Immunology

Author Correction: T-bet-dependent NKp46<sup>+</sup> innate lymphoid cells regulate the onset of T<sub>H</sub>17-induced neuroinflammation

Nature Immunology - 29 June 2018 - 12:00am

Author Correction: T-bet-dependent NKp46+ innate lymphoid cells regulate the onset of TH17-induced neuroinflammation

Author Correction: T-bet-dependent NKp46<sup>+</sup> innate lymphoid cells regulate the onset of T<sub>H</sub>17-induced neuroinflammation, Published online: 29 June 2018; doi:10.1038/s41590-018-0139-6

Author Correction: T-bet-dependent NKp46+ innate lymphoid cells regulate the onset of TH17-induced neuroinflammation
Categories: Immunology

Publisher Correction: Macrophages: damage control

Nature Immunology - 28 June 2018 - 12:00am

Publisher Correction: Macrophages: damage control

Publisher Correction: Macrophages: damage control, Published online: 28 June 2018; doi:10.1038/s41590-018-0159-2

Publisher Correction: Macrophages: damage control
Categories: Immunology

Publisher Correction: Feeling stressed? It might be your T cells

Nature Immunology - 28 June 2018 - 12:00am

Publisher Correction: Feeling stressed? It might be your T cells

Publisher Correction: Feeling stressed? It might be your T cells, Published online: 28 June 2018; doi:10.1038/s41590-018-0140-0

Publisher Correction: Feeling stressed? It might be your T cells
Categories: Immunology

Author Correction: A gammaherpesvirus provides protection against allergic asthma by inducing the replacement of resident alveolar macrophages with regulatory monocytes

Nature Immunology - 28 June 2018 - 12:00am

Author Correction: A gammaherpesvirus provides protection against allergic asthma by inducing the replacement of resident alveolar macrophages with regulatory monocytes

Author Correction: A gammaherpesvirus provides protection against allergic asthma by inducing the replacement of resident alveolar macrophages with regulatory monocytes, Published online: 28 June 2018; doi:10.1038/s41590-017-0024-8

Author Correction: A gammaherpesvirus provides protection against allergic asthma by inducing the replacement of resident alveolar macrophages with regulatory monocytes
Categories: Immunology

The E3 ligases Itch and WWP2 cooperate to limit T<sub>H</sub>2 differentiation by enhancing signaling through the TCR

Nature Immunology - 20 June 2018 - 12:00am

The E3 ligases Itch and WWP2 cooperate to limit TH2 differentiation by enhancing signaling through the TCR

The E3 ligases Itch and WWP2 cooperate to limit T<sub>H</sub>2 differentiation by enhancing signaling through the TCR, Published online: 20 June 2018; doi:10.1038/s41590-018-0137-8

Liu and colleagues show that the ubiquitin E3 ligases Itch and WWP2 act together in regulating the strength of the TCR signal and differentiation toward the TH2 lineage.
Categories: Immunology

Plasmacytoid dendritic cells: origin matters

Nature Immunology - 20 June 2018 - 12:00am

Plasmacytoid dendritic cells: origin matters

Plasmacytoid dendritic cells: origin matters, Published online: 20 June 2018; doi:10.1038/s41590-018-0143-x

Plasmacytoid dendritic cells (pDCs) are type I interferon–producing cells with antigen-presenting potential. pDC populations are composed of transcriptionally and functionally heterogeneous cellular subsets with distinct hematopoietic precursor origin.
Categories: Immunology

TILs on standby

Nature Immunology - 20 June 2018 - 12:00am

TILs on standby

TILs on standby, Published online: 20 June 2018; doi:10.1038/s41590-018-0150-y

TILs on standby
Categories: Immunology

Thymic tolerance as a key brake on autoimmunity

Nature Immunology - 20 June 2018 - 12:00am

Thymic tolerance as a key brake on autoimmunity

Thymic tolerance as a key brake on autoimmunity, Published online: 20 June 2018; doi:10.1038/s41590-018-0128-9

The thymus has a critical role in the establishment of appropriately educated and self-tolerant T cells. In their Focus Review, Cheng and Anderson discuss the most recent insights into how the thymus establishes self-tolerance.
Categories: Immunology

Fiber against flu

Nature Immunology - 20 June 2018 - 12:00am

Fiber against flu

Fiber against flu, Published online: 20 June 2018; doi:10.1038/s41590-018-0147-6

Fiber against flu
Categories: Immunology

Regulatory T cells in autoimmune disease

Nature Immunology - 20 June 2018 - 12:00am

Regulatory T cells in autoimmune disease

Regulatory T cells in autoimmune disease, Published online: 20 June 2018; doi:10.1038/s41590-018-0120-4

Treg cells have a critical role in maintaining peripheral tolerance. In this Focus Review, Dominguez-Villar and Hafler describe how the instability and plasticity of Treg cells can contribute to the breakdown of tolerance and lead to autoimmune disease.
Categories: Immunology

Dysbiosis shapes vaccine responses

Nature Immunology - 20 June 2018 - 12:00am

Dysbiosis shapes vaccine responses

Dysbiosis shapes vaccine responses, Published online: 20 June 2018; doi:10.1038/s41590-018-0151-x

Dysbiosis shapes vaccine responses
Categories: Immunology

Approaches and advances in the genetic causes of autoimmune disease and their implications

Nature Immunology - 20 June 2018 - 12:00am

Approaches and advances in the genetic causes of autoimmune disease and their implications

