Medicine

[Department of Error] Department of Error

Lancet - 11 April 2018 - 12:30am
Das P, Horton R. Pollution, health, and the planet: time for decisive action. Lancet 2018; 391: 407–08—In the acknowledgments section of this Comment (published online first on Oct 19, 2017), the Governments of Germany, Norway, and Sweden should have been thanked for their “funding of the report, input, or both”. This correction has been made to the online version as of April 10, 2018.
Categories: Medicine

[Comment] Public Health Science Conference: a call for abstracts

Lancet - 10 April 2018 - 12:30am
We are delighted to invite abstract submissions for Public Health Science: A National Conference Dedicated to New Research in UK Public Health, to be held in Belfast, UK, on Nov 23, 2018. This is our seventh annual conference to showcase the creativity of the public health research community in the UK and Ireland. The conference provides a forum for academics, practitioners, and policy makers to discuss important public health issues, and learn about the latest public health science and its role in advancing and supporting public health practice, policy, and health services.
Categories: Medicine

Corrigendum: Suppression of luteinizing hormone enhances HSC recovery after hematopoietic injury

Nature Medicine - 10 April 2018 - 12:00am

Corrigendum: Suppression of luteinizing hormone enhances HSC recovery after hematopoietic injury

Corrigendum: Suppression of luteinizing hormone enhances HSC recovery after hematopoietic injury, Published online: 10 April 2018; doi:10.1038/nm0418-525b

Corrigendum: Suppression of luteinizing hormone enhances HSC recovery after hematopoietic injury
Categories: Medicine

Corrigendum: Sex-specific transcriptional signatures in human depression

Nature Medicine - 10 April 2018 - 12:00am

Corrigendum: Sex-specific transcriptional signatures in human depression

Corrigendum: Sex-specific transcriptional signatures in human depression, Published online: 10 April 2018; doi:10.1038/nm0418-525d

Corrigendum: Sex-specific transcriptional signatures in human depression
Categories: Medicine

Current understanding of the human microbiome

Nature Medicine - 10 April 2018 - 12:00am

Current understanding of the human microbiome

Current understanding of the human microbiome, Published online: 10 April 2018; doi:10.1038/nm.4517

Current understanding of the human microbiome
Categories: Medicine

Erratum: The molecular landscape of pediatric acute myeloid leukemia reveals recurrent structural alterations and age-specific mutational interactions

Nature Medicine - 10 April 2018 - 12:00am

Erratum: The molecular landscape of pediatric acute myeloid leukemia reveals recurrent structural alterations and age-specific mutational interactions

Erratum: The molecular landscape of pediatric acute myeloid leukemia reveals recurrent structural alterations and age-specific mutational interactions, Published online: 10 April 2018; doi:10.1038/nm0418-526b

Erratum: The molecular landscape of pediatric acute myeloid leukemia reveals recurrent structural alterations and age-specific mutational interactions
Categories: Medicine

Transplanted neural progenitors bridge gaps to benefit cord–injured monkeys

Nature Medicine - 10 April 2018 - 12:00am

Transplanted neural progenitors bridge gaps to benefit cord–injured monkeys

Transplanted neural progenitors bridge gaps to benefit cord–injured monkeys, Published online: 10 April 2018; doi:10.1038/nm.4531

Human neural progenitor cells have been grafted successfully into rhesus monkeys with spinal cord hemisection, resulting in anatomic integration and improved neurological function.
Categories: Medicine

Predicting leukemia relapse

Nature Medicine - 10 April 2018 - 12:00am

Predicting leukemia relapse

Predicting leukemia relapse, Published online: 10 April 2018; doi:10.1038/nm.4529

Mass cytometry of acute B cell lymphoblastic leukemias at diagnosis reveals intrapatient phenotypic heterogeneity and specific signatures that mimic cell developmental stage and predict future relapse.
Categories: Medicine

A new site of attack for a malaria vaccine

Nature Medicine - 10 April 2018 - 12:00am

A new site of attack for a malaria vaccine

A new site of attack for a malaria vaccine, Published online: 10 April 2018; doi:10.1038/nm.4533

A newly discovered antibody epitope on the liver-infective form of the parasite that causes malaria opens new doors for vaccine development.
Categories: Medicine

A checkup for the flu vaccine

Nature Medicine - 10 April 2018 - 12:00am

A checkup for the flu vaccine

A checkup for the flu vaccine, Published online: 10 April 2018; doi:10.1038/nm.4535

Influenza causes almost 650,000 deaths worldwide each year, yet a long-lasting, protective vaccine remains elusive. Global investment—both scientific and financial—in a universal flu vaccine is overdue.
Categories: Medicine

Gain of toxic apolipoprotein E4 effects in human iPSC-derived neurons is ameliorated by a small-molecule structure corrector

Nature Medicine - 9 April 2018 - 12:00am

Gain of toxic apolipoprotein E4 effects in human iPSC-derived neurons is ameliorated by a small-molecule structure corrector

