A causal mechanism for childhood acute lymphoblastic leukaemia
A causal mechanism for childhood acute lymphoblastic leukaemia, Published online: 21 May 2018; doi:10.1038/s41568-018-0015-6In this Review, Greaves describes the evidence supporting the model that infections early in life reduce the risk of childhood common B cell precursor acute lymphoblastic leukaemia (BCP-ALL) development. Given this evidence, paediatric BCP-ALL may be a preventable cancer.
Artificial intelligence in radiology
Artificial intelligence in radiology, Published online: 17 May 2018; doi:10.1038/s41568-018-0016-5In this Opinion article, Hosny et al. discuss the application of artificial intelligence to image-based tasks in the field of radiology and consider the advantages and challenges of its clinical implementation.
Early detection: a long road ahead
Early detection: a long road ahead, Published online: 16 May 2018; doi:10.1038/s41568-018-0021-8Recent data on blood-based tests for early cancer detection are promising, but many issues must be addressed before we have clinically useful blood-based screening tests.
Author Correction: Inflammatory breast cancer biology: the tumour microenvironment is key
Author Correction: Inflammatory breast cancer biology: the tumour microenvironment is key, Published online: 10 May 2018; doi:10.1038/s41568-018-0022-7Author Correction: Inflammatory breast cancer biology: the tumour microenvironment is key
Publisher Correction: Oncolytic viruses as engineering platforms for combination immunotherapy
Publisher Correction: Oncolytic viruses as engineering platforms for combination immunotherapy, Published online: 04 May 2018; doi:10.1038/s41568-018-0019-2Publisher Correction: Oncolytic viruses as engineering platforms for combination immunotherapy
On the cutting edge
On the cutting edge, Published online: 30 April 2018; doi:10.1038/s41568-018-0017-4A recent study published in Science Translational Medicine generated a mouse model to study the link between surgical wounding and distant tumour growth, showing that the systemic wound healing response induced by surgery can promote tumour growth.
Inflammatory breast cancer biology: the tumour microenvironment is key
Inflammatory breast cancer biology: the tumour microenvironment is key, Published online: 27 April 2018; doi:10.1038/s41568-018-0010-yAlthough the aggressive underlying biology of inflammatory breast cancer (IBC) remains largely undefined, the tumour microenvironment (TME) has emerged as a key contributor. This Review discusses intrinsic characteristics of IBC, extrinsic features of the TME and intrinsic–extrinsic communication.
Organoid diversity, Published online: 26 April 2018; doi:10.1038/s41568-018-0018-3Roerink et al. have used organoids derived from multiple single cells of colorectal cancers from three patients as well as from normal colorectal epithelium of the same patients to comprehensively study intratumoural heterogeneity.
A history of exploring cancer in context
A history of exploring cancer in context, Published online: 26 April 2018; doi:10.1038/s41568-018-0006-7In this Timeline article, Maman and Witz describe how much progress has been made in understanding how the tumour microenvironment influences tumour progression since its initial description, highlighting the controversies in the field and the potential of targeting components of the microenvironment for cancer therapy.
Oncolytic viruses as engineering platforms for combination immunotherapy
Oncolytic viruses as engineering platforms for combination immunotherapy, Published online: 25 April 2018; doi:10.1038/s41568-018-0009-4In this Opinion article, Twumasi-Boateng et al. discuss the use of oncolytic viruses as multiplexed immune-modulating platforms with the potential to improve the effectiveness of immunotherapies through novel synergistic mechanisms promoting antitumour immune activity.
Pap seeking new challenges
Pap seeking new challenges, Published online: 24 April 2018; doi:10.1038/s41568-018-0013-8Wang et al. have developed a diagnostic tool (based on the widely used Papanicolaou (Pap) test) to detect endometrial and ovarian cancer in patients by using PCR-based analyses of genetic mutations and aneuploidy.
Cell genesis, Published online: 24 April 2018; doi:10.1038/s41568-018-0014-7Cell genesis
Non-canonical functions of the RB protein in cancer
Non-canonical functions of the RB protein in cancer, Published online: 24 April 2018; doi:10.1038/s41568-018-0008-5This Opinion discusses studies indicating a direct role of RB in chromatin regulation and DNA repair. The authors propose that a non-canonical RB pathway exists, which is independent of the function of RB in cell cycle regulation and which contributes to cancer progression.
Organoids in cancer research
Organoids in cancer research, Published online: 24 April 2018; doi:10.1038/s41568-018-0007-6In this Review, Drost and Clevers discuss the recent advances in organoid models of cancer and how they can be exploited to drive the translation of basic cancer research into novel patient-specific treatment regimens in the clinic.
A Glial Signature and Wnt7 Signaling Regulate Glioma-Vascular Interactions and Tumor Microenvironment
Known and novel roles of the MET oncogene in cancer: a coherent approach to targeted therapy
Known and novel roles of the <i>MET</i> oncogene in cancer: a coherent approach to targeted therapy, Published online: 19 April 2018; doi:10.1038/s41568-018-0002-yThe MET oncogene encodes a receptor tyrosine kinase with pleiotropic functions. In this Review, Comoglio et al. describe the known and novel MET-mediated biological responses in cancer and discuss how clinical trials testing anti-MET therapies should be designed with careful consideration of these oncogenic functions of MET.
Stop the shedding
Stop the shedding, Published online: 17 April 2018; doi:10.1038/s41568-018-0012-9Ferrari de Andrade et al. find that monoclonal antibodies that prevent shedding of MICA and MICB from tumour cells can restore antitumour immunity by natural killer cells.
Structural underpinnings of oestrogen receptor mutations in endocrine therapy resistance
Structural underpinnings of oestrogen receptor mutations in endocrine therapy resistance, Published online: 16 April 2018; doi:10.1038/s41568-018-0001-zThis Opinion article highlights how activating mutations in the gene encoding oestrogen receptor-α (ERα), a major driver in breast cancer, undermine structural features of wild-type ERα that maintain the ‘off-state’ in the absence of oestrogens, thus making ERα constitutively active and endocrine-therapy resistant.
Take a left here
Take a left here, Published online: 16 April 2018; doi:10.1038/s41568-018-0011-xWhether lymph node metastases can be a source of cancer cells for distant metastases has been debated. Now, two studies have used mouse models to show that tumour cells can colonize distant organs by invading lymph node blood vessels.