Neuroscience

Author Correction: Retrieval induces adaptive forgetting of competing memories via cortical pattern suppression

Nature Neuroscience - 15 August 2018 - 12:00am

Author Correction: Retrieval induces adaptive forgetting of competing memories via cortical pattern suppression

Author Correction: Retrieval induces adaptive forgetting of competing memories via cortical pattern suppression, Published online: 15 August 2018; doi:10.1038/s41593-018-0220-3

Author Correction: Retrieval induces adaptive forgetting of competing memories via cortical pattern suppression
Categories: Neuroscience

Auditory advances

Nature Rev. Neurosc. - 15 August 2018 - 12:00am

Auditory advances

Auditory advances, Published online: 15 August 2018; doi:10.1038/s41583-018-0052-x

Spontaneous activity in the developing auditory system is maintained by a homeostatic mechanism and is important for cochlear neuron subtype specification.
Categories: Neuroscience

Can neocortical feedback alter the sign of plasticity?

Nature Rev. Neurosc. - 14 August 2018 - 12:00am

Can neocortical feedback alter the sign of plasticity?

Can neocortical feedback alter the sign of plasticity?, Published online: 14 August 2018; doi:10.1038/s41583-018-0049-5

Can neocortical feedback alter the sign of plasticity?
Categories: Neuroscience

Reply to ‘Can neocortical feedback alter the sign of plasticity?’

Nature Rev. Neurosc. - 14 August 2018 - 12:00am

Reply to ‘Can neocortical feedback alter the sign of plasticity?’

Reply to ‘Can neocortical feedback alter the sign of plasticity?’, Published online: 14 August 2018; doi:10.1038/s41583-018-0048-6

Reply to ‘Can neocortical feedback alter the sign of plasticity?’
Categories: Neuroscience

Voluntary urination control by brainstem neurons that relax the urethral sphincter

Nature Neuroscience - 13 August 2018 - 12:00am

Voluntary urination control by brainstem neurons that relax the urethral sphincter

Voluntary urination control by brainstem neurons that relax the urethral sphincter, Published online: 13 August 2018; doi:10.1038/s41593-018-0204-3

Controlling urination is a fundamental social need. Keller et al. develop a voluntary urination assay and uncover a subset of brainstem neurons that relax the urethral sphincter, providing insight into urinary control and its dysfunction.
Categories: Neuroscience

Serotonin receptor 2c-expressing cells in the ventral CA1 control attention via innervation of the Edinger–Westphal nucleus

Nature Neuroscience - 13 August 2018 - 12:00am

Serotonin receptor 2c-expressing cells in the ventral CA1 control attention via innervation of the Edinger–Westphal nucleus

Serotonin receptor 2c-expressing cells in the ventral CA1 control attention via innervation of the Edinger–Westphal nucleus, Published online: 13 August 2018; doi:10.1038/s41593-018-0207-0

This study shows that excitatory neurons in the ventral hippocampus that express the serotonin receptor 2c gene control attention through direct innervation of the mouse equivalent of the Edinger–Westphal nucleus.
Categories: Neuroscience

Mapping projections of molecularly defined dopamine neuron subtypes using intersectional genetic approaches

Nature Neuroscience - 13 August 2018 - 12:00am

Mapping projections of molecularly defined dopamine neuron subtypes using intersectional genetic approaches

Mapping projections of molecularly defined dopamine neuron subtypes using intersectional genetic approaches, Published online: 13 August 2018; doi:10.1038/s41593-018-0203-4

Poulin et al. developed intersectional genetic approaches to target dopamine neuron subtypes defined by combinatorial gene expression. They demonstrate that dopamine neuron subtypes display distinctive projection patterns to forebrain regions.
Categories: Neuroscience

Sexually dimorphic behavior, neuronal activity, and gene expression in Chd8-mutant mice

Nature Neuroscience - 13 August 2018 - 12:00am

Sexually dimorphic behavior, neuronal activity, and gene expression in Chd8-mutant mice

Sexually dimorphic behavior, neuronal activity, and gene expression in Chd8-mutant mice, Published online: 13 August 2018; doi:10.1038/s41593-018-0208-z

Autism is ~4 times more common in males. Jung et al. reveal male-preponderant abnormal behaviors in mice lacking CHD8, a chromatin remodeler, accompanying sexually dimorphic changes in neuronal firing, synaptic transmission, and gene expression.
Categories: Neuroscience

Author Correction: Synaptic <i>N</i><sup>6</sup>-methyladenosine (m<sup>6</sup>A) epitranscriptome reveals functional partitioning of localized transcripts

Nature Neuroscience - 10 August 2018 - 12:00am

Author Correction: Synaptic N6-methyladenosine (m6A) epitranscriptome reveals functional partitioning of localized transcripts

Author Correction: Synaptic <i>N</i><sup>6</sup>-methyladenosine (m<sup>6</sup>A) epitranscriptome reveals functional partitioning of localized transcripts, Published online: 10 August 2018; doi:10.1038/s41593-018-0219-9

Author Correction: Synaptic N6-methyladenosine (m6A) epitranscriptome reveals functional partitioning of localized transcripts
Categories: Neuroscience

Hands of (cell) fate

Nature Rev. Neurosc. - 8 August 2018 - 12:00am

Hands of (cell) fate

Hands of (cell) fate, Published online: 08 August 2018; doi:10.1038/s41583-018-0050-z

Progressive hyperpolarization of ventricular zone progenitors regulates their sequential differentiation and migration in mouse primary sensory cortex.
Categories: Neuroscience

