Immunology

cDC1 cross-priming

Nature Immunology - 11 December 2018 - 12:00am

cDC1 cross-priming

cDC1 cross-priming, Published online: 11 December 2018; doi:10.1038/s41590-018-0283-z

cDC1 cross-priming
Categories: Immunology

Self-renewing resident cardiac macrophages limit adverse remodeling following myocardial infarction

Nature Immunology - 11 December 2018 - 12:00am

Self-renewing resident cardiac macrophages limit adverse remodeling following myocardial infarction

Self-renewing resident cardiac macrophages limit adverse remodeling following myocardial infarction, Published online: 11 December 2018; doi:10.1038/s41590-018-0272-2

Epelman and colleagues use fate mapping and single-cell transcriptomics to describe the dynamics of resident and recruited cardiac macrophages during ischemic injury.
Categories: Immunology

DELineating resolution of inflammation

Nature Immunology - 11 December 2018 - 12:00am

DELineating resolution of inflammation

DELineating resolution of inflammation, Published online: 11 December 2018; doi:10.1038/s41590-018-0278-9

The resolution of inflammation is a protective response. The identification and characterization of new players that boost this response might inform the development of novel therapies for non-resolving inflammatory diseases.
Categories: Immunology

Mst kinase roles

Nature Immunology - 11 December 2018 - 12:00am

Mst kinase roles

Mst kinase roles, Published online: 11 December 2018; doi:10.1038/s41590-018-0284-y

Mst kinase roles
Categories: Immunology

Stem cell–immune cell cross-talk

Nature Immunology - 11 December 2018 - 12:00am

Stem cell–immune cell cross-talk

Stem cell–immune cell cross-talk, Published online: 11 December 2018; doi:10.1038/s41590-018-0282-0

Stem cell–immune cell cross-talk
Categories: Immunology

G3BP1 enhances cytoplasmic DNA pattern recognition

Nature Immunology - 11 December 2018 - 12:00am

G3BP1 enhances cytoplasmic DNA pattern recognition

G3BP1 enhances cytoplasmic DNA pattern recognition, Published online: 11 December 2018; doi:10.1038/s41590-018-0279-8

The stress-granule protein G3BP1 forms a high-molecular-weight protein complex with the sensor cGAS and enhances its detection of cytoplasmic DNA.
Categories: Immunology

Blood–brain barrier integrity

Nature Immunology - 11 December 2018 - 12:00am

Blood–brain barrier integrity

Blood–brain barrier integrity, Published online: 11 December 2018; doi:10.1038/s41590-018-0286-9

Blood–brain barrier integrity
Categories: Immunology

Cas9-directed immunity

Nature Immunology - 11 December 2018 - 12:00am

Cas9-directed immunity

Cas9-directed immunity, Published online: 11 December 2018; doi:10.1038/s41590-018-0285-x

Cas9-directed immunity
Categories: Immunology

The transcription factor c-Maf is essential for the commitment of IL-17-producing γδ T cells

Nature Immunology - 10 December 2018 - 12:00am

The transcription factor c-Maf is essential for the commitment of IL-17-producing γδ T cells

The transcription factor c-Maf is essential for the commitment of IL-17-producing γδ T cells, Published online: 10 December 2018; doi:10.1038/s41590-018-0274-0

Ciofani and colleagues identify the transcription factor c-Maf as a universal regulator of the differentiation of IL-17-producing γδ T cells.
Categories: Immunology

B cells turn on, tune in with LSD1

Nature Immunology - 10 December 2018 - 12:00am

B cells turn on, tune in with LSD1

B cells turn on, tune in with LSD1, Published online: 10 December 2018; doi:10.1038/s41590-018-0281-1

The histone demethylase LSD1 partners with the transcription factor BCL6 to initiate the formation of germinal centers.
Categories: Immunology

The IL-15–AKT–XBP1s signaling pathway contributes to effector functions and survival in human NK cells

Nature Immunology - 10 December 2018 - 12:00am

The IL-15–AKT–XBP1s signaling pathway contributes to effector functions and survival in human NK cells

The IL-15–AKT–XBP1s signaling pathway contributes to effector functions and survival in human NK cells, Published online: 10 December 2018; doi:10.1038/s41590-018-0265-1

Yu and colleagues show that the transcription factor XBP1s positively regulates the cytolytic activity of human NK cells and is required for the IL-15-mediated survival of NK cells.
Categories: Immunology

Myocardial infarction cell by cell

Nature Immunology - 10 December 2018 - 12:00am

Myocardial infarction cell by cell

Myocardial infarction cell by cell, Published online: 10 December 2018; doi:10.1038/s41590-018-0277-x

