Nature Rev. Neurosc.

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The control of release probability at nerve terminals

15 January 2019 - 12:00am

The control of release probability at nerve terminals

The control of release probability at nerve terminals, Published online: 15 January 2019; doi:10.1038/s41583-018-0111-3

Neurosecretion is controlled by SNAREs and SNARE-binding proteins and is initiated by the influx of Ca2+ ions through voltage-gated calcium channels (VGCCs). In this Review, Dittman and Ryan discuss progress in our understanding of the molecular mechanisms underlying the function of VGCCs and fusion machinery.
Categories: Neuroscience

Beyond the neuron–cellular interactions early in Alzheimer disease pathogenesis

14 January 2019 - 12:00am

Beyond the neuron–cellular interactions early in Alzheimer disease pathogenesis

Beyond the neuron–cellular interactions early in Alzheimer disease pathogenesis, Published online: 14 January 2019; doi:10.1038/s41583-018-0113-1

Understanding the complex interplay of cells that protect neurons early in Alzheimer disease but later contribute to neurodegeneration is important for developing effective therapeutics. In this Review, Henstridge and colleagues discuss the contributions of multiple cell types to disease pathogenesis.
Categories: Neuroscience

Deconstructing cortical folding: genetic, cellular and mechanical determinants

4 January 2019 - 12:00am

Deconstructing cortical folding: genetic, cellular and mechanical determinants

Deconstructing cortical folding: genetic, cellular and mechanical determinants, Published online: 04 January 2019; doi:10.1038/s41583-018-0112-2

Why is the human cerebral cortex folded? Llinares-Benadero and Borrell provide an overview of the mechanical, cellular and molecular factors — and the interactions among them — that influence cortical folding in gyrencephalic species.
Categories: Neuroscience

From sleeping to waking

2 January 2019 - 12:00am

From sleeping to waking

From sleeping to waking, Published online: 02 January 2019; doi:10.1038/s41583-018-0119-8

From sleeping to waking
Categories: Neuroscience

Seeds of change

2 January 2019 - 12:00am

Seeds of change

Seeds of change, Published online: 02 January 2019; doi:10.1038/s41583-018-0118-9

Seeds of change
Categories: Neuroscience

All wrapped up

2 January 2019 - 12:00am

All wrapped up

All wrapped up, Published online: 02 January 2019; doi:10.1038/s41583-018-0117-x

All wrapped up
Categories: Neuroscience

A glial contribution to ‘chemobrain’

2 January 2019 - 12:00am

A glial contribution to ‘chemobrain’

A glial contribution to ‘chemobrain’, Published online: 02 January 2019; doi:10.1038/s41583-018-0115-z

A mouse model reveals a central role for microglial activation and altered glial cell dynamics in the lasting neurological and cognitive dysfunction following methotrexate chemotherapy.
Categories: Neuroscience

Too hungry to sleep

20 December 2018 - 12:00am

Too hungry to sleep

Too hungry to sleep, Published online: 20 December 2018; doi:10.1038/s41583-018-0116-y

Too hungry to sleep
Categories: Neuroscience

Exploring phylogeny to find the function of sleep

20 December 2018 - 12:00am

Exploring phylogeny to find the function of sleep

Exploring phylogeny to find the function of sleep, Published online: 20 December 2018; doi:10.1038/s41583-018-0098-9

The core function of sleep remains unclear. In this Opinion, Anafi, Kayser and Raizen give an overview of sleep states in various phyla and propose that the original function of sleep was likely metabolic.
Categories: Neuroscience

Circadian blueprint of metabolic pathways in the brain

17 December 2018 - 12:00am

Circadian blueprint of metabolic pathways in the brain

Circadian blueprint of metabolic pathways in the brain, Published online: 17 December 2018; doi:10.1038/s41583-018-0096-y

In addition to the central pacemaker, the mammalian brain contains additional circadian clocks. In this Review, Greco and Sassone–Corsi discuss how systemic homeostasis relies on the coordinated communication between these clocks.
Categories: Neuroscience

