Nature Immunology
Mitochondria–ER hubs
Mitochondria–ER hubs
Mitochondria–ER hubs, Published online: 18 April 2018; doi:10.1038/s41590-018-0097-z
Mitochondria–ER hubsAdaptive responses of innate lymphocytes
Adaptive responses of innate lymphocytes
Adaptive responses of innate lymphocytes, Published online: 18 April 2018; doi:10.1038/s41590-018-0088-0
The activating natural killer cell receptor NKG2C can specifically recognize peptides derived from the cytomegalovirus protein UL40 in the context of HLA-E. This drives the expansion of a population of adaptive NKG2C+ natural killer cells.Synthetic benefits
Synthetic benefits
Synthetic benefits, Published online: 18 April 2018; doi:10.1038/s41590-018-0100-8
Synthetic benefitsGot my γδ17 T cells to keep me warm
Got my γδ17 T cells to keep me warm
Got my γδ17 T cells to keep me warm, Published online: 18 April 2018; doi:10.1038/s41590-018-0090-6
γδ T cells accumulate with age in adipose tissue and produce the cytokine IL-17, which controls the homeostasis of regulatory T cells and adaptive thermogenesis. Thus, maintenance of core body temperature unexpectedly relies on these adipose tissue–resident γδ17 T cells.Traumatic meningeal injury and repair mechanisms
Traumatic meningeal injury and repair mechanisms
Traumatic meningeal injury and repair mechanisms, Published online: 18 April 2018; doi:10.1038/s41590-018-0093-3
Myeloid cells exhibit different inflammatory phenotypes after brain injury, yet the relative mechanistic roles for these diverse cell types in post-traumatic tissue damage and repair remain controversial.PP2A in B cells
PP2A in B cells
PP2A in B cells, Published online: 18 April 2018; doi:10.1038/s41590-018-0098-y
PP2A in B cellsCrisis management
Crisis management
Crisis management, Published online: 18 April 2018; doi:10.1038/s41590-018-0101-7
Crisis managementB cells on the brain
B cells on the brain
B cells on the brain, Published online: 18 April 2018; doi:10.1038/s41590-018-0096-0
B cells on the brainc-Maf controls immune responses by regulating disease-specific gene networks and repressing IL-2 in CD4<sup>+</sup> T cells
c-Maf controls immune responses by regulating disease-specific gene networks and repressing IL-2 in CD4+ T cells
c-Maf controls immune responses by regulating disease-specific gene networks and repressing IL-2 in CD4<sup>+</sup> T cells, Published online: 16 April 2018; doi:10.1038/s41590-018-0083-5
The transcription factor c-Maf controls IL-10 production in T cells. O’Garra and colleagues use systems and in vivo functional analysis of T cell subsets to reveal distinct context-specific roles for c-Maf.Distinct myeloid cell subsets promote meningeal remodeling and vascular repair after mild traumatic brain injury
Distinct myeloid cell subsets promote meningeal remodeling and vascular repair after mild traumatic brain injury
Distinct myeloid cell subsets promote meningeal remodeling and vascular repair after mild traumatic brain injury, Published online: 16 April 2018; doi:10.1038/s41590-018-0086-2
Meningeal vascular damage accompanies mild traumatic brain injury, which persists in a fraction of patients. McGavern and colleagues report that distinct myeloid cell subsets are temporally recruited to the wound site during tissue repair; however, re-injury at early time points impairs recovery.Fatal demyelinating disease is induced by monocyte-derived macrophages in the absence of TGF-β signaling
Fatal demyelinating disease is induced by monocyte-derived macrophages in the absence of TGF-β signaling
Fatal demyelinating disease is induced by monocyte-derived macrophages in the absence of TGF-β signaling, Published online: 16 April 2018; doi:10.1038/s41590-018-0091-5
Harris and colleagues show that the cytokine TGF-β is required for colonization of the microglial niche and maintenance of central nervous system integrity. Acute loss of TGF-β leads to proinflammatory responses and fatal demyelinating disease.Monomeric TCRs drive T cell antigen recognition
Monomeric TCRs drive T cell antigen recognition
Monomeric TCRs drive T cell antigen recognition, Published online: 16 April 2018; doi:10.1038/s41590-018-0092-4
Higher-order TCRs have been postulated to maintain high antigen sensitivity and trigger signaling. Huppa and colleagues use various investigative techniques and find exclusively monomeric TCR–CD3 complexes that drive the recognition of antigenic pMHC.Bruno Kyewski 1950–2018
Bruno Kyewski 1950–2018
Bruno Kyewski 1950–2018, Published online: 11 April 2018; doi:10.1038/s41590-018-0095-1
Bruno Kyewski 1950–2018Peptide-specific recognition of human cytomegalovirus strains controls adaptive natural killer cells
Peptide-specific recognition of human cytomegalovirus strains controls adaptive natural killer cells
Peptide-specific recognition of human cytomegalovirus strains controls adaptive natural killer cells, Published online: 09 April 2018; doi:10.1038/s41590-018-0082-6
NK cells constrain infection by cytomegalovirus. Romagnani and colleagues show that human NKG2C+ NK cells recognize distinct HCMV UL40 viral peptides, which can vary among viral isolates. NKG2C+ NK cells thereby demonstrate adaptive-like recognition that can discriminate between closely related viral strains.IL-33 meets allergens at the gate
IL-33 meets allergens at the gate
IL-33 meets allergens at the gate, Published online: 21 March 2018; doi:10.1038/s41590-018-0069-3
IL-33 is a mediator of allergic inflammation and is localized in mucosal tissues to respond rapidly to environmental insults. These include allergens themselves, which can directly activate IL-33 through their intrinsic proteolytic activity.Mast cells in autoimmune disease
Mast cells in autoimmune disease
Mast cells in autoimmune disease, Published online: 21 March 2018; doi:10.1038/s41590-018-0080-8
Mast cells in autoimmune diseaseTargeting TGF-β in cancer
Targeting TGF-β in cancer
Targeting TGF-β in cancer, Published online: 21 March 2018; doi:10.1038/s41590-018-0076-4
Targeting TGF-β in cancerIL-17-receptor-associated adaptor Act1 directly stabilizes mRNAs to mediate IL-17 inflammatory signaling
IL-17-receptor-associated adaptor Act1 directly stabilizes mRNAs to mediate IL-17 inflammatory signaling
IL-17-receptor-associated adaptor Act1 directly stabilizes mRNAs to mediate IL-17 inflammatory signaling, Published online: 21 March 2018; doi:10.1038/s41590-018-0071-9
Act1 is an adaptor protein that associates with the IL-17 receptor at the cell membrane. Li and colleagues show that Act1 also exhibits unexpected RNA-binding activity and directly stabilizes select mRNAs encoding inflammatory cytokines and chemokines.Asymmetry in PI(3)K activity
Asymmetry in PI(3)K activity
Asymmetry in PI(3)K activity, Published online: 21 March 2018; doi:10.1038/s41590-018-0079-1
Asymmetry in PI(3)K activityCD1c caves in on lipids
CD1c caves in on lipids
CD1c caves in on lipids, Published online: 21 March 2018; doi:10.1038/s41590-018-0074-6
Autoreactive T cells exclusively recognize the roof of the binding groove of the antigen-presenting molecule CD1c after it has caved in on short headless self lipids.