Nature Rev. Neurosc.

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CNS infection and immune privilege

11 October 2018 - 12:00am

CNS infection and immune privilege

CNS infection and immune privilege, Published online: 11 October 2018; doi:10.1038/s41583-018-0070-8

Traditionally, the CNS is described to have immune privilege, largely because of its immunological barriers. Here, Forrester, McMenamin and Dando describe how this immune privilege may sometimes not be beneficial, as it enables invading pathogens to exist as latent CNS infections.
Categories: Neuroscience

Maintenance, reserve and compensation: the cognitive neuroscience of healthy ageing

10 October 2018 - 12:00am

Maintenance, reserve and compensation: the cognitive neuroscience of healthy ageing

Maintenance, reserve and compensation: the cognitive neuroscience of healthy ageing, Published online: 10 October 2018; doi:10.1038/s41583-018-0068-2

Age-related changes in cognitive ability are the focus of a growing field of research. Cabeza, Rajah and colleagues aim to promote clarity in the field by agreeing upon consensual definitions for three widely discussed concepts: maintenance, compensation and reserve.
Categories: Neuroscience

Imaging-based parcellations of the human brain

9 October 2018 - 12:00am

Imaging-based parcellations of the human brain

Imaging-based parcellations of the human brain, Published online: 09 October 2018; doi:10.1038/s41583-018-0071-7

The brain can be parcellated into areas or networks with different structural or functional properties. Eickhoff, Yeo and Genon describe various imaging-based strategies to parcellate the human brain, including those based on local properties, such as cytoarchitecture, and global properties, such as connectivity.
Categories: Neuroscience

The neural mechanisms and circuitry of the pair bond

9 October 2018 - 12:00am

The neural mechanisms and circuitry of the pair bond

The neural mechanisms and circuitry of the pair bond, Published online: 09 October 2018; doi:10.1038/s41583-018-0072-6

Recent research advances have yielded fresh insights into the fundamental neural processes underlying pair bonding. In this Review, Walum and Young discuss how neural representations of a partner become inherently rewarding, providing intriguing insights into the neural origins of love.
Categories: Neuroscience

A position on vision

9 October 2018 - 12:00am

A position on vision

A position on vision, Published online: 09 October 2018; doi:10.1038/s41583-018-0076-2

A new study finds that, in mice, location-related signals affect activity in the primary visual cortex.
Categories: Neuroscience

Author Correction: The emerging field of epigenetics in neurodegeneration and neuroprotection

5 October 2018 - 12:00am

Author Correction: The emerging field of epigenetics in neurodegeneration and neuroprotection

Author Correction: The emerging field of epigenetics in neurodegeneration and neuroprotection, Published online: 05 October 2018; doi:10.1038/s41583-018-0065-5

Author Correction: The emerging field of epigenetics in neurodegeneration and neuroprotection
Categories: Neuroscience

Rewarding gut feeling

5 October 2018 - 12:00am

Rewarding gut feeling

Rewarding gut feeling, Published online: 05 October 2018; doi:10.1038/s41583-018-0075-3

Vagal afferents projecting from the gut to the brainstem and then relayed on to the midbrain carry reward signals that trigger dopamine release in the dorsal striatum.
Categories: Neuroscience

Number crunching

5 October 2018 - 12:00am

Number crunching

Number crunching, Published online: 05 October 2018; doi:10.1038/s41583-018-0073-5

Number neurons encoding symbolic and nonsymbolical representations of numerical value are identified in the human medial temporal lobe
Categories: Neuroscience

In or out of synch

5 October 2018 - 12:00am

In or out of synch

In or out of synch, Published online: 05 October 2018; doi:10.1038/s41583-018-0074-4

In a genetic mouse model related to schizophrenia, restoring the excitability of parvalbumin-expressing interneurons in hippocampal CA1 ameliorates network dysfunction and behavioural deficits.
Categories: Neuroscience

It’s about time

1 October 2018 - 12:00am

It’s about time

It’s about time, Published online: 01 October 2018; doi:10.1038/s41583-018-0066-4

