Metastasis: Go with the flow
Metastasis: Go with the flow, Published online: 22 March 2018; doi:10.1038/nrc.2018.25Metastasis: Go with the flow
Targeted therapy: Tipping the splicing balance to kill cancer cells
Targeted therapy: Tipping the splicing balance to kill cancer cells, Published online: 22 March 2018; doi:10.1038/nrc.2018.27A paper in Nature Medicine describes a novel, orally available splicing modulator that preferentially kills cancer cells with mutations in splicing factors in culture and in mouse models.
Cell motility in cancer invasion and metastasis: insights from simple model organisms
Cell motility in cancer invasion and metastasis: insights from simple model organisms, Published online: 16 March 2018; doi:10.1038/nrc.2018.15In this Review, Stuelten et al. outline insights with relevance to human cancer invasion and metastasis that have come from the study of cell motility in non-mammalian model organisms.
Dysregulated IL-18 Is a Key Driver of Immunosuppression and a Possible Therapeutic Target in the Multiple Myeloma Microenvironment
NRL and CRX Define Photoreceptor Identity and Reveal Subgroup-Specific Dependencies in Medulloblastoma
Tumor-Repopulating Cells Induce PD-1 Expression in CD8+ T Cells by Transferring Kynurenine and AhR Activation
Loss of KDM6A Activates Super-Enhancers to Induce Gender-Specific Squamous-like Pancreatic Cancer and Confers Sensitivity to BET Inhibitors
Sense-Antisense lncRNA Pair Encoded by Locus 6p22.3 Determines Neuroblastoma Susceptibility via the USP36-CHD7-SOX9 Regulatory Axis
BRD4 Inhibition Is Synthetic Lethal with PARP Inhibitors through the Induction of Homologous Recombination Deficiency
Non-angiogenic tumours and their influence on cancer biology
Non-angiogenic tumours and their influence on cancer biology, Published online: 09 March 2018; doi:10.1038/nrc.2018.14In this Opinion article, Donnem et al. outline the evidence for non-angiogenic tumours, which use pre-existing blood vessels to support tumour growth, and discuss the studies that are beginning to define their unique biology.
Immunotherapy: Tear down this wall
Immunotherapy: Tear down this wall, Published online: 09 March 2018; doi:10.1038/nrc.2018.22Activation of TGFβ signalling in invasive margins of metastatic tumours can contribute to T cell exclusion and reduced immune checkpoint therapy response. Inhibition of TGFβ in non-responders can potentially help to improve outcomes in these patients.
Epigenetics: Methylating patterns
Epigenetics: Methylating patterns, Published online: 09 March 2018; doi:10.1038/nrc.2018.21Xie et al. show that senescence-associated DNA methylation changes evolve independently of stochastic tumour-associated methylation changes and that a subset of commonly methylated genes with the highest gains are associated with early tumorigenesis and ageing.
Metastasis: Staying organized
Metastasis: Staying organized, Published online: 02 March 2018; doi:10.1038/nrc.2018.20A recent study published in Nature Cell Biology has shown that tumour spheres that maintain an inverted epithelial architecture originate from primary colorectal cancers and can collectively invade the peritoneum, initiating metastasis.