Cancer

Targeting ATR in cancer

Nature Rev. Cancer - 13 June 2018 - 12:00am

Targeting ATR in cancer

Targeting ATR in cancer, Published online: 13 June 2018; doi:10.1038/s41568-018-0034-3

This Opinion provides insight into the potential of targeting the replication stress response in cancer and discusses the strategy of inhibiting ataxia telangiectasia and Rad3-related protein (ATR) and the need for reliable biomarkers to enable patient stratification.
Categories: Cancer

Eco-evolutionary causes and consequences of temporal changes in intratumoural blood flow

Nature Rev. Cancer - 11 June 2018 - 12:00am

Eco-evolutionary causes and consequences of temporal changes in intratumoural blood flow

Eco-evolutionary causes and consequences of temporal changes in intratumoural blood flow, Published online: 11 June 2018; doi:10.1038/s41568-018-0030-7

This Opinion proposes that temporal variations in intratumoural blood flow are the result of eco-evolutionary dynamics. It describes adaptive strategies to stochastically varying environments that may strongly affect observed cancer phenotypes and clinical outcomes including formation of metastases and response to treatment.
Categories: Cancer

Insights on cancer resistance in vertebrates: reptiles as a parallel system to mammals

Nature Rev. Cancer - 11 June 2018 - 12:00am

Insights on cancer resistance in vertebrates: reptiles as a parallel system to mammals

Insights on cancer resistance in vertebrates: reptiles as a parallel system to mammals, Published online: 11 June 2018; doi:10.1038/s41568-018-0033-4

Insights on cancer resistance in vertebrates: reptiles as a parallel system to mammals
Categories: Cancer

It’s all Greek to me

Nature Rev. Cancer - 6 June 2018 - 12:00am

It’s all Greek to me

It’s all Greek to me, Published online: 06 June 2018; doi:10.1038/s41568-018-0032-5

Tumour-associated neutrophils can inhibit the proliferation of pro-tumoural interleukin-17 (IL-17)+ γδ T cells via production of reactive oxygen species.
Categories: Cancer

Lethally high ROS levels thwart resistance

Nature Rev. Cancer - 5 June 2018 - 12:00am

Lethally high ROS levels thwart resistance

Lethally high ROS levels thwart resistance, Published online: 05 June 2018; doi:10.1038/s41568-018-0031-6

Wang, Leite de Oliveira et al. show that BRAFV600E-mutant melanomas that are resistant to BRAF and MEK inhibitors are vulnerable to increased levels of reactive oxygen species and that this can be exploited therapeutically using a histone deacetylase inhibitor.
Categories: Cancer

Author Correction: A causal mechanism for childhood acute lymphoblastic leukaemia

Nature Rev. Cancer - 30 May 2018 - 12:00am

Author Correction: A causal mechanism for childhood acute lymphoblastic leukaemia

Author Correction: A causal mechanism for childhood acute lymphoblastic leukaemia, Published online: 30 May 2018; doi:10.1038/s41568-018-0029-0

Author Correction: A causal mechanism for childhood acute lymphoblastic leukaemia
Categories: Cancer

Deciphering the cells of origin of squamous cell carcinomas

Nature Rev. Cancer - 30 May 2018 - 12:00am

Deciphering the cells of origin of squamous cell carcinomas

Deciphering the cells of origin of squamous cell carcinomas, Published online: 30 May 2018; doi:10.1038/s41568-018-0024-5

This Review discusses the origins of squamous cell carcinoma (SCC), with a focus on skin, lung, oesophageal and head and neck cancer, and describes how oncogenic mutations and the cell of origin cooperate in determining the rise of SCC.
Categories: Cancer

Inverted architecture

Nature Rev. Cancer - 25 May 2018 - 12:00am

Inverted architecture

Inverted architecture, Published online: 25 May 2018; doi:10.1038/s41568-018-0025-4

Single-cell RNA sequencing analysis in paediatric diffuse midline gliomas with histone H3 lysine 27 to methionine mutations indicates that these aggressive tumours contain many stem-like cells and that lineage-based therapeutic targeting might be beneficial.
Categories: Cancer

Ciliary signalling in cancer

Nature Rev. Cancer - 25 May 2018 - 12:00am

Ciliary signalling in cancer

Ciliary signalling in cancer, Published online: 25 May 2018; doi:10.1038/s41568-018-0023-6

This Opinion discusses the role of the primary cilium as a platform for pathways implicated in cancer and how changes in the ciliation of cells in the tumour microenvironment can affect cancer progression.
Categories: Cancer

Adapting to stress — chaperome networks in cancer

Nature Rev. Cancer - 23 May 2018 - 12:00am

Adapting to stress — chaperome networks in cancer

Adapting to stress — chaperome networks in cancer, Published online: 23 May 2018; doi:10.1038/s41568-018-0020-9

In this Opinion, Joshi et al. argue that in cancer cells, a state of chaperome hyperconnectivity is obtained by increasing the interaction strength among chaperome machinery members. These chaperome scaffolding platforms act to increase the functional diversity of oncogenic processes and have implications for the development of chaperome inhibitors.
Categories: Cancer

