Cancer

A causal mechanism for childhood acute lymphoblastic leukaemia

Nature Rev. Cancer - 21 May 2018 - 12:00am

A causal mechanism for childhood acute lymphoblastic leukaemia

A causal mechanism for childhood acute lymphoblastic leukaemia, Published online: 21 May 2018; doi:10.1038/s41568-018-0015-6

In this Review, Greaves describes the evidence supporting the model that infections early in life reduce the risk of childhood common B cell precursor acute lymphoblastic leukaemia (BCP-ALL) development. Given this evidence, paediatric BCP-ALL may be a preventable cancer.
Categories: Cancer

Artificial intelligence in radiology

Nature Rev. Cancer - 17 May 2018 - 12:00am

Artificial intelligence in radiology

Artificial intelligence in radiology, Published online: 17 May 2018; doi:10.1038/s41568-018-0016-5

In this Opinion article, Hosny et al. discuss the application of artificial intelligence to image-based tasks in the field of radiology and consider the advantages and challenges of its clinical implementation.
Categories: Cancer

Early detection: a long road ahead

Nature Rev. Cancer - 16 May 2018 - 12:00am

Early detection: a long road ahead

Early detection: a long road ahead, Published online: 16 May 2018; doi:10.1038/s41568-018-0021-8

Recent data on blood-based tests for early cancer detection are promising, but many issues must be addressed before we have clinically useful blood-based screening tests.
Categories: Cancer

Author Correction: Inflammatory breast cancer biology: the tumour microenvironment is key

Nature Rev. Cancer - 10 May 2018 - 12:00am

Author Correction: Inflammatory breast cancer biology: the tumour microenvironment is key

Author Correction: Inflammatory breast cancer biology: the tumour microenvironment is key, Published online: 10 May 2018; doi:10.1038/s41568-018-0022-7

Author Correction: Inflammatory breast cancer biology: the tumour microenvironment is key
Categories: Cancer

Publisher Correction: Oncolytic viruses as engineering platforms for combination immunotherapy

Nature Rev. Cancer - 4 May 2018 - 12:00am

Publisher Correction: Oncolytic viruses as engineering platforms for combination immunotherapy

Publisher Correction: Oncolytic viruses as engineering platforms for combination immunotherapy, Published online: 04 May 2018; doi:10.1038/s41568-018-0019-2

Publisher Correction: Oncolytic viruses as engineering platforms for combination immunotherapy
Categories: Cancer

On the cutting edge

Nature Rev. Cancer - 30 April 2018 - 12:00am

On the cutting edge

On the cutting edge, Published online: 30 April 2018; doi:10.1038/s41568-018-0017-4

A recent study published in Science Translational Medicine generated a mouse model to study the link between surgical wounding and distant tumour growth, showing that the systemic wound healing response induced by surgery can promote tumour growth.
Categories: Cancer

Inflammatory breast cancer biology: the tumour microenvironment is key

Nature Rev. Cancer - 27 April 2018 - 12:00am

Inflammatory breast cancer biology: the tumour microenvironment is key

Inflammatory breast cancer biology: the tumour microenvironment is key, Published online: 27 April 2018; doi:10.1038/s41568-018-0010-y

Although the aggressive underlying biology of inflammatory breast cancer (IBC) remains largely undefined, the tumour microenvironment (TME) has emerged as a key contributor. This Review discusses intrinsic characteristics of IBC, extrinsic features of the TME and intrinsic–extrinsic communication.
Categories: Cancer

Organoid diversity

Nature Rev. Cancer - 26 April 2018 - 12:00am

Organoid diversity

Organoid diversity, Published online: 26 April 2018; doi:10.1038/s41568-018-0018-3

Roerink et al. have used organoids derived from multiple single cells of colorectal cancers from three patients as well as from normal colorectal epithelium of the same patients to comprehensively study intratumoural heterogeneity.
Categories: Cancer

A history of exploring cancer in context

Nature Rev. Cancer - 26 April 2018 - 12:00am

A history of exploring cancer in context

A history of exploring cancer in context, Published online: 26 April 2018; doi:10.1038/s41568-018-0006-7

In this Timeline article, Maman and Witz describe how much progress has been made in understanding how the tumour microenvironment influences tumour progression since its initial description, highlighting the controversies in the field and the potential of targeting components of the microenvironment for cancer therapy.
Categories: Cancer

Oncolytic viruses as engineering platforms for combination immunotherapy

Nature Rev. Cancer - 25 April 2018 - 12:00am

Oncolytic viruses as engineering platforms for combination immunotherapy

Oncolytic viruses as engineering platforms for combination immunotherapy, Published online: 25 April 2018; doi:10.1038/s41568-018-0009-4

In this Opinion article, Twumasi-Boateng et al. discuss the use of oncolytic viruses as multiplexed immune-modulating platforms with the potential to improve the effectiveness of immunotherapies through novel synergistic mechanisms promoting antitumour immune activity.
Categories: Cancer

