Immunology

GC B cells ‘AKT’ to blunt BCR signaling

Nature Immunology - 22 April 2019 - 12:00am

GC B cells ‘AKT’ to blunt BCR signaling

GC B cells ‘AKT’ to blunt BCR signaling, Published online: 22 April 2019; doi:10.1038/s41590-019-0384-3

A novel feedback loop coordinated by germinal center–specific signaling via the kinase AKT activates negative regulators of upstream BCR signaling to attenuate responses to antigen stimulation.
Categories: Immunology

T<sub>reg</sub> cell IL-10 and IL-35 exhaust CD8<sup>+</sup> T cells in tumors

Nature Immunology - 22 April 2019 - 12:00am

Treg cell IL-10 and IL-35 exhaust CD8+ T cells in tumors

T<sub>reg</sub> cell IL-10 and IL-35 exhaust CD8<sup>+</sup> T cells in tumors, Published online: 22 April 2019; doi:10.1038/s41590-019-0389-y

Expression of the immunosuppressive cytokines IL-10 and IL-35 by tumor-infiltrating regulatory T cells drives exhaustion of intratumoral CD8+ T cells through a common pathway dependent on the transcription factor BLIMP-1.
Categories: Immunology

The AKT kinase signaling network is rewired by PTEN to control proximal BCR signaling in germinal center B cells

Nature Immunology - 22 April 2019 - 12:00am

The AKT kinase signaling network is rewired by PTEN to control proximal BCR signaling in germinal center B cells

The AKT kinase signaling network is rewired by PTEN to control proximal BCR signaling in germinal center B cells, Published online: 22 April 2019; doi:10.1038/s41590-019-0376-3

BCR signaling in naive B cells and in GC B cells differs. Shlomchik and colleagues report that GC B cells are ‘rewired’ in their Akt activation module, increasing p-T308 over p-S473, leading to increases of negative regulators of BCR signaling and ultimately higher thresholds for BCR activation.
Categories: Immunology

CARD9<sup>+</sup> microglia promote antifungal immunity via IL-1β- and CXCL1-mediated neutrophil recruitment

Nature Immunology - 17 April 2019 - 12:00am

CARD9+ microglia promote antifungal immunity via IL-1β- and CXCL1-mediated neutrophil recruitment

CARD9<sup>+</sup> microglia promote antifungal immunity via IL-1β- and CXCL1-mediated neutrophil recruitment, Published online: 17 April 2019; doi:10.1038/s41590-019-0377-2

Innate immunity protects the central nervous system against fungal pathogens. Lionakis and colleagues identify Candidalysin, a Candida virulence factor that elicits microglial expression of the cytokine IL-1β and chemokine CXCL1 and facilitates neutrophil recruitment. Alteration of this pathway impairs antifungal responses.
Categories: Immunology

Signaling platforms

Nature Immunology - 17 April 2019 - 12:00am

Signaling platforms

Signaling platforms, Published online: 17 April 2019; doi:10.1038/s41590-019-0391-4

Signaling platforms
Categories: Immunology

Macrophages light the way

Nature Immunology - 17 April 2019 - 12:00am

Macrophages light the way

Macrophages light the way, Published online: 17 April 2019; doi:10.1038/s41590-019-0394-1

Macrophages light the way
Categories: Immunology

Functional degradation

Nature Immunology - 17 April 2019 - 12:00am

Functional degradation

Functional degradation, Published online: 17 April 2019; doi:10.1038/s41590-019-0392-3

Functional degradation
Categories: Immunology

Heterogeneity in the retina

Nature Immunology - 17 April 2019 - 12:00am

Heterogeneity in the retina

Heterogeneity in the retina, Published online: 17 April 2019; doi:10.1038/s41590-019-0390-5

Heterogeneity in the retina
Categories: Immunology

Distinct S1PR roles

Nature Immunology - 17 April 2019 - 12:00am

Distinct S1PR roles

Distinct S1PR roles, Published online: 17 April 2019; doi:10.1038/s41590-019-0393-2

Distinct S1PR roles
Categories: Immunology

Author Correction: Mosaic nanoparticle display of diverse influenza virus hemagglutinins elicits broad B cell responses

Nature Immunology - 12 April 2019 - 12:00am

Author Correction: Mosaic nanoparticle display of diverse influenza virus hemagglutinins elicits broad B cell responses

Author Correction: Mosaic nanoparticle display of diverse influenza virus hemagglutinins elicits broad B cell responses, Published online: 12 April 2019; doi:10.1038/s41590-019-0395-0

Author Correction: Mosaic nanoparticle display of diverse influenza virus hemagglutinins elicits broad B cell responses
Categories: Immunology

SUCNR1 controls an anti-inflammatory program in macrophages to regulate the metabolic response to obesity

Nature Immunology - 8 April 2019 - 12:00am

SUCNR1 controls an anti-inflammatory program in macrophages to regulate the metabolic response to obesity

SUCNR1 controls an anti-inflammatory program in macrophages to regulate the metabolic response to obesity, Published online: 08 April 2019; doi:10.1038/s41590-019-0372-7

Succinate is a signaling metabolite sensed extracellularly by SUNCR1. Fernandez-Veledo and colleagues show that activation of SUCNR1 promotes an anti-inflammatory phenotype in adipose-tissue macrophages in lean mice and people.
Categories: Immunology

