Nature Neuroscience

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Nature Neuroscience offers a unique mix of opinion and reviews alongside top-quality research papers. Published monthly, in print and online, the journal reflects the entire spectrum of neuroscience, from molecular to cognitive.
Updated: 9 hours 37 min ago

Author Correction: Transneuronal propagation of mutant huntingtin contributes to non–cell autonomous pathology in neurons

17 July 2018 - 12:00am

Author Correction: Transneuronal propagation of mutant huntingtin contributes to non–cell autonomous pathology in neurons

Author Correction: Transneuronal propagation of mutant huntingtin contributes to non–cell autonomous pathology in neurons, Published online: 17 July 2018; doi:10.1038/s41593-018-0201-6

Author Correction: Transneuronal propagation of mutant huntingtin contributes to non–cell autonomous pathology in neurons
Categories: Neuroscience

Author Correction: Dopamine transients are sufficient and necessary for acquisition of model-based associations

17 July 2018 - 12:00am

Author Correction: Dopamine transients are sufficient and necessary for acquisition of model-based associations

Author Correction: Dopamine transients are sufficient and necessary for acquisition of model-based associations, Published online: 17 July 2018; doi:10.1038/s41593-018-0202-5

Author Correction: Dopamine transients are sufficient and necessary for acquisition of model-based associations
Categories: Neuroscience

Publisher Correction: Tuned thalamic excitation is amplified by visual cortical circuits

16 July 2018 - 12:00am

Publisher Correction: Tuned thalamic excitation is amplified by visual cortical circuits

Publisher Correction: Tuned thalamic excitation is amplified by visual cortical circuits, Published online: 16 July 2018; doi:10.1038/s41593-018-0181-6

Publisher Correction: Tuned thalamic excitation is amplified by visual cortical circuits
Categories: Neuroscience

PKCα integrates spatiotemporally distinct Ca<sup>2+</sup> and autocrine BDNF signaling to facilitate synaptic plasticity

16 July 2018 - 12:00am

PKCα integrates spatiotemporally distinct Ca2+ and autocrine BDNF signaling to facilitate synaptic plasticity

PKCα integrates spatiotemporally distinct Ca<sup>2+</sup> and autocrine BDNF signaling to facilitate synaptic plasticity, Published online: 16 July 2018; doi:10.1038/s41593-018-0184-3

Through the development of novel PKC biosensors, the authors describe how PKCα, but not other classical isozymes, facilitates plasticity in dendritic regions through the integration of recent synaptic plasticity with current, local synaptic input.
Categories: Neuroscience

Author Correction: PV plasticity sustained through D1/5 dopamine signaling required for long-term memory consolidation

16 July 2018 - 12:00am

Author Correction: PV plasticity sustained through D1/5 dopamine signaling required for long-term memory consolidation

Author Correction: PV plasticity sustained through D1/5 dopamine signaling required for long-term memory consolidation, Published online: 16 July 2018; doi:10.1038/s41593-018-0179-0

Author Correction: PV plasticity sustained through D1/5 dopamine signaling required for long-term memory consolidation
Categories: Neuroscience

FRETting over postsynaptic PKC signaling

16 July 2018 - 12:00am

FRETting over postsynaptic PKC signaling

FRETting over postsynaptic PKC signaling, Published online: 16 July 2018; doi:10.1038/s41593-018-0190-5

Protein kinases are key regulators of excitatory synapse plasticity. In this issue, using novel optical reporters of protein kinase C (PKC) activity, Colgan et al. identify PKCα as critical for integrating NMDA receptor and neurotrophin signaling to control dendritic spine structural plasticity, synaptic potentiation, and learning and memory.
Categories: Neuroscience

The maternal vaginal microbiome partially mediates the effects of prenatal stress on offspring gut and hypothalamus

9 July 2018 - 12:00am

The maternal vaginal microbiome partially mediates the effects of prenatal stress on offspring gut and hypothalamus

The maternal vaginal microbiome partially mediates the effects of prenatal stress on offspring gut and hypothalamus, Published online: 09 July 2018; doi:10.1038/s41593-018-0182-5

Maternal stress during pregnancy is a risk factor for neurodevelopmental disorders. Jasarevic and colleagues show that the maternal vaginal microbiota partially mediates the lasting effects of prenatal stress on the gut and hypothalamus in mice.
Categories: Neuroscience

Author Correction: Hippocampus-driven feed-forward inhibition of the prefrontal cortex mediates relapse of extinguished fear

9 July 2018 - 12:00am

Author Correction: Hippocampus-driven feed-forward inhibition of the prefrontal cortex mediates relapse of extinguished fear

Author Correction: Hippocampus-driven feed-forward inhibition of the prefrontal cortex mediates relapse of extinguished fear, Published online: 09 July 2018; doi:10.1038/s41593-018-0183-4

Author Correction: Hippocampus-driven feed-forward inhibition of the prefrontal cortex mediates relapse of extinguished fear
Categories: Neuroscience

Publisher Correction: Learning by neural reassociation

5 July 2018 - 12:00am

Publisher Correction: Learning by neural reassociation

Publisher Correction: Learning by neural reassociation, Published online: 05 July 2018; doi:10.1038/s41593-018-0185-2

Publisher Correction: Learning by neural reassociation
Categories: Neuroscience

Author Correction: Selective synaptic remodeling of amygdalocortical connections associated with fear memory

2 July 2018 - 12:00am

Author Correction: Selective synaptic remodeling of amygdalocortical connections associated with fear memory

Author Correction: Selective synaptic remodeling of amygdalocortical connections associated with fear memory, Published online: 02 July 2018; doi:10.1038/s41593-018-0180-7

Author Correction: Selective synaptic remodeling of amygdalocortical connections associated with fear memory
Categories: Neuroscience

