Cancer

Breast cancer: External communication

Nature Rev. Cancer - 3 April 2018 - 12:00am

Breast cancer: External communication

Breast cancer: External communication, Published online: 03 April 2018; doi:10.1038/nrc.2018.30

In a new study, researchers show that basal-like breast cancer can be converted into the luminal subtype by inhibiting platelet-derived growth factor (PDGF)-CC signalling in the tumour microenvironment, thereby potentially broadening treatment options for oestrogen receptor-negative breast cancer patients.
Categories: Cancer

Leukaemia: Powers of prediction

Nature Rev. Cancer - 3 April 2018 - 12:00am

Leukaemia: Powers of prediction

Leukaemia: Powers of prediction, Published online: 03 April 2018; doi:10.1038/nrc.2018.28

Good et al. use deep phenotypic single-cell analyses and machine learning to identify developmentally dependent cell signalling states in B cell precursor acute lymphoblastic leukaemia that are predictive of relapse.
Categories: Cancer

Pancreatic cancer: The COMPASS shows the way

Nature Rev. Cancer - 3 April 2018 - 12:00am

Pancreatic cancer: The COMPASS shows the way

Pancreatic cancer: The COMPASS shows the way, Published online: 03 April 2018; doi:10.1038/nrc.2018.29

Deregulation of the COMPASS-like complex, via loss of KDM6A in females and loss of both KDM6A and its Y chromosome homologue UTY in males, is important for activation of oncogene-associated super-enhancers and the development of pancreatic adenocarcinoma of the squamous subtype.
Categories: Cancer

A Comprehensive Pan-Cancer Molecular Study of Gynecologic and Breast Cancers

Cell Cancer - 2 April 2018 - 12:00am
By performing molecular analyses of 2,579 TCGA gynecological (OV, UCEC, CESC, and UCS) and breast tumors, Berger et al. identify five prognostic subtypes using 16 key molecular features and propose a decision tree based on six clinically assessable features that classifies patients into the subtypes.
Categories: Cancer

Comparative Molecular Analysis of Gastrointestinal Adenocarcinomas

Cell Cancer - 2 April 2018 - 12:00am
Liu et al. analyze 921 gastrointestinal (GI) tract adenocarcinomas and find that hypermutated tumors are enriched for insertions/deletions, upper GI tumors with chromosomal instability harbor fragmented genomes, and a group of genome-stable colorectal tumors are enriched in mutations in SOX9 and PCBP1.
Categories: Cancer

Genomic and Functional Approaches to Understanding Cancer Aneuploidy

Cell Cancer - 2 April 2018 - 12:00am
Analyzing >10,000 human cancers, Taylor et al. show that aneuploidy is correlated with somatic mutation rate, expression of proliferation genes, and decreased leukocyte infiltration. Loss of chromosome arm 3p is common in squamous cancers, but deletion of chromosome 3p reduces cell proliferation in vitro.
Categories: Cancer

lncRNA Epigenetic Landscape Analysis Identifies EPIC1 as an Oncogenic lncRNA that Interacts with MYC and Promotes Cell-Cycle Progression in Cancer

Cell Cancer - 2 April 2018 - 12:00am
Wang et al. characterize the epigenetic landscape of lncRNAs genes across a large number of human tumors and cancer cell lines and observe recurrent hypomethylation of lncRNA genes, including EPIC1. EPIC1 RNA promotes cell-cycle progression by interacting with MYC and enhancing its binding to target genes.
Categories: Cancer

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