Neighbourly deaths dictate fate
Neighbourly deaths dictate fate, Published online: 09 October 2018; doi:10.1038/s41568-018-0064-xSeehawer, Heinzmann et al. show that lineage commitment in liver cancer is independent of oncogenic driver expression and is instead dictated by the type of cell death occurring in the nearby liver microenvironment.
The COSMIC Cancer Gene Census: describing genetic dysfunction across all human cancers
The COSMIC Cancer Gene Census: describing genetic dysfunction across all human cancers, Published online: 06 October 2018; doi:10.1038/s41568-018-0060-1This Review discusses the 2018 Catalogue of Somatic Mutations in Cancer (COSMIC) Cancer Gene Census (CGC), an expert-curated description of human cancer genes, which has recently been expanded to include functional descriptions of how each gene contributes to cancer.
A multiplexed view of immune infiltration
A multiplexed view of immune infiltration, Published online: 04 October 2018; doi:10.1038/s41568-018-0063-yKeren et al. have used multiplexed imaging in intact samples from breast cancer patients to gain insights into the architecture of the tumour immune microenvironment.
STAT3’s true colours
STAT3’s true colours, Published online: 03 October 2018; doi:10.1038/s41568-018-0062-zD’Amico et al. show that, in the presence of oncogenic RAS mutations, STAT3 acts as a tumour modifier by regulating the epithelial differentiation of pancreatic and lung cancer cells via p63.