Medicine

The DNA methylation landscape of glioblastoma disease progression shows extensive heterogeneity in time and space

Nature Medicine - 27 August 2018 - 12:00am

The DNA methylation landscape of glioblastoma disease progression shows extensive heterogeneity in time and space

The DNA methylation landscape of glioblastoma disease progression shows extensive heterogeneity in time and space, Published online: 27 August 2018; doi:10.1038/s41591-018-0156-x

In-depth methylation analysis of formalin-fixed paraffin-embedded glioblastoma samples demonstrates heterogeneity between primary and recurring tumors and enables prediction of composition of the tumor microenvironment and insights into progression.
Categories: Medicine

When the golden years turn blue

Nature Medicine - 23 August 2018 - 12:00am

When the golden years turn blue

When the golden years turn blue, Published online: 23 August 2018; doi:10.1038/s41591-018-0174-8

Evolving research sheds light on a possibly unique form of depression among the elderly.
Categories: Medicine

Just the messenger

Nature Medicine - 23 August 2018 - 12:00am

Just the messenger

Just the messenger, Published online: 23 August 2018; doi:10.1038/s41591-018-0183-7

A new class of therapeutics instruct the body to make its own drugs.
Categories: Medicine

Publisher Correction: Single-cell profiling of breast cancer T cells reveals a tissue-resident memory subset associated with improved prognosis

Nature Medicine - 22 August 2018 - 12:00am

Publisher Correction: Single-cell profiling of breast cancer T cells reveals a tissue-resident memory subset associated with improved prognosis

Publisher Correction: Single-cell profiling of breast cancer T cells reveals a tissue-resident memory subset associated with improved prognosis, Published online: 22 August 2018; doi:10.1038/s41591-018-0176-6

Publisher Correction: Single-cell profiling of breast cancer T cells reveals a tissue-resident memory subset associated with improved prognosis
Categories: Medicine

De novo NAD<sup>+</sup> biosynthetic impairment in acute kidney injury in humans

Nature Medicine - 20 August 2018 - 12:00am

De novo NAD+ biosynthetic impairment in acute kidney injury in humans

De novo NAD<sup>+</sup> biosynthetic impairment in acute kidney injury in humans, Published online: 20 August 2018; doi:10.1038/s41591-018-0138-z

Impaired NAD+ biosynthesis may be a common feature of high-risk hospitalizations for which NAD+ augmentation could improve therapeutic outcome.
Categories: Medicine

Modeling sporadic ALS in iPSC-derived motor neurons identifies a potential therapeutic agent

Nature Medicine - 20 August 2018 - 12:00am

Modeling sporadic ALS in iPSC-derived motor neurons identifies a potential therapeutic agent

Modeling sporadic ALS in iPSC-derived motor neurons identifies a potential therapeutic agent, Published online: 20 August 2018; doi:10.1038/s41591-018-0140-5

iPSC-derived motor neurons from over 30 heterogeneous sporadic ALS cases exhibit pathologies correlated with clinical disease progression, are more similar to FUS/TDP-43 familial ALS than SOD1-ALS and are corrected by repurposing of ropinirole.
Categories: Medicine

Signatures of T cell dysfunction and exclusion predict cancer immunotherapy response

Nature Medicine - 20 August 2018 - 12:00am

Signatures of T cell dysfunction and exclusion predict cancer immunotherapy response

Signatures of T cell dysfunction and exclusion predict cancer immunotherapy response, Published online: 20 August 2018; doi:10.1038/s41591-018-0136-1

An algorithm-selected gene signature focused on tumor immune evasion and suppression predicts response to immune checkpoint blockade in melanoma, exceeding the accuracy of current clinical biomarkers.
Categories: Medicine

Genetically engineered human cortical spheroid models of tuberous sclerosis

Nature Medicine - 20 August 2018 - 12:00am

Genetically engineered human cortical spheroid models of tuberous sclerosis

Genetically engineered human cortical spheroid models of tuberous sclerosis, Published online: 20 August 2018; doi:10.1038/s41591-018-0139-y

CRISPR–Cas9-mediated gene editing of TSC1 and TSC2 in human pluripotent stem cells is used to investigate the contribution of tuberous sclerosis complex–mechanistic target of rapamycin complex 1 signaling to human neural development in two-dimensional monolayer and three-dimensional spheroid models of the neurodevelopmental disorder tuberous sclerosis complex.
Categories: Medicine

Robust prediction of response to immune checkpoint blockade therapy in metastatic melanoma

Nature Medicine - 20 August 2018 - 12:00am

Robust prediction of response to immune checkpoint blockade therapy in metastatic melanoma

Robust prediction of response to immune checkpoint blockade therapy in metastatic melanoma, Published online: 20 August 2018; doi:10.1038/s41591-018-0157-9

A gene signature identified in spontaneously regressing neuroblastoma identifies responders to immune checkpoint blockade among patients with melanoma with accuracy superior to previously reported biomarkers.
Categories: Medicine

Publisher Correction: Inactivating hepatic follistatin alleviates hyperglycemia

Nature Medicine - 15 August 2018 - 12:00am

Publisher Correction: Inactivating hepatic follistatin alleviates hyperglycemia

Publisher Correction: Inactivating hepatic follistatin alleviates hyperglycemia, Published online: 15 August 2018; doi:10.1038/s41591-018-0129-0

Publisher Correction: Inactivating hepatic follistatin alleviates hyperglycemia
Categories: Medicine

Automated deep-neural-network surveillance of cranial images for acute neurologic events

Nature Medicine - 13 August 2018 - 12:00am

Automated deep-neural-network surveillance of cranial images for acute neurologic events

