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Nature Medicine is the premier journal for biomedical research. Respected internationally for the quality of its papers on areas ranging from infectious disease to cancer and neurodegeneration, Nature Medicine aims to bridge the gap between basic research and medical advances and is consistently ranked the number one journal by the Institute of Scientific Investigation in the Medicine, Research and Experimental category.
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Stimulation of entorhinal cortex–dentate gyrus circuitry is antidepressive

16 April 2018 - 12:00am

Stimulation of entorhinal cortex–dentate gyrus circuitry is antidepressive

Stimulation of entorhinal cortex–dentate gyrus circuitry is antidepressive, Published online: 16 April 2018; doi:10.1038/s41591-018-0002-1

In mouse models of stress-induced depression, molecular and chemogenetic stimulation of the entorhinal cortex induces the production of adult-born hippocampal neurons and generates antidepressive-like effects.
Categories: Medicine

Targeting sphingosine-1-phosphate lyase as an anabolic therapy for bone loss

16 April 2018 - 12:00am

Targeting sphingosine-1-phosphate lyase as an anabolic therapy for bone loss

Targeting sphingosine-1-phosphate lyase as an anabolic therapy for bone loss, Published online: 16 April 2018; doi:10.1038/s41591-018-0005-y

Promoting more bone growth is of keen interest in the treatment of osteoporosis, and preventing the degradation of S1P offers a new therapeutic avenue for this approach.
Categories: Medicine

Differential glucose requirement in skin homeostasis and injury identifies a therapeutic target for psoriasis

16 April 2018 - 12:00am

Differential glucose requirement in skin homeostasis and injury identifies a therapeutic target for psoriasis

Differential glucose requirement in skin homeostasis and injury identifies a therapeutic target for psoriasis, Published online: 16 April 2018; doi:10.1038/s41591-018-0003-0

Keratinocytes require glucose for injury- or inflammation-driven but not homeostatic proliferation, and glucose-transport blockade blocks psoriasis-like pathology in experimental models.
Categories: Medicine

A single injection of crystallizable fragment domain–modified antibodies elicits durable protection from SHIV infection

16 April 2018 - 12:00am

A single injection of crystallizable fragment domain–modified antibodies elicits durable protection from SHIV infection

A single injection of crystallizable fragment domain–modified antibodies elicits durable protection from SHIV infection, Published online: 16 April 2018; doi:10.1038/s41591-018-0001-2

Long-lived antibodies that can prevent viral infection of monkeys for 6 months may be a future alternative to an HIV vaccine.
Categories: Medicine

Potent antitumor efficacy of anti-GD2 CAR T cells in H3-K27M<sup>+</sup> diffuse midline gliomas

16 April 2018 - 12:00am

Potent antitumor efficacy of anti-GD2 CAR T cells in H3-K27M+ diffuse midline gliomas

Potent antitumor efficacy of anti-GD2 CAR T cells in H3-K27M<sup>+</sup> diffuse midline gliomas, Published online: 16 April 2018; doi:10.1038/s41591-018-0006-x

Lethal pediatric tumors bearing a particular histone H3 mutation upregulate the disialoganglioside GD2, thereby making these tumors susceptible to chimeric antigen receptor T cell–based immunotherapy.
Categories: Medicine

Corrigendum: Suppression of luteinizing hormone enhances HSC recovery after hematopoietic injury

10 April 2018 - 12:00am

Corrigendum: Suppression of luteinizing hormone enhances HSC recovery after hematopoietic injury

Corrigendum: Suppression of luteinizing hormone enhances HSC recovery after hematopoietic injury, Published online: 10 April 2018; doi:10.1038/nm0418-525b

Corrigendum: Suppression of luteinizing hormone enhances HSC recovery after hematopoietic injury
Categories: Medicine

Corrigendum: Sex-specific transcriptional signatures in human depression

10 April 2018 - 12:00am

Corrigendum: Sex-specific transcriptional signatures in human depression

Corrigendum: Sex-specific transcriptional signatures in human depression, Published online: 10 April 2018; doi:10.1038/nm0418-525d

Corrigendum: Sex-specific transcriptional signatures in human depression
Categories: Medicine

Current understanding of the human microbiome

10 April 2018 - 12:00am

Current understanding of the human microbiome

Current understanding of the human microbiome, Published online: 10 April 2018; doi:10.1038/nm.4517

Current understanding of the human microbiome
Categories: Medicine

Erratum: The molecular landscape of pediatric acute myeloid leukemia reveals recurrent structural alterations and age-specific mutational interactions

10 April 2018 - 12:00am

Erratum: The molecular landscape of pediatric acute myeloid leukemia reveals recurrent structural alterations and age-specific mutational interactions

Erratum: The molecular landscape of pediatric acute myeloid leukemia reveals recurrent structural alterations and age-specific mutational interactions, Published online: 10 April 2018; doi:10.1038/nm0418-526b

Erratum: The molecular landscape of pediatric acute myeloid leukemia reveals recurrent structural alterations and age-specific mutational interactions
Categories: Medicine

Transplanted neural progenitors bridge gaps to benefit cord–injured monkeys

10 April 2018 - 12:00am

Transplanted neural progenitors bridge gaps to benefit cord–injured monkeys

Transplanted neural progenitors bridge gaps to benefit cord–injured monkeys, Published online: 10 April 2018; doi:10.1038/nm.4531

Human neural progenitor cells have been grafted successfully into rhesus monkeys with spinal cord hemisection, resulting in anatomic integration and improved neurological function.
Categories: Medicine

