Immunology

Author Correction: Cytotoxic and regulatory roles of mucosal-associated invariant T cells in type 1 diabetes

Nature Immunology - 7 June 2018 - 12:00am

Author Correction: Cytotoxic and regulatory roles of mucosal-associated invariant T cells in type 1 diabetes

Author Correction: Cytotoxic and regulatory roles of mucosal-associated invariant T cells in type 1 diabetes, Published online: 07 June 2018; doi:10.1038/s41590-017-0023-9

Author Correction: Cytotoxic and regulatory roles of mucosal-associated invariant T cells in type 1 diabetes
Categories: Immunology

Integration of multi-omics data and deep phenotyping enables prediction of cytokine responses

Nature Immunology - 21 May 2018 - 12:00am

Integration of multi-omics data and deep phenotyping enables prediction of cytokine responses

Integration of multi-omics data and deep phenotyping enables prediction of cytokine responses, Published online: 21 May 2018; doi:10.1038/s41590-018-0121-3

The immune response to pathogens varies substantially among humans. Netea and colleagues show that integration of multi-omics data and deep phenotyping enables prediction of cytokine production in responses to pathogens.
Categories: Immunology

A more natural response

Nature Immunology - 18 May 2018 - 12:00am

A more natural response

A more natural response, Published online: 18 May 2018; doi:10.1038/s41590-018-0122-2

A more natural response
Categories: Immunology

Training and tolerance

Nature Immunology - 18 May 2018 - 12:00am

Training and tolerance

Training and tolerance, Published online: 18 May 2018; doi:10.1038/s41590-018-0127-x

Training and tolerance
Categories: Immunology

Influenza’s signature move

Nature Immunology - 18 May 2018 - 12:00am

Influenza’s signature move

Influenza’s signature move, Published online: 18 May 2018; doi:10.1038/s41590-018-0115-1

Analysis of whole-blood transcriptional profiles in adults hospitalized with influenza reveals time- and severity-related gene-expression signatures.
Categories: Immunology

TORching a semaphore for alternative macrophage activation

Nature Immunology - 18 May 2018 - 12:00am

TORching a semaphore for alternative macrophage activation

TORching a semaphore for alternative macrophage activation, Published online: 18 May 2018; doi:10.1038/s41590-018-0117-z

The metabolic master regulator mTORC1 is shown to promote alternative macrophage activation via Semaphorin 6D reverse signaling and reprogramming of lipid metabolism.
Categories: Immunology

Semaphorin 6D reverse signaling controls macrophage lipid metabolism and anti-inflammatory polarization

Nature Immunology - 18 May 2018 - 12:00am

Semaphorin 6D reverse signaling controls macrophage lipid metabolism and anti-inflammatory polarization

Semaphorin 6D reverse signaling controls macrophage lipid metabolism and anti-inflammatory polarization, Published online: 18 May 2018; doi:10.1038/s41590-018-0108-0

Semaphorins play well-known roles in axon guidance. Kumanogoh and colleagues demonstrate that Semaphorin 6D cell-intrinsically activates anti-inflammatory macrophage polarization.
Categories: Immunology

Re-evaluating microglia expression profiles using RiboTag and cell isolation strategies

Nature Immunology - 18 May 2018 - 12:00am

Re-evaluating microglia expression profiles using RiboTag and cell isolation strategies

Re-evaluating microglia expression profiles using RiboTag and cell isolation strategies, Published online: 18 May 2018; doi:10.1038/s41590-018-0110-6

Isolating tissue-resident cells runs the risk of altering their expression profile. Jung and colleagues use a RiboTagging approach to describe the microglial translatome and demonstrate that macrophage extraction from their tissue environment results in significant transcriptional alterations.
Categories: Immunology

Regulation of macrophage immunometabolism in atherosclerosis

Nature Immunology - 18 May 2018 - 12:00am

Regulation of macrophage immunometabolism in atherosclerosis

Regulation of macrophage immunometabolism in atherosclerosis, Published online: 18 May 2018; doi:10.1038/s41590-018-0113-3

In this Review, Moore and colleagues discuss regulation of macrophage immunometabolism in atherosclerosis.
Categories: Immunology

CCR7 fuels and LFA-1 grips

Nature Immunology - 18 May 2018 - 12:00am

CCR7 fuels and LFA-1 grips

CCR7 fuels and LFA-1 grips, Published online: 18 May 2018; doi:10.1038/s41590-018-0118-y

Naive T cells migrate rapidly through the lymph node. A high-resolution look at the chemokine receptor CCR7 and integrin LFA-1 reveals that T cells remain highly responsive to their microenvironment via instantaneous tuning of chemokine-regulated actin flow and integrin-regulated adhesion.
Categories: Immunology

High-affinity IgA against microbial glycans

Nature Immunology - 18 May 2018 - 12:00am

High-affinity IgA against microbial glycans

High-affinity IgA against microbial glycans, Published online: 18 May 2018; doi:10.1038/s41590-018-0116-0

Human affinity-matured antibodies to Klebsiella pneumoniae lipopolysaccharide O-antigen have different patterns of glycan fine specificity without being polyreactive. These antibodies might constitute an important mechanism for homeostatic control of the intestinal microbiome.
Categories: Immunology

Chemokines and integrins independently tune actin flow and substrate friction during intranodal migration of T cells

Nature Immunology - 18 May 2018 - 12:00am

Chemokines and integrins independently tune actin flow and substrate friction during intranodal migration of T cells