Innate immunity to intracellular LPS

Nature Immunology - 8 April 2019 - 12:00am

Innate immunity to intracellular LPS

Innate immunity to intracellular LPS, Published online: 08 April 2019; doi:10.1038/s41590-019-0368-3

Comprehensive immunity requires that cells sense intracellular pathogens. In their Review, Shao and colleagues describe mechanisms for the recognition of intracellular lipopolysaccharide and its essential role in responses to Gram-negative bacteria.
Categories: Immunology

IL-17 instructs lymphoid stromal cells

Nature Immunology - 8 April 2019 - 12:00am

IL-17 instructs lymphoid stromal cells

IL-17 instructs lymphoid stromal cells, Published online: 08 April 2019; doi:10.1038/s41590-019-0375-4

The cytokine IL-17 augments metabolism in fibroblastic reticular cells in lymph nodes, which enhances their proliferation and survival to support B cell responses during autoimmunity.
Categories: Immunology

Transcriptome networks identify mechanisms of viral and nonviral asthma exacerbations in children

Nature Immunology - 8 April 2019 - 12:00am

Transcriptome networks identify mechanisms of viral and nonviral asthma exacerbations in children

Transcriptome networks identify mechanisms of viral and nonviral asthma exacerbations in children, Published online: 08 April 2019; doi:10.1038/s41590-019-0347-8

Respiratory infections are the principal cause of asthma exacerbations in children. Altman and colleagues use a systems approach to describe the pathways associated with asthma exacerbations in a cohort of inner-city children.
Categories: Immunology

Old dog PU.1 reveals new tricks

Nature Immunology - 8 April 2019 - 12:00am

Old dog PU.1 reveals new tricks

Old dog PU.1 reveals new tricks, Published online: 08 April 2019; doi:10.1038/s41590-019-0380-7

The transcription factor PU.1 is not needed for the maintenance of neutrophil identity but is essential for the prevention of excessive tissue damage due to a prolonged immune response. PU.1 restrains the activation of neutrophils by antagonizing the AP-1 transcription factor JunB.
Categories: Immunology

IL-17 metabolically reprograms activated fibroblastic reticular cells for proliferation and survival

Nature Immunology - 8 April 2019 - 12:00am

IL-17 metabolically reprograms activated fibroblastic reticular cells for proliferation and survival

IL-17 metabolically reprograms activated fibroblastic reticular cells for proliferation and survival, Published online: 08 April 2019; doi:10.1038/s41590-019-0367-4

Fibroblastic reticular cells support lymph-node function and adaptive immunity. McGeachy and colleagues show that the cytokine IL-17 is needed to trigger metabolic changes required for the proliferation and survival of these cells in reactive lymph nodes.
Categories: Immunology

Author Correction: Deciphering CD4<sup>+</sup> T cell specificity using novel MHC–TCR chimeric receptors

Nature Immunology - 3 April 2019 - 12:00am

Author Correction: Deciphering CD4+ T cell specificity using novel MHC–TCR chimeric receptors

Author Correction: Deciphering CD4<sup>+</sup> T cell specificity using novel MHC–TCR chimeric receptors, Published online: 03 April 2019; doi:10.1038/s41590-019-0383-4

Author Correction: Deciphering CD4+ T cell specificity using novel MHC–TCR chimeric receptors
Categories: Immunology

Adaptive plasticity of IL-10<sup>+</sup> and IL-35<sup>+</sup> T<sub>reg</sub> cells cooperatively promotes tumor T cell exhaustion

Nature Immunology - 1 April 2019 - 12:00am

Adaptive plasticity of IL-10+ and IL-35+ Treg cells cooperatively promotes tumor T cell exhaustion

Adaptive plasticity of IL-10<sup>+</sup> and IL-35<sup>+</sup> T<sub>reg</sub> cells cooperatively promotes tumor T cell exhaustion, Published online: 01 April 2019; doi:10.1038/s41590-019-0346-9

Regulatory T cells obstruct effective anti-cancer immune responses. Vignali and colleagues demonstrate that IL-10 production and IL-35 production by tumor-infiltrating regulatory T cells mediate differential and non-redundant suppressive effects on tumor-reactive cytotoxic T cells.
Categories: Immunology

The lung environment controls alveolar macrophage metabolism and responsiveness in type 2 inflammation

Nature Immunology - 1 April 2019 - 12:00am

The lung environment controls alveolar macrophage metabolism and responsiveness in type 2 inflammation

The lung environment controls alveolar macrophage metabolism and responsiveness in type 2 inflammation, Published online: 01 April 2019; doi:10.1038/s41590-019-0352-y

Control of macrophage activation in the lungs is essential for the prevention of tissue damage. MacDonald and colleagues show that alveolar macrophages have impaired glycolysis and are hyporesponsive during type 2 inflammation in a manner controlled by the lung environment.
Categories: Immunology

Dynamic changes to lipid mediators support transitions among macrophage subtypes during muscle regeneration

Nature Immunology - 1 April 2019 - 12:00am

Dynamic changes to lipid mediators support transitions among macrophage subtypes during muscle regeneration

Dynamic changes to lipid mediators support transitions among macrophage subtypes during muscle regeneration, Published online: 01 April 2019; doi:10.1038/s41590-019-0356-7

Muscle damage elicits a sterile immune response that facilitates complete regeneration. Nagy and colleagues map the mediator lipidome during the transition from inflammation to resolution in skeletal muscle injury.
Categories: Immunology

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