Predicting leukemia relapse

10 April 2018 - 12:00am

Predicting leukemia relapse

Predicting leukemia relapse, Published online: 10 April 2018; doi:10.1038/nm.4529

Mass cytometry of acute B cell lymphoblastic leukemias at diagnosis reveals intrapatient phenotypic heterogeneity and specific signatures that mimic cell developmental stage and predict future relapse.
Categories: Medicine

A new site of attack for a malaria vaccine

10 April 2018 - 12:00am

A new site of attack for a malaria vaccine

A new site of attack for a malaria vaccine, Published online: 10 April 2018; doi:10.1038/nm.4533

A newly discovered antibody epitope on the liver-infective form of the parasite that causes malaria opens new doors for vaccine development.
Categories: Medicine

A checkup for the flu vaccine

10 April 2018 - 12:00am

A checkup for the flu vaccine

A checkup for the flu vaccine, Published online: 10 April 2018; doi:10.1038/nm.4535

Influenza causes almost 650,000 deaths worldwide each year, yet a long-lasting, protective vaccine remains elusive. Global investment—both scientific and financial—in a universal flu vaccine is overdue.
Categories: Medicine

Gain of toxic apolipoprotein E4 effects in human iPSC-derived neurons is ameliorated by a small-molecule structure corrector

9 April 2018 - 12:00am

Gain of toxic apolipoprotein E4 effects in human iPSC-derived neurons is ameliorated by a small-molecule structure corrector

Gain of toxic apolipoprotein E4 effects in human iPSC-derived neurons is ameliorated by a small-molecule structure corrector, Published online: 09 April 2018; doi:10.1038/s41591-018-0004-z

Human iPSC-derived neurons are generated from individuals with or without Alzheimer's disease carrying different APOE alleles and reveal a toxic, neuron-intrinsic gain of function of the ApoE4 variant that is a strong genetic risk factor for AD.
Categories: Medicine

Combinatorial inhibition of PTPN12-regulated receptors leads to a broadly effective therapeutic strategy in triple-negative breast cancer

26 March 2018 - 12:00am

Combinatorial inhibition of PTPN12-regulated receptors leads to a broadly effective therapeutic strategy in triple-negative breast cancer

Combinatorial inhibition of PTPN12-regulated receptors leads to a broadly effective therapeutic strategy in triple-negative breast cancer, Published online: 26 March 2018; doi:10.1038/nm.4507

Targeting tyrosine kinase receptors that share the feedback inhibitor PTPN12 leads to broad spectrum therapeutic suppression of triple-negative breast cancer.
Categories: Medicine

Targeting hepatic glutaminase activity to ameliorate hyperglycemia

26 March 2018 - 12:00am

Targeting hepatic glutaminase activity to ameliorate hyperglycemia

Targeting hepatic glutaminase activity to ameliorate hyperglycemia, Published online: 26 March 2018; doi:10.1038/nm.4514

In mice, elevated glucagon during type 2 diabetes promotes more hepatic glutamine flux and greater gluconeogenesis, while reducing glutamine metabolism in the liver lowers hyperglycemia.
Categories: Medicine

A public antibody lineage that potently inhibits malaria infection through dual binding to the circumsporozoite protein

19 March 2018 - 12:00am

A public antibody lineage that potently inhibits malaria infection through dual binding to the circumsporozoite protein

A public antibody lineage that potently inhibits malaria infection through dual binding to the circumsporozoite protein, Published online: 19 March 2018; doi:10.1038/nm.4513

Volunteers who develop protection against malaria produce potent antibodies binding to a site of vulnerability on the parasite circumsporozoite protein that is absent in vaccines currently being tested in humans
Categories: Medicine

A human monoclonal antibody prevents malaria infection by targeting a new site of vulnerability on the parasite

19 March 2018 - 12:00am

A human monoclonal antibody prevents malaria infection by targeting a new site of vulnerability on the parasite

A human monoclonal antibody prevents malaria infection by targeting a new site of vulnerability on the parasite, Published online: 19 March 2018; doi:10.1038/nm.4512

The identification of antibodies targeting a conserved site of vulnerability in the Plasmodium falciparum circumsporozoite protein reveals opportunities for passive prevention of malaria in vulnerable individuals and provides insights for rational vaccine design.
Categories: Medicine

Microenvironmental control of breast cancer subtype elicited through paracrine platelet-derived growth factor-CC signaling

12 March 2018 - 12:00am

Microenvironmental control of breast cancer subtype elicited through paracrine platelet-derived growth factor-CC signaling

Microenvironmental control of breast cancer subtype elicited through paracrine platelet-derived growth factor-CC signaling, Published online: 12 March 2018; doi:10.1038/nm.4494

Paracrine signaling networks in the breast cancer microenvironment uncover determinants of hormone receptor status and offer opportunities for therapeutic intervention.
Categories: Medicine

Dentate granule cell recruitment of feedforward inhibition governs engram maintenance and remote memory generalization

12 March 2018 - 12:00am

Dentate granule cell recruitment of feedforward inhibition governs engram maintenance and remote memory generalization

Dentate granule cell recruitment of feedforward inhibition governs engram maintenance and remote memory generalization, Published online: 12 March 2018; doi:10.1038/nm.4491

Dynamic regulation of the cytoskeletal factor ABLIM3 controls the precision of memory representations in rodent models of post-traumatic stress disorder and age-related cognitive impairment.
Categories: Medicine

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