Breast cancer: External communication
Breast cancer: External communication, Published online: 03 April 2018; doi:10.1038/nrc.2018.30In a new study, researchers show that basal-like breast cancer can be converted into the luminal subtype by inhibiting platelet-derived growth factor (PDGF)-CC signalling in the tumour microenvironment, thereby potentially broadening treatment options for oestrogen receptor-negative breast cancer patients.
Leukaemia: Powers of prediction
Leukaemia: Powers of prediction, Published online: 03 April 2018; doi:10.1038/nrc.2018.28Good et al. use deep phenotypic single-cell analyses and machine learning to identify developmentally dependent cell signalling states in B cell precursor acute lymphoblastic leukaemia that are predictive of relapse.
Pancreatic cancer: The COMPASS shows the way
Pancreatic cancer: The COMPASS shows the way, Published online: 03 April 2018; doi:10.1038/nrc.2018.29Deregulation of the COMPASS-like complex, via loss of KDM6A in females and loss of both KDM6A and its Y chromosome homologue UTY in males, is important for activation of oncogene-associated super-enhancers and the development of pancreatic adenocarcinoma of the squamous subtype.