Pap seeking new challenges

Nature Rev. Cancer - 24 April 2018 - 12:00am

Pap seeking new challenges

Pap seeking new challenges, Published online: 24 April 2018; doi:10.1038/s41568-018-0013-8

Wang et al. have developed a diagnostic tool (based on the widely used Papanicolaou (Pap) test) to detect endometrial and ovarian cancer in patients by using PCR-based analyses of genetic mutations and aneuploidy.
Categories: Cancer

Cell genesis

Nature Rev. Cancer - 24 April 2018 - 12:00am

Cell genesis

Cell genesis, Published online: 24 April 2018; doi:10.1038/s41568-018-0014-7

Cell genesis
Categories: Cancer

Non-canonical functions of the RB protein in cancer

Nature Rev. Cancer - 24 April 2018 - 12:00am

Non-canonical functions of the RB protein in cancer

Non-canonical functions of the RB protein in cancer, Published online: 24 April 2018; doi:10.1038/s41568-018-0008-5

This Opinion discusses studies indicating a direct role of RB in chromatin regulation and DNA repair. The authors propose that a non-canonical RB pathway exists, which is independent of the function of RB in cell cycle regulation and which contributes to cancer progression.
Categories: Cancer

Organoids in cancer research

Nature Rev. Cancer - 24 April 2018 - 12:00am

Organoids in cancer research

Organoids in cancer research, Published online: 24 April 2018; doi:10.1038/s41568-018-0007-6

In this Review, Drost and Clevers discuss the recent advances in organoid models of cancer and how they can be exploited to drive the translation of basic cancer research into novel patient-specific treatment regimens in the clinic.
Categories: Cancer

Germline Genetic IKZF1 Variation and Predisposition to Childhood Acute Lymphoblastic Leukemia

Cell Cancer - 19 April 2018 - 12:00am
Churchman et al. identify 28 unique germline IKZF1 coding variants in 45 children with acute lymphoblastic leukemia. Many of these variants are not predicted to be damaging using in silico prediction tools, but functional tests reveal that the majority of them have deleterious effects on IKAROS function.
Categories: Cancer

A Glial Signature and Wnt7 Signaling Regulate Glioma-Vascular Interactions and Tumor Microenvironment

Cell Cancer - 19 April 2018 - 12:00am
Griveau et al. show that Olig2+ glioma cells invade by single-cell vessel co-option, whereas Olig2− glioma cells promote angiogenesis and that anti-VEGF treatment selects for the Olig2+/Wnt7+ phenotype. Wnt7 is necessary for vessel co-option, and Wnt inhibition enhances the response to temozolomide treatment.
Categories: Cancer

Known and novel roles of the <i>MET</i> oncogene in cancer: a coherent approach to targeted therapy

Nature Rev. Cancer - 19 April 2018 - 12:00am

Known and novel roles of the MET oncogene in cancer: a coherent approach to targeted therapy

Known and novel roles of the <i>MET</i> oncogene in cancer: a coherent approach to targeted therapy, Published online: 19 April 2018; doi:10.1038/s41568-018-0002-y

The MET oncogene encodes a receptor tyrosine kinase with pleiotropic functions. In this Review, Comoglio et al. describe the known and novel MET-mediated biological responses in cancer and discuss how clinical trials testing anti-MET therapies should be designed with careful consideration of these oncogenic functions of MET.
Categories: Cancer

Stop the shedding

Nature Rev. Cancer - 17 April 2018 - 12:00am

Stop the shedding

Stop the shedding, Published online: 17 April 2018; doi:10.1038/s41568-018-0012-9

Ferrari de Andrade et al. find that monoclonal antibodies that prevent shedding of MICA and MICB from tumour cells can restore antitumour immunity by natural killer cells.
Categories: Cancer

Structural underpinnings of oestrogen receptor mutations in endocrine therapy resistance

Nature Rev. Cancer - 16 April 2018 - 12:00am

Structural underpinnings of oestrogen receptor mutations in endocrine therapy resistance

Structural underpinnings of oestrogen receptor mutations in endocrine therapy resistance, Published online: 16 April 2018; doi:10.1038/s41568-018-0001-z

This Opinion article highlights how activating mutations in the gene encoding oestrogen receptor-α (ERα), a major driver in breast cancer, undermine structural features of wild-type ERα that maintain the ‘off-state’ in the absence of oestrogens, thus making ERα constitutively active and endocrine-therapy resistant.
Categories: Cancer

Take a left here

Nature Rev. Cancer - 16 April 2018 - 12:00am

Take a left here

Take a left here, Published online: 16 April 2018; doi:10.1038/s41568-018-0011-x

Whether lymph node metastases can be a source of cancer cells for distant metastases has been debated. Now, two studies have used mouse models to show that tumour cells can colonize distant organs by invading lymph node blood vessels.
Categories: Cancer

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