Study shows that population activity in the rat lateral entorhinal cortex can encode the passage of time, which may contribute to temporal aspects of episodic memory.
Categories: Neuroscience

Imaging the evolution and pathophysiology of Alzheimer disease

28 September 2018 - 12:00am

Imaging the evolution and pathophysiology of Alzheimer disease

Imaging the evolution and pathophysiology of Alzheimer disease, Published online: 28 September 2018; doi:10.1038/s41583-018-0067-3

Various techniques can be used to image aspects of the pathophysiology of Alzheimer disease in humans, notably protein deposition and neurodegeneration. In this Review, William Jagust discusses how human neuroimaging studies have shaped our understanding of this disease.
Categories: Neuroscience

Incidental associations

26 September 2018 - 12:00am

Incidental associations

Incidental associations, Published online: 26 September 2018; doi:10.1038/s41583-018-0069-1

Hippocampal cannabinoid 1 receptors are shown to be involved in the formation of incidental associations between pairs of low-salience sensory stimuli, which can then become indirectly associated with certain cues and thus influence behaviour.
Categories: Neuroscience

Receptor replacement

12 September 2018 - 12:00am

Receptor replacement

Receptor replacement, Published online: 12 September 2018; doi:10.1038/s41583-018-0060-x

Mice receiving autoantibodies against the GluA2 AMPA receptor subunit from individuals with autoimmune encephalitis exhibit changes in AMPA receptor subunit composition and impaired synaptic plasticity and memory.
Categories: Neuroscience

Catching waves

11 September 2018 - 12:00am

Catching waves

Catching waves, Published online: 11 September 2018; doi:10.1038/s41583-018-0062-8

Catching waves
Categories: Neuroscience

Untangling tau structure

11 September 2018 - 12:00am

Untangling tau structure

Untangling tau structure, Published online: 11 September 2018; doi:10.1038/s41583-018-0063-7

Untangling tau structure
Categories: Neuroscience

Planning a path

11 September 2018 - 12:00am

Planning a path

Planning a path, Published online: 11 September 2018; doi:10.1038/s41583-018-0061-9

Planning a path
Categories: Neuroscience

Microglial signatures and their role in health and disease

11 September 2018 - 12:00am

Microglial signatures and their role in health and disease

Microglial signatures and their role in health and disease, Published online: 11 September 2018; doi:10.1038/s41583-018-0057-5

Technological advances have allowed the molecular ‘signatures’ of microglia to be characterized, providing insight into their roles in CNS function. Weiner and Butovsky discuss the plasticity of these signatures in health and disease and consider the mechanisms underlying their establishment, maintenance and regulation.
Categories: Neuroscience

Novel inhibition

11 September 2018 - 12:00am

Novel inhibition

Novel inhibition, Published online: 11 September 2018; doi:10.1038/s41583-018-0064-6

Novel inhibition
Categories: Neuroscience

Inflammasome signalling in brain function and neurodegenerative disease

11 September 2018 - 12:00am

Inflammasome signalling in brain function and neurodegenerative disease

Inflammasome signalling in brain function and neurodegenerative disease, Published online: 11 September 2018; doi:10.1038/s41583-018-0055-7

Inflammasomes are pro-inflammatory protein complexes that become activated in a range of neurodegenerative conditions. In this review, Heneka and colleagues discuss recent findings that provide fresh insights on the role of inflammasomes across cell types and disease states in the brain.
Categories: Neuroscience

Rodent models for Alzheimer disease

7 September 2018 - 12:00am

Rodent models for Alzheimer disease

Rodent models for Alzheimer disease, Published online: 07 September 2018; doi:10.1038/s41583-018-0054-8

Rodent models are extensively used to investigate the pathophysiology of Alzheimer disease. In this Review, Götz, Bodea and Goedert critically examine the approaches that have been adopted to generate rodent Alzheimer disease models and touch on some of the lessons that have been learned from their use.
Categories: Neuroscience

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