Automated deep-neural-network surveillance of cranial images for acute neurologic events, Published online: 13 August 2018; doi:10.1038/s41591-018-0147-y

A deep-learning algorithm is developed to provide rapid and accurate diagnosis of clinical 3D head CT-scan images to triage and prioritize urgent neurological events, thus potentially accelerating time to diagnosis and care in clinical settings.
Categories: Medicine

Clinically applicable deep learning for diagnosis and referral in retinal disease

Nature Medicine - 13 August 2018 - 12:00am

Clinically applicable deep learning for diagnosis and referral in retinal disease

Clinically applicable deep learning for diagnosis and referral in retinal disease, Published online: 13 August 2018; doi:10.1038/s41591-018-0107-6

A novel deep learning architecture performs device-independent tissue segmentation of clinical 3D retinal images followed by separate diagnostic classification that meets or exceeds human expert clinical diagnoses of retinal disease.
Categories: Medicine

Author Correction: Mutations in the SWI/SNF complex induce a targetable dependence on oxidative phosphorylation in lung cancer

Nature Medicine - 13 August 2018 - 12:00am

Author Correction: Mutations in the SWI/SNF complex induce a targetable dependence on oxidative phosphorylation in lung cancer

Author Correction: Mutations in the SWI/SNF complex induce a targetable dependence on oxidative phosphorylation in lung cancer, Published online: 13 August 2018; doi:10.1038/s41591-018-0173-9

Author Correction: Mutations in the SWI/SNF complex induce a targetable dependence on oxidative phosphorylation in lung cancer
Categories: Medicine

Sequestration of T cells in bone marrow in the setting of glioblastoma and other intracranial tumors

Nature Medicine - 13 August 2018 - 12:00am

Sequestration of T cells in bone marrow in the setting of glioblastoma and other intracranial tumors

Sequestration of T cells in bone marrow in the setting of glioblastoma and other intracranial tumors, Published online: 13 August 2018; doi:10.1038/s41591-018-0135-2

Patients with glioblastoma experience lymphopenia and sequestration of T cells in the bone marrow, which is recapitulated in mice with brain tumors, where the reversible nature of this effect is demonstrated by an approach that enables the efficacy of other immunotherapeutics.
Categories: Medicine

Author Correction: Metformin reverses established lung fibrosis in a bleomycin model

Nature Medicine - 13 August 2018 - 12:00am

Author Correction: Metformin reverses established lung fibrosis in a bleomycin model

Author Correction: Metformin reverses established lung fibrosis in a bleomycin model, Published online: 13 August 2018; doi:10.1038/s41591-018-0170-z

Author Correction: Metformin reverses established lung fibrosis in a bleomycin model
Categories: Medicine

Publisher Correction: Global characterization of T cells in non-small-cell lung cancer by single-cell sequencing

Nature Medicine - 9 August 2018 - 12:00am

Publisher Correction: Global characterization of T cells in non-small-cell lung cancer by single-cell sequencing

Publisher Correction: Global characterization of T cells in non-small-cell lung cancer by single-cell sequencing, Published online: 09 August 2018; doi:10.1038/s41591-018-0167-7

Publisher Correction: Global characterization of T cells in non-small-cell lung cancer by single-cell sequencing
Categories: Medicine

Author Correction: Targeting wild-type <i>KRAS</i>-amplified gastroesophageal cancer through combined MEK and SHP2 inhibition

Nature Medicine - 9 August 2018 - 12:00am

Author Correction: Targeting wild-type KRAS-amplified gastroesophageal cancer through combined MEK and SHP2 inhibition

Author Correction: Targeting wild-type <i>KRAS</i>-amplified gastroesophageal cancer through combined MEK and SHP2 inhibition, Published online: 09 August 2018; doi:10.1038/s41591-018-0168-6

Author Correction: Targeting wild-type KRAS-amplified gastroesophageal cancer through combined MEK and SHP2 inhibition
Categories: Medicine

Publisher Correction: Global characterization of T cells in non-small-cell lung cancer by single-cell sequencing

Nature Medicine - 9 August 2018 - 12:00am

Publisher Correction: Global characterization of T cells in non-small-cell lung cancer by single-cell sequencing

Publisher Correction: Global characterization of T cells in non-small-cell lung cancer by single-cell sequencing, Published online: 09 August 2018; doi:10.1038/s41591-018-0169-5

Publisher Correction: Global characterization of T cells in non-small-cell lung cancer by single-cell sequencing
Categories: Medicine

Author Correction: Cold-induced epigenetic programming of the sperm enhances brown adipose tissue activity in the offspring

Nature Medicine - 7 August 2018 - 12:00am

Author Correction: Cold-induced epigenetic programming of the sperm enhances brown adipose tissue activity in the offspring

Author Correction: Cold-induced epigenetic programming of the sperm enhances brown adipose tissue activity in the offspring, Published online: 07 August 2018; doi:10.1038/s41591-018-0162-z

Author Correction: Cold-induced epigenetic programming of the sperm enhances brown adipose tissue activity in the offspring
Categories: Medicine

Publisher Correction: Cold-induced epigenetic programming of the sperm enhances brown adipose tissue activity in the offspring

Nature Medicine - 7 August 2018 - 12:00am

Publisher Correction: Cold-induced epigenetic programming of the sperm enhances brown adipose tissue activity in the offspring

Publisher Correction: Cold-induced epigenetic programming of the sperm enhances brown adipose tissue activity in the offspring, Published online: 07 August 2018; doi:10.1038/s41591-018-0163-y

Publisher Correction: Cold-induced epigenetic programming of the sperm enhances brown adipose tissue activity in the offspring
Categories: Medicine

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