Adipocyte p62/SQSTM1 Suppresses Tumorigenesis through Opposite Regulations of Metabolism in Adipose Tissue and Tumor
Too many targets, not enough patients: rethinking neuroblastoma clinical trials
Too many targets, not enough patients: rethinking neuroblastoma clinical trials, Published online: 09 April 2018; doi:10.1038/s41568-018-0003-xThis Perspective provides an update on targeted therapy development for neuroblastoma and proposes that clinical trial design needs to be rethought in order to provide rigorous, evidence-based assessment of these new therapies in this rare and often deadly paediatric tumour.
Breast cancer: Obesity — tipping the scales of resistance
Breast cancer: Obesity — tipping the scales of resistance, Published online: 06 April 2018; doi:10.1038/nrc.2018.31Using clinical tissue specimens and mouse models of breast cancer, Incio et al. show that obesity promotes the upregulation of interleukin-6 and fibroblast growth factor 2 in the tumour microenvironment, which confer resistance to anti-vascular endothelial growth factor therapy.
Mechanisms of cancer resistance in long-lived mammals
Mechanisms of cancer resistance in long-lived mammals, Published online: 05 April 2018; doi:10.1038/s41568-018-0004-9In this Opinion article, Seluanov et al. discuss the diverse mechanisms of cancer resistance found in long-lived mammals and argue that studies of unconventional long-lived and cancer-resistant animal species could provide breakthroughs in cancer therapy and prevention.
Breast cancer: External communication
Breast cancer: External communication, Published online: 03 April 2018; doi:10.1038/nrc.2018.30In a new study, researchers show that basal-like breast cancer can be converted into the luminal subtype by inhibiting platelet-derived growth factor (PDGF)-CC signalling in the tumour microenvironment, thereby potentially broadening treatment options for oestrogen receptor-negative breast cancer patients.
Leukaemia: Powers of prediction
Leukaemia: Powers of prediction, Published online: 03 April 2018; doi:10.1038/nrc.2018.28Good et al. use deep phenotypic single-cell analyses and machine learning to identify developmentally dependent cell signalling states in B cell precursor acute lymphoblastic leukaemia that are predictive of relapse.
Pancreatic cancer: The COMPASS shows the way
Pancreatic cancer: The COMPASS shows the way, Published online: 03 April 2018; doi:10.1038/nrc.2018.29Deregulation of the COMPASS-like complex, via loss of KDM6A in females and loss of both KDM6A and its Y chromosome homologue UTY in males, is important for activation of oncogene-associated super-enhancers and the development of pancreatic adenocarcinoma of the squamous subtype.
lncRNA Epigenetic Landscape Analysis Identifies EPIC1 as an Oncogenic lncRNA that Interacts with MYC and Promotes Cell-Cycle Progression in Cancer
Angiogenin/Ribonuclease 5 Is an EGFR Ligand and a Serum Biomarker for Erlotinib Sensitivity in Pancreatic Cancer
Complex Interplay between Epitope Specificity and Isotype Dictates the Biological Activity of Anti-human CD40 Antibodies
Immunosurveillance: Presentation skills
Immunosurveillance: Presentation skills, Published online: 22 March 2018; doi:10.1038/nrc.2018.24Immunosurveillance: Presentation skills
Immunotherapy: iPSC-based vaccines provoke a response
Immunotherapy: iPSC-based vaccines provoke a response, Published online: 22 March 2018; doi:10.1038/nrc.2018.26Immunotherapy: iPSC-based vaccines provoke a response
Immunotherapy: A therapeutic reservoir
Immunotherapy: A therapeutic reservoir, Published online: 22 March 2018; doi:10.1038/nrc.2018.23Wang, C., Wang, J. et al. show that local injection of a hydrogel scaffold degraded by reactive oxygen species in the tumour microenvironment releases chemotherapy and an immune checkpoint inhibitor with kinetics that increase antitumour responses.