Gain of toxic apolipoprotein E4 effects in human iPSC-derived neurons is ameliorated by a small-molecule structure corrector, Published online: 09 April 2018; doi:10.1038/s41591-018-0004-z

Human iPSC-derived neurons are generated from individuals with or without Alzheimer's disease carrying different APOE alleles and reveal a toxic, neuron-intrinsic gain of function of the ApoE4 variant that is a strong genetic risk factor for AD.
Categories: Medicine

[Seminar] Malaria

Lancet - 7 April 2018 - 12:30am
Following unsuccessful eradication attempts there was a resurgence of malaria towards the end of the 20th century. Renewed control efforts using a range of improved tools, such as long-lasting insecticide-treated bednets and artemisinin-based combination therapies, have more than halved the global burden of disease, but it remains high with 445 000 deaths and more than 200 million cases in 2016. Pitfalls in individual patient management are delayed diagnosis and overzealous fluid resuscitation in severe malaria.
Categories: Medicine

[Editorial] The collapse of the Venezuelan health system

Lancet - 7 April 2018 - 12:00am
When Hugo Chavez became Venezuela's new president in 1998, he promised to provide free health care to all and enshrined this right within Venezuela's new constitution, rewritten in 1999. Progress was rapid and initial results were promising: according to the World Bank, life expectancy at birth rose from 71·8 to 74·1 years for both genders and infant mortality fell from 26·7 to 14·6 deaths per 1000 live births between 1998 and 2013, the period of Chavez's rule. Success was recognised on the international stage and Venezuela achieved most of the UN's Millennium Development Goals set for 2010.
Categories: Medicine

[Editorial] Privatising versus prioritising veterans' health

Lancet - 7 April 2018 - 12:00am
On March 28, President Donald Trump relayed on Twitter that Ronny L Jackson, personal physician to the president and a rear admiral in the US Navy, but with no prior experience in administration, would replace Veterans Affairs (VA) Secretary David Shulkin. The announcement was met with shock and dismay as Shulkin, who had been at the VA since 2015 and who was the sole holdover from the Obama years, was well regarded by Republicans and Democrats alike. Trump himself had even referred to Shulkin as “our David”, an unusual term of endearment for anyone from the previous administration.
Categories: Medicine

[Editorial] Health-care system transition in China

Lancet - 7 April 2018 - 12:00am
On March 27, the National Health Commission replaced China's National Health and Family Planning Commission (NHFPC) as the ministry responsible for health. The new commission is now headed by Ma Xiaowei, who was the former deputy head of the dismantled NHFPC. Chinese media have described Xiaowei as the person who understands China's health and hospital situation best, owing to his strong background in medicine. Since his graduation from the medical treatment department of China Medical University in 1982, Xiaowei has served many key roles in various health sectors such as the president of the First Affiliated Hospital of China Medical University and director of Liaoning Provincial Health Department.
Categories: Medicine

[Comment] Clinical Pictures in The Lancet: a good eye for detail

Lancet - 7 April 2018 - 12:00am
A key part of medical training is developing the ability to recognise physical signs of illness in a patient and associate them with the causative pathology. The acquisition of this skill, through training and experience, marks the transition of student to clinician. In recent years, the required repertoire has changed, expanding to include recognition of pathological and radiological signs. But the passing of this diagnostic expertise from one generation to the next remains remarkably unchanged across the globe.
Categories: Medicine

[Comment] Measuring Humanity: hip-hop as evidence for health inequalities

Lancet - 7 April 2018 - 12:00am
Dear Human (video), a hip-hop video was developed as part of the project Measuring Humanity.1 Working with marginalised groups, the participant-led research programme uses bottom-up creative community engagement to challenge policy makers and academics to reassess what counts as evidence when developing policies, practices, and recommendations. The video features rapping written using co-produced data from marginalised community members, health and voluntary sector practitioners, and researchers.
Categories: Medicine

[Comment] Offline: UHC—one promise and two misunderstandings

Lancet - 7 April 2018 - 12:00am
On April 7, 2018, World Health Day, WHO launches a new campaign—Universal Health Coverage: Everyone, Everywhere. This is a noble cause. As the agency notes: half the world's population is unable to access essential health services; 100 million people are pushed into extreme poverty each year because of out-of-pocket expenditures on health; and catastrophic spending on illness and disease is a truly global problem. Therefore, “our next historic achievement is right in front of us: health for all humankind…Together, we can make universal health coverage happen in our lifetime.” The campaign will run throughout 2018.
Categories: Medicine

[World Report] Violence rife in Mexico, affecting medical community

Lancet - 7 April 2018 - 12:00am
The medical community is caught in the middle of omnipresent violence in Mexico, where homicide rates reached record levels in 2017. David Agren reports from Villahermosa.
Categories: Medicine

[World Report] Progress in influenza surveillance in Africa

Lancet - 7 April 2018 - 12:00am
Influenza could be an overlooked cause of death in Africa. Although rapid progress has been made, there is still limited surveillance capacity to assess the risk of epidemic. Andrew Green reports.
Categories: Medicine

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