Nature Immunology

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Nature Immunology is a multidisciplinary journal that publishes papers of the highest quality and significance in all areas of immunology. Priority is given to work that provides fundamental insight into the workings of the immune system. Areas covered include, but are not limited to, innate immunity and inflammation; development; immune receptors, signaling and apoptosis; antigen presentation; gene regulation and recombination; cellular and systemic immunity; vaccines; immune tolerance; autoimmunity and tumor immunology, microbial immunopathology; and transplantation.
Updated: 11 hours 36 min ago

Flat-lying antibody prevents disease enhancement

15 October 2018 - 12:00am

Flat-lying antibody prevents disease enhancement

Flat-lying antibody prevents disease enhancement, Published online: 15 October 2018; doi:10.1038/s41590-018-0239-3

An antibody to dengue virus that lies flat on its target, neutralizes the virus and also prevents antibody-dependent enhancement of infection is now identified.
Categories: Immunology

Characterization of a potent and highly unusual minimally enhancing antibody directed against dengue virus

15 October 2018 - 12:00am

Characterization of a potent and highly unusual minimally enhancing antibody directed against dengue virus

Characterization of a potent and highly unusual minimally enhancing antibody directed against dengue virus, Published online: 15 October 2018; doi:10.1038/s41590-018-0227-7

Immunity to one serotype of dengue virus can worsen disease following exposure to another serotype, a process called ‘antibody-dependent enhancement’. Grimes and colleagues characterize the function and structural basis of an unusual, potent and broadly neutralizing antibody that lacks such activity.
Categories: Immunology

Transcription-factor-mediated supervision of global genome architecture maintains B cell identity

15 October 2018 - 12:00am

Transcription-factor-mediated supervision of global genome architecture maintains B cell identity

Transcription-factor-mediated supervision of global genome architecture maintains B cell identity, Published online: 15 October 2018; doi:10.1038/s41590-018-0234-8

The transcription factor Pax5 enforces B cell identity. Nutt, Allan and colleagues show that Pax5 is needed to establish and maintain the three-dimensional genome organization of B cells throughout their lineage development.
Categories: Immunology

Targeting fibrin in neurodegeneration

15 October 2018 - 12:00am

Targeting fibrin in neurodegeneration

Targeting fibrin in neurodegeneration, Published online: 15 October 2018; doi:10.1038/s41590-018-0241-9

Deposition of fibrin in the brain and central nervous system occurs after injury or disease. This process unmasks a conserved cryptic epitope of fibrin that activates microglia; blocking this interaction can limit inflammation and neurotoxicity.
Categories: Immunology

Remote control of γc expression by arginine methylation

15 October 2018 - 12:00am

Remote control of γc expression by arginine methylation

Remote control of γc expression by arginine methylation, Published online: 15 October 2018; doi:10.1038/s41590-018-0240-x

Arginine methylation is a post-translational modification that controls the abundance of γc cytokine receptor on mature T cells by a post-transcriptional mechanism.
Categories: Immunology

Arginine methylation controls the strength of γc-family cytokine signaling in T cell maintenance

15 October 2018 - 12:00am

Arginine methylation controls the strength of γc-family cytokine signaling in T cell maintenance

Arginine methylation controls the strength of γc-family cytokine signaling in T cell maintenance, Published online: 15 October 2018; doi:10.1038/s41590-018-0222-z

PRMT arginine methyltransferases mediate post-translational modification. Takayanagi and colleagues show that a lack of PRMT5 in cells of the T cell lineage compromises their response to cytokines dependent on the common γ-chain, due to aberrant splicing of mRNA transcripts encoding the common γ-chain and its associated kinase JAK3.
Categories: Immunology

Fibrin-targeting immunotherapy protects against neuroinflammation and neurodegeneration

15 October 2018 - 12:00am

Fibrin-targeting immunotherapy protects against neuroinflammation and neurodegeneration

Fibrin-targeting immunotherapy protects against neuroinflammation and neurodegeneration, Published online: 15 October 2018; doi:10.1038/s41590-018-0232-x

Fibrin deposition occurs after the blood–brain barrier is breached. Akassoglou and colleagues generate a therapeutic monoclonal antibody that targets a cryptic fibrin epitope to suppress activation of innate immune responses in the CNS and diminish neuroinflammation.
Categories: Immunology

Unique pattern of neutrophil migration and function during tumor progression

15 October 2018 - 12:00am

Unique pattern of neutrophil migration and function during tumor progression

Unique pattern of neutrophil migration and function during tumor progression, Published online: 15 October 2018; doi:10.1038/s41590-018-0229-5

Neutrophils are linked to tumor progression. Gabrilovich and colleagues demonstrate that neutrophils have tumor-stage-dependent alterations in motility, function and metabolism: in early phases, they are highly motile with altered metabolism, whereas at later stages, they become highly suppressive.
Categories: Immunology

