Immunology

Old vaccines, new diseases: when BCG meets SPPL2a

Nature Immunology - 20 August 2018 - 12:00am

Old vaccines, new diseases: when BCG meets SPPL2a

Old vaccines, new diseases: when BCG meets SPPL2a, Published online: 20 August 2018; doi:10.1038/s41590-018-0193-0

In the current issue of Nature Immunology, Casanova and colleagues demonstrate that humans (and mouse models) with autosomal-recessive SPPL2a deficiency have a severe defect in conventional dendritic cell 2 survival and production of IL-12 and IL-23, and diminished IFN-γ secretion by mycobacterium-specific memory T cells, thus resulting in increased susceptibility to mycobacterial diseases.
Categories: Immunology

Control of inducible gene expression links cohesin to hematopoietic progenitor self-renewal and differentiation

Nature Immunology - 20 August 2018 - 12:00am

Control of inducible gene expression links cohesin to hematopoietic progenitor self-renewal and differentiation

Control of inducible gene expression links cohesin to hematopoietic progenitor self-renewal and differentiation, Published online: 20 August 2018; doi:10.1038/s41590-018-0184-1

Cohesin is a chromatin-binding factor that interacts at CTCF motifs to organize chromatin looping domains. Merkenschlager and colleagues show that cohesin regulates the inducible expression of inflammatory genes in macrophages and HSPCs and in human AML.
Categories: Immunology

PLD3 and PLD4 are single-stranded acid exonucleases that regulate endosomal nucleic-acid sensing

Nature Immunology - 13 August 2018 - 12:00am

PLD3 and PLD4 are single-stranded acid exonucleases that regulate endosomal nucleic-acid sensing

PLD3 and PLD4 are single-stranded acid exonucleases that regulate endosomal nucleic-acid sensing, Published online: 13 August 2018; doi:10.1038/s41590-018-0179-y

Nemazee and colleagues show that PLD3 and PLD4 are endolysosomal exonucleases that digest ingested nucleic acids and thereby prevent activation of endosomal TLRs. Mice that lack PLD3 and PLD4 develop autoinflammatory disease.
Categories: Immunology

Kimishige Ishizaka 1925–2018

Nature Immunology - 13 August 2018 - 12:00am

Kimishige Ishizaka 1925–2018

Kimishige Ishizaka 1925–2018, Published online: 13 August 2018; doi:10.1038/s41590-018-0187-y

Kimishige Ishizaka 1925–2018
Categories: Immunology

Harald von Boehmer 1942–2018

Nature Immunology - 13 August 2018 - 12:00am

Harald von Boehmer 1942–2018

Harald von Boehmer 1942–2018, Published online: 13 August 2018; doi:10.1038/s41590-018-0192-1

Harald von Boehmer 1942–2018
Categories: Immunology

IgG3 regulates tissue-like memory B cells in HIV-infected individuals

Nature Immunology - 13 August 2018 - 12:00am

IgG3 regulates tissue-like memory B cells in HIV-infected individuals

IgG3 regulates tissue-like memory B cells in HIV-infected individuals, Published online: 13 August 2018; doi:10.1038/s41590-018-0180-5

Circulating IgG3 increases in chronic HIV infection. Moir and colleagues describe a negative regulatory role of secreted IgG3 in response to chronic HIV infection through its action on nonconventional CD27– memory B cells.
Categories: Immunology

Singling out the out-of-tune in lymphoma

Nature Immunology - 13 August 2018 - 12:00am

Singling out the out-of-tune in lymphoma

Singling out the out-of-tune in lymphoma, Published online: 13 August 2018; doi:10.1038/s41590-018-0189-9

Single-cell transcriptomic analysis shows that B cells experience a continuum of cyclic transitional states during the germinal center (GC) reaction; this pattern is lost in GC-derived follicular lymphoma cells, which seem to be heterogeneous and desynchronized.
Categories: Immunology

Human germinal center transcriptional programs are de-synchronized in B cell lymphoma

Nature Immunology - 13 August 2018 - 12:00am

Human germinal center transcriptional programs are de-synchronized in B cell lymphoma

Human germinal center transcriptional programs are de-synchronized in B cell lymphoma, Published online: 13 August 2018; doi:10.1038/s41590-018-0181-4

Human follicular lymphomas arise from germinal center B cells. Milpied and colleagues use single-cell transcriptomic analysis to show that follicular lymphoma cells lose synchronized gene-expression patterns that characterize normal germinal center B cells.
Categories: Immunology

The immunoproteasome and thymoproteasome: functions, evolution and human disease

Nature Immunology - 13 August 2018 - 12:00am

The immunoproteasome and thymoproteasome: functions, evolution and human disease

The immunoproteasome and thymoproteasome: functions, evolution and human disease, Published online: 13 August 2018; doi:10.1038/s41590-018-0186-z

