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NETs awaken sleeping cancer cells

16 October 2018 - 12:00am

NETs awaken sleeping cancer cells

NETs awaken sleeping cancer cells, Published online: 16 October 2018; doi:10.1038/s41577-018-0081-8

Neutrophil extracellular traps awaken dormant cancer cells by remodelling the extracellular matrix.

A new guide to immunopharmacology

16 October 2018 - 12:00am

A new guide to immunopharmacology

A new guide to immunopharmacology, Published online: 16 October 2018; doi:10.1038/s41577-018-0079-2

A new guide to immunopharmacology seeks to bring the most valuable pharmacological data into the hands of immunology researchers.

lncRNA NKILA: a killer regulator

12 October 2018 - 12:00am

lncRNA NKILA: a killer regulator

lncRNA NKILA: a killer regulator, Published online: 12 October 2018; doi:10.1038/s41577-018-0078-3

The long non-coding RNA NKILA sensitizes antitumour T cells to activation-induced cell death. Targeting this pathway can improve adoptive T cell therapy for cancer.

Author Correction: Natural killer cells and other innate lymphoid cells in cancer

12 October 2018 - 12:00am

Author Correction: Natural killer cells and other innate lymphoid cells in cancer

Author Correction: Natural killer cells and other innate lymphoid cells in cancer, Published online: 12 October 2018; doi:10.1038/s41577-018-0077-4

Author Correction: Natural killer cells and other innate lymphoid cells in cancer

Small RNA-based antimicrobial immunity

9 October 2018 - 12:00am

Small RNA-based antimicrobial immunity

Small RNA-based antimicrobial immunity, Published online: 09 October 2018; doi:10.1038/s41577-018-0071-x

The authors review the latest research revealing conserved antiviral activity of virus-derived small interfering RNAs (siRNAs) in fungi, plants, invertebrates and mammals.

Publisher Correction: T cells under starter’s orders

9 October 2018 - 12:00am

Publisher Correction: T cells under starter’s orders

Publisher Correction: T cells under starter’s orders, Published online: 09 October 2018; doi:10.1038/s41577-018-0074-7

Publisher Correction: T cells under starter’s orders

There’s NO limit

9 October 2018 - 12:00am

There’s NO limit

There’s NO limit, Published online: 09 October 2018; doi:10.1038/s41577-018-0075-6

A quorum-sensing mechanism downregulates tissue inflammation by regulating metabolism in monocyte-derived cells.

Statins as adjuvants

8 October 2018 - 12:00am

Statins as adjuvants

Statins as adjuvants, Published online: 08 October 2018; doi:10.1038/s41577-018-0076-5

Besides cholesterol lowering, statins boost antigen presentation and adaptive immune responses, suggesting new uses as adjuvants for cancer immunotherapy.

Autoreactive T cells in narcolepsy

4 October 2018 - 12:00am

Autoreactive T cells in narcolepsy

Autoreactive T cells in narcolepsy, Published online: 04 October 2018; doi:10.1038/s41577-018-0073-8

This study supports the suspected autoimmune nature of narcolepsy by showing that patients have memory T cells targeting self-antigens expressed by hypocretin neurons.

Are tolerance and training required to end TB?

28 September 2018 - 12:00am

Are tolerance and training required to end TB?

Are tolerance and training required to end TB?, Published online: 28 September 2018; doi:10.1038/s41577-018-0070-y

Host defence strategies against Mycobacterium tuberculosis (Mtb), the bacterium that causes tuberculosis (TB), include host resistance and disease tolerance. To date, most studies have focused on resistance mechanisms, but developing new strategies to eradicate Mtb will require an understanding of the entire landscape of immunity in TB. Here I discuss two evolutionarily conserved host defence strategies, disease tolerance and trained immunity (memory-like innate immune responses), and their role in Mtb infection.

