Neuroscience

Author Correction: Stay alert, don’t get hurt

Nature Neuroscience - 11 May 2018 - 12:00am

Author Correction: Stay alert, don’t get hurt

Author Correction: Stay alert, don’t get hurt, Published online: 11 May 2018; doi:10.1038/s41593-018-0111-7

Author Correction: Stay alert, don’t get hurt
Categories: Neuroscience

Publisher Correction: Single-cell analysis of experience-dependent transcriptomic states in the mouse visual cortex

Nature Neuroscience - 11 May 2018 - 12:00am

Publisher Correction: Single-cell analysis of experience-dependent transcriptomic states in the mouse visual cortex

Publisher Correction: Single-cell analysis of experience-dependent transcriptomic states in the mouse visual cortex, Published online: 11 May 2018; doi:10.1038/s41593-018-0112-6

Publisher Correction: Single-cell analysis of experience-dependent transcriptomic states in the mouse visual cortex
Categories: Neuroscience

Publisher Correction: The C-terminal tails of endogenous GluA1 and GluA2 differentially contribute to hippocampal synaptic plasticity and learning

Nature Neuroscience - 11 May 2018 - 12:00am

Publisher Correction: The C-terminal tails of endogenous GluA1 and GluA2 differentially contribute to hippocampal synaptic plasticity and learning

Publisher Correction: The C-terminal tails of endogenous GluA1 and GluA2 differentially contribute to hippocampal synaptic plasticity and learning, Published online: 11 May 2018; doi:10.1038/s41593-018-0116-2

Publisher Correction: The C-terminal tails of endogenous GluA1 and GluA2 differentially contribute to hippocampal synaptic plasticity and learning
Categories: Neuroscience

Foraging for foundations in decision neuroscience: insights from ethology

Nature Rev. Neurosc. - 11 May 2018 - 12:00am

Foraging for foundations in decision neuroscience: insights from ethology

Foraging for foundations in decision neuroscience: insights from ethology, Published online: 11 May 2018; doi:10.1038/s41583-018-0010-7

In this Opinion article, Mobbs and colleagues argue that more should be done to combine the approaches taken in neuroscience with those taken in ethology and behavioural ecology to study decision-making. They illustrate how this has been achieved in the context of studies on foraging.
Categories: Neuroscience

A regional divide

Nature Rev. Neurosc. - 9 May 2018 - 12:00am

A regional divide

A regional divide, Published online: 09 May 2018; doi:10.1038/s41583-018-0015-2

Two molecularly and functionally distinct populations of pyramidal cells in the hippocampal subiculum are characterized
Categories: Neuroscience

Creating a diversion

Nature Rev. Neurosc. - 9 May 2018 - 12:00am

Creating a diversion

Creating a diversion, Published online: 09 May 2018; doi:10.1038/s41583-018-0016-1

Elevated maternal IL-6 in the maternal circulation can enter the fetus via the maternal—placental—fetal route and alter neurodevelopmental processes, with potentially wide-ranging effects on brain function later in life.
Categories: Neuroscience

An expanding role

Nature Rev. Neurosc. - 8 May 2018 - 12:00am

An expanding role

An expanding role, Published online: 08 May 2018; doi:10.1038/s41583-018-0017-0

A new study suggests an evolutionary mechanism — involving abnormal spindle-like microcephaly-associated protein — that, in part, underlies cerebral cortical expansion.
Categories: Neuroscience

Breathing matters

Nature Rev. Neurosc. - 8 May 2018 - 12:00am

Breathing matters

Breathing matters, Published online: 08 May 2018; doi:10.1038/s41583-018-0003-6

Breathing is a crucial yet surprisingly complex behaviour. Del Negro, Funk and Feldman describe the neural mechanisms underlying different phases of the breathing cycle, and how breathing affects, and is affected by, emotion, cognition and other behaviours.
Categories: Neuroscience

Rett syndrome: insights into genetic, molecular and circuit mechanisms

Nature Rev. Neurosc. - 8 May 2018 - 12:00am

Rett syndrome: insights into genetic, molecular and circuit mechanisms

Rett syndrome: insights into genetic, molecular and circuit mechanisms, Published online: 08 May 2018; doi:10.1038/s41583-018-0006-3

The neurodevelopmental disorder Rett syndrome is caused by a deficiency in methyl-CpG-binding protein 2 (MeCP2). Ip, Mellios and Sur describe the many functions of MeCP2 and the effects of MeCP2 loss on gene expression, excitation–inhibition balance and activity-dependent plasticity.
Categories: Neuroscience

The power of 3′ UTRs

Nature Rev. Neurosc. - 8 May 2018 - 12:00am

The power of 3′ UTRs

The power of 3′ UTRs, Published online: 08 May 2018; doi:10.1038/s41583-018-0011-6

Neurons comprise several different compartments — for example, dendrites and soma — and mRNA transcripts can be targeted to various neuronal compartments to facilitate efficient local translation. Information encoded in the 3′ untranslated region (3′ UTR) of mRNA transcripts may affect such mRNA localization, as well as transcript stability and translation. In a new study, Tushev et al. examine the 3′ UTRs of mRNA transcripts in different neuronal compartments and report new insights about the importance of these sequences in localization, translation, stability and plasticity.
Categories: Neuroscience

Microglial immune checkpoint mechanisms

Nature Neuroscience - 7 May 2018 - 12:00am

Microglial immune checkpoint mechanisms

Microglial immune checkpoint mechanisms, Published online: 07 May 2018; doi:10.1038/s41593-018-0145-x

Microglial immune checkpoint mechanisms are signaling pathways that limit immune responsiveness and promote homeostatic activities of micrroglia throughout life, but can interfere with repair mechanisms in disease.
Categories: Neuroscience

Synaptic nibbling

Nature Rev. Neurosc. - 1 May 2018 - 12:00am

Synaptic nibbling

Synaptic nibbling, Published online: 01 May 2018; doi:10.1038/s41583-018-0008-1

Synaptic nibbling
Categories: Neuroscience

Pathways to contextual control

Nature Rev. Neurosc. - 1 May 2018 - 12:00am

Pathways to contextual control

Pathways to contextual control, Published online: 01 May 2018; doi:10.1038/s41583-018-0009-0

Pathways to contextual control
Categories: Neuroscience

Precise multimodal optical control of neural ensemble activity

Nature Neuroscience - 30 April 2018 - 12:00am

Precise multimodal optical control of neural ensemble activity

Precise multimodal optical control of neural ensemble activity, Published online: 30 April 2018; doi:10.1038/s41593-018-0139-8

The authors present a new approach to create and edit custom spatiotemporal neural activity patterns in awake, behaving animals with extremely high spatial and temporal precision. They present novel opsins optimized for multiphoton optogenetics.
Categories: Neuroscience

Complex formation between the vasopressin 1b receptor, β-arrestin-2, and the μ-opioid receptor underlies morphine tolerance

Nature Neuroscience - 30 April 2018 - 12:00am

Complex formation between the vasopressin 1b receptor, β-arrestin-2, and the μ-opioid receptor underlies morphine tolerance

Complex formation between the vasopressin 1b receptor, β-arrestin-2, and the μ-opioid receptor underlies morphine tolerance, Published online: 30 April 2018; doi:10.1038/s41593-018-0144-y

Chronic morphine use can lead to tolerance and AC superactivation. This paper identifies a molecular mechanism by which V1bR signaling promotes this process, providing a potential approach to enhance morphine analgesia without increasing tolerance.
Categories: Neuroscience

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