Cancer

Cancer in wildlife: patterns of emergence

Nature Rev. Cancer - 16 August 2018 - 12:00am

Cancer in wildlife: patterns of emergence

Cancer in wildlife: patterns of emergence, Published online: 16 August 2018; doi:10.1038/s41568-018-0045-0

Cancer is ubiquitous in wildlife and is an increasing concern for endangered species. This Review discusses the impact of cancer on animal species and highlights how studying these effects could reveal shared mechanisms of cancer predisposition between animals and humans.
Categories: Cancer

Nutrient scavenging in cancer

Nature Rev. Cancer - 10 August 2018 - 12:00am

Nutrient scavenging in cancer

Nutrient scavenging in cancer, Published online: 10 August 2018; doi:10.1038/s41568-018-0048-x

This Review discusses nutrient scavenging, a process by which cancer cells use macromolecules from their environment to fuel cell metabolism and growth even when nutrients are limiting.
Categories: Cancer

The sugar loop

Nature Rev. Cancer - 2 August 2018 - 12:00am

The sugar loop

The sugar loop, Published online: 02 August 2018; doi:10.1038/s41568-018-0049-9

PI3K inhibition in solid cancers driven by PI3K catalytic subunit-α has shown limited clinical benefit. This might be due to activation of a glucose–insulin feedback loop, which can be interrupted by dietary or pharmaceutical approaches, thereby improving therapy outcome.
Categories: Cancer

Subclones work together

Nature Rev. Cancer - 30 July 2018 - 12:00am

Subclones work together

Subclones work together, Published online: 30 July 2018; doi:10.1038/s41568-018-0047-y

Vinci et al. provide evidence for subclonal cooperation driving the maintenance of tumour heterogeneity in paediatric high-grade gliomas.
Categories: Cancer

How to predict the future

Nature Rev. Cancer - 26 July 2018 - 12:00am

How to predict the future

How to predict the future, Published online: 26 July 2018; doi:10.1038/s41568-018-0046-z

Two groups have used targeted sequencing to identify features of clonal haematopoiesis in healthy individuals including the number of somatic mutations, the presence of specific mutations and clonal size, which predict risk of developing acute myeloid leukaemia years before diagnosis.
Categories: Cancer

Clinical tumour sequencing for precision oncology: time for a universal strategy

Nature Rev. Cancer - 20 July 2018 - 12:00am

Clinical tumour sequencing for precision oncology: time for a universal strategy

Clinical tumour sequencing for precision oncology: time for a universal strategy, Published online: 20 July 2018; doi:10.1038/s41568-018-0043-2

Comprehensive genomic characterization of patient tumours has the potential to advance therapies and inform basic cancer research. In this Comment, David B. Solit and colleagues provide their personal perspective on the implementation of an enterprise-wide, prospective clinical sequencing strategy and make a call for a universal approach to next-generation sequencing-based tumour profiling.
Categories: Cancer

Second chances

Nature Rev. Cancer - 18 July 2018 - 12:00am

Second chances

Second chances, Published online: 18 July 2018; doi:10.1038/s41568-018-0044-1

Mutant KRAS has so far proven to be an undruggable target for lung adenocarcinoma and a widely held assumption is that KRAS mutations confer independence from upstream signalling. Two groups have now independently shown this might not be the case and suggest pan-ERBB inhibitors could be used to treat patients with KRAS-driven lung cancer
Categories: Cancer

Extracellular ATP and P2 purinergic signalling in the tumour microenvironment

Nature Rev. Cancer - 13 July 2018 - 12:00am

Extracellular ATP and P2 purinergic signalling in the tumour microenvironment

Extracellular ATP and P2 purinergic signalling in the tumour microenvironment, Published online: 13 July 2018; doi:10.1038/s41568-018-0037-0

In this Review, Di Virgilio et al. describe how extracellular ATP and P2 purinergic signalling can shape the tumour microenvironment to both promote and restrain tumour progression and outline the opportunities to harness nucleotide receptor signalling as an anticancer strategy.
Categories: Cancer

Every step of the way: integrins in cancer progression and metastasis

Nature Rev. Cancer - 12 July 2018 - 12:00am

Every step of the way: integrins in cancer progression and metastasis

Every step of the way: integrins in cancer progression and metastasis, Published online: 12 July 2018; doi:10.1038/s41568-018-0038-z

In this Review, Hamidi and Ivaska discuss the contribution of integrins to the different steps of cancer progression, highlighting some of the recently identified unconventional roles of integrins and novel opportunities to target integrin signalling.
Categories: Cancer

STAT3 on the brain

Nature Rev. Cancer - 9 July 2018 - 12:00am

STAT3 on the brain

STAT3 on the brain, Published online: 09 July 2018; doi:10.1038/s41568-018-0042-3