A causal mechanism for childhood acute lymphoblastic leukaemia

Nature Rev. Cancer - 21 May 2018 - 12:00am

A causal mechanism for childhood acute lymphoblastic leukaemia

A causal mechanism for childhood acute lymphoblastic leukaemia, Published online: 21 May 2018; doi:10.1038/s41568-018-0015-6

In this Review, Greaves describes the evidence supporting the model that infections early in life reduce the risk of childhood common B cell precursor acute lymphoblastic leukaemia (BCP-ALL) development. Given this evidence, paediatric BCP-ALL may be a preventable cancer.
Categories: Cancer

Artificial intelligence in radiology

Nature Rev. Cancer - 17 May 2018 - 12:00am

Artificial intelligence in radiology

Artificial intelligence in radiology, Published online: 17 May 2018; doi:10.1038/s41568-018-0016-5

In this Opinion article, Hosny et al. discuss the application of artificial intelligence to image-based tasks in the field of radiology and consider the advantages and challenges of its clinical implementation.
Categories: Cancer

Early detection: a long road ahead

Nature Rev. Cancer - 16 May 2018 - 12:00am

Early detection: a long road ahead

Early detection: a long road ahead, Published online: 16 May 2018; doi:10.1038/s41568-018-0021-8

Recent data on blood-based tests for early cancer detection are promising, but many issues must be addressed before we have clinically useful blood-based screening tests.
Categories: Cancer

Author Correction: Inflammatory breast cancer biology: the tumour microenvironment is key

Nature Rev. Cancer - 10 May 2018 - 12:00am

Author Correction: Inflammatory breast cancer biology: the tumour microenvironment is key

Author Correction: Inflammatory breast cancer biology: the tumour microenvironment is key, Published online: 10 May 2018; doi:10.1038/s41568-018-0022-7

Author Correction: Inflammatory breast cancer biology: the tumour microenvironment is key
Categories: Cancer

Publisher Correction: Oncolytic viruses as engineering platforms for combination immunotherapy

Nature Rev. Cancer - 4 May 2018 - 12:00am

Publisher Correction: Oncolytic viruses as engineering platforms for combination immunotherapy

Publisher Correction: Oncolytic viruses as engineering platforms for combination immunotherapy, Published online: 04 May 2018; doi:10.1038/s41568-018-0019-2

Publisher Correction: Oncolytic viruses as engineering platforms for combination immunotherapy
Categories: Cancer

On the cutting edge

Nature Rev. Cancer - 30 April 2018 - 12:00am

On the cutting edge

On the cutting edge, Published online: 30 April 2018; doi:10.1038/s41568-018-0017-4

A recent study published in Science Translational Medicine generated a mouse model to study the link between surgical wounding and distant tumour growth, showing that the systemic wound healing response induced by surgery can promote tumour growth.
Categories: Cancer

Inflammatory breast cancer biology: the tumour microenvironment is key

Nature Rev. Cancer - 27 April 2018 - 12:00am

Inflammatory breast cancer biology: the tumour microenvironment is key

Inflammatory breast cancer biology: the tumour microenvironment is key, Published online: 27 April 2018; doi:10.1038/s41568-018-0010-y

Although the aggressive underlying biology of inflammatory breast cancer (IBC) remains largely undefined, the tumour microenvironment (TME) has emerged as a key contributor. This Review discusses intrinsic characteristics of IBC, extrinsic features of the TME and intrinsic–extrinsic communication.
Categories: Cancer

Organoid diversity

Nature Rev. Cancer - 26 April 2018 - 12:00am

Organoid diversity

Organoid diversity, Published online: 26 April 2018; doi:10.1038/s41568-018-0018-3

Roerink et al. have used organoids derived from multiple single cells of colorectal cancers from three patients as well as from normal colorectal epithelium of the same patients to comprehensively study intratumoural heterogeneity.
Categories: Cancer

A history of exploring cancer in context

Nature Rev. Cancer - 26 April 2018 - 12:00am

A history of exploring cancer in context

A history of exploring cancer in context, Published online: 26 April 2018; doi:10.1038/s41568-018-0006-7

In this Timeline article, Maman and Witz describe how much progress has been made in understanding how the tumour microenvironment influences tumour progression since its initial description, highlighting the controversies in the field and the potential of targeting components of the microenvironment for cancer therapy.
Categories: Cancer

Oncolytic viruses as engineering platforms for combination immunotherapy

Nature Rev. Cancer - 25 April 2018 - 12:00am

Oncolytic viruses as engineering platforms for combination immunotherapy

Oncolytic viruses as engineering platforms for combination immunotherapy, Published online: 25 April 2018; doi:10.1038/s41568-018-0009-4

In this Opinion article, Twumasi-Boateng et al. discuss the use of oncolytic viruses as multiplexed immune-modulating platforms with the potential to improve the effectiveness of immunotherapies through novel synergistic mechanisms promoting antitumour immune activity.
Categories: Cancer

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