Viral exploitation of mTOR

24 September 2018 - 12:00am

Viral exploitation of mTOR

Viral exploitation of mTOR, Published online: 24 September 2018; doi:10.1038/s41590-018-0223-y

Viral exploitation of mTOR
Categories: Immunology

Infection perturbs Bach2- and Bach1-dependent erythroid lineage ‘choice’ to cause anemia

24 September 2018 - 12:00am

Infection perturbs Bach2- and Bach1-dependent erythroid lineage ‘choice’ to cause anemia

Infection perturbs Bach2- and Bach1-dependent erythroid lineage ‘choice’ to cause anemia, Published online: 24 September 2018; doi:10.1038/s41590-018-0202-3

Environmental cues instruct cell fate during hematopoiesis. Igarashi and colleagues show that the transcription factors Bach1 and Bach2 promote erythropoiesis and suppress myelopoiesis. Infection and inflammatory signals suppress Bach expression, which results in anemia.
Categories: Immunology

Bleeding anti-inflammatory

24 September 2018 - 12:00am

Bleeding anti-inflammatory

Bleeding anti-inflammatory, Published online: 24 September 2018; doi:10.1038/s41590-018-0221-0

Bleeding anti-inflammatory
Categories: Immunology

The identity and function of microglia in neurodegeneration

24 September 2018 - 12:00am

The identity and function of microglia in neurodegeneration

The identity and function of microglia in neurodegeneration, Published online: 24 September 2018; doi:10.1038/s41590-018-0212-1

Song and Colonna provide an overview of the common microglial response to neurodegeneration and discuss insights from mouse models and the study of human disease-associated genes.
Categories: Immunology

Iron strength

24 September 2018 - 12:00am

Iron strength

Iron strength, Published online: 24 September 2018; doi:10.1038/s41590-018-0218-8

Iron strength
Categories: Immunology

Anti-tumor role of metformin

24 September 2018 - 12:00am

Anti-tumor role of metformin

Anti-tumor role of metformin, Published online: 24 September 2018; doi:10.1038/s41590-018-0224-x

Anti-tumor role of metformin
Categories: Immunology

TB prognostic marker

24 September 2018 - 12:00am

TB prognostic marker

TB prognostic marker, Published online: 24 September 2018; doi:10.1038/s41590-018-0219-7

TB prognostic marker
Categories: Immunology

A more human mouse

24 September 2018 - 12:00am

A more human mouse

A more human mouse, Published online: 24 September 2018; doi:10.1038/s41590-018-0220-1

A more human mouse
Categories: Immunology

Humoral immunity goes hormonal

19 September 2018 - 12:00am

Humoral immunity goes hormonal

Humoral immunity goes hormonal, Published online: 19 September 2018; doi:10.1038/s41590-018-0216-x

Studies of mice demonstrate a link between the female hormone estrogen and protection against bacteremia and sepsis through the induction of natural antibodies to Eshcerichia coli.
Categories: Immunology

NKILA lncRNA promotes tumor immune evasion by sensitizing T cells to activation-induced cell death

17 September 2018 - 12:00am

NKILA lncRNA promotes tumor immune evasion by sensitizing T cells to activation-induced cell death

NKILA lncRNA promotes tumor immune evasion by sensitizing T cells to activation-induced cell death, Published online: 17 September 2018; doi:10.1038/s41590-018-0207-y

lncRNAs can regulate immune responses at a number of levels. Song and colleagues demonstrate that the lncRNA NKILA is expressed by tumor-associated cytotoxic T cells, and this predisposes them to activation-induced cell death and escape of tumors from immunologically mediated destruction.
Categories: Immunology

NK cell receptor NKG2D sets activation threshold for the NCR1 receptor early in NK cell development

17 September 2018 - 12:00am

NK cell receptor NKG2D sets activation threshold for the NCR1 receptor early in NK cell development

NK cell receptor NKG2D sets activation threshold for the NCR1 receptor early in NK cell development, Published online: 17 September 2018; doi:10.1038/s41590-018-0209-9

Polić and colleagues show that the activating receptor NKG2D specifically sets the activation threshold for the activating receptor NCR1, providing a mechanism distinct from previously known mechanisms of NK cell education.
Categories: Immunology

The effect of cellular context on miR-155-mediated gene regulation in four major immune cell types

17 September 2018 - 12:00am

The effect of cellular context on miR-155-mediated gene regulation in four major immune cell types

The effect of cellular context on miR-155-mediated gene regulation in four major immune cell types, Published online: 17 September 2018; doi:10.1038/s41590-018-0208-x

MicroRNAs regulate gene expression by targeting mRNAs via complementarity with seed sequences. Rudensky and colleagues provide genome-wide profiles of the microRNA miR-155 in multiple immune cell lineages and identify its cell-type effects on gene expression.
Categories: Immunology

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