While important evidence for the role of myeloid cells in myocardial infarction has accumulated in recent years, single-cell transcriptomics fully delineates the functional heterogeneity of the myeloid cell compartment.
Categories: Immunology

Histone demethylase LSD1 is required for germinal center formation and BCL6-driven lymphomagenesis

Nature Immunology - 10 December 2018 - 12:00am

Histone demethylase LSD1 is required for germinal center formation and BCL6-driven lymphomagenesis

Histone demethylase LSD1 is required for germinal center formation and BCL6-driven lymphomagenesis, Published online: 10 December 2018; doi:10.1038/s41590-018-0273-1

Germinal center B cells undergo reiterative rounds of proliferation and selection. Melnick and colleagues show that the histone demethylase LSD1 is necessary for this reiterative process via its interactions with the transcription factor BCL6.
Categories: Immunology

G3BP1 promotes DNA binding and activation of cGAS

Nature Immunology - 3 December 2018 - 12:00am

G3BP1 promotes DNA binding and activation of cGAS

G3BP1 promotes DNA binding and activation of cGAS, Published online: 03 December 2018; doi:10.1038/s41590-018-0262-4

Li and colleagues show that G3BP1, a protein known to regulate the RNA stress response, is critical for DNA sensing and efficient activation of the cytoplasmic DNA sensor cGAS.
Categories: Immunology

The establishment of resident memory B cells in the lung requires local antigen encounter

Nature Immunology - 3 December 2018 - 12:00am

The establishment of resident memory B cells in the lung requires local antigen encounter

The establishment of resident memory B cells in the lung requires local antigen encounter, Published online: 03 December 2018; doi:10.1038/s41590-018-0260-6

Tissue-resident memory cells are functionally distinct from lymph node memory cells. Randall and colleagues show that lung infection establishes B cell memory in situ and confers superior responses following challenge infection, which will inform vaccine design for respiratory viruses.
Categories: Immunology

Macrophage de novo NAD<sup>+</sup> synthesis specifies immune function in aging and inflammation

Nature Immunology - 26 November 2018 - 12:00am

Macrophage de novo NAD+ synthesis specifies immune function in aging and inflammation

Macrophage de novo NAD<sup>+</sup> synthesis specifies immune function in aging and inflammation, Published online: 26 November 2018; doi:10.1038/s41590-018-0255-3

Macrophages alter their metabolism in response to infection. The authors show that resting macrophages generate nicotinamide adenine dinucleotide via de novo synthesis, but activated and aged cells suppress the rate-limiting enzyme quinolinate phosphoribosyltransferase to regulate mitochondrial and immunological functions.
Categories: Immunology

Alarmin S100A11 initiates a chemokine response to the human pathogen <i>Toxoplasma gondii</i>

Nature Immunology - 19 November 2018 - 12:00am

Alarmin S100A11 initiates a chemokine response to the human pathogen Toxoplasma gondii

Alarmin S100A11 initiates a chemokine response to the human pathogen <i>Toxoplasma gondii</i>, Published online: 19 November 2018; doi:10.1038/s41590-018-0250-8

Yarovinsky and colleagues identify the alarmin S100A11, which is released from Toxoplasma gondii–infected cells, as the trigger for immune responses in humans. S100A11 induces expression of the chemokine CCL2, which recruits inflammatory CCR2+ monocytes to the sites of infection.
Categories: Immunology

DEL-1 promotes macrophage efferocytosis and clearance of inflammation

Nature Immunology - 19 November 2018 - 12:00am

DEL-1 promotes macrophage efferocytosis and clearance of inflammation

DEL-1 promotes macrophage efferocytosis and clearance of inflammation, Published online: 19 November 2018; doi:10.1038/s41590-018-0249-1

DEL-1 protein interferes with leukocyte adhesion to prevent inflammation. Chavakis and colleagues now show that DEL-1 contributes to tissue resolution after inflammation by promoting macrophage-mediated efferocytosis and M2-like pro-resolving activities.
Categories: Immunology

Publisher Correction: An immunoregulatory and tissue-residency program modulated by c-MAF in human T<sub>H</sub>17 cells

Nature Immunology - 17 November 2018 - 12:00am

Publisher Correction: An immunoregulatory and tissue-residency program modulated by c-MAF in human TH17 cells

Publisher Correction: An immunoregulatory and tissue-residency program modulated by c-MAF in human T<sub>H</sub>17 cells, Published online: 17 November 2018; doi:10.1038/s41590-018-0264-2

Publisher Correction: An immunoregulatory and tissue-residency program modulated by c-MAF in human TH17 cells
Categories: Immunology

Rules of engagement

Nature Immunology - 16 November 2018 - 12:00am

Rules of engagement

Rules of engagement, Published online: 16 November 2018; doi:10.1038/s41590-018-0267-z

Rules of engagement
Categories: Immunology

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