Immunology

MicroRNA says no to mass production

Nature Immunology - 17 September 2018 - 12:00am

MicroRNA says no to mass production

MicroRNA says no to mass production, Published online: 17 September 2018; doi:10.1038/s41590-018-0215-y

Cell-type-specific regulation of gene expression by transcription factors is a fundamental principle of biology. New findings show that microRNA-mediated control of target-gene expression is also dependent on the cellular context.
Categories: Immunology

It takes a village

Nature Immunology - 17 September 2018 - 12:00am

It takes a village

It takes a village, Published online: 17 September 2018; doi:10.1038/s41590-018-0213-0

New insights into how NK cells are educated by the receptor NKG2D, which leads to effects on another receptor, NCR1, raise interesting questions about why so many receptors are linked to the education of NK cells.
Categories: Immunology

Mysterious ILC2 tissue adaptation

Nature Immunology - 10 September 2018 - 12:00am

Mysterious ILC2 tissue adaptation

Mysterious ILC2 tissue adaptation, Published online: 10 September 2018; doi:10.1038/s41590-018-0214-z

Group 2 innate lymphoid cells (ILC2s) that produce the cytokine IL-5 are found in lung, gut, fat and skin tissues. New findings indicate that ILC2s in different tissues selectively express distinct functional cytokine receptors for cell activation in response to the local environment.
Categories: Immunology

An immunoregulatory and tissue-residency program modulated by c-MAF in human T<sub>H</sub>17 cells

Nature Immunology - 10 September 2018 - 12:00am

An immunoregulatory and tissue-residency program modulated by c-MAF in human TH17 cells

An immunoregulatory and tissue-residency program modulated by c-MAF in human T<sub>H</sub>17 cells, Published online: 10 September 2018; doi:10.1038/s41590-018-0200-5

TH17 cells contribute to anti-fungal and anti-bacterial adaptive immune responses. Sallusto and colleagues show that the transcription factor c-Maf has an immunoregulatory role in directing gene expression and tissue residency in human IL-10+ TH17 cell subsets.
Categories: Immunology

Combating herpesvirus encephalitis by potentiating a TLR3–mTORC2 axis

Nature Immunology - 10 September 2018 - 12:00am

Combating herpesvirus encephalitis by potentiating a TLR3–mTORC2 axis

Combating herpesvirus encephalitis by potentiating a TLR3–mTORC2 axis, Published online: 10 September 2018; doi:10.1038/s41590-018-0203-2

The receptor TLR3 is essential for effective responses to herpes simplex virus type 1. Miyake and colleagues demonstrate that a neuron- and astrocyte-intrinsic pathway of TLR3 and the metabolic checkpoint kinase complex mTORC2 is needed to prevent fulminant infection with this virus and encephalitis.
Categories: Immunology

Tissue signals imprint ILC2 identity with anticipatory function

Nature Immunology - 10 September 2018 - 12:00am

Tissue signals imprint ILC2 identity with anticipatory function

Tissue signals imprint ILC2 identity with anticipatory function, Published online: 10 September 2018; doi:10.1038/s41590-018-0201-4

Locksley et al. show tissue-specific imprinting dictates the activating receptors ILC2s express, even in germ-free mice. Skin ILC2s are preferentially activated by IL-18, and IL-18 contributes to inflammation in a mouse model of atopic dermatitis.
Categories: Immunology

Author Correction: The twilight of immunity: emerging concepts in aging of the immune system

Nature Immunology - 3 September 2018 - 12:00am

Author Correction: The twilight of immunity: emerging concepts in aging of the immune system

Author Correction: The twilight of immunity: emerging concepts in aging of the immune system, Published online: 03 September 2018; doi:10.1038/s41590-018-0205-0

Author Correction: The twilight of immunity: emerging concepts in aging of the immune system
Categories: Immunology

Publisher Correction: Gene regulation: c-Maf in CD4<sup>+</sup> T cells: it’s all about context

Nature Immunology - 24 August 2018 - 12:00am

Publisher Correction: Gene regulation: c-Maf in CD4+ T cells: it’s all about context

Publisher Correction: Gene regulation: c-Maf in CD4<sup>+</sup> T cells: it’s all about context, Published online: 24 August 2018; doi:10.1038/s41590-018-0204-1

Publisher Correction: Gene regulation: c-Maf in CD4+ T cells: it’s all about context
Categories: Immunology

Brain lymphatic (dys)function

Nature Immunology - 21 August 2018 - 12:00am

Brain lymphatic (dys)function

Brain lymphatic (dys)function, Published online: 21 August 2018; doi:10.1038/s41590-018-0194-z

