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Nature Medicine is the premier journal for biomedical research. Respected internationally for the quality of its papers on areas ranging from infectious disease to cancer and neurodegeneration, Nature Medicine aims to bridge the gap between basic research and medical advances and is consistently ranked the number one journal by the Institute of Scientific Investigation in the Medicine, Research and Experimental category.
Updated: 11 hours 35 min ago

Precision identification of diverse bloodstream pathogens in the gut microbiome

15 October 2018 - 12:00am

Precision identification of diverse bloodstream pathogens in the gut microbiome

Precision identification of diverse bloodstream pathogens in the gut microbiome, Published online: 15 October 2018; doi:10.1038/s41591-018-0202-8

A new bioinformatic tool identifies a candidate source of bloodstream infection for better management and prevention of hospital-acquired infections.
Categories: Medicine

Going to waste

8 October 2018 - 12:00am

Going to waste

Going to waste, Published online: 08 October 2018; doi:10.1038/s41591-018-0218-0

Virologists say sewage systems are flush with opportunity.
Categories: Medicine

Gene editing for Duchenne muscular dystrophy

8 October 2018 - 12:00am

Gene editing for Duchenne muscular dystrophy

Gene editing for Duchenne muscular dystrophy, Published online: 08 October 2018; doi:10.1038/s41591-018-0225-1

Gene editing for Duchenne muscular dystrophy
Categories: Medicine

Treatment of a metabolic liver disease by in vivo genome base editing in adult mice

8 October 2018 - 12:00am

Treatment of a metabolic liver disease by in vivo genome base editing in adult mice

Treatment of a metabolic liver disease by in vivo genome base editing in adult mice, Published online: 08 October 2018; doi:10.1038/s41591-018-0209-1

AAV-mediated base editing corrects an autosomal recessive mutation in the Pahenu2 gene and ameliorates molecular deficits in a mouse model of metabolic liver disease.
Categories: Medicine

Structure-guided combination therapy to potently improve the function of mutant CFTRs

8 October 2018 - 12:00am

Structure-guided combination therapy to potently improve the function of mutant CFTRs

Structure-guided combination therapy to potently improve the function of mutant CFTRs, Published online: 08 October 2018; doi:10.1038/s41591-018-0200-x

Targeting different aspects of mutant CFTR structural defects with combination therapy leads to more potent rescue of function than that following single therapy.
Categories: Medicine

Wireless bioresorbable electronic system enables sustained nonpharmacological neuroregenerative therapy

8 October 2018 - 12:00am

Wireless bioresorbable electronic system enables sustained nonpharmacological neuroregenerative therapy

Wireless bioresorbable electronic system enables sustained nonpharmacological neuroregenerative therapy, Published online: 08 October 2018; doi:10.1038/s41591-018-0196-2

A biocompatible device built from naturally dissolving components and controlled by wireless technology enables programmable electrical stimulation of injured rodent peripheral nerves to accelerate regeneration and recovery.
Categories: Medicine

In utero CRISPR-mediated therapeutic editing of metabolic genes

8 October 2018 - 12:00am

In utero CRISPR-mediated therapeutic editing of metabolic genes

In utero CRISPR-mediated therapeutic editing of metabolic genes, Published online: 08 October 2018; doi:10.1038/s41591-018-0184-6

Viral-mediated base editing in utero enables therapeutic editing of two metabolic genes in mice.
Categories: Medicine

Towards poliovirus eradication

8 October 2018 - 12:00am

Towards poliovirus eradication

Towards poliovirus eradication, Published online: 08 October 2018; doi:10.1038/s41591-018-0228-y

Towards poliovirus eradication
Categories: Medicine

Early immune development

8 October 2018 - 12:00am

Early immune development

Early immune development, Published online: 08 October 2018; doi:10.1038/s41591-018-0226-0

Early immune development
Categories: Medicine

Publisher Correction: Clinical activity and molecular correlates of response to atezolizumab alone or in combination with bevacizumab versus sunitinib in renal cell carcinoma

5 October 2018 - 12:00am

Publisher Correction: Clinical activity and molecular correlates of response to atezolizumab alone or in combination with bevacizumab versus sunitinib in renal cell carcinoma

Publisher Correction: Clinical activity and molecular correlates of response to atezolizumab alone or in combination with bevacizumab versus sunitinib in renal cell carcinoma, Published online: 05 October 2018; doi:10.1038/s41591-018-0235-z

Publisher Correction: Clinical activity and molecular correlates of response to atezolizumab alone or in combination with bevacizumab versus sunitinib in renal cell carcinoma
Categories: Medicine

Author Correction: MitoTALEN reduces mutant mtDNA load and restores tRNA<sup>Ala</sup> levels in a mouse model of heteroplasmic mtDNA mutation

5 October 2018 - 12:00am

Author Correction: MitoTALEN reduces mutant mtDNA load and restores tRNAAla levels in a mouse model of heteroplasmic mtDNA mutation

Author Correction: MitoTALEN reduces mutant mtDNA load and restores tRNA<sup>Ala</sup> levels in a mouse model of heteroplasmic mtDNA mutation, Published online: 05 October 2018; doi:10.1038/s41591-018-0234-0

