Immunology

Fighting influenza through hemagglutinin diversity

Nature Immunology - 11 February 2019 - 12:00am

Fighting influenza through hemagglutinin diversity

Fighting influenza through hemagglutinin diversity, Published online: 11 February 2019; doi:10.1038/s41590-019-0317-1

A multivalent vaccine that presents diverse influenza virus subtype H1 hemagglutinins on its surface induces broadly neutralizing antibodies in an animal model by displaying conserved epitopes at higher density than strain-specific epitopes.
Categories: Immunology

Macrophages, rather than DCs, are responsible for inflammasome activity in the GM-CSF BMDC model

Nature Immunology - 11 February 2019 - 12:00am

Macrophages, rather than DCs, are responsible for inflammasome activity in the GM-CSF BMDC model

Macrophages, rather than DCs, are responsible for inflammasome activity in the GM-CSF BMDC model, Published online: 11 February 2019; doi:10.1038/s41590-019-0313-5

Dendritic cells (DCs) have been suggested to express a functional NLRP3 inflammasome. Gerlic and colleagues demonstrate, however, that bone marrow–derived DCs completely lack NLRP3 inflammasome activity and that the bulk of splenic DCs lack or have only minimal activity.
Categories: Immunology

Mosaic nanoparticle display of diverse influenza virus hemagglutinins elicits broad B cell responses

Nature Immunology - 11 February 2019 - 12:00am

Mosaic nanoparticle display of diverse influenza virus hemagglutinins elicits broad B cell responses

Mosaic nanoparticle display of diverse influenza virus hemagglutinins elicits broad B cell responses, Published online: 11 February 2019; doi:10.1038/s41590-018-0305-x

Antigenic variation of influenza A viruses necessitates the annual reformulation of vaccines. Kanekiyo et al. develop a mosaic nanoparticle vaccine against influenza virus that is able to elicit neutralizing antibodies that span nearly 100 years of variation of influenza A virus.
Categories: Immunology

Pre-birth memory

Nature Immunology - 11 February 2019 - 12:00am

Pre-birth memory

Pre-birth memory, Published online: 11 February 2019; doi:10.1038/s41590-019-0326-0

The transition of the fetus from the womb to the external world represents an extraordinary challenge. The generation of memory T cells before birth may serve an important role in preparation for this fundamental transition.
Categories: Immunology

Publisher Correction: c-Maf controls immune responses by regulating disease-specific gene networks and repressing IL-2 in CD4<sup>+</sup> T cells

Nature Immunology - 8 February 2019 - 12:00am

Publisher Correction: c-Maf controls immune responses by regulating disease-specific gene networks and repressing IL-2 in CD4+ T cells

Publisher Correction: c-Maf controls immune responses by regulating disease-specific gene networks and repressing IL-2 in CD4<sup>+</sup> T cells, Published online: 08 February 2019; doi:10.1038/s41590-019-0331-3

Publisher Correction: c-Maf controls immune responses by regulating disease-specific gene networks and repressing IL-2 in CD4+ T cells
Categories: Immunology

Publisher Correction: Approaches and advances in the genetic causes of autoimmune disease and their implications

Nature Immunology - 7 February 2019 - 12:00am

Publisher Correction: Approaches and advances in the genetic causes of autoimmune disease and their implications

Publisher Correction: Approaches and advances in the genetic causes of autoimmune disease and their implications, Published online: 07 February 2019; doi:10.1038/s41590-019-0327-z

Publisher Correction: Approaches and advances in the genetic causes of autoimmune disease and their implications
Categories: Immunology

Author Correction: Progression of whole-blood transcriptional signatures from interferon-induced to neutrophil-associated patterns in severe influenza

Nature Immunology - 7 February 2019 - 12:00am

Author Correction: Progression of whole-blood transcriptional signatures from interferon-induced to neutrophil-associated patterns in severe influenza

Author Correction: Progression of whole-blood transcriptional signatures from interferon-induced to neutrophil-associated patterns in severe influenza, Published online: 07 February 2019; doi:10.1038/s41590-019-0328-y

Author Correction: Progression of whole-blood transcriptional signatures from interferon-induced to neutrophil-associated patterns in severe influenza
Categories: Immunology

Author Correction: γδ T cells producing interleukin-17A regulate adipose regulatory T cell homeostasis and thermogenesis

Nature Immunology - 7 February 2019 - 12:00am

Author Correction: γδ T cells producing interleukin-17A regulate adipose regulatory T cell homeostasis and thermogenesis

Author Correction: γδ T cells producing interleukin-17A regulate adipose regulatory T cell homeostasis and thermogenesis, Published online: 07 February 2019; doi:10.1038/s41590-019-0330-4

Author Correction: γδ T cells producing interleukin-17A regulate adipose regulatory T cell homeostasis and thermogenesis
Categories: Immunology

N-myristoyltransferase deficiency impairs activation of kinase AMPK and promotes synovial tissue inflammation

Nature Immunology - 4 February 2019 - 12:00am

N-myristoyltransferase deficiency impairs activation of kinase AMPK and promotes synovial tissue inflammation

N-myristoyltransferase deficiency impairs activation of kinase AMPK and promotes synovial tissue inflammation, Published online: 04 February 2019; doi:10.1038/s41590-018-0296-7

Pathogenic human CD4+ T cells in rheumatoid arthritis have hyperactivated metabolism. Weyand and colleagues show that this phenotype is associated with less myristoylation of the energy sensor AMPK and dysregulated metabolic sensor mTORC1.
Categories: Immunology