Portraits of communication in neuronal networks

14 December 2018 - 12:00am

Portraits of communication in neuronal networks

Portraits of communication in neuronal networks, Published online: 14 December 2018; doi:10.1038/s41583-018-0094-0

In this Opinion article, Hahn, Kumar and colleagues propose that synchrony- and oscillation-based communication between brain networks can be described by a common theoretical framework. They also suggest a mechanism for control of the flow of information in the brain through nesting of slow and fast oscillations.
Categories: Neuroscience

Disarming the guards of change

14 December 2018 - 12:00am

Disarming the guards of change

Disarming the guards of change, Published online: 14 December 2018; doi:10.1038/s41583-018-0114-0

Repetitive sensory input induces long-term potentiation of pyramidal cell synapses in mouse somatosensory cortex by activation of higher-order thalamic projections and disinhibition of local interneurons.
Categories: Neuroscience

Author Correction: Epigenetic regulation in psychiatric disorders

13 December 2018 - 12:00am

Author Correction: Epigenetic regulation in psychiatric disorders

Author Correction: Epigenetic regulation in psychiatric disorders, Published online: 13 December 2018; doi:10.1038/s41583-018-0089-x

Author Correction: Epigenetic regulation in psychiatric disorders
Categories: Neuroscience

The neurobiological basis of narcolepsy

13 December 2018 - 12:00am

The neurobiological basis of narcolepsy

The neurobiological basis of narcolepsy, Published online: 13 December 2018; doi:10.1038/s41583-018-0097-x

Narcolepsy is a sleep disorder caused by selective loss of orexin-producing neurons. Scammell and colleagues describe the functions of orexin neurons and the effects of their loss and review evidence implicating the immune system in the pathogenesis of the disorder.
Categories: Neuroscience

When remembering is rewarding

6 December 2018 - 12:00am

When remembering is rewarding

When remembering is rewarding, Published online: 06 December 2018; doi:10.1038/s41583-018-0110-4

In mice, long-term potentiation of hippocampal–nucleus accumbens synapses is required for the formation of reward-related memories.
Categories: Neuroscience

Food intake — feeling the heat

5 December 2018 - 12:00am

Food intake — feeling the heat

Food intake — feeling the heat, Published online: 05 December 2018; doi:10.1038/s41583-018-0104-2

Meal-associated thermogenesis in brown fat is triggered by the gut hormone secretin and signals to the brain to promote satiation in mice.
Categories: Neuroscience

Restoring walking

5 December 2018 - 12:00am

Restoring walking

Restoring walking, Published online: 05 December 2018; doi:10.1038/s41583-018-0109-x

A study shows that application of spatiotemporally patterned epidural electrical stimulation alongside rehabilitation allowed individuals with spinal cord injury and severe locomotor deficits to walk with limited assistance.
Categories: Neuroscience

Closing the loop

5 December 2018 - 12:00am

Closing the loop

Closing the loop, Published online: 05 December 2018; doi:10.1038/s41583-018-0107-z

Closing the loop
Categories: Neuroscience

Gone FISHing

5 December 2018 - 12:00am

Gone FISHing

Gone FISHing, Published online: 05 December 2018; doi:10.1038/s41583-018-0105-1

Gone FISHing
Categories: Neuroscience

Non-nociceptive roles of opioids in the CNS: opioids’ effects on neurogenesis, learning, memory and affect

5 December 2018 - 12:00am

Non-nociceptive roles of opioids in the CNS: opioids’ effects on neurogenesis, learning, memory and affect

Non-nociceptive roles of opioids in the CNS: opioids’ effects on neurogenesis, learning, memory and affect, Published online: 05 December 2018; doi:10.1038/s41583-018-0092-2

Maladaptive modulation of learning, memory and affect by opioids is linked to dysfunctional neurogenesis. In this Review, Kibaly and colleagues discuss this link and how strategies that target neurogenesis to rescue opioid-dependent learning, memory and affect impairments constitute future directions for anti-addiction therapies.
Categories: Neuroscience

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