Immunology

Characterization of a potent and highly unusual minimally enhancing antibody directed against dengue virus

Nature Immunology - 15 October 2018 - 12:00am

Characterization of a potent and highly unusual minimally enhancing antibody directed against dengue virus

Characterization of a potent and highly unusual minimally enhancing antibody directed against dengue virus, Published online: 15 October 2018; doi:10.1038/s41590-018-0227-7

Immunity to one serotype of dengue virus can worsen disease following exposure to another serotype, a process called ‘antibody-dependent enhancement’. Grimes and colleagues characterize the function and structural basis of an unusual, potent and broadly neutralizing antibody that lacks such activity.
Categories: Immunology

Transcription-factor-mediated supervision of global genome architecture maintains B cell identity

Nature Immunology - 15 October 2018 - 12:00am

Transcription-factor-mediated supervision of global genome architecture maintains B cell identity

Transcription-factor-mediated supervision of global genome architecture maintains B cell identity, Published online: 15 October 2018; doi:10.1038/s41590-018-0234-8

The transcription factor Pax5 enforces B cell identity. Nutt, Allan and colleagues show that Pax5 is needed to establish and maintain the three-dimensional genome organization of B cells throughout their lineage development.
Categories: Immunology

Targeting fibrin in neurodegeneration

Nature Immunology - 15 October 2018 - 12:00am

Targeting fibrin in neurodegeneration

Targeting fibrin in neurodegeneration, Published online: 15 October 2018; doi:10.1038/s41590-018-0241-9

Deposition of fibrin in the brain and central nervous system occurs after injury or disease. This process unmasks a conserved cryptic epitope of fibrin that activates microglia; blocking this interaction can limit inflammation and neurotoxicity.
Categories: Immunology

Remote control of γc expression by arginine methylation

Nature Immunology - 15 October 2018 - 12:00am

Remote control of γc expression by arginine methylation

Remote control of γc expression by arginine methylation, Published online: 15 October 2018; doi:10.1038/s41590-018-0240-x

Arginine methylation is a post-translational modification that controls the abundance of γc cytokine receptor on mature T cells by a post-transcriptional mechanism.
Categories: Immunology

Arginine methylation controls the strength of γc-family cytokine signaling in T cell maintenance

Nature Immunology - 15 October 2018 - 12:00am

Arginine methylation controls the strength of γc-family cytokine signaling in T cell maintenance

Arginine methylation controls the strength of γc-family cytokine signaling in T cell maintenance, Published online: 15 October 2018; doi:10.1038/s41590-018-0222-z

PRMT arginine methyltransferases mediate post-translational modification. Takayanagi and colleagues show that a lack of PRMT5 in cells of the T cell lineage compromises their response to cytokines dependent on the common γ-chain, due to aberrant splicing of mRNA transcripts encoding the common γ-chain and its associated kinase JAK3.
Categories: Immunology

Fibrin-targeting immunotherapy protects against neuroinflammation and neurodegeneration

Nature Immunology - 15 October 2018 - 12:00am

Fibrin-targeting immunotherapy protects against neuroinflammation and neurodegeneration

Fibrin-targeting immunotherapy protects against neuroinflammation and neurodegeneration, Published online: 15 October 2018; doi:10.1038/s41590-018-0232-x

Fibrin deposition occurs after the blood–brain barrier is breached. Akassoglou and colleagues generate a therapeutic monoclonal antibody that targets a cryptic fibrin epitope to suppress activation of innate immune responses in the CNS and diminish neuroinflammation.
Categories: Immunology

Unique pattern of neutrophil migration and function during tumor progression

Nature Immunology - 15 October 2018 - 12:00am

Unique pattern of neutrophil migration and function during tumor progression

Unique pattern of neutrophil migration and function during tumor progression, Published online: 15 October 2018; doi:10.1038/s41590-018-0229-5

Neutrophils are linked to tumor progression. Gabrilovich and colleagues demonstrate that neutrophils have tumor-stage-dependent alterations in motility, function and metabolism: in early phases, they are highly motile with altered metabolism, whereas at later stages, they become highly suppressive.
Categories: Immunology

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