Artificial intelligence for the electrocardiogram, Published online: 07 January 2019; doi:10.1038/s41591-018-0306-1

Deep-learning algorithms can be applied to large datasets of electrocardiograms, are capable of identifying abnormal heart rhythms and mechanical dysfunction, and could aid healthcare decisions.
Categories: Medicine

Toward a clearer picture of health

Nature Medicine - 7 January 2019 - 12:00am

Toward a clearer picture of health

Toward a clearer picture of health, Published online: 07 January 2019; doi:10.1038/s41591-018-0318-x

Rima Arnaout is an assistant professor of cardiology and a member of the University of California San Francisco Bakar Computational Health Sciences Institute. She has received a Chan Zuckerberg Biohub Intercampus Research Award, as well as funding support from the US National Institutes of Health and the American Heart Association’s Institute for Precision Cardiovascular Medicine.
Categories: Medicine

Publisher Correction: Myelodysplastic syndrome progression to acute myeloid leukemia at the stem cell level

Nature Medicine - 19 December 2018 - 12:00am

Publisher Correction: Myelodysplastic syndrome progression to acute myeloid leukemia at the stem cell level

Publisher Correction: Myelodysplastic syndrome progression to acute myeloid leukemia at the stem cell level, Published online: 19 December 2018; doi:10.1038/s41591-018-0333-y

Publisher Correction: Myelodysplastic syndrome progression to acute myeloid leukemia at the stem cell level
Categories: Medicine

Artificial intelligence pinpoints nine different abnormalities in head scans

Nature Medicine - 19 December 2018 - 12:00am

Artificial intelligence pinpoints nine different abnormalities in head scans

Artificial intelligence pinpoints nine different abnormalities in head scans, Published online: 19 December 2018; doi:10.1038/d41591-018-00003-4

The new algorithms could help emergency clinics identify serious head trauma cases faster
Categories: Medicine

Publisher Correction: Ultraviolet radiation–induced DNA damage is prognostic for outcome in melanoma

Nature Medicine - 18 December 2018 - 12:00am

Publisher Correction: Ultraviolet radiation–induced DNA damage is prognostic for outcome in melanoma

Publisher Correction: Ultraviolet radiation–induced DNA damage is prognostic for outcome in melanoma, Published online: 18 December 2018; doi:10.1038/s41591-018-0325-y

Publisher Correction: Ultraviolet radiation–induced DNA damage is prognostic for outcome in melanoma
Categories: Medicine

Effect of an intravitreal antisense oligonucleotide on vision in Leber congenital amaurosis due to a photoreceptor cilium defect

Nature Medicine - 17 December 2018 - 12:00am

Effect of an intravitreal antisense oligonucleotide on vision in Leber congenital amaurosis due to a photoreceptor cilium defect

Effect of an intravitreal antisense oligonucleotide on vision in Leber congenital amaurosis due to a photoreceptor cilium defect, Published online: 17 December 2018; doi:10.1038/s41591-018-0295-0

RNA antisense oligonucleotide therapy to restore normal splicing of a ciliopathy gene shows promising safety and efficacy results in a clinical trial to treat a form of childhood blindness.
Categories: Medicine

Calibration of CAR activation potential directs alternative T cell fates and therapeutic potency

Nature Medicine - 17 December 2018 - 12:00am

Calibration of CAR activation potential directs alternative T cell fates and therapeutic potency

Calibration of CAR activation potential directs alternative T cell fates and therapeutic potency, Published online: 17 December 2018; doi:10.1038/s41591-018-0290-5

A novel chimeric antigen receptor (CAR) T cell design improves therapeutic efficacy by balancing effector and memory profiles.
Categories: Medicine

RAF inhibitor PLX8394 selectively disrupts BRAF dimers and RAS-independent BRAF-mutant-driven signaling

Nature Medicine - 17 December 2018 - 12:00am

RAF inhibitor PLX8394 selectively disrupts BRAF dimers and RAS-independent BRAF-mutant-driven signaling

RAF inhibitor PLX8394 selectively disrupts BRAF dimers and RAS-independent BRAF-mutant-driven signaling, Published online: 17 December 2018; doi:10.1038/s41591-018-0274-5

The new RAF inhibitor PLX8394 selectively blocks ERK signaling in tumors driven by class 1 and/or class 2 BRAF mutations and BRAF fusions while maintaining a broad therapeutic window.
Categories: Medicine

Tumor-derived IFN triggers chronic pathway agonism and sensitivity to ADAR loss

Nature Medicine - 17 December 2018 - 12:00am

Tumor-derived IFN triggers chronic pathway agonism and sensitivity to ADAR loss

Tumor-derived IFN triggers chronic pathway agonism and sensitivity to ADAR loss, Published online: 17 December 2018; doi:10.1038/s41591-018-0302-5

RNA editing enzyme ADAR1 is a therapeutic vulnerability in tumors with constitutive cell-autonomous production of interferon-stimulated genes
Categories: Medicine

Author Correction: A human monoclonal antibody prevents malaria infection by targeting a new site of vulnerability on the parasite

Nature Medicine - 14 December 2018 - 12:00am

Author Correction: A human monoclonal antibody prevents malaria infection by targeting a new site of vulnerability on the parasite

Author Correction: A human monoclonal antibody prevents malaria infection by targeting a new site of vulnerability on the parasite, Published online: 14 December 2018; doi:10.1038/s41591-018-0315-0

Author Correction: A human monoclonal antibody prevents malaria infection by targeting a new site of vulnerability on the parasite
Categories: Medicine

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