Recent insights into targeting the IL-6 cytokine family in inflammatory diseases and cancer

25 September 2018 - 12:00am

Recent insights into targeting the IL-6 cytokine family in inflammatory diseases and cancer

Recent insights into targeting the IL-6 cytokine family in inflammatory diseases and cancer, Published online: 25 September 2018; doi:10.1038/s41577-018-0066-7

This Review considers the key roles of the IL-6 cytokine family in regulating innate and adaptive immunity, as well as other physiological responses. The authors highlight the potential of targeting IL-6 family members to treat inflammatory diseases and cancer.

The emerging role of ADAM metalloproteinases in immunity

21 September 2018 - 12:00am

The emerging role of ADAM metalloproteinases in immunity

The emerging role of ADAM metalloproteinases in immunity, Published online: 21 September 2018; doi:10.1038/s41577-018-0068-5

A-DAM good Review discussing the role of ADAM protein-mediated cleavage of a wide range of substrates in the development and regulation of the immune system, with a focus on ADAM10 and ADAM17.

Cardioimmunology: the immune system in cardiac homeostasis and disease

18 September 2018 - 12:00am

Cardioimmunology: the immune system in cardiac homeostasis and disease

Cardioimmunology: the immune system in cardiac homeostasis and disease, Published online: 18 September 2018; doi:10.1038/s41577-018-0065-8

Recent studies have characterized complex interactions between resident and infiltrating immune cells in the heart and cardiac cells, including cardiomyocytes, fibroblasts and endothelial cells. This Review explores the role of immune cells in cardiac development and physiological function, as well as heart disease.

T cells home in on brain cancer

17 September 2018 - 12:00am

T cells home in on brain cancer

T cells home in on brain cancer, Published online: 17 September 2018; doi:10.1038/s41577-018-0069-4

T cells are engineered to home specifically to brain tumours.

Natural killer cells and other innate lymphoid cells in cancer

12 September 2018 - 12:00am

Natural killer cells and other innate lymphoid cells in cancer

Natural killer cells and other innate lymphoid cells in cancer, Published online: 12 September 2018; doi:10.1038/s41577-018-0061-z

Eric Vivier and colleagues discuss the emerging roles for natural killer (NK) cells and other innate lymphoid cell populations in cancer immunity. The authors highlight the current immunotherapy trials that are targeting NK cells to treat patients with cancer.

Making new memories

12 September 2018 - 12:00am

Making new memories

Making new memories, Published online: 12 September 2018; doi:10.1038/s41577-018-0064-9

Laura Mackay describes two landmark papers by Gebhardt et al. and Masopust et al., published in 2009 and 2010, that signified the advent of tissue-resident memory T cells as a distinct T cell subset.

T cells under starter’s orders

11 September 2018 - 12:00am

T cells under starter’s orders

T cells under starter’s orders, Published online: 11 September 2018; doi:10.1038/s41577-018-0067-6

Naive CD4+ T cells are prepared for rapid activation and metabolic remodelling through the derepression of a poised translational machinery, which occurs independently of nutrient-sensing pathways.

Bacteria-primed T cells identified as culprit in glaucoma

5 September 2018 - 12:00am

Bacteria-primed T cells identified as culprit in glaucoma

Bacteria-primed T cells identified as culprit in glaucoma, Published online: 05 September 2018; doi:10.1038/s41577-018-0063-x

Bacterially primed T cells reactive against heat shock proteins enter the eye and cause neurodegeneration in glaucoma.

Forkhead box transcription factors as context-dependent regulators of lymphocyte homeostasis

3 September 2018 - 12:00am

Forkhead box transcription factors as context-dependent regulators of lymphocyte homeostasis

Forkhead box transcription factors as context-dependent regulators of lymphocyte homeostasis, Published online: 03 September 2018; doi:10.1038/s41577-018-0048-9

This Review highlights the key roles of forkhead box transcription factors (FTFs) in regulating lymphocyte responses. The authors discuss how FTFs function as context-dependent rheostats, allowing lymphocytes to fine-tune their responses to diverse environmental challenges.

Baby steps for the immune system

30 August 2018 - 12:00am

Baby steps for the immune system

Baby steps for the immune system, Published online: 30 August 2018; doi:10.1038/s41577-018-0062-y

Infant immune systems are highly diverse at birth but then show convergence in the first three months of life.

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