Neuroscience

CNS infection and immune privilege

Nature Rev. Neurosc. - 11 October 2018 - 12:00am

CNS infection and immune privilege

CNS infection and immune privilege, Published online: 11 October 2018; doi:10.1038/s41583-018-0070-8

Traditionally, the CNS is described to have immune privilege, largely because of its immunological barriers. Here, Forrester, McMenamin and Dando describe how this immune privilege may sometimes not be beneficial, as it enables invading pathogens to exist as latent CNS infections.
Categories: Neuroscience

Maintenance, reserve and compensation: the cognitive neuroscience of healthy ageing

Nature Rev. Neurosc. - 10 October 2018 - 12:00am

Maintenance, reserve and compensation: the cognitive neuroscience of healthy ageing

Maintenance, reserve and compensation: the cognitive neuroscience of healthy ageing, Published online: 10 October 2018; doi:10.1038/s41583-018-0068-2

Age-related changes in cognitive ability are the focus of a growing field of research. Cabeza, Rajah and colleagues aim to promote clarity in the field by agreeing upon consensual definitions for three widely discussed concepts: maintenance, compensation and reserve.
Categories: Neuroscience

Imaging-based parcellations of the human brain

Nature Rev. Neurosc. - 9 October 2018 - 12:00am

Imaging-based parcellations of the human brain

Imaging-based parcellations of the human brain, Published online: 09 October 2018; doi:10.1038/s41583-018-0071-7

The brain can be parcellated into areas or networks with different structural or functional properties. Eickhoff, Yeo and Genon describe various imaging-based strategies to parcellate the human brain, including those based on local properties, such as cytoarchitecture, and global properties, such as connectivity.
Categories: Neuroscience

The neural mechanisms and circuitry of the pair bond

Nature Rev. Neurosc. - 9 October 2018 - 12:00am

The neural mechanisms and circuitry of the pair bond

The neural mechanisms and circuitry of the pair bond, Published online: 09 October 2018; doi:10.1038/s41583-018-0072-6

Recent research advances have yielded fresh insights into the fundamental neural processes underlying pair bonding. In this Review, Walum and Young discuss how neural representations of a partner become inherently rewarding, providing intriguing insights into the neural origins of love.
Categories: Neuroscience

A position on vision

Nature Rev. Neurosc. - 9 October 2018 - 12:00am

A position on vision

A position on vision, Published online: 09 October 2018; doi:10.1038/s41583-018-0076-2

A new study finds that, in mice, location-related signals affect activity in the primary visual cortex.
Categories: Neuroscience

Integration of gene expression and brain-wide connectivity reveals the multiscale organization of mouse hippocampal networks

Nature Neuroscience - 8 October 2018 - 12:00am

Integration of gene expression and brain-wide connectivity reveals the multiscale organization of mouse hippocampal networks

Integration of gene expression and brain-wide connectivity reveals the multiscale organization of mouse hippocampal networks, Published online: 08 October 2018; doi:10.1038/s41593-018-0241-y

Bienkowski et al. have created a new subregional atlas of the mouse hippocampus that integrates gene expression with anatomical connectivity to reveal the multiscale organization of the hippocampus and its connections throughout the brain.
Categories: Neuroscience

Author Correction: The emerging field of epigenetics in neurodegeneration and neuroprotection

Nature Rev. Neurosc. - 5 October 2018 - 12:00am

Author Correction: The emerging field of epigenetics in neurodegeneration and neuroprotection

Author Correction: The emerging field of epigenetics in neurodegeneration and neuroprotection, Published online: 05 October 2018; doi:10.1038/s41583-018-0065-5

Author Correction: The emerging field of epigenetics in neurodegeneration and neuroprotection
Categories: Neuroscience

Rewarding gut feeling

Nature Rev. Neurosc. - 5 October 2018 - 12:00am

Rewarding gut feeling

Rewarding gut feeling, Published online: 05 October 2018; doi:10.1038/s41583-018-0075-3

Vagal afferents projecting from the gut to the brainstem and then relayed on to the midbrain carry reward signals that trigger dopamine release in the dorsal striatum.
Categories: Neuroscience

Number crunching

Nature Rev. Neurosc. - 5 October 2018 - 12:00am

Number crunching

Number crunching, Published online: 05 October 2018; doi:10.1038/s41583-018-0073-5

Number neurons encoding symbolic and nonsymbolical representations of numerical value are identified in the human medial temporal lobe
Categories: Neuroscience

In or out of synch

Nature Rev. Neurosc. - 5 October 2018 - 12:00am

In or out of synch

In or out of synch, Published online: 05 October 2018; doi:10.1038/s41583-018-0074-4

In a genetic mouse model related to schizophrenia, restoring the excitability of parvalbumin-expressing interneurons in hippocampal CA1 ameliorates network dysfunction and behavioural deficits.
Categories: Neuroscience

It’s about time

Nature Rev. Neurosc. - 1 October 2018 - 12:00am

It’s about time

It’s about time, Published online: 01 October 2018; doi:10.1038/s41583-018-0066-4

Study shows that population activity in the rat lateral entorhinal cortex can encode the passage of time, which may contribute to temporal aspects of episodic memory.
Categories: Neuroscience

Imaging the evolution and pathophysiology of Alzheimer disease

Nature Rev. Neurosc. - 28 September 2018 - 12:00am

Imaging the evolution and pathophysiology of Alzheimer disease

Imaging the evolution and pathophysiology of Alzheimer disease, Published online: 28 September 2018; doi:10.1038/s41583-018-0067-3

Various techniques can be used to image aspects of the pathophysiology of Alzheimer disease in humans, notably protein deposition and neurodegeneration. In this Review, William Jagust discusses how human neuroimaging studies have shaped our understanding of this disease.
Categories: Neuroscience

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