Neuroscience

Food intake — feeling the heat

Nature Rev. Neurosc. - 5 December 2018 - 12:00am

Food intake — feeling the heat

Food intake — feeling the heat, Published online: 05 December 2018; doi:10.1038/s41583-018-0104-2

Meal-associated thermogenesis in brown fat is triggered by the gut hormone secretin and signals to the brain to promote satiation in mice.
Categories: Neuroscience

Restoring walking

Nature Rev. Neurosc. - 5 December 2018 - 12:00am

Restoring walking

Restoring walking, Published online: 05 December 2018; doi:10.1038/s41583-018-0109-x

A study shows that application of spatiotemporally patterned epidural electrical stimulation alongside rehabilitation allowed individuals with spinal cord injury and severe locomotor deficits to walk with limited assistance.
Categories: Neuroscience

Closing the loop

Nature Rev. Neurosc. - 5 December 2018 - 12:00am

Closing the loop

Closing the loop, Published online: 05 December 2018; doi:10.1038/s41583-018-0107-z

Closing the loop
Categories: Neuroscience

Gone FISHing

Nature Rev. Neurosc. - 5 December 2018 - 12:00am

Gone FISHing

Gone FISHing, Published online: 05 December 2018; doi:10.1038/s41583-018-0105-1

Gone FISHing
Categories: Neuroscience

Non-nociceptive roles of opioids in the CNS: opioids’ effects on neurogenesis, learning, memory and affect

Nature Rev. Neurosc. - 5 December 2018 - 12:00am

Non-nociceptive roles of opioids in the CNS: opioids’ effects on neurogenesis, learning, memory and affect

Non-nociceptive roles of opioids in the CNS: opioids’ effects on neurogenesis, learning, memory and affect, Published online: 05 December 2018; doi:10.1038/s41583-018-0092-2

Maladaptive modulation of learning, memory and affect by opioids is linked to dysfunctional neurogenesis. In this Review, Kibaly and colleagues discuss this link and how strategies that target neurogenesis to rescue opioid-dependent learning, memory and affect impairments constitute future directions for anti-addiction therapies.
Categories: Neuroscience

To sleep, to remember

Nature Rev. Neurosc. - 5 December 2018 - 12:00am

To sleep, to remember

To sleep, to remember, Published online: 05 December 2018; doi:10.1038/s41583-018-0108-y

To sleep, to remember
Categories: Neuroscience

Patchwork subiculum

Nature Rev. Neurosc. - 5 December 2018 - 12:00am

Patchwork subiculum

Patchwork subiculum, Published online: 05 December 2018; doi:10.1038/s41583-018-0106-0

Patchwork subiculum
Categories: Neuroscience

Complements lead to insults

Nature Rev. Neurosc. - 30 November 2018 - 12:00am

Complements lead to insults

Complements lead to insults, Published online: 30 November 2018; doi:10.1038/s41583-018-0099-8

Two studies show that tau pathology drives the expression of complement molecules that in turn promote the phagocytosis of synapses and neuroinflammation.
Categories: Neuroscience

Model potential

Nature Rev. Neurosc. - 28 November 2018 - 12:00am

Model potential

Model potential, Published online: 28 November 2018; doi:10.1038/s41583-018-0101-5

Model potential
Categories: Neuroscience

Imagine no fear

Nature Rev. Neurosc. - 28 November 2018 - 12:00am

Imagine no fear

Imagine no fear, Published online: 28 November 2018; doi:10.1038/s41583-018-0102-4

Imagine no fear
Categories: Neuroscience

Merkel cells touch a nerve

Nature Rev. Neurosc. - 28 November 2018 - 12:00am

Merkel cells touch a nerve

Merkel cells touch a nerve, Published online: 28 November 2018; doi:10.1038/s41583-018-0100-6

Merkel cells touch a nerve
Categories: Neuroscience

Do flies like fizz?

Nature Rev. Neurosc. - 28 November 2018 - 12:00am

Do flies like fizz?

