Nature Immunology

Subscribe to Nature Immunology feed Nature Immunology
Nature Immunology is a multidisciplinary journal that publishes papers of the highest quality and significance in all areas of immunology. Priority is given to work that provides fundamental insight into the workings of the immune system. Areas covered include, but are not limited to, innate immunity and inflammation; development; immune receptors, signaling and apoptosis; antigen presentation; gene regulation and recombination; cellular and systemic immunity; vaccines; immune tolerance; autoimmunity and tumor immunology, microbial immunopathology; and transplantation.
Updated: 9 hours 36 min ago

TILs show the way

19 July 2018 - 12:00am

TILs show the way

TILs show the way, Published online: 19 July 2018; doi:10.1038/s41590-018-0175-2

TILs show the way
Categories: Immunology

Natural killer cell specificity for viral infections

19 July 2018 - 12:00am

Natural killer cell specificity for viral infections

Natural killer cell specificity for viral infections, Published online: 19 July 2018; doi:10.1038/s41590-018-0163-6

Romagnani and colleagues discuss the specific recognition of viral antigens and peptides by NK cells and its implications for the composition of the NK cell repertoire and the selection of viral variants.
Categories: Immunology

Symbionts and metabolites

19 July 2018 - 12:00am

Symbionts and metabolites

Symbionts and metabolites, Published online: 19 July 2018; doi:10.1038/s41590-018-0170-7

Symbionts and metabolites
Categories: Immunology

Autophagy & MDSCs

19 July 2018 - 12:00am

Autophagy & MDSCs

Autophagy & MDSCs, Published online: 19 July 2018; doi:10.1038/s41590-018-0173-4

Autophagy & MDSCs
Categories: Immunology

Comment on: Evidence of innate lymphoid cell redundancy in humans

19 July 2018 - 12:00am

Comment on: Evidence of innate lymphoid cell redundancy in humans

Comment on: Evidence of innate lymphoid cell redundancy in humans, Published online: 19 July 2018; doi:10.1038/s41590-018-0164-5

Comment on: Evidence of innate lymphoid cell redundancy in humans
Categories: Immunology

Modeling AD

19 July 2018 - 12:00am

Modeling AD

Modeling AD, Published online: 19 July 2018; doi:10.1038/s41590-018-0171-6

Modeling AD
Categories: Immunology

A harmful pairing

19 July 2018 - 12:00am

A harmful pairing

A harmful pairing, Published online: 19 July 2018; doi:10.1038/s41590-018-0174-3

A harmful pairing
Categories: Immunology

Reply to ‘Comment on: Evidence of innate lymphoid cell redundancy in humans’

19 July 2018 - 12:00am

Reply to ‘Comment on: Evidence of innate lymphoid cell redundancy in humans’

Reply to ‘Comment on: Evidence of innate lymphoid cell redundancy in humans’, Published online: 19 July 2018; doi:10.1038/s41590-018-0165-4

Reply to ‘Comment on: Evidence of innate lymphoid cell redundancy in humans’
Categories: Immunology

T cell cytolytic capacity is independent of initial stimulation strength

16 July 2018 - 12:00am

T cell cytolytic capacity is independent of initial stimulation strength

T cell cytolytic capacity is independent of initial stimulation strength, Published online: 16 July 2018; doi:10.1038/s41590-018-0160-9

Lymphocytes interpret antigenic signals into a functional response. Richard et al. demonstrate that the overall qualitative response by CTLs is independent of TCR ligand strength; instead, ligands determine the rate and uniformity at which CTLs respond.
Categories: Immunology

Epithelial damage and tissue γδ T cells promote a unique tumor-protective IgE response

16 July 2018 - 12:00am

Epithelial damage and tissue γδ T cells promote a unique tumor-protective IgE response

Epithelial damage and tissue γδ T cells promote a unique tumor-protective IgE response, Published online: 16 July 2018; doi:10.1038/s41590-018-0161-8

Evidence of protective and homeostatic roles for IgE is relatively limited. Strid and colleagues demonstrate that γδ T cells induce switching to IgE that provides protection against experimentally induced epithelial cancer.
Categories: Immunology

CD8<sup>+</sup> T cells have commitment issues

16 July 2018 - 12:00am

CD8+ T cells have commitment issues

CD8<sup>+</sup> T cells have commitment issues, Published online: 16 July 2018; doi:10.1038/s41590-018-0169-0

T cell activation is ‘digital’: exhaustive single-cell analysis shows that only the proportion of cells that cross the activation threshold is reduced when the affinity of the TCR for its ligand is reduced.
Categories: Immunology

Adjustment of dendritic cells to the breast-cancer microenvironment is subset specific

16 July 2018 - 12:00am

Adjustment of dendritic cells to the breast-cancer microenvironment is subset specific

