Nature Rev. Neurosc.
CNS infection and immune privilege
CNS infection and immune privilege, Published online: 11 October 2018; doi:10.1038/s41583-018-0070-8Traditionally, the CNS is described to have immune privilege, largely because of its immunological barriers. Here, Forrester, McMenamin and Dando describe how this immune privilege may sometimes not be beneficial, as it enables invading pathogens to exist as latent CNS infections.
Maintenance, reserve and compensation: the cognitive neuroscience of healthy ageing
Maintenance, reserve and compensation: the cognitive neuroscience of healthy ageing, Published online: 10 October 2018; doi:10.1038/s41583-018-0068-2Age-related changes in cognitive ability are the focus of a growing field of research. Cabeza, Rajah and colleagues aim to promote clarity in the field by agreeing upon consensual definitions for three widely discussed concepts: maintenance, compensation and reserve.
Imaging-based parcellations of the human brain
Imaging-based parcellations of the human brain, Published online: 09 October 2018; doi:10.1038/s41583-018-0071-7The brain can be parcellated into areas or networks with different structural or functional properties. Eickhoff, Yeo and Genon describe various imaging-based strategies to parcellate the human brain, including those based on local properties, such as cytoarchitecture, and global properties, such as connectivity.
The neural mechanisms and circuitry of the pair bond
The neural mechanisms and circuitry of the pair bond, Published online: 09 October 2018; doi:10.1038/s41583-018-0072-6Recent research advances have yielded fresh insights into the fundamental neural processes underlying pair bonding. In this Review, Walum and Young discuss how neural representations of a partner become inherently rewarding, providing intriguing insights into the neural origins of love.
A position on vision
A position on vision, Published online: 09 October 2018; doi:10.1038/s41583-018-0076-2A new study finds that, in mice, location-related signals affect activity in the primary visual cortex.
Author Correction: The emerging field of epigenetics in neurodegeneration and neuroprotection
Author Correction: The emerging field of epigenetics in neurodegeneration and neuroprotection, Published online: 05 October 2018; doi:10.1038/s41583-018-0065-5Author Correction: The emerging field of epigenetics in neurodegeneration and neuroprotection
Rewarding gut feeling
Rewarding gut feeling, Published online: 05 October 2018; doi:10.1038/s41583-018-0075-3Vagal afferents projecting from the gut to the brainstem and then relayed on to the midbrain carry reward signals that trigger dopamine release in the dorsal striatum.
Number crunching, Published online: 05 October 2018; doi:10.1038/s41583-018-0073-5Number neurons encoding symbolic and nonsymbolical representations of numerical value are identified in the human medial temporal lobe
In or out of synch
In or out of synch, Published online: 05 October 2018; doi:10.1038/s41583-018-0074-4In a genetic mouse model related to schizophrenia, restoring the excitability of parvalbumin-expressing interneurons in hippocampal CA1 ameliorates network dysfunction and behavioural deficits.
It’s about time
It’s about time, Published online: 01 October 2018; doi:10.1038/s41583-018-0066-4Study shows that population activity in the rat lateral entorhinal cortex can encode the passage of time, which may contribute to temporal aspects of episodic memory.
Imaging the evolution and pathophysiology of Alzheimer disease
Imaging the evolution and pathophysiology of Alzheimer disease, Published online: 28 September 2018; doi:10.1038/s41583-018-0067-3Various techniques can be used to image aspects of the pathophysiology of Alzheimer disease in humans, notably protein deposition and neurodegeneration. In this Review, William Jagust discusses how human neuroimaging studies have shaped our understanding of this disease.
Incidental associations, Published online: 26 September 2018; doi:10.1038/s41583-018-0069-1Hippocampal cannabinoid 1 receptors are shown to be involved in the formation of incidental associations between pairs of low-salience sensory stimuli, which can then become indirectly associated with certain cues and thus influence behaviour.
Receptor replacement, Published online: 12 September 2018; doi:10.1038/s41583-018-0060-xMice receiving autoantibodies against the GluA2 AMPA receptor subunit from individuals with autoimmune encephalitis exhibit changes in AMPA receptor subunit composition and impaired synaptic plasticity and memory.
Catching waves, Published online: 11 September 2018; doi:10.1038/s41583-018-0062-8Catching waves
Untangling tau structure
Untangling tau structure, Published online: 11 September 2018; doi:10.1038/s41583-018-0063-7Untangling tau structure
Planning a path
Planning a path, Published online: 11 September 2018; doi:10.1038/s41583-018-0061-9Planning a path
Microglial signatures and their role in health and disease
Microglial signatures and their role in health and disease, Published online: 11 September 2018; doi:10.1038/s41583-018-0057-5Technological advances have allowed the molecular ‘signatures’ of microglia to be characterized, providing insight into their roles in CNS function. Weiner and Butovsky discuss the plasticity of these signatures in health and disease and consider the mechanisms underlying their establishment, maintenance and regulation.
Novel inhibition, Published online: 11 September 2018; doi:10.1038/s41583-018-0064-6Novel inhibition
Inflammasome signalling in brain function and neurodegenerative disease
Inflammasome signalling in brain function and neurodegenerative disease, Published online: 11 September 2018; doi:10.1038/s41583-018-0055-7Inflammasomes are pro-inflammatory protein complexes that become activated in a range of neurodegenerative conditions. In this review, Heneka and colleagues discuss recent findings that provide fresh insights on the role of inflammasomes across cell types and disease states in the brain.
Rodent models for Alzheimer disease
Rodent models for Alzheimer disease, Published online: 07 September 2018; doi:10.1038/s41583-018-0054-8Rodent models are extensively used to investigate the pathophysiology of Alzheimer disease. In this Review, Götz, Bodea and Goedert critically examine the approaches that have been adopted to generate rodent Alzheimer disease models and touch on some of the lessons that have been learned from their use.