Nature Immunology
Not immune to modification
Not immune to modification
Not immune to modification, Published online: 14 January 2019; doi:10.1038/s41590-018-0301-1
The N6-methyladenosine (m6A) RNA-modification pathway substantially affects the outcome of viral infection. Studies now show that m6A modification of transcripts encoding type I interferons limits the duration of anti-viral signaling.The Ca<sup>2+</sup> sensor STIM1 regulates the type I interferon response by retaining the signaling adaptor STING at the endoplasmic reticulum
The Ca2+ sensor STIM1 regulates the type I interferon response by retaining the signaling adaptor STING at the endoplasmic reticulum
The Ca<sup>2+</sup> sensor STIM1 regulates the type I interferon response by retaining the signaling adaptor STING at the endoplasmic reticulum, Published online: 14 January 2019; doi:10.1038/s41590-018-0287-8
STIM1 is a calcium sensor that is essential for functional lymphocyte responses. Gwack and colleagues demonstrate a calcium-independent role for STIM1 in macrophages that regulates their production of type I interferons.A noncanonical role for the engulfment gene <i>ELMO1</i> in neutrophils that promotes inflammatory arthritis
A noncanonical role for the engulfment gene ELMO1 in neutrophils that promotes inflammatory arthritis
A noncanonical role for the engulfment gene <i>ELMO1</i> in neutrophils that promotes inflammatory arthritis, Published online: 14 January 2019; doi:10.1038/s41590-018-0293-x
ELMO1 is a protein centrally involved in controlling the engulfment of apoptotic cells. Ravichandran and colleagues demonstrate a noncanonical role for ELMO1 in the promotion of neutrophil migration and inflammatory arthritis.IL-13 secreted by ILC2s promotes the self-renewal of intestinal stem cells through circular RNA circPan3
IL-13 secreted by ILC2s promotes the self-renewal of intestinal stem cells through circular RNA circPan3
IL-13 secreted by ILC2s promotes the self-renewal of intestinal stem cells through circular RNA circPan3, Published online: 14 January 2019; doi:10.1038/s41590-018-0297-6
Fan and colleagues show that circular RNA circPan3 controls expression of the cytokine receptor IL-13Rα1 on intestinal stem cells and, thus, the renewal of those cells in response to IL-13 derived from group 2 innate lymphoid cells.Transcription factor Foxp1 regulates Foxp3 chromatin binding and coordinates regulatory T cell function
Transcription factor Foxp1 regulates Foxp3 chromatin binding and coordinates regulatory T cell function
Transcription factor Foxp1 regulates Foxp3 chromatin binding and coordinates regulatory T cell function, Published online: 14 January 2019; doi:10.1038/s41590-018-0291-z
The transcription factor Foxp1 regulates the quiescence of naïve T cells. Rudensky and colleagues show that Foxp1 has a role that is cooperative and synergistic with that of Foxp3 in regulatory T cells, distinct from its roles in conventional CD4+ T cells.CIRCling the wagons to protect intestinal stem cells
CIRCling the wagons to protect intestinal stem cells
CIRCling the wagons to protect intestinal stem cells, Published online: 14 January 2019; doi:10.1038/s41590-018-0302-0
Innate lymphoid cell–derived cytokine IL-13 promotes the maintenance of intestinal stem cells through stabilization of β-catenin. The circular RNA circPan3 regulates mRNA encoding the cytokine receptor subunit IL-13Rα and downstream IL-13 signaling to stabilize the β-catenin pathway in intestinal stem cells.Regulatory T cells mediate specific suppression by depleting peptide–MHC class II from dendritic cells
Regulatory T cells mediate specific suppression by depleting peptide–MHC class II from dendritic cells
Regulatory T cells mediate specific suppression by depleting peptide–MHC class II from dendritic cells, Published online: 14 January 2019; doi:10.1038/s41590-018-0280-2
Regulatory T cells suppress target cells through diverse mechanisms. Shevach and colleagues demonstrate that regulatory T cells in vivo strip complexes of cognate peptide and major histocompatibility complex class II from dendritic cells and thereby help to maintain immune homeostasis.STIM1 moonlights as an anchor for STING
STIM1 moonlights as an anchor for STING
STIM1 moonlights as an anchor for STING, Published online: 14 January 2019; doi:10.1038/s41590-018-0300-2