The immunoproteasome and thymoproteasome are specialized proteasomes operating within the immune system. In this Review, Murata et al. recount the discovery of the immunoproteasome and thymoproteasome and delve into their function, context in evolution and relation to human disease.
Categories: Immunology

Silencing of TLM B cells by chronic HIV infection

Nature Immunology - 13 August 2018 - 12:00am

Silencing of TLM B cells by chronic HIV infection

Silencing of TLM B cells by chronic HIV infection, Published online: 13 August 2018; doi:10.1038/s41590-018-0191-2

Chronic infection with human immunodeficiency virus impairs B cell antigen receptor signaling via a newly described mechanism of inhibitory signaling mediated by IgG3 and the IgG Fc receptor FcRγIIb (CD32b).
Categories: Immunology

Epigenetic control of innate and adaptive immune memory

Nature Immunology - 6 August 2018 - 12:00am

Epigenetic control of innate and adaptive immune memory

Epigenetic control of innate and adaptive immune memory, Published online: 06 August 2018; doi:10.1038/s41590-018-0176-1

Natural killer (NK) cells can acquire ‘memory’ signatures. Sun and colleagues examine the dynamic ATAC-seq and functional RNA-seq changes observed upon generation of NK cell memory and show distinct roles for transcription factors STAT1 and STAT4.
Categories: Immunology

IL-9 receptor signaling in memory B cells regulates humoral recall responses

Nature Immunology - 6 August 2018 - 12:00am

IL-9 receptor signaling in memory B cells regulates humoral recall responses

IL-9 receptor signaling in memory B cells regulates humoral recall responses, Published online: 06 August 2018; doi:10.1038/s41590-018-0177-0

Signaling via the cytokine IL-9 receptor regulates humoral recall responses. Kitamura and colleagues report that IL-9 triggers memory B cells to proliferate and terminally differentiate into antibody-secreting cells rather than re-entering germinal centers.
Categories: Immunology

TILs show the way

Nature Immunology - 19 July 2018 - 12:00am

TILs show the way

TILs show the way, Published online: 19 July 2018; doi:10.1038/s41590-018-0175-2

TILs show the way
Categories: Immunology

Natural killer cell specificity for viral infections

Nature Immunology - 19 July 2018 - 12:00am

Natural killer cell specificity for viral infections

Natural killer cell specificity for viral infections, Published online: 19 July 2018; doi:10.1038/s41590-018-0163-6

Romagnani and colleagues discuss the specific recognition of viral antigens and peptides by NK cells and its implications for the composition of the NK cell repertoire and the selection of viral variants.
Categories: Immunology

Symbionts and metabolites

Nature Immunology - 19 July 2018 - 12:00am

Symbionts and metabolites

Symbionts and metabolites, Published online: 19 July 2018; doi:10.1038/s41590-018-0170-7

Symbionts and metabolites
Categories: Immunology

Autophagy & MDSCs

Nature Immunology - 19 July 2018 - 12:00am

Autophagy & MDSCs

Autophagy & MDSCs, Published online: 19 July 2018; doi:10.1038/s41590-018-0173-4

Autophagy & MDSCs
Categories: Immunology

Comment on: Evidence of innate lymphoid cell redundancy in humans

Nature Immunology - 19 July 2018 - 12:00am

Comment on: Evidence of innate lymphoid cell redundancy in humans

Comment on: Evidence of innate lymphoid cell redundancy in humans, Published online: 19 July 2018; doi:10.1038/s41590-018-0164-5

Comment on: Evidence of innate lymphoid cell redundancy in humans
Categories: Immunology

Modeling AD

Nature Immunology - 19 July 2018 - 12:00am

Modeling AD

Modeling AD, Published online: 19 July 2018; doi:10.1038/s41590-018-0171-6

Modeling AD
Categories: Immunology

A harmful pairing

Nature Immunology - 19 July 2018 - 12:00am

A harmful pairing

A harmful pairing, Published online: 19 July 2018; doi:10.1038/s41590-018-0174-3

A harmful pairing
Categories: Immunology

Reply to ‘Comment on: Evidence of innate lymphoid cell redundancy in humans’

Nature Immunology - 19 July 2018 - 12:00am

Reply to ‘Comment on: Evidence of innate lymphoid cell redundancy in humans’

Reply to ‘Comment on: Evidence of innate lymphoid cell redundancy in humans’, Published online: 19 July 2018; doi:10.1038/s41590-018-0165-4

Reply to ‘Comment on: Evidence of innate lymphoid cell redundancy in humans’
Categories: Immunology

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