Nature Immunology

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Nature Immunology is a multidisciplinary journal that publishes papers of the highest quality and significance in all areas of immunology. Priority is given to work that provides fundamental insight into the workings of the immune system. Areas covered include, but are not limited to, innate immunity and inflammation; development; immune receptors, signaling and apoptosis; antigen presentation; gene regulation and recombination; cellular and systemic immunity; vaccines; immune tolerance; autoimmunity and tumor immunology, microbial immunopathology; and transplantation.
Updated: 2 hours 39 min ago

Mitochondria–ER hubs

18 April 2018 - 12:00am

Mitochondria–ER hubs

Mitochondria–ER hubs, Published online: 18 April 2018; doi:10.1038/s41590-018-0097-z

Mitochondria–ER hubs
Categories: Immunology

Adaptive responses of innate lymphocytes

18 April 2018 - 12:00am

Adaptive responses of innate lymphocytes

Adaptive responses of innate lymphocytes, Published online: 18 April 2018; doi:10.1038/s41590-018-0088-0

The activating natural killer cell receptor NKG2C can specifically recognize peptides derived from the cytomegalovirus protein UL40 in the context of HLA-E. This drives the expansion of a population of adaptive NKG2C+ natural killer cells.
Categories: Immunology

Synthetic benefits

18 April 2018 - 12:00am

Synthetic benefits

Synthetic benefits, Published online: 18 April 2018; doi:10.1038/s41590-018-0100-8

Synthetic benefits
Categories: Immunology

Got my γδ17 T cells to keep me warm

18 April 2018 - 12:00am

Got my γδ17 T cells to keep me warm

Got my γδ17 T cells to keep me warm, Published online: 18 April 2018; doi:10.1038/s41590-018-0090-6

γδ T cells accumulate with age in adipose tissue and produce the cytokine IL-17, which controls the homeostasis of regulatory T cells and adaptive thermogenesis. Thus, maintenance of core body temperature unexpectedly relies on these adipose tissue–resident γδ17 T cells.
Categories: Immunology

Traumatic meningeal injury and repair mechanisms

18 April 2018 - 12:00am

Traumatic meningeal injury and repair mechanisms

Traumatic meningeal injury and repair mechanisms, Published online: 18 April 2018; doi:10.1038/s41590-018-0093-3

Myeloid cells exhibit different inflammatory phenotypes after brain injury, yet the relative mechanistic roles for these diverse cell types in post-traumatic tissue damage and repair remain controversial.
Categories: Immunology

PP2A in B cells

18 April 2018 - 12:00am

PP2A in B cells

PP2A in B cells, Published online: 18 April 2018; doi:10.1038/s41590-018-0098-y

PP2A in B cells
Categories: Immunology

Crisis management

18 April 2018 - 12:00am

Crisis management

Crisis management, Published online: 18 April 2018; doi:10.1038/s41590-018-0101-7

Crisis management
Categories: Immunology

B cells on the brain

18 April 2018 - 12:00am

B cells on the brain

B cells on the brain, Published online: 18 April 2018; doi:10.1038/s41590-018-0096-0

B cells on the brain
Categories: Immunology

c-Maf controls immune responses by regulating disease-specific gene networks and repressing IL-2 in CD4<sup>+</sup> T cells

16 April 2018 - 12:00am

c-Maf controls immune responses by regulating disease-specific gene networks and repressing IL-2 in CD4+ T cells

c-Maf controls immune responses by regulating disease-specific gene networks and repressing IL-2 in CD4<sup>+</sup> T cells, Published online: 16 April 2018; doi:10.1038/s41590-018-0083-5

The transcription factor c-Maf controls IL-10 production in T cells. O’Garra and colleagues use systems and in vivo functional analysis of T cell subsets to reveal distinct context-specific roles for c-Maf.
Categories: Immunology

Distinct myeloid cell subsets promote meningeal remodeling and vascular repair after mild traumatic brain injury

16 April 2018 - 12:00am

Distinct myeloid cell subsets promote meningeal remodeling and vascular repair after mild traumatic brain injury

Distinct myeloid cell subsets promote meningeal remodeling and vascular repair after mild traumatic brain injury, Published online: 16 April 2018; doi:10.1038/s41590-018-0086-2

Meningeal vascular damage accompanies mild traumatic brain injury, which persists in a fraction of patients. McGavern and colleagues report that distinct myeloid cell subsets are temporally recruited to the wound site during tissue repair; however, re-injury at early time points impairs recovery.
Categories: Immunology