Activation of STING requires its translocation from the endoplasmic reticulum (ER) through the Golgi to vesicles, but the mechanisms that control its localization have been unclear. The ER calcium sensor STIM1 acts as an ER-retention factor that anchors STING on the ER and limits STING signaling.Publisher Correction: m6A modification controls the innate immune response to infection by targeting type I interferons
Publisher Correction: m6A modification controls the innate immune response to infection by targeting type I interferons
Publisher Correction: m6A modification controls the innate immune response to infection by targeting type I interferons, Published online: 11 January 2019; doi:10.1038/s41590-019-0314-4
Publisher Correction: m6A modification controls the innate immune response to infection by targeting type I interferonsm<sup>6</sup>A modification controls the innate immune response to infection by targeting type I interferons
m6A modification controls the innate immune response to infection by targeting type I interferons
m<sup>6</sup>A modification controls the innate immune response to infection by targeting type I interferons, Published online: 17 December 2018; doi:10.1038/s41590-018-0275-z
RNAs can be dynamically modified by N6-methylation of adenosine (m6A), which leads to their destabilization. Stern-Ginossar and colleagues demonstrate a role for m6A modification of host transcripts encoding type I interferons during viral infection.cDC1 cross-priming
cDC1 cross-priming
cDC1 cross-priming, Published online: 11 December 2018; doi:10.1038/s41590-018-0283-z
cDC1 cross-primingSelf-renewing resident cardiac macrophages limit adverse remodeling following myocardial infarction
Self-renewing resident cardiac macrophages limit adverse remodeling following myocardial infarction
Self-renewing resident cardiac macrophages limit adverse remodeling following myocardial infarction, Published online: 11 December 2018; doi:10.1038/s41590-018-0272-2
Epelman and colleagues use fate mapping and single-cell transcriptomics to describe the dynamics of resident and recruited cardiac macrophages during ischemic injury.DELineating resolution of inflammation
DELineating resolution of inflammation
DELineating resolution of inflammation, Published online: 11 December 2018; doi:10.1038/s41590-018-0278-9
The resolution of inflammation is a protective response. The identification and characterization of new players that boost this response might inform the development of novel therapies for non-resolving inflammatory diseases.Mst kinase roles
Mst kinase roles
Mst kinase roles, Published online: 11 December 2018; doi:10.1038/s41590-018-0284-y
Mst kinase rolesStem cell–immune cell cross-talk
Stem cell–immune cell cross-talk
Stem cell–immune cell cross-talk, Published online: 11 December 2018; doi:10.1038/s41590-018-0282-0
Stem cell–immune cell cross-talkG3BP1 enhances cytoplasmic DNA pattern recognition
G3BP1 enhances cytoplasmic DNA pattern recognition
G3BP1 enhances cytoplasmic DNA pattern recognition, Published online: 11 December 2018; doi:10.1038/s41590-018-0279-8
The stress-granule protein G3BP1 forms a high-molecular-weight protein complex with the sensor cGAS and enhances its detection of cytoplasmic DNA.Blood–brain barrier integrity
Blood–brain barrier integrity
Blood–brain barrier integrity, Published online: 11 December 2018; doi:10.1038/s41590-018-0286-9
Blood–brain barrier integrityCas9-directed immunity
Cas9-directed immunity
Cas9-directed immunity, Published online: 11 December 2018; doi:10.1038/s41590-018-0285-x
Cas9-directed immunityThe transcription factor c-Maf is essential for the commitment of IL-17-producing γδ T cells
The transcription factor c-Maf is essential for the commitment of IL-17-producing γδ T cells
The transcription factor c-Maf is essential for the commitment of IL-17-producing γδ T cells, Published online: 10 December 2018; doi:10.1038/s41590-018-0274-0
Ciofani and colleagues identify the transcription factor c-Maf as a universal regulator of the differentiation of IL-17-producing γδ T cells.B cells turn on, tune in with LSD1
B cells turn on, tune in with LSD1
B cells turn on, tune in with LSD1, Published online: 10 December 2018; doi:10.1038/s41590-018-0281-1
The histone demethylase LSD1 partners with the transcription factor BCL6 to initiate the formation of germinal centers.