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Chemoresistance Evolution in Triple-Negative Breast Cancer Delineated by Single-Cell Sequencing

19 April 2018 - 12:00am
Combination of single-cell DNA and RNA sequencing depicts the evolutionary trajectories of chemoresistance in human triple-negative breast cancer at the genomic and transcriptomic level, highlighting the presence of pre-existing genomic alterations and transcriptional reprogramming of resistant signatures.

The Structure of the Necrosome RIPK1-RIPK3 Core, a Human Hetero-Amyloid Signaling Complex

19 April 2018 - 12:00am
Solid-state NMR structures of the human necroptosis RIPK1-RIPK3 complex reveal a hetero-oligomeric amyloid signaling complex.

Dissociable Structural and Functional Hippocampal Outputs via Distinct Subiculum Cell Classes

19 April 2018 - 12:00am
Within the serially connected subfields of the hippocampus, specific elements of memory are processed via functionally distinct pathways in the subiculum.

The Evolutionary Landscape of Localized Prostate Cancers Drives Clinical Aggression

19 April 2018 - 12:00am
Tumors evolve during their natural life history. We studied the evolution of newly diagnosed prostate tumors and identified specific genes mutated early or late in a tumor’s life history. Considering subclonality improved predictions of disease aggressivity, identifying those patients who might be good candidates for receiving less treatment.

Chemistry-First Approach for Nomination of Personalized Treatment in Lung Cancer

19 April 2018 - 12:00am
Application of a chemistry-first approach matches chemicals with targetable, diverse genetic lesions and cancer-promoting mechanisms in human lung cancer, providing guidance for development of personalized cancer treatment.

Revolutionizing Precision Oncology through Collaborative Proteogenomics and Data Sharing

19 April 2018 - 12:00am
The integration of proteomics into precision oncology presents opportunities that may transform the molecular analysis of cancer and accelerate basic and clinical cancer research. This Commentary discusses the importance of international collaboration and data sharing inspired by the Cancer Moonshot to accelerate the progress of multi-omic precision medicine–an approach that addresses the global diversity of people and of cancers.

Artificial Intelligence Is Becoming Natural

19 April 2018 - 12:00am
You don’t have to sit in a self-driving Tesla to feel the impact of artificial intelligence (AI) on your daily life. From voice-powered personal assistants like Alexa or Siri to help you track and organize information to tailored online shopping, AI is no longer in the realm of science fiction.

Seeing More: A Future of Augmented Microscopy

19 April 2018 - 12:00am
Microscope images are information rich. In this issue of Cell, Christiansen et al. show that label-free images of cells can be used to predict fluorescent labels representing cell type, state, and organelle distribution using a deep-learning framework. This paves the way for computationally multiplexed assays derived from inexpensive label-free microscopy.

Beyond the Transport Function of Import Receptors: What’s All the FUS about?

19 April 2018 - 12:00am
Nuclear import receptors regulate supramolecular assemblies by fine-tuning the phase separating properties of RNA-binding proteins, which has implications for a variety of neurodegenerative disorders.

A Mechanosensitive GPCR that Detects the Bloody Force

19 April 2018 - 12:00am
Mechanoreceptors mediate a wide variety of physiological processes, such as hearing, touch, proprioception, and blood flow regulation. It is generally believed that mechanoreceptors are force-gated ion channels. Now, Xu et al. uncover a GPCR that is activated by shear force in endothelial cells of blood vessels.

AttrActin’ Attention to Early Mouse Development

19 April 2018 - 12:00am
A new study by Zenker et al. uses time-lapse imaging to discover how dynamic actin movements contribute to epithelialization of living mouse embryos. Together with work from other labs, this study presents exciting new ways to think about the emergence of cell fates during mammalian development.

Multi-regional Sequencing Elucidates the Evolution of Clear Cell Renal Cell Carcinoma

19 April 2018 - 12:00am
Extensive multi-regional whole-genome and -exome sequencing performed in tumors from patients with localized, as well as metastatic, clear cell renal cell carcinoma provides a comprehensive description of the tumor origin, intratumoral heterogeneity, evolution, and route to metastasis, laying the foundation for the development of precision clinical management.

GPR68 Senses Flow and Is Essential for Vascular Physiology

19 April 2018 - 12:00am
A GPCR is a critical sensor for fluid shear stress in blood vessels.

FUS Phase Separation Is Modulated by a Molecular Chaperone and Methylation of Arginine Cation-π Interactions

19 April 2018 - 12:00am
Phase transition of the RNA-binding protein FUS is mediated by cation-π interactions between C-terminal arginines and N-terminal tyrosines and is modulated by arginine methlylation.

Physiological and Genetic Adaptations to Diving in Sea Nomads

19 April 2018 - 12:00am
Genetic and physiological adaptations enable the remarkable breath-holding ability of marine nomads.

An Integrated Genome-wide CRISPRa Approach to Functionalize lncRNAs in Drug Resistance

19 April 2018 - 12:00am
A CRISPR activation screen identifies both coding and noncoding pathways involved in resistance to chemotherapy.

Structural Basis for Teneurin Function in Circuit-Wiring: A Toxin Motif at the Synapse

19 April 2018 - 12:00am
An adhesion protein with an unexpected, toxin-like fold shows how alternative splicing can regulate synaptic connections.

Beyond Host Defense: Emerging Functions of the Immune System in Regulating Complex Tissue Physiology

19 April 2018 - 12:00am
In non-pathogenic situations, the immune system interacts with the nervous system and diet components to regulate complex physiological processes, including metabolic homeostasis, thermogenesis, and tissue repair.

Phase Separation of FUS Is Suppressed by Its Nuclear Import Receptor and Arginine Methylation

19 April 2018 - 12:00am
Phase separation of FUS is regulated by both arginine methylation and binding to the nuclear import receptor Transportin/Karyopherin-β2, and this control can be compromised in the neurodegenerative diseases FTD and ALS.

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