Fatal demyelinating disease is induced by monocyte-derived macrophages in the absence of TGF-β signaling

16 April 2018 - 12:00am

Fatal demyelinating disease is induced by monocyte-derived macrophages in the absence of TGF-β signaling

Fatal demyelinating disease is induced by monocyte-derived macrophages in the absence of TGF-β signaling, Published online: 16 April 2018; doi:10.1038/s41590-018-0091-5

Harris and colleagues show that the cytokine TGF-β is required for colonization of the microglial niche and maintenance of central nervous system integrity. Acute loss of TGF-β leads to proinflammatory responses and fatal demyelinating disease.
Categories: Immunology

Monomeric TCRs drive T cell antigen recognition

16 April 2018 - 12:00am

Monomeric TCRs drive T cell antigen recognition

Monomeric TCRs drive T cell antigen recognition, Published online: 16 April 2018; doi:10.1038/s41590-018-0092-4

Higher-order TCRs have been postulated to maintain high antigen sensitivity and trigger signaling. Huppa and colleagues use various investigative techniques and find exclusively monomeric TCR–CD3 complexes that drive the recognition of antigenic pMHC.
Categories: Immunology

Bruno Kyewski 1950–2018

11 April 2018 - 12:00am

Bruno Kyewski 1950–2018

Bruno Kyewski 1950–2018, Published online: 11 April 2018; doi:10.1038/s41590-018-0095-1

Bruno Kyewski 1950–2018
Categories: Immunology

Peptide-specific recognition of human cytomegalovirus strains controls adaptive natural killer cells

9 April 2018 - 12:00am

Peptide-specific recognition of human cytomegalovirus strains controls adaptive natural killer cells

Peptide-specific recognition of human cytomegalovirus strains controls adaptive natural killer cells, Published online: 09 April 2018; doi:10.1038/s41590-018-0082-6

NK cells constrain infection by cytomegalovirus. Romagnani and colleagues show that human NKG2C+ NK cells recognize distinct HCMV UL40 viral peptides, which can vary among viral isolates. NKG2C+ NK cells thereby demonstrate adaptive-like recognition that can discriminate between closely related viral strains.
Categories: Immunology

IL-33 meets allergens at the gate

21 March 2018 - 12:00am

IL-33 meets allergens at the gate

IL-33 meets allergens at the gate, Published online: 21 March 2018; doi:10.1038/s41590-018-0069-3

IL-33 is a mediator of allergic inflammation and is localized in mucosal tissues to respond rapidly to environmental insults. These include allergens themselves, which can directly activate IL-33 through their intrinsic proteolytic activity.
Categories: Immunology

Mast cells in autoimmune disease

21 March 2018 - 12:00am

Mast cells in autoimmune disease

Mast cells in autoimmune disease, Published online: 21 March 2018; doi:10.1038/s41590-018-0080-8

Mast cells in autoimmune disease
Categories: Immunology

Targeting TGF-β in cancer

21 March 2018 - 12:00am

Targeting TGF-β in cancer

Targeting TGF-β in cancer, Published online: 21 March 2018; doi:10.1038/s41590-018-0076-4

Targeting TGF-β in cancer
Categories: Immunology

IL-17-receptor-associated adaptor Act1 directly stabilizes mRNAs to mediate IL-17 inflammatory signaling

21 March 2018 - 12:00am

IL-17-receptor-associated adaptor Act1 directly stabilizes mRNAs to mediate IL-17 inflammatory signaling

IL-17-receptor-associated adaptor Act1 directly stabilizes mRNAs to mediate IL-17 inflammatory signaling, Published online: 21 March 2018; doi:10.1038/s41590-018-0071-9

Act1 is an adaptor protein that associates with the IL-17 receptor at the cell membrane. Li and colleagues show that Act1 also exhibits unexpected RNA-binding activity and directly stabilizes select mRNAs encoding inflammatory cytokines and chemokines.
Categories: Immunology

Asymmetry in PI(3)K activity

21 March 2018 - 12:00am

Asymmetry in PI(3)K activity

Asymmetry in PI(3)K activity, Published online: 21 March 2018; doi:10.1038/s41590-018-0079-1

Asymmetry in PI(3)K activity
Categories: Immunology

CD1c caves in on lipids

21 March 2018 - 12:00am

CD1c caves in on lipids

CD1c caves in on lipids, Published online: 21 March 2018; doi:10.1038/s41590-018-0074-6

Autoreactive T cells exclusively recognize the roof of the binding groove of the antigen-presenting molecule CD1c after it has caved in on short headless self lipids.
Categories: Immunology

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