Priego et al. show that a subpopulation of reactive astrocytes expressing signal transducer and activator of transcription 3 (STAT3) is crucial for the development of brain metastases and report positive initial clinical data that inhibiting STAT3 can reduce metastasis.
Categories: Cancer

From rock ‘n’ roll to heavy metal

Nature Rev. Cancer - 28 June 2018 - 12:00am

From rock ‘n’ roll to heavy metal

From rock ‘n’ roll to heavy metal, Published online: 28 June 2018; doi:10.1038/s41568-018-0041-4

Three studies published in Developmental Cell, Nature and Nature Medicine shed new light on mechanisms of cancer-associated cachexia in early and advanced disease.
Categories: Cancer

Success stories

Nature Rev. Cancer - 22 June 2018 - 12:00am

Success stories

Success stories, Published online: 22 June 2018; doi:10.1038/s41568-018-0039-y

Analyses of clinical trial patients with exceptional responses show that adoptive T cell therapy can be optimised to improve effectiveness in patients of chronic lymphocytic leukaemia and breast cancer.
Categories: Cancer

Tumours trigger systemic disruption

Nature Rev. Cancer - 21 June 2018 - 12:00am

Tumours trigger systemic disruption

Tumours trigger systemic disruption, Published online: 21 June 2018; doi:10.1038/s41568-018-0040-5

Breast tumours in mice promote metabolic changes in the liver and sleep disruption through increasing activity of hypocretin (also known as orexin) neurons (HO neurons).
Categories: Cancer

Falling short to compete

Nature Rev. Cancer - 19 June 2018 - 12:00am

Falling short to compete

Falling short to compete, Published online: 19 June 2018; doi:10.1038/s41568-018-0036-1

Increased shortening of RNA 3′ untranslated regions associated with tumorigenic transformation interferes with competing endogenous RNA (eRNA) networks, which results in trans-repression of tumour suppressors through microRNA-mediated silencing.
Categories: Cancer

Metabolizing microbes in control

Nature Rev. Cancer - 18 June 2018 - 12:00am

Metabolizing microbes in control

Metabolizing microbes in control, Published online: 18 June 2018; doi:10.1038/s41568-018-0035-2

The gut microbiota can metabolize bile acids to affect immunosurveillance in the liver of mice and indirectly control the growth of primary liver tumours and liver metastases.
Categories: Cancer

Targeting ATR in cancer

Nature Rev. Cancer - 13 June 2018 - 12:00am

Targeting ATR in cancer

Targeting ATR in cancer, Published online: 13 June 2018; doi:10.1038/s41568-018-0034-3

This Opinion provides insight into the potential of targeting the replication stress response in cancer and discusses the strategy of inhibiting ataxia telangiectasia and Rad3-related protein (ATR) and the need for reliable biomarkers to enable patient stratification.
Categories: Cancer

Eco-evolutionary causes and consequences of temporal changes in intratumoural blood flow

Nature Rev. Cancer - 11 June 2018 - 12:00am

Eco-evolutionary causes and consequences of temporal changes in intratumoural blood flow

Eco-evolutionary causes and consequences of temporal changes in intratumoural blood flow, Published online: 11 June 2018; doi:10.1038/s41568-018-0030-7

This Opinion proposes that temporal variations in intratumoural blood flow are the result of eco-evolutionary dynamics. It describes adaptive strategies to stochastically varying environments that may strongly affect observed cancer phenotypes and clinical outcomes including formation of metastases and response to treatment.
Categories: Cancer

Insights on cancer resistance in vertebrates: reptiles as a parallel system to mammals

Nature Rev. Cancer - 11 June 2018 - 12:00am

Insights on cancer resistance in vertebrates: reptiles as a parallel system to mammals

Insights on cancer resistance in vertebrates: reptiles as a parallel system to mammals, Published online: 11 June 2018; doi:10.1038/s41568-018-0033-4

Insights on cancer resistance in vertebrates: reptiles as a parallel system to mammals
Categories: Cancer

It’s all Greek to me

Nature Rev. Cancer - 6 June 2018 - 12:00am

It’s all Greek to me

It’s all Greek to me, Published online: 06 June 2018; doi:10.1038/s41568-018-0032-5

Tumour-associated neutrophils can inhibit the proliferation of pro-tumoural interleukin-17 (IL-17)+ γδ T cells via production of reactive oxygen species.
Categories: Cancer

Lethally high ROS levels thwart resistance

Nature Rev. Cancer - 5 June 2018 - 12:00am

Lethally high ROS levels thwart resistance

Lethally high ROS levels thwart resistance, Published online: 05 June 2018; doi:10.1038/s41568-018-0031-6

Wang, Leite de Oliveira et al. show that BRAFV600E-mutant melanomas that are resistant to BRAF and MEK inhibitors are vulnerable to increased levels of reactive oxygen species and that this can be exploited therapeutically using a histone deacetylase inhibitor.
Categories: Cancer

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