Nature Immunology

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Nature Immunology is a multidisciplinary journal that publishes papers of the highest quality and significance in all areas of immunology. Priority is given to work that provides fundamental insight into the workings of the immune system. Areas covered include, but are not limited to, innate immunity and inflammation; development; immune receptors, signaling and apoptosis; antigen presentation; gene regulation and recombination; cellular and systemic immunity; vaccines; immune tolerance; autoimmunity and tumor immunology, microbial immunopathology; and transplantation.
Updated: 10 hours 14 min ago

Not immune to modification

14 January 2019 - 12:00am

Not immune to modification

Not immune to modification, Published online: 14 January 2019; doi:10.1038/s41590-018-0301-1

The N6-methyladenosine (m6A) RNA-modification pathway substantially affects the outcome of viral infection. Studies now show that m6A modification of transcripts encoding type I interferons limits the duration of anti-viral signaling.
Categories: Immunology

The Ca<sup>2+</sup> sensor STIM1 regulates the type I interferon response by retaining the signaling adaptor STING at the endoplasmic reticulum

14 January 2019 - 12:00am

The Ca2+ sensor STIM1 regulates the type I interferon response by retaining the signaling adaptor STING at the endoplasmic reticulum

The Ca<sup>2+</sup> sensor STIM1 regulates the type I interferon response by retaining the signaling adaptor STING at the endoplasmic reticulum, Published online: 14 January 2019; doi:10.1038/s41590-018-0287-8

STIM1 is a calcium sensor that is essential for functional lymphocyte responses. Gwack and colleagues demonstrate a calcium-independent role for STIM1 in macrophages that regulates their production of type I interferons.
Categories: Immunology

A noncanonical role for the engulfment gene <i>ELMO1</i> in neutrophils that promotes inflammatory arthritis

14 January 2019 - 12:00am

A noncanonical role for the engulfment gene ELMO1 in neutrophils that promotes inflammatory arthritis

A noncanonical role for the engulfment gene <i>ELMO1</i> in neutrophils that promotes inflammatory arthritis, Published online: 14 January 2019; doi:10.1038/s41590-018-0293-x

ELMO1 is a protein centrally involved in controlling the engulfment of apoptotic cells. Ravichandran and colleagues demonstrate a noncanonical role for ELMO1 in the promotion of neutrophil migration and inflammatory arthritis.
Categories: Immunology

IL-13 secreted by ILC2s promotes the self-renewal of intestinal stem cells through circular RNA circPan3

14 January 2019 - 12:00am

IL-13 secreted by ILC2s promotes the self-renewal of intestinal stem cells through circular RNA circPan3

IL-13 secreted by ILC2s promotes the self-renewal of intestinal stem cells through circular RNA circPan3, Published online: 14 January 2019; doi:10.1038/s41590-018-0297-6

Fan and colleagues show that circular RNA circPan3 controls expression of the cytokine receptor IL-13Rα1 on intestinal stem cells and, thus, the renewal of those cells in response to IL-13 derived from group 2 innate lymphoid cells.
Categories: Immunology

Transcription factor Foxp1 regulates Foxp3 chromatin binding and coordinates regulatory T cell function

14 January 2019 - 12:00am

Transcription factor Foxp1 regulates Foxp3 chromatin binding and coordinates regulatory T cell function

Transcription factor Foxp1 regulates Foxp3 chromatin binding and coordinates regulatory T cell function, Published online: 14 January 2019; doi:10.1038/s41590-018-0291-z

The transcription factor Foxp1 regulates the quiescence of naïve T cells. Rudensky and colleagues show that Foxp1 has a role that is cooperative and synergistic with that of Foxp3 in regulatory T cells, distinct from its roles in conventional CD4+ T cells.
Categories: Immunology

CIRCling the wagons to protect intestinal stem cells

14 January 2019 - 12:00am

CIRCling the wagons to protect intestinal stem cells

CIRCling the wagons to protect intestinal stem cells, Published online: 14 January 2019; doi:10.1038/s41590-018-0302-0

Innate lymphoid cell–derived cytokine IL-13 promotes the maintenance of intestinal stem cells through stabilization of β-catenin. The circular RNA circPan3 regulates mRNA encoding the cytokine receptor subunit IL-13Rα and downstream IL-13 signaling to stabilize the β-catenin pathway in intestinal stem cells.
Categories: Immunology

Regulatory T cells mediate specific suppression by depleting peptide–MHC class II from dendritic cells

14 January 2019 - 12:00am

Regulatory T cells mediate specific suppression by depleting peptide–MHC class II from dendritic cells

Regulatory T cells mediate specific suppression by depleting peptide–MHC class II from dendritic cells, Published online: 14 January 2019; doi:10.1038/s41590-018-0280-2

Regulatory T cells suppress target cells through diverse mechanisms. Shevach and colleagues demonstrate that regulatory T cells in vivo strip complexes of cognate peptide and major histocompatibility complex class II from dendritic cells and thereby help to maintain immune homeostasis.
Categories: Immunology