Chemokines and integrins independently tune actin flow and substrate friction during intranodal migration of T cells, Published online: 18 May 2018; doi:10.1038/s41590-018-0109-z

Sixt, Stein and colleagues show that during T cell migration within lymphatic organs, the chemokine receptor CCR7 quantitatively controls the speed of a continuous actin flow, which is coupled to the environment by the integrin LFA-1.
Categories: Immunology

Tissue-resident memory T cells at the center of immunity to solid tumors

Nature Immunology - 18 May 2018 - 12:00am

Tissue-resident memory T cells at the center of immunity to solid tumors

Tissue-resident memory T cells at the center of immunity to solid tumors, Published online: 18 May 2018; doi:10.1038/s41590-018-0114-2

Tissue-resident memory T cells provide immunological protection in peripheral tissues. Amsen et al. discuss the role of these cells in the context of anti-tumor immunity.
Categories: Immunology

Cross-specificity of protective human antibodies against <i>Klebsiella pneumoniae</i> LPS O-antigen

Nature Immunology - 14 May 2018 - 12:00am

Cross-specificity of protective human antibodies against Klebsiella pneumoniae LPS O-antigen

Cross-specificity of protective human antibodies against <i>Klebsiella pneumoniae</i> LPS O-antigen, Published online: 14 May 2018; doi:10.1038/s41590-018-0106-2

Carbohydrate-specific antibodies are typically thought to be of low affinity and produced by T cell–independent pathways. Wardemann and colleagues identify human memory B cells that can produce specific ‘affinity-matured’ antibodies to the O antigen of Klebsiella lipopolysaccharides.
Categories: Immunology

Apoptotic cell–induced AhR activity is required for immunological tolerance and suppression of systemic lupus erythematosus in mice and humans

Nature Immunology - 14 May 2018 - 12:00am

Apoptotic cell–induced AhR activity is required for immunological tolerance and suppression of systemic lupus erythematosus in mice and humans

Apoptotic cell–induced AhR activity is required for immunological tolerance and suppression of systemic lupus erythematosus in mice and humans, Published online: 14 May 2018; doi:10.1038/s41590-018-0107-1

McGaha and colleagues show that phagocytosis of apoptotic cells leads to activation of the transcription factor AhR and production of the cytokine IL-10 in phagocytes, in a manner dependent on the recognition of DNA.
Categories: Immunology

Nuclear pore complex-mediated modulation of TCR signaling is required for naïve CD4<sup>+</sup> T cell homeostasis

Nature Immunology - 7 May 2018 - 12:00am

Nuclear pore complex-mediated modulation of TCR signaling is required for naïve CD4+ T cell homeostasis

Nuclear pore complex-mediated modulation of TCR signaling is required for naïve CD4<sup>+</sup> T cell homeostasis, Published online: 07 May 2018; doi:10.1038/s41590-018-0103-5

D’Angelo and colleagues show that the nucleoporin Nup210 plays a specific role in naïve CD4+ T cell homeostasis by regulating expression of Caveolin-2, which is required for tonic TCR signaling.
Categories: Immunology

Publisher Correction: Single-cell gene expression reveals a landscape of regulatory T cell phenotypes shaped by the TCR

Nature Immunology - 3 May 2018 - 12:00am

Publisher Correction: Single-cell gene expression reveals a landscape of regulatory T cell phenotypes shaped by the TCR

Publisher Correction: Single-cell gene expression reveals a landscape of regulatory T cell phenotypes shaped by the TCR, Published online: 03 May 2018; doi:10.1038/s41590-018-0104-4

Publisher Correction: Single-cell gene expression reveals a landscape of regulatory T cell phenotypes shaped by the TCR
Categories: Immunology

Publisher Correction: Natural variation in the parameters of innate immune cells is preferentially driven by genetic factors

Nature Immunology - 3 May 2018 - 12:00am

Publisher Correction: Natural variation in the parameters of innate immune cells is preferentially driven by genetic factors

Publisher Correction: Natural variation in the parameters of innate immune cells is preferentially driven by genetic factors, Published online: 03 May 2018; doi:10.1038/s41590-018-0105-3

Publisher Correction: Natural variation in the parameters of innate immune cells is preferentially driven by genetic factors
Categories: Immunology

Atherogenic dyslipidemia promotes autoimmune follicular helper T cell responses via IL-27

Nature Immunology - 30 April 2018 - 12:00am

Atherogenic dyslipidemia promotes autoimmune follicular helper T cell responses via IL-27

Atherogenic dyslipidemia promotes autoimmune follicular helper T cell responses via IL-27, Published online: 30 April 2018; doi:10.1038/s41590-018-0102-6

Dyslipidemia and autoimmune disease are often associated. Chung and colleagues demonstrate a mechanistic pathway by which dyslipidemia leads to the induction of pathogenic autoantibodies.
Categories: Immunology

Recasting Human Vδ1 Lymphocytes in an Adaptive Role

Trends Immunology - 18 April 2018 - 12:00am
γδ T cells are unconventional lymphocytes commonly described as ‘innate-like’ in function, which can respond in both a T cell receptor (TCR)-independent and also major histocompatibility complex (MHC)-unrestricted TCR-dependent manner. While the relative importance of TCR recognition had remained unclear, recent studies revealed that human Vδ1 T cells display unexpected parallels with adaptive αβ T cells. Vδ1 T cells undergo profound and highly focussed clonal expansion from an initially diverse and private TCR repertoire, most likely in response to specific immune challenges.
Categories: Immunology

Pages