Nature Immunology
TILs show the way
TILs show the way
TILs show the way, Published online: 19 July 2018; doi:10.1038/s41590-018-0175-2
TILs show the wayNatural killer cell specificity for viral infections
Natural killer cell specificity for viral infections
Natural killer cell specificity for viral infections, Published online: 19 July 2018; doi:10.1038/s41590-018-0163-6
Romagnani and colleagues discuss the specific recognition of viral antigens and peptides by NK cells and its implications for the composition of the NK cell repertoire and the selection of viral variants.Symbionts and metabolites
Symbionts and metabolites
Symbionts and metabolites, Published online: 19 July 2018; doi:10.1038/s41590-018-0170-7
Symbionts and metabolitesAutophagy & MDSCs
Autophagy & MDSCs
Autophagy & MDSCs, Published online: 19 July 2018; doi:10.1038/s41590-018-0173-4
Autophagy & MDSCsComment on: Evidence of innate lymphoid cell redundancy in humans
Comment on: Evidence of innate lymphoid cell redundancy in humans
Comment on: Evidence of innate lymphoid cell redundancy in humans, Published online: 19 July 2018; doi:10.1038/s41590-018-0164-5
Comment on: Evidence of innate lymphoid cell redundancy in humansModeling AD
Modeling AD
Modeling AD, Published online: 19 July 2018; doi:10.1038/s41590-018-0171-6
Modeling ADA harmful pairing
A harmful pairing
A harmful pairing, Published online: 19 July 2018; doi:10.1038/s41590-018-0174-3
A harmful pairingReply to ‘Comment on: Evidence of innate lymphoid cell redundancy in humans’
Reply to ‘Comment on: Evidence of innate lymphoid cell redundancy in humans’
Reply to ‘Comment on: Evidence of innate lymphoid cell redundancy in humans’, Published online: 19 July 2018; doi:10.1038/s41590-018-0165-4
Reply to ‘Comment on: Evidence of innate lymphoid cell redundancy in humans’T cell cytolytic capacity is independent of initial stimulation strength
T cell cytolytic capacity is independent of initial stimulation strength
T cell cytolytic capacity is independent of initial stimulation strength, Published online: 16 July 2018; doi:10.1038/s41590-018-0160-9
Lymphocytes interpret antigenic signals into a functional response. Richard et al. demonstrate that the overall qualitative response by CTLs is independent of TCR ligand strength; instead, ligands determine the rate and uniformity at which CTLs respond.Epithelial damage and tissue γδ T cells promote a unique tumor-protective IgE response
Epithelial damage and tissue γδ T cells promote a unique tumor-protective IgE response
Epithelial damage and tissue γδ T cells promote a unique tumor-protective IgE response, Published online: 16 July 2018; doi:10.1038/s41590-018-0161-8
Evidence of protective and homeostatic roles for IgE is relatively limited. Strid and colleagues demonstrate that γδ T cells induce switching to IgE that provides protection against experimentally induced epithelial cancer.CD8<sup>+</sup> T cells have commitment issues
CD8+ T cells have commitment issues
CD8<sup>+</sup> T cells have commitment issues, Published online: 16 July 2018; doi:10.1038/s41590-018-0169-0
T cell activation is ‘digital’: exhaustive single-cell analysis shows that only the proportion of cells that cross the activation threshold is reduced when the affinity of the TCR for its ligand is reduced.Adjustment of dendritic cells to the breast-cancer microenvironment is subset specific
Adjustment of dendritic cells to the breast-cancer microenvironment is subset specific
Adjustment of dendritic cells to the breast-cancer microenvironment is subset specific, Published online: 16 July 2018; doi:10.1038/s41590-018-0145-8
Soumelis and colleagues use RNA-based sequencing to define the transcriptional signatures of DC subsets and monocytes-macrophages in human primary breast cancer.γδ T cells and IgE team up to prevent tumors
γδ T cells and IgE team up to prevent tumors
γδ T cells and IgE team up to prevent tumors, Published online: 16 July 2018; doi:10.1038/s41590-018-0167-2