Decision-making in sensorimotor control

Nature Rev. Neurosc. - 8 August 2018 - 12:00am

Decision-making in sensorimotor control

Decision-making in sensorimotor control, Published online: 08 August 2018; doi:10.1038/s41583-018-0045-9

The planning and execution of goal-directed actions require numerous decisions to be made, from action selection to the continuous refinement of movement plans. Here, Gallivan et al. discuss these sensorimotor decision-making processes and their interactions with mechanisms of action planning and control.
Categories: Neuroscience

Identity kit

Nature Rev. Neurosc. - 7 August 2018 - 12:00am

Identity kit

Identity kit, Published online: 07 August 2018; doi:10.1038/s41583-018-0046-8

Synapse formation and function at hippocampal CA1 synapses are shown to be regulated by three classes of leucine-rich repeat-containing adhesion molecules, which act in a modular manner to regulate spine density and synapse function.
Categories: Neuroscience

Delivering gene therapy

Nature Rev. Neurosc. - 7 August 2018 - 12:00am

Delivering gene therapy

Delivering gene therapy, Published online: 07 August 2018; doi:10.1038/s41583-018-0051-y

A study shows that, in a mouse model of neuronopathic Gaucher disease, delivery of a gene therapy into the brains of fetal animals prevents neurodegeneration, ameliorates associated neuroinflammation and promotes survival.
Categories: Neuroscience

Hierarchy of transcriptomic specialization across human cortex captured by structural neuroimaging topography

Nature Neuroscience - 6 August 2018 - 12:00am

Hierarchy of transcriptomic specialization across human cortex captured by structural neuroimaging topography

Hierarchy of transcriptomic specialization across human cortex captured by structural neuroimaging topography, Published online: 06 August 2018; doi:10.1038/s41593-018-0195-0

Burt et al. analyze patterns of gene expression across human cortex and show expression primarily varies along a sensory-association hierarchy captured by noninvasive neuroimaging, suggesting an organizing principle for microcircuit specialization.
Categories: Neuroscience

Unsilencing spared spinal neurons

Nature Rev. Neurosc. - 2 August 2018 - 12:00am

Unsilencing spared spinal neurons

Unsilencing spared spinal neurons, Published online: 02 August 2018; doi:10.1038/s41583-018-0047-7

Restoring function of the K+/Cl– co-transporter KCC2 in spinal inhibitory interneurons spared after spinal cord injury helps the recovery of hindlimb function in mice.
Categories: Neuroscience

Brain circuit dysfunction in post-traumatic stress disorder: from mouse to man

Nature Rev. Neurosc. - 27 July 2018 - 12:00am

Brain circuit dysfunction in post-traumatic stress disorder: from mouse to man

Brain circuit dysfunction in post-traumatic stress disorder: from mouse to man, Published online: 27 July 2018; doi:10.1038/s41583-018-0039-7

Advanced techniques for the imaging and manipulation of neural circuits are increasingly being used to advance our understanding of psychiatric disorders. Ressler and colleagues describe our current understanding of the circuit dysfunction that underlies the symptoms of post-traumatic stress disorder.
Categories: Neuroscience

Developmental and genetic regulation of the human cortex transcriptome illuminate schizophrenia pathogenesis

Nature Neuroscience - 26 July 2018 - 12:00am

Developmental and genetic regulation of the human cortex transcriptome illuminate schizophrenia pathogenesis

Developmental and genetic regulation of the human cortex transcriptome illuminate schizophrenia pathogenesis, Published online: 26 July 2018; doi:10.1038/s41593-018-0197-y

The authors surveyed gene expression across cortical development and in individuals with schizophrenia. Three-fold more risk variants influenced expression than known. Risk genes showed developmental regulation, while diagnosis changes implicated largely treatment effects.
Categories: Neuroscience

Enteric nervous system development: what could possibly go wrong?

Nature Rev. Neurosc. - 25 July 2018 - 12:00am

Enteric nervous system development: what could possibly go wrong?

Enteric nervous system development: what could possibly go wrong?, Published online: 25 July 2018; doi:10.1038/s41583-018-0041-0

The gastrointestinal tract is innervated by the enteric nervous system (ENS), and disruption of ENS development can result in various gastrointestinal disorders. Here, Rao and Gershon review the complex processes involved in ENS development, including cell migration, proliferation and organization.
Categories: Neuroscience

Disease strays to evolution’s bounds

Nature Neuroscience - 23 July 2018 - 12:00am

Disease strays to evolution’s bounds

Disease strays to evolution’s bounds, Published online: 23 July 2018; doi:10.1038/s41593-018-0199-9

Phenotypic diversity confers the benefits of adaptation to an evolving species. Random perturbations in our genetic structure may result in new functions required for some change in our environment, and we can survive outside of our happy niche for generations. But where are the limits on this sort of diversity?
Categories: Neuroscience

Parallel circuits from the bed nuclei of stria terminalis to the lateral hypothalamus drive opposing emotional states

Nature Neuroscience - 23 July 2018 - 12:00am

Parallel circuits from the bed nuclei of stria terminalis to the lateral hypothalamus drive opposing emotional states

Parallel circuits from the bed nuclei of stria terminalis to the lateral hypothalamus drive opposing emotional states, Published online: 23 July 2018; doi:10.1038/s41593-018-0198-x

Using genetically encoded physiological tools for monitoring, manipulating, and mapping discrete neural circuits, Giardino et al. characterize 2 discrete amygdala→hypothalamus pathways that promote opposite behavioral responses to emotional stimuli.
Categories: Neuroscience

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