Dorsal tegmental dopamine neurons gate associative learning of fear

27 June 2018 - 12:00am

Dorsal tegmental dopamine neurons gate associative learning of fear

Dorsal tegmental dopamine neurons gate associative learning of fear, Published online: 27 June 2018; doi:10.1038/s41593-018-0174-5

Unpredicted aversive experiences activate DA neurons in dorsal tegmentum; these neurons are important for fear learning. This prediction-error circuit module linking amygdala and dorsal tegmentum enables a solution to an associative learning problem.
Categories: Neuroscience

Modeling Alzheimer’s disease brains in vitro

27 June 2018 - 12:00am

Modeling Alzheimer’s disease brains in vitro

Modeling Alzheimer’s disease brains in vitro, Published online: 27 June 2018; doi:10.1038/s41593-018-0177-2

Alzheimer’s disease (AD) research is hampered by a lack of models that recapitulate all key disease features. Park et al. introduce a microfluidic device containing a 3D culture of human neurons, astrocytes, and microglia that develop AD-like pathology, revealing a potentially important inflammatory mechanism of neurodegeneration.
Categories: Neuroscience

A 3D human triculture system modeling neurodegeneration and neuroinflammation in Alzheimer’s disease

27 June 2018 - 12:00am

A 3D human triculture system modeling neurodegeneration and neuroinflammation in Alzheimer’s disease

A 3D human triculture system modeling neurodegeneration and neuroinflammation in Alzheimer’s disease, Published online: 27 June 2018; doi:10.1038/s41593-018-0175-4

This study describes a 3D human neuron-astrocyte-microglia triculture model of Alzheimer’s disease using a microfluidic platform and recapitulating plaque and tangle pathology, microglial recruitment, neuroinflammation, and cell death.
Categories: Neuroscience

Synaptic <i>N</i><sup>6</sup>-methyladenosine (m<sup>6</sup>A) epitranscriptome reveals functional partitioning of localized transcripts

27 June 2018 - 12:00am

Synaptic N6-methyladenosine (m6A) epitranscriptome reveals functional partitioning of localized transcripts

Synaptic <i>N</i><sup>6</sup>-methyladenosine (m<sup>6</sup>A) epitranscriptome reveals functional partitioning of localized transcripts, Published online: 27 June 2018; doi:10.1038/s41593-018-0173-6

A localized set of mRNA at the synapse facilitates synapse formation and plasticity. The authors show an enrichment of N6-methyladenosine (m6A) modifications of these mRNA at the synapse and link m6A recognition by molecular readers to synaptic function.
Categories: Neuroscience

Author Correction: Microglial immune checkpoint mechanisms

25 June 2018 - 12:00am

Author Correction: Microglial immune checkpoint mechanisms

Author Correction: Microglial immune checkpoint mechanisms, Published online: 25 June 2018; doi:10.1038/s41593-018-0186-1

Author Correction: Microglial immune checkpoint mechanisms
Categories: Neuroscience

Stressing the other paraventricular nucleus

25 June 2018 - 12:00am

Stressing the other paraventricular nucleus

Stressing the other paraventricular nucleus, Published online: 25 June 2018; doi:10.1038/s41593-018-0178-1

Often overlooked, the paraventricular nucleus of the thalamus is a stress-sensitive region in the midline thalamus essential for stress-induced adaptations. Using cutting edge in vivo monitoring approaches, Beas, Wright et al. identify a circuit by which stress disinhibits the midline thalamus through dopaminergic modulation arising from the locus coeruleus.
Categories: Neuroscience

The mysterious origins of microglia

25 June 2018 - 12:00am

The mysterious origins of microglia

The mysterious origins of microglia, Published online: 25 June 2018; doi:10.1038/s41593-018-0176-3

The origin of microglia, the resident macrophage population of the CNS, has been a long-standing matter of debate. Here we discuss two seminal studies published in 2007 in Nature Neuroscience that significantly contributed to a better understanding of microglia ontogeny and homeostasis in the adult brain.
Categories: Neuroscience

Investigating large-scale brain dynamics using field potential recordings: analysis and interpretation

25 June 2018 - 12:00am

Investigating large-scale brain dynamics using field potential recordings: analysis and interpretation

Investigating large-scale brain dynamics using field potential recordings: analysis and interpretation, Published online: 25 June 2018; doi:10.1038/s41593-018-0171-8

This article presents best practices on how field potential recordings (EEG, MEG, ECoG and LFP) can be analyzed to identify large-scale brain dynamics, and highlights issues and limitations of interpretation.
Categories: Neuroscience

The locus coeruleus drives disinhibition in the midline thalamus via a dopaminergic mechanism

18 June 2018 - 12:00am

The locus coeruleus drives disinhibition in the midline thalamus via a dopaminergic mechanism

The locus coeruleus drives disinhibition in the midline thalamus via a dopaminergic mechanism, Published online: 18 June 2018; doi:10.1038/s41593-018-0167-4

Beas et al. show that stress exposure drives disinhibition of PVT projection neurons. This process involves an LC-mediated rise in extracellular DA in the midline thalamus, requires D2 receptors on PVT neurons, and increases stress sensitivity.
Categories: Neuroscience

Optimization of interneuron function by direct coupling of cell migration and axonal targeting

18 June 2018 - 12:00am

Optimization of interneuron function by direct coupling of cell migration and axonal targeting

Optimization of interneuron function by direct coupling of cell migration and axonal targeting, Published online: 18 June 2018; doi:10.1038/s41593-018-0162-9

Circuit assembly relies on several developmental processes that are often considered independently. Lim and colleagues now reveal that cell migration and axon targeting may be mechanistically linked for Martinotti cells during cortical development.
Categories: Neuroscience

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