Approaches and advances in the genetic causes of autoimmune disease and their implications, Published online: 20 June 2018; doi:10.1038/s41590-018-0129-8

Autoimmune disease has been the subject of intense genetic study. In this Focus Review, Todd and colleagues describe recent advances and approaches in the genetic analysis of autoimmune disease.
Categories: Immunology

Publisher Correction: Atherogenic dyslipidemia promotes autoimmune follicular helper T cell responses via IL-27

Nature Immunology - 19 June 2018 - 12:00am

Publisher Correction: Atherogenic dyslipidemia promotes autoimmune follicular helper T cell responses via IL-27

Publisher Correction: Atherogenic dyslipidemia promotes autoimmune follicular helper T cell responses via IL-27, Published online: 19 June 2018; doi:10.1038/s41590-018-0158-3

Publisher Correction: Atherogenic dyslipidemia promotes autoimmune follicular helper T cell responses via IL-27
Categories: Immunology

Lck promotes Zap70-dependent LAT phosphorylation by bridging Zap70 to LAT

Nature Immunology - 18 June 2018 - 12:00am

Lck promotes Zap70-dependent LAT phosphorylation by bridging Zap70 to LAT

Lck promotes Zap70-dependent LAT phosphorylation by bridging Zap70 to LAT, Published online: 18 June 2018; doi:10.1038/s41590-018-0131-1

TCR signaling initiates a signaling cascade involving the kinases Lck and Zap70 and the adaptor LAT. Weiss and colleagues discover a proline-rich motif in LAT, which facilitates interactions among Lck, LAT and Zap70 for efficient TCR signaling.
Categories: Immunology

Suppression of IL-17F, but not of IL-17A, provides protection against colitis by inducing T<sub>reg</sub> cells through modification of the intestinal microbiota

Nature Immunology - 18 June 2018 - 12:00am

Suppression of IL-17F, but not of IL-17A, provides protection against colitis by inducing Treg cells through modification of the intestinal microbiota

Suppression of IL-17F, but not of IL-17A, provides protection against colitis by inducing T<sub>reg</sub> cells through modification of the intestinal microbiota, Published online: 18 June 2018; doi:10.1038/s41590-018-0134-y

The cytokines IL-17A and IL-17F bind via same receptor. Iwakura and colleagues demonstrate different functions for IL-17A and IL-17F in the gut, with the latter altering the production of antimicrobial peptides with consequent effects on the microbiota, the induction of Treg cells and immune-system homeostasis.
Categories: Immunology

Publisher Correction: Transcription factor Hoxb5 reprograms B cells into functional T lymphocytes

Nature Immunology - 18 June 2018 - 12:00am

Publisher Correction: Transcription factor Hoxb5 reprograms B cells into functional T lymphocytes

Publisher Correction: Transcription factor Hoxb5 reprograms B cells into functional T lymphocytes, Published online: 18 June 2018; doi:10.1038/s41590-018-0154-7

Publisher Correction: Transcription factor Hoxb5 reprograms B cells into functional T lymphocytes
Categories: Immunology

Get the IL-17F outta here!

Nature Immunology - 18 June 2018 - 12:00am

Get the IL-17F outta here!

Get the IL-17F outta here!, Published online: 18 June 2018; doi:10.1038/s41590-018-0141-z

The cytokine IL-17F constrains the growth of immunoregulatory Clostridium cluster XIVa species and represents a potential therapeutic target for the treatment of inflammatory bowel disease.
Categories: Immunology

Blockade of the checkpoint receptor TIGIT prevents NK cell exhaustion and elicits potent anti-tumor immunity

Nature Immunology - 18 June 2018 - 12:00am

Blockade of the checkpoint receptor TIGIT prevents NK cell exhaustion and elicits potent anti-tumor immunity

Blockade of the checkpoint receptor TIGIT prevents NK cell exhaustion and elicits potent anti-tumor immunity, Published online: 18 June 2018; doi:10.1038/s41590-018-0132-0

TIGIT is a co-inhibitory receptor associated with T cell exhaustion. Tian and colleagues demonstrate that TIGIT is the predominant inhibitory receptor on NK cells in both humans and mice and that its blockade enhances NK cell–dependent rejection of tumors in experimental models.
Categories: Immunology

Publisher Correction: A tumor–myeloid cell axis, mediated via the cytokines IL-1α and TSLP, promotes the progression of breast cancer

Nature Immunology - 18 June 2018 - 12:00am

Publisher Correction: A tumor–myeloid cell axis, mediated via the cytokines IL-1α and TSLP, promotes the progression of breast cancer

Publisher Correction: A tumor–myeloid cell axis, mediated via the cytokines IL-1α and TSLP, promotes the progression of breast cancer, Published online: 18 June 2018; doi:10.1038/s41590-018-0152-9

Publisher Correction: A tumor–myeloid cell axis, mediated via the cytokines IL-1α and TSLP, promotes the progression of breast cancer
Categories: Immunology

Checkpoint inhibition: NK cells enter the scene

Nature Immunology - 18 June 2018 - 12:00am

Checkpoint inhibition: NK cells enter the scene

Checkpoint inhibition: NK cells enter the scene, Published online: 18 June 2018; doi:10.1038/s41590-018-0142-y

Tumor-associated natural killer cells have elevated expression of the checkpoint inhibitory receptor TIGIT. Monoclonal antibody–mediated blockade targeting TIGIT unleashes the anti-tumor activity of both natural killer cells and T cells in preclinical mouse models and efficiently delays tumor growth.
Categories: Immunology

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