Revisiting the old and learning the new of zinc in immunity

Nature Immunology - 4 February 2019 - 12:00am

Revisiting the old and learning the new of zinc in immunity

Revisiting the old and learning the new of zinc in immunity, Published online: 04 February 2019; doi:10.1038/s41590-019-0319-z

The zinc transporter ZIP7 positively regulates signaling via the BCR during early B cell development in mice and humans. Impairment of ZIP7 function results in a novel primary immunodeficiency.
Categories: Immunology

N-myristoylation of AMPK controls T cell inflammatory function

Nature Immunology - 4 February 2019 - 12:00am

N-myristoylation of AMPK controls T cell inflammatory function

N-myristoylation of AMPK controls T cell inflammatory function, Published online: 04 February 2019; doi:10.1038/s41590-019-0322-4

In patients with rheumatoid arthritis, decreased abundance of the N-myristoyltransferase NMT1 in CD4+ T cells prevents N-myristoylation of the AMP-activated protein kinase AMPK and its localization to the lysosomal membrane, which leads to increased activation of the metabolic checkpoint kinase complex mTORC1 and proinflammatory T cell phenotypes.
Categories: Immunology

An essential role for the Zn<sup>2+</sup> transporter ZIP7 in B cell development

Nature Immunology - 4 February 2019 - 12:00am

An essential role for the Zn2+ transporter ZIP7 in B cell development

An essential role for the Zn<sup>2+</sup> transporter ZIP7 in B cell development, Published online: 04 February 2019; doi:10.1038/s41590-018-0295-8

Zinc is important for normal immunity but its mechanistic actions are poorly understood. Hambleton and colleagues identify defects in Zn2+ transport that underpin a novel human immunodeficiency characterized by loss of mature B cells.
Categories: Immunology

Publisher Correction: Recent progress in broadly neutralizing antibodies to HIV

Nature Immunology - 1 February 2019 - 12:00am

Publisher Correction: Recent progress in broadly neutralizing antibodies to HIV

Publisher Correction: Recent progress in broadly neutralizing antibodies to HIV, Published online: 01 February 2019; doi:10.1038/s41590-019-0329-x

Publisher Correction: Recent progress in broadly neutralizing antibodies to HIV
Categories: Immunology

Publisher Correction: Get the IL-17F outta here!

Nature Immunology - 1 February 2019 - 12:00am

Publisher Correction: Get the IL-17F outta here!

Publisher Correction: Get the IL-17F outta here!, Published online: 01 February 2019; doi:10.1038/s41590-019-0332-2

Publisher Correction: Get the IL-17F outta here!
Categories: Immunology

SERPINB1-mediated checkpoint of inflammatory caspase activation

Nature Immunology - 28 January 2019 - 12:00am

SERPINB1-mediated checkpoint of inflammatory caspase activation

SERPINB1-mediated checkpoint of inflammatory caspase activation, Published online: 28 January 2019; doi:10.1038/s41590-018-0303-z

Serpins are a large family of serine protease inhibitors. Jae Jung and colleagues show that SERPINB1 serves an endogenous regulatory role for pro-inflammatory caspases by preventing CARD–CARD polymerization and, hence, inflammasome activation.
Categories: Immunology

Hobit- and Blimp-1-driven CD4<sup>+</sup> tissue-resident memory T cells control chronic intestinal inflammation

Nature Immunology - 28 January 2019 - 12:00am

Hobit- and Blimp-1-driven CD4+ tissue-resident memory T cells control chronic intestinal inflammation

Hobit- and Blimp-1-driven CD4<sup>+</sup> tissue-resident memory T cells control chronic intestinal inflammation, Published online: 28 January 2019; doi:10.1038/s41590-018-0298-5

Tissue-resident memory T cells (TRM cells) have well-described functions in the protective response to infectious agents. Neurath and colleagues demonstrate that intestinal TRM cells can also have key pathogenic roles in inflammatory bowel disease.
Categories: Immunology

Metabolic requirements for expanding and arming a clone army

Nature Immunology - 21 January 2019 - 12:00am

Metabolic requirements for expanding and arming a clone army

Metabolic requirements for expanding and arming a clone army, Published online: 21 January 2019; doi:10.1038/s41590-018-0299-4

A new target for controlling T cell responses adds to the list of key processes dependent on the synthesis of tetrahydrobiopterin, which is essential for neurotransmitter and nitric-oxide production and pain control.
Categories: Immunology

New ligand for LAG-3

Nature Immunology - 21 January 2019 - 12:00am

New ligand for LAG-3

New ligand for LAG-3, Published online: 21 January 2019; doi:10.1038/s41590-018-0307-8

New ligand for LAG-3
Categories: Immunology

Memory CD4<sup>+</sup> T cells are generated in the human fetal intestine

Nature Immunology - 21 January 2019 - 12:00am

Memory CD4+ T cells are generated in the human fetal intestine

Memory CD4<sup>+</sup> T cells are generated in the human fetal intestine, Published online: 21 January 2019; doi:10.1038/s41590-018-0294-9

Koning and colleagues used mass cytometry, single-cell RNA-seq and high-throughput TCR sequencing to characterize the CD4+ T cell compartment in the human fetal intestine.
Categories: Immunology

γδ TCR ligands: the quest to solve a 500-million-year-old mystery

Nature Immunology - 21 January 2019 - 12:00am

γδ TCR ligands: the quest to solve a 500-million-year-old mystery

γδ TCR ligands: the quest to solve a 500-million-year-old mystery, Published online: 21 January 2019; doi:10.1038/s41590-018-0304-y

In this Perspective, Willcox and Willcox discuss the inherent challenges and future possibilities in identifying the ligands recognized by the γδ TCR.
Categories: Immunology

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