Author Correction: MitoTALEN reduces mutant mtDNA load and restores tRNAAla levels in a mouse model of heteroplasmic mtDNA mutation
Categories: Medicine

The influence of ethnicity and geography on human gut microbiome composition

1 October 2018 - 12:00am

The influence of ethnicity and geography on human gut microbiome composition

The influence of ethnicity and geography on human gut microbiome composition, Published online: 01 October 2018; doi:10.1038/s41591-018-0210-8

The taxonomic composition of the gut microbiome associates with patient ethnicity and geographic location. This association impacts the development of microbiome-based applications for personalized medicine.
Categories: Medicine

Induction of resistance to chimeric antigen receptor T cell therapy by transduction of a single leukemic B cell

1 October 2018 - 12:00am

Induction of resistance to chimeric antigen receptor T cell therapy by transduction of a single leukemic B cell

Induction of resistance to chimeric antigen receptor T cell therapy by transduction of a single leukemic B cell, Published online: 01 October 2018; doi:10.1038/s41591-018-0201-9

A CAR gene unintentionally introduced in a contaminating leukemia cell during the manufacturing of CAR T cells caused a patient to relapse after therapy.
Categories: Medicine

Renal compartment–specific genetic variation analyses identify new pathways in chronic kidney disease

1 October 2018 - 12:00am

Renal compartment–specific genetic variation analyses identify new pathways in chronic kidney disease

Renal compartment–specific genetic variation analyses identify new pathways in chronic kidney disease, Published online: 01 October 2018; doi:10.1038/s41591-018-0194-4

Kidney compartment–specific eQTL analysis goes beyond GWAS to reveal causal genes and pathways involved in renal disease development.
Categories: Medicine

Genetic mechanisms of target antigen loss in CAR19 therapy of acute lymphoblastic leukemia

1 October 2018 - 12:00am

Genetic mechanisms of target antigen loss in CAR19 therapy of acute lymphoblastic leukemia

Genetic mechanisms of target antigen loss in CAR19 therapy of acute lymphoblastic leukemia, Published online: 01 October 2018; doi:10.1038/s41591-018-0146-z

Mutations in the CD19 gene suggesting irreversible loss of its surface expression are identified in the majority of analyzed cases of CD19– relapse in two clinical trials of pediatric ALL CD19 CAR T therapy, offering considerations for the rational choice of follow-up therapies.
Categories: Medicine

Dynamics of genetically engineered hematopoietic stem and progenitor cells after autologous transplantation in humans

1 October 2018 - 12:00am

Dynamics of genetically engineered hematopoietic stem and progenitor cells after autologous transplantation in humans

Dynamics of genetically engineered hematopoietic stem and progenitor cells after autologous transplantation in humans, Published online: 01 October 2018; doi:10.1038/s41591-018-0195-3

In vivo tracking of hematopoietic stem and progenitor cells in humans treated with lentiviral gene therapy unveils the resilience of hematopoietic stem cells and the long-term survival of lymphoid-biased precursors.
Categories: Medicine

Safety and antiviral activity of combination HIV-1 broadly neutralizing antibodies in viremic individuals

26 September 2018 - 12:00am

Safety and antiviral activity of combination HIV-1 broadly neutralizing antibodies in viremic individuals

Safety and antiviral activity of combination HIV-1 broadly neutralizing antibodies in viremic individuals, Published online: 26 September 2018; doi:10.1038/s41591-018-0186-4

Combination of two broadly neutralizing antibodies is effective in reducing HIV-1 viremia and in limiting the emergence of resistant viral variants in individuals harboring antibody-sensitive viruses.
Categories: Medicine

Genome editing in mitochondria corrects a pathogenic mtDNA mutation in vivo

24 September 2018 - 12:00am

Genome editing in mitochondria corrects a pathogenic mtDNA mutation in vivo

Genome editing in mitochondria corrects a pathogenic mtDNA mutation in vivo, Published online: 24 September 2018; doi:10.1038/s41591-018-0165-9

Mitochondrially targeted zinc-finger nucleases reduce mutational burden and correct biochemical defects in a mouse model of mitochondrial disease.
Categories: Medicine

Meeting brain–computer interface user performance expectations using a deep neural network decoding framework

24 September 2018 - 12:00am

Meeting brain–computer interface user performance expectations using a deep neural network decoding framework

Meeting brain–computer interface user performance expectations using a deep neural network decoding framework, Published online: 24 September 2018; doi:10.1038/s41591-018-0171-y

Intracortical activity data recorded over 2 years in a tetraplegic patient is used to develop an artificial intelligence algorithm that achieves fast, accurate, and stable movement decoding to reenable real-time control of the paralyzed forearm.
Categories: Medicine

Neuromodulation of lumbosacral spinal networks enables independent stepping after complete paraplegia

24 September 2018 - 12:00am

Neuromodulation of lumbosacral spinal networks enables independent stepping after complete paraplegia

Neuromodulation of lumbosacral spinal networks enables independent stepping after complete paraplegia, Published online: 24 September 2018; doi:10.1038/s41591-018-0175-7

In a human subject with chronic paraplegia, a combination of epidural electrical stimulation and long-term rehabilitative training have culminated in the first report of unassisted, voluntary independent stepping in a paralyzed individual.
Categories: Medicine

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