Brain lymphatic (dys)function
Categories: Immunology

All about timing

Nature Immunology - 21 August 2018 - 12:00am

All about timing

All about timing, Published online: 21 August 2018; doi:10.1038/s41590-018-0195-y

All about timing
Categories: Immunology

Starved NK cells

Nature Immunology - 21 August 2018 - 12:00am

Starved NK cells

Starved NK cells, Published online: 21 August 2018; doi:10.1038/s41590-018-0197-9

Starved NK cells
Categories: Immunology

Keeper of specificity

Nature Immunology - 21 August 2018 - 12:00am

Keeper of specificity

Keeper of specificity, Published online: 21 August 2018; doi:10.1038/s41590-018-0196-x

Keeper of specificity
Categories: Immunology

ICAM-1 in ILC2s

Nature Immunology - 21 August 2018 - 12:00am

ICAM-1 in ILC2s

ICAM-1 in ILC2s, Published online: 21 August 2018; doi:10.1038/s41590-018-0198-8

ICAM-1 in ILC2s
Categories: Immunology

RIP kinases as modulators of inflammation and immunity

Nature Immunology - 21 August 2018 - 12:00am

RIP kinases as modulators of inflammation and immunity

RIP kinases as modulators of inflammation and immunity, Published online: 21 August 2018; doi:10.1038/s41590-018-0188-x

He and Wang review the immunological functions of RIP kinases in inflammatory responses to microbial infection and tissue injury, as well as their potential roles in the pathogenesis of inflammatory disease and aging.
Categories: Immunology

cGAS liquid droplets

Nature Immunology - 21 August 2018 - 12:00am

cGAS liquid droplets

cGAS liquid droplets, Published online: 21 August 2018; doi:10.1038/s41590-018-0199-7

cGAS liquid droplets
Categories: Immunology

Hyperactivated PI3Kδ promotes self and commensal reactivity at the expense of optimal humoral immunity

Nature Immunology - 20 August 2018 - 12:00am

Hyperactivated PI3Kδ promotes self and commensal reactivity at the expense of optimal humoral immunity

Hyperactivated PI3Kδ promotes self and commensal reactivity at the expense of optimal humoral immunity, Published online: 20 August 2018; doi:10.1038/s41590-018-0182-3

Patients who express a hyperactive mutant of the kinase PI3K exhibit defective humoral immunity. Preite et al. show that overactive PI3K leads to defective class-switched antigen-specific responses to immunization, despite augmented germinal-center formation and reactivity to commensal microbes and self antigens.
Categories: Immunology

Endogenous glucocorticoids control host resistance to viral infection through the tissue-specific regulation of PD-1 expression on NK cells

Nature Immunology - 20 August 2018 - 12:00am

Endogenous glucocorticoids control host resistance to viral infection through the tissue-specific regulation of PD-1 expression on NK cells

Endogenous glucocorticoids control host resistance to viral infection through the tissue-specific regulation of PD-1 expression on NK cells, Published online: 20 August 2018; doi:10.1038/s41590-018-0185-0

Ugolini and colleagues show that glucocorticoid signaling induces expression of the checkpoint receptor PD-1 on NK cells to control immunopathology in a tissue-specific way.
Categories: Immunology

Disruption of an antimycobacterial circuit between dendritic and helper T cells in human SPPL2a deficiency

Nature Immunology - 20 August 2018 - 12:00am

Disruption of an antimycobacterial circuit between dendritic and helper T cells in human SPPL2a deficiency

Disruption of an antimycobacterial circuit between dendritic and helper T cells in human SPPL2a deficiency, Published online: 20 August 2018; doi:10.1038/s41590-018-0178-z

Primary immunodeficiency can predispose patients to mycobacterial disease. Casanova and colleagues identify novel human mutations in the enzyme SPPL2A that result in selective accumulation of CD74 in a dendritic cell subset and lead to their death and the failure to mount effective TH1 responses.
Categories: Immunology

PI3Kδ: Too much of a good thing

Nature Immunology - 20 August 2018 - 12:00am

PI3Kδ: Too much of a good thing

PI3Kδ: Too much of a good thing, Published online: 20 August 2018; doi:10.1038/s41590-018-0183-2

PI3Kδ regulates adaptive immune thresholds and limits immunity to endogenous microbiota.
Categories: Immunology

Glucocorticoids and NK cell PD-1

Nature Immunology - 20 August 2018 - 12:00am

Glucocorticoids and NK cell PD-1

Glucocorticoids and NK cell PD-1, Published online: 20 August 2018; doi:10.1038/s41590-018-0190-3

Immune responses have the potential to induce life-threatening conditions. A novel multi-system pathway in which neuroendocrine signaling induces expression of the checkpoint receptor PD-1 on NK cells is an important mechanism for protection against cytokine-mediated disease during viral infection.
Categories: Immunology

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