Do flies like fizz?, Published online: 28 November 2018; doi:10.1038/s41583-018-0103-3

Do flies like fizz?
Categories: Neuroscience

Publisher Correction: Enhancers active in dopamine neurons are a primary link between genetic variation and neuropsychiatric disease

Nature Neuroscience - 27 November 2018 - 12:00am

Publisher Correction: Enhancers active in dopamine neurons are a primary link between genetic variation and neuropsychiatric disease

Publisher Correction: Enhancers active in dopamine neurons are a primary link between genetic variation and neuropsychiatric disease, Published online: 27 November 2018; doi:10.1038/s41593-018-0277-z

Publisher Correction: Enhancers active in dopamine neurons are a primary link between genetic variation and neuropsychiatric disease
Categories: Neuroscience

Boosting a bad signal

Nature Rev. Neurosc. - 27 November 2018 - 12:00am

Boosting a bad signal

Boosting a bad signal, Published online: 27 November 2018; doi:10.1038/s41583-018-0095-z

Dopamine released in the rodent prefrontal cortex increases the signal-to-noise ratio of responses to aversive stimuli that are transmitted to the periaqueductal grey.
Categories: Neuroscience

Loss of neuronal network resilience precedes seizures and determines the ictogenic nature of interictal synaptic perturbations

Nature Neuroscience - 26 November 2018 - 12:00am

Loss of neuronal network resilience precedes seizures and determines the ictogenic nature of interictal synaptic perturbations

Loss of neuronal network resilience precedes seizures and determines the ictogenic nature of interictal synaptic perturbations, Published online: 26 November 2018; doi:10.1038/s41593-018-0278-y

How seizures emerge in epileptic brain remains an enigma. The authors show that the transition to seizure follows a ubiquitous dynamical principle inherent to many processes in nature characterized by repeated transitions between contrasting regimes.
Categories: Neuroscience

Practice makes plasticity

Nature Neuroscience - 26 November 2018 - 12:00am

Practice makes plasticity

Practice makes plasticity, Published online: 26 November 2018; doi:10.1038/s41593-018-0280-4

Landmark papers in 2005 and 2009 provided the first evidence of links between development, training, and white-matter plasticity in humans, contributing to a shift in our understanding of brain wiring that has inspired fundamental research into the role of genes, the environment, and the mechanisms underlying training-related plasticity.
Categories: Neuroscience

Motor primitives in space and time via targeted gain modulation in cortical networks

Nature Neuroscience - 26 November 2018 - 12:00am

Motor primitives in space and time via targeted gain modulation in cortical networks

Motor primitives in space and time via targeted gain modulation in cortical networks, Published online: 26 November 2018; doi:10.1038/s41593-018-0276-0

Many behavioral tasks require fast, reliable switching of the shape and duration of cortical activity. Stroud et al. show that modulation of neural excitability in recurrent network models provides flexible spatiotemporal control of neural activity.
Categories: Neuroscience

Midbrain activity can explain perceptual decisions during an attention task

Nature Neuroscience - 26 November 2018 - 12:00am

Midbrain activity can explain perceptual decisions during an attention task

Midbrain activity can explain perceptual decisions during an attention task, Published online: 26 November 2018; doi:10.1038/s41593-018-0271-5

Herman et al. exploit the reliable effects of perturbing superior colliculus (SC) neuronal activity on perceptual choice behavior to demonstrate a plausible mechanism by which SC may contribute to perceptual judgments during covert attention tasks.
Categories: Neuroscience

Large-scale associations between the leukocyte transcriptome and BOLD responses to speech differ in autism early language outcome subtypes

Nature Neuroscience - 26 November 2018 - 12:00am

Large-scale associations between the leukocyte transcriptome and BOLD responses to speech differ in autism early language outcome subtypes

Large-scale associations between the leukocyte transcriptome and BOLD responses to speech differ in autism early language outcome subtypes, Published online: 26 November 2018; doi:10.1038/s41593-018-0281-3

Lombardo et al. find large-scale associations between the leukocyte transcriptome and neural responses to speech in toddlers, and these associations differ between toddlers with ASD who have good versus poor language outcomes.
Categories: Neuroscience

Transancestral GWAS of alcohol dependence reveals common genetic underpinnings with psychiatric disorders

Nature Neuroscience - 26 November 2018 - 12:00am

Transancestral GWAS of alcohol dependence reveals common genetic underpinnings with psychiatric disorders

Transancestral GWAS of alcohol dependence reveals common genetic underpinnings with psychiatric disorders, Published online: 26 November 2018; doi:10.1038/s41593-018-0275-1

Different functional variants in ADH1B (and elsewhere) in Europeans and Africans strongly affect risk for alcohol dependence. Dependence only partly genetically correlates with consumption, with strong correlations to other psychiatric disorders.
Categories: Neuroscience

Pages