The molecular landscape of head and neck cancer
The molecular landscape of head and neck cancer, Published online: 02 March 2018; doi:10.1038/nrc.2018.11Head and neck cancer is an unexpectedly heterogeneous disease. In this Review, Leemans, Snijders and Brakenhoff provide an update on the molecular biology of head and neck cancer, outline the role of human papillomavirus and discuss the functional role of genes involved in malignant progression to identify subgroups to personalize treatment.
Opportunities and challenges for human papillomavirus vaccination in cancer
Opportunities and challenges for human papillomavirus vaccination in cancer, Published online: 02 March 2018; doi:10.1038/nrc.2018.13To efficiently prevent cancers associated with human papillomavirus (HPV) infection, especially cervical cancer, effective vaccines and high vaccination coverage are required. This Review provides insight into virological, immunological and strategical progress in HPV vaccines as well as implementation and potential advances.
Drug delivery: DNA nanorobots — seek and destroy
Drug delivery: DNA nanorobots — seek and destroy, Published online: 02 March 2018; doi:10.1038/nrc.2018.19Li et al. report the development of 'DNA nanorobots' carrying a thrombin protease payload that induce coagulation and necrosis at the tumour site, illustrating their therapeutic potential as drug delivery systems.
Genome-wide CRISPR-Cas9 Screen Identifies Leukemia-Specific Dependence on a Pre-mRNA Metabolic Pathway Regulated by DCPS
Genomic instability: The sting of metastasis
Genomic instability: The sting of metastasis, Published online: 22 February 2018; doi:10.1038/nrc.2018.16Data presented by Bakhoum, Ngo et al. suggest that chromosomal instability can promote metastasis through a cGAS–STING-dependent response to cytosolic DNA.
Tumour microenvironment: Fibroblast subtype provides niche for cancer stem cells
Tumour microenvironment: Fibroblast subtype provides niche for cancer stem cells, Published online: 22 February 2018; doi:10.1038/nrc.2018.18A subset of cancer-associated firboblasts, defined by the presence of the cell surface markers CD10 and GPR77, promotes tumour formation and chemoresistance by providing a niche for cancer stem cells.
Breast cancer: Staying silent
Breast cancer: Staying silent, Published online: 22 February 2018; doi:10.1038/nrc.2018.17Mitogen- and stress-activated kinase 1 (MSK1) has been identified as an epigenetic modulator of luminal gene expression in breast cancer, maintaining latency of bone micrometastases.
Gut microbiota injury in allogeneic haematopoietic stem cell transplantation
Gut microbiota injury in allogeneic haematopoietic stem cell transplantation, Published online: 16 February 2018; doi:10.1038/nrc.2018.10Allogeneic haematopoietic stem cell transplantation (allo-HSCT) is a well-established treatment for many haematopoietic malignancies but often results in life-threatening complications, such as graft-versus-host disease, relapse and infections. This Review discusses the potential role of intestinal microbiota in complications after allo-HSCT.
Using immunotherapy to boost the abscopal effect
Using immunotherapy to boost the abscopal effect, Published online: 16 February 2018; doi:10.1038/nrc.2018.6The abscopal effect, which is the regression of metastatic cancer at distant sites during radiotherapy, is somewhat rare but can be promoted by immunotherapy. This Opinion article describes emerging concepts and limitations of using a combination of radiotherapy and immunotherapy to boost the abscopal effect.