STIM1 moonlights as an anchor for STING

14 January 2019 - 12:00am

STIM1 moonlights as an anchor for STING

STIM1 moonlights as an anchor for STING, Published online: 14 January 2019; doi:10.1038/s41590-018-0300-2

Activation of STING requires its translocation from the endoplasmic reticulum (ER) through the Golgi to vesicles, but the mechanisms that control its localization have been unclear. The ER calcium sensor STIM1 acts as an ER-retention factor that anchors STING on the ER and limits STING signaling.
Categories: Immunology

Publisher Correction: m6A modification controls the innate immune response to infection by targeting type I interferons

11 January 2019 - 12:00am

Publisher Correction: m6A modification controls the innate immune response to infection by targeting type I interferons

Publisher Correction: m6A modification controls the innate immune response to infection by targeting type I interferons, Published online: 11 January 2019; doi:10.1038/s41590-019-0314-4

Publisher Correction: m6A modification controls the innate immune response to infection by targeting type I interferons
Categories: Immunology

m<sup>6</sup>A modification controls the innate immune response to infection by targeting type I interferons

17 December 2018 - 12:00am

m6A modification controls the innate immune response to infection by targeting type I interferons

m<sup>6</sup>A modification controls the innate immune response to infection by targeting type I interferons, Published online: 17 December 2018; doi:10.1038/s41590-018-0275-z

RNAs can be dynamically modified by N6-methylation of adenosine (m6A), which leads to their destabilization. Stern-Ginossar and colleagues demonstrate a role for m6A modification of host transcripts encoding type I interferons during viral infection.
Categories: Immunology

cDC1 cross-priming

11 December 2018 - 12:00am

cDC1 cross-priming

cDC1 cross-priming, Published online: 11 December 2018; doi:10.1038/s41590-018-0283-z

cDC1 cross-priming
Categories: Immunology

Self-renewing resident cardiac macrophages limit adverse remodeling following myocardial infarction

11 December 2018 - 12:00am

Self-renewing resident cardiac macrophages limit adverse remodeling following myocardial infarction

Self-renewing resident cardiac macrophages limit adverse remodeling following myocardial infarction, Published online: 11 December 2018; doi:10.1038/s41590-018-0272-2

Epelman and colleagues use fate mapping and single-cell transcriptomics to describe the dynamics of resident and recruited cardiac macrophages during ischemic injury.
Categories: Immunology

DELineating resolution of inflammation

11 December 2018 - 12:00am

DELineating resolution of inflammation

DELineating resolution of inflammation, Published online: 11 December 2018; doi:10.1038/s41590-018-0278-9

The resolution of inflammation is a protective response. The identification and characterization of new players that boost this response might inform the development of novel therapies for non-resolving inflammatory diseases.
Categories: Immunology

Mst kinase roles

11 December 2018 - 12:00am

Mst kinase roles

Mst kinase roles, Published online: 11 December 2018; doi:10.1038/s41590-018-0284-y

Mst kinase roles
Categories: Immunology

Stem cell–immune cell cross-talk

11 December 2018 - 12:00am

Stem cell–immune cell cross-talk

Stem cell–immune cell cross-talk, Published online: 11 December 2018; doi:10.1038/s41590-018-0282-0

Stem cell–immune cell cross-talk
Categories: Immunology

G3BP1 enhances cytoplasmic DNA pattern recognition

11 December 2018 - 12:00am

G3BP1 enhances cytoplasmic DNA pattern recognition

G3BP1 enhances cytoplasmic DNA pattern recognition, Published online: 11 December 2018; doi:10.1038/s41590-018-0279-8

The stress-granule protein G3BP1 forms a high-molecular-weight protein complex with the sensor cGAS and enhances its detection of cytoplasmic DNA.
Categories: Immunology

Blood–brain barrier integrity

11 December 2018 - 12:00am

Blood–brain barrier integrity

Blood–brain barrier integrity, Published online: 11 December 2018; doi:10.1038/s41590-018-0286-9

Blood–brain barrier integrity
Categories: Immunology

Cas9-directed immunity

11 December 2018 - 12:00am

Cas9-directed immunity

Cas9-directed immunity, Published online: 11 December 2018; doi:10.1038/s41590-018-0285-x

Cas9-directed immunity
Categories: Immunology

The transcription factor c-Maf is essential for the commitment of IL-17-producing γδ T cells

10 December 2018 - 12:00am

The transcription factor c-Maf is essential for the commitment of IL-17-producing γδ T cells

The transcription factor c-Maf is essential for the commitment of IL-17-producing γδ T cells, Published online: 10 December 2018; doi:10.1038/s41590-018-0274-0

Ciofani and colleagues identify the transcription factor c-Maf as a universal regulator of the differentiation of IL-17-producing γδ T cells.
Categories: Immunology

B cells turn on, tune in with LSD1

10 December 2018 - 12:00am

B cells turn on, tune in with LSD1

B cells turn on, tune in with LSD1, Published online: 10 December 2018; doi:10.1038/s41590-018-0281-1

The histone demethylase LSD1 partners with the transcription factor BCL6 to initiate the formation of germinal centers.
Categories: Immunology

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