In response to epithelial DNA damage, tissue-resident γδ T cells initiate and shape a tumor-protective IgE response that requires CD4+ T cells and immune effector cells expressing the high-affinity IgE receptor FcεRI.TCRs are randomly distributed on the plasma membrane of resting antigen-experienced T cells
TCRs are randomly distributed on the plasma membrane of resting antigen-experienced T cells
TCRs are randomly distributed on the plasma membrane of resting antigen-experienced T cells, Published online: 16 July 2018; doi:10.1038/s41590-018-0162-7
TCRs are often thought to be pre-clustered before T cell activation. Rossboth et al. use super-resolution microscopy and statistical image analysis to demonstrate that TCRs are in fact randomly distributed on resting T cells.An RNA checkpoint that keeps immunological memory at bay
An RNA checkpoint that keeps immunological memory at bay
An RNA checkpoint that keeps immunological memory at bay, Published online: 09 July 2018; doi:10.1038/s41590-018-0168-1
What keeps memory T cells functionally silent in the absence of infection is unclear. New data reveal the existence of a deterministic halt in the protein-synthesis machinery of memory T cells and expose the discriminatory functions of a family of RNA-binding proteins.Second signals rescue B cells from activation-induced mitochondrial dysfunction and death
Second signals rescue B cells from activation-induced mitochondrial dysfunction and death
Second signals rescue B cells from activation-induced mitochondrial dysfunction and death, Published online: 09 July 2018; doi:10.1038/s41590-018-0156-5
B cells need at least two signals to terminally differentiate into antibody-secreting cells. Pierce and colleagues show that persistent exposure to antigen in the absence of T cell help or ‘pathogen pattern motifs’ leads to B cell death via a calcium-dependent ‘metabolic timer’.B cells race the clock to get a second wind
B cells race the clock to get a second wind
B cells race the clock to get a second wind, Published online: 09 July 2018; doi:10.1038/s41590-018-0166-3
Co-stimulatory second signals delivered through TLRs or CD40 rescue antigen-stimulated B cells from metabolic dysfunction and apoptosis. This identifies a critical time-limited window during which B cells integrate sequential signals to successfully initiate humoral immunity.Maintenance of CD4 T cell fitness through regulation of Foxo1
Maintenance of CD4 T cell fitness through regulation of Foxo1
Maintenance of CD4 T cell fitness through regulation of Foxo1, Published online: 09 July 2018; doi:10.1038/s41590-018-0157-4
Foxo proteins are required for maintaining T cell quiescence. Turka and colleagues use a constitutively active Foxo1 in Treg cells to show that its downregulation is essential for maintaining their fitness in a competitive environment.Translational repression of pre-formed cytokine-encoding mRNA prevents chronic activation of memory T cells
Translational repression of pre-formed cytokine-encoding mRNA prevents chronic activation of memory T cells
Translational repression of pre-formed cytokine-encoding mRNA prevents chronic activation of memory T cells, Published online: 09 July 2018; doi:10.1038/s41590-018-0155-6
Wolkers and colleagues show that the RNA-binding protein ZFP36L2 represses the translation of pre-formed cytokine-encoding mRNAs in memory T cells.The transcription factor Rfx7 limits metabolism of NK cells and promotes their maintenance and immunity
The transcription factor Rfx7 limits metabolism of NK cells and promotes their maintenance and immunity
The transcription factor Rfx7 limits metabolism of NK cells and promotes their maintenance and immunity, Published online: 02 July 2018; doi:10.1038/s41590-018-0144-9
Regulatory factor X (RFX) is a transcription factor family comprising seven known members, yet the functional roles of RFX7 remain unknown. Guarda and colleagues show that RFX7 regulates natural killer (NK) cell survival and activity by limiting their cellular metabolism.