Adjustment of dendritic cells to the breast-cancer microenvironment is subset specific, Published online: 16 July 2018; doi:10.1038/s41590-018-0145-8

Soumelis and colleagues use RNA-based sequencing to define the transcriptional signatures of DC subsets and monocytes-macrophages in human primary breast cancer.
Categories: Immunology

γδ T cells and IgE team up to prevent tumors

16 July 2018 - 12:00am

γδ T cells and IgE team up to prevent tumors

γδ T cells and IgE team up to prevent tumors, Published online: 16 July 2018; doi:10.1038/s41590-018-0167-2

In response to epithelial DNA damage, tissue-resident γδ T cells initiate and shape a tumor-protective IgE response that requires CD4+ T cells and immune effector cells expressing the high-affinity IgE receptor FcεRI.
Categories: Immunology

TCRs are randomly distributed on the plasma membrane of resting antigen-experienced T cells

16 July 2018 - 12:00am

TCRs are randomly distributed on the plasma membrane of resting antigen-experienced T cells

TCRs are randomly distributed on the plasma membrane of resting antigen-experienced T cells, Published online: 16 July 2018; doi:10.1038/s41590-018-0162-7

TCRs are often thought to be pre-clustered before T cell activation. Rossboth et al. use super-resolution microscopy and statistical image analysis to demonstrate that TCRs are in fact randomly distributed on resting T cells.
Categories: Immunology

An RNA checkpoint that keeps immunological memory at bay

9 July 2018 - 12:00am

An RNA checkpoint that keeps immunological memory at bay

An RNA checkpoint that keeps immunological memory at bay, Published online: 09 July 2018; doi:10.1038/s41590-018-0168-1

What keeps memory T cells functionally silent in the absence of infection is unclear. New data reveal the existence of a deterministic halt in the protein-synthesis machinery of memory T cells and expose the discriminatory functions of a family of RNA-binding proteins.
Categories: Immunology

Second signals rescue B cells from activation-induced mitochondrial dysfunction and death

9 July 2018 - 12:00am

Second signals rescue B cells from activation-induced mitochondrial dysfunction and death

Second signals rescue B cells from activation-induced mitochondrial dysfunction and death, Published online: 09 July 2018; doi:10.1038/s41590-018-0156-5

B cells need at least two signals to terminally differentiate into antibody-secreting cells. Pierce and colleagues show that persistent exposure to antigen in the absence of T cell help or ‘pathogen pattern motifs’ leads to B cell death via a calcium-dependent ‘metabolic timer’.
Categories: Immunology

B cells race the clock to get a second wind

9 July 2018 - 12:00am

B cells race the clock to get a second wind

B cells race the clock to get a second wind, Published online: 09 July 2018; doi:10.1038/s41590-018-0166-3

Co-stimulatory second signals delivered through TLRs or CD40 rescue antigen-stimulated B cells from metabolic dysfunction and apoptosis. This identifies a critical time-limited window during which B cells integrate sequential signals to successfully initiate humoral immunity.
Categories: Immunology

Maintenance of CD4 T cell fitness through regulation of Foxo1

9 July 2018 - 12:00am

Maintenance of CD4 T cell fitness through regulation of Foxo1

Maintenance of CD4 T cell fitness through regulation of Foxo1, Published online: 09 July 2018; doi:10.1038/s41590-018-0157-4

Foxo proteins are required for maintaining T cell quiescence. Turka and colleagues use a constitutively active Foxo1 in Treg cells to show that its downregulation is essential for maintaining their fitness in a competitive environment.
Categories: Immunology

Translational repression of pre-formed cytokine-encoding mRNA prevents chronic activation of memory T cells

9 July 2018 - 12:00am

Translational repression of pre-formed cytokine-encoding mRNA prevents chronic activation of memory T cells

Translational repression of pre-formed cytokine-encoding mRNA prevents chronic activation of memory T cells, Published online: 09 July 2018; doi:10.1038/s41590-018-0155-6

Wolkers and colleagues show that the RNA-binding protein ZFP36L2 represses the translation of pre-formed cytokine-encoding mRNAs in memory T cells.
Categories: Immunology

The transcription factor Rfx7 limits metabolism of NK cells and promotes their maintenance and immunity

2 July 2018 - 12:00am

The transcription factor Rfx7 limits metabolism of NK cells and promotes their maintenance and immunity

The transcription factor Rfx7 limits metabolism of NK cells and promotes their maintenance and immunity, Published online: 02 July 2018; doi:10.1038/s41590-018-0144-9

Regulatory factor X (RFX) is a transcription factor family comprising seven known members, yet the functional roles of RFX7 remain unknown. Guarda and colleagues show that RFX7 regulates natural killer (NK) cell survival and activity by limiting their cellular metabolism.
Categories: Immunology

Pages