Neuroscience

Publisher Correction: Learning by neural reassociation

Nature Neuroscience - 5 July 2018 - 12:00am

Publisher Correction: Learning by neural reassociation

Publisher Correction: Learning by neural reassociation, Published online: 05 July 2018; doi:10.1038/s41593-018-0185-2

Publisher Correction: Learning by neural reassociation
Categories: Neuroscience

Modelling microglial function with induced pluripotent stem cells: an update

Nature Rev. Neurosc. - 5 July 2018 - 12:00am

Modelling microglial function with induced pluripotent stem cells: an update

Modelling microglial function with induced pluripotent stem cells: an update, Published online: 05 July 2018; doi:10.1038/s41583-018-0030-3

In recent years, several studies have reported the production of microglia-like cells from induced pluripotent stem cells. Pocock and Piers describe the methods used to produce and analyse these cells and their potential to improve our understanding of microglial function.
Categories: Neuroscience

The role of engram cells in the systems consolidation of memory

Nature Rev. Neurosc. - 3 July 2018 - 12:00am

The role of engram cells in the systems consolidation of memory

The role of engram cells in the systems consolidation of memory, Published online: 03 July 2018; doi:10.1038/s41583-018-0031-2

Long-term episodic memory storage has been proposed to require a reorganization of neural circuits and networks in a process known as systems consolidation. Tonegawa and colleagues discuss recent advances in our understanding of the contribution of engram cells to this process.
Categories: Neuroscience

Author Correction: Selective synaptic remodeling of amygdalocortical connections associated with fear memory

Nature Neuroscience - 2 July 2018 - 12:00am

Author Correction: Selective synaptic remodeling of amygdalocortical connections associated with fear memory

Author Correction: Selective synaptic remodeling of amygdalocortical connections associated with fear memory, Published online: 02 July 2018; doi:10.1038/s41593-018-0180-7

Author Correction: Selective synaptic remodeling of amygdalocortical connections associated with fear memory
Categories: Neuroscience

Dorsal tegmental dopamine neurons gate associative learning of fear

Nature Neuroscience - 27 June 2018 - 12:00am

Dorsal tegmental dopamine neurons gate associative learning of fear

Dorsal tegmental dopamine neurons gate associative learning of fear, Published online: 27 June 2018; doi:10.1038/s41593-018-0174-5

Unpredicted aversive experiences activate DA neurons in dorsal tegmentum; these neurons are important for fear learning. This prediction-error circuit module linking amygdala and dorsal tegmentum enables a solution to an associative learning problem.
Categories: Neuroscience

Modeling Alzheimer’s disease brains in vitro

Nature Neuroscience - 27 June 2018 - 12:00am

Modeling Alzheimer’s disease brains in vitro

Modeling Alzheimer’s disease brains in vitro, Published online: 27 June 2018; doi:10.1038/s41593-018-0177-2

Alzheimer’s disease (AD) research is hampered by a lack of models that recapitulate all key disease features. Park et al. introduce a microfluidic device containing a 3D culture of human neurons, astrocytes, and microglia that develop AD-like pathology, revealing a potentially important inflammatory mechanism of neurodegeneration.
Categories: Neuroscience

A 3D human triculture system modeling neurodegeneration and neuroinflammation in Alzheimer’s disease

Nature Neuroscience - 27 June 2018 - 12:00am

A 3D human triculture system modeling neurodegeneration and neuroinflammation in Alzheimer’s disease

A 3D human triculture system modeling neurodegeneration and neuroinflammation in Alzheimer’s disease, Published online: 27 June 2018; doi:10.1038/s41593-018-0175-4

This study describes a 3D human neuron-astrocyte-microglia triculture model of Alzheimer’s disease using a microfluidic platform and recapitulating plaque and tangle pathology, microglial recruitment, neuroinflammation, and cell death.
Categories: Neuroscience

Synaptic <i>N</i><sup>6</sup>-methyladenosine (m<sup>6</sup>A) epitranscriptome reveals functional partitioning of localized transcripts

Nature Neuroscience - 27 June 2018 - 12:00am

Synaptic N6-methyladenosine (m6A) epitranscriptome reveals functional partitioning of localized transcripts

Synaptic <i>N</i><sup>6</sup>-methyladenosine (m<sup>6</sup>A) epitranscriptome reveals functional partitioning of localized transcripts, Published online: 27 June 2018; doi:10.1038/s41593-018-0173-6

A localized set of mRNA at the synapse facilitates synapse formation and plasticity. The authors show an enrichment of N6-methyladenosine (m6A) modifications of these mRNA at the synapse and link m6A recognition by molecular readers to synaptic function.
Categories: Neuroscience

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