Nature Rev. Imm.
Histone deacetylase function in CD4+ T cells
Histone deacetylase function in CD4<sup>+</sup> T cells, Published online: 18 July 2018; doi:10.1038/s41577-018-0037-zHistone deacetylases (HDACs) and histone acetyltransferases mediate reversible acetylation of histones and many other non-histone proteins to regulate gene expression and protein function. Here, the authors describe the myriad activities of HDACs in CD4+ T cells and the potential use of HDAC inhibitors as therapeutics for immune-mediated diseases.
Chance favours the prepared mind
Chance favours the prepared mind, Published online: 17 July 2018; doi:10.1038/s41577-018-0043-1Jeffrey Bluestone describes a 1987 study of anergic T cells by Marc Jenkins and Ron Schwartz that altered his thoughts about T cell tolerance and eventually gave birth to the field of checkpoint inhibition.
Quorum sensing in the immune system
Quorum sensing in the immune system, Published online: 13 July 2018; doi:10.1038/s41577-018-0040-4Quorum sensing is the regulation of gene expression programmes in response to changes in population density. It is probably best recognized as a mechanism through which bacterial communities can synchronize behaviours, such as biofilm formation and bioluminescence. This Comment article highlights the emerging evidence suggesting that quorum sensing also contributes to the regulation of immune cell responses.
P2RX7 keeps memory T cells fit
P2RX7 keeps memory T cells fit, Published online: 10 July 2018; doi:10.1038/s41577-018-0041-3The ATP sensor P2RX7 maintains mitochondrial function in long-lived memory CD8+ T cells.
Tumour decides immune cell ins and outs
Tumour decides immune cell ins and outs, Published online: 09 July 2018; doi:10.1038/s41577-018-0038-yTumour cell-intrinsic factors determine the infiltration of T cells into tumours and their response to immunotherapy.
RFX7 keeps killers quiescent
RFX7 keeps killers quiescent, Published online: 06 July 2018; doi:10.1038/s41577-018-0039-xThe metabolism and maintenance of natural killer (NK) cells is regulated by a previously uncharacterized transcription factor called regulatory factor X7 (RFX7).
Neuroendocrine cells amplify asthma
Neuroendocrine cells amplify asthma, Published online: 03 July 2018; doi:10.1038/s41577-018-0036-0Pulmonary neuroendocrine cells communicate with type 2 innate lymphoid cells and goblet cells to promote allergic asthma.
Tissue-specific functions of invariant natural killer T cells
Tissue-specific functions of invariant natural killer T cells, Published online: 02 July 2018; doi:10.1038/s41577-018-0034-2Here, the authors examine the functions of different subsets of invariant natural killer T (iNKT) cells. They explain how iNKT cells contribute to tissue homeostasis and protection against infection, with a focus on the liver, intestine, lungs and adipose tissue.
Viperin breaks viral chains
Viperin breaks viral chains, Published online: 27 June 2018; doi:10.1038/s41577-018-0035-1The antiviral protein viperin catalyses the production of a small molecule inhibitor of viral RNA polymerization.
TH9 cells tackle advanced tumours
T<sub>H</sub>9 cells tackle advanced tumours, Published online: 26 June 2018; doi:10.1038/s41577-018-0032-4CD4+ TH9 cells show superior activity in adoptive cell transfer approach in melanoma mouse model.
Publisher Correction: To respond or not to respond — a personal perspective of intestinal tolerance
Publisher Correction: To respond or not to respond — a personal perspective of intestinal tolerance, Published online: 22 June 2018; doi:10.1038/s41577-018-0033-3Publisher Correction: To respond or not to respond — a personal perspective of intestinal tolerance
Author Correction: Integrating oncolytic viruses in combination cancer immunotherapy
Author Correction: Integrating oncolytic viruses in combination cancer immunotherapy, Published online: 21 June 2018; doi:10.1038/s41577-018-0031-5Author Correction: Integrating oncolytic viruses in combination cancer immunotherapy
IFNγ: signalling, epigenetics and roles in immunity, metabolism, disease and cancer immunotherapy
IFNγ: signalling, epigenetics and roles in immunity, metabolism, disease and cancer immunotherapy, Published online: 19 June 2018; doi:10.1038/s41577-018-0029-zLionel Ivashkiv discusses new insight into the functions of IFNγ and summarizes our current understanding of IFNγ receptor signalling. In particular, the author focuses on recent studies on how IFNγ influences autoimmunity, immunometabolism, neurological diseases and cancer immunotherapy.
Calming the cytokine storm
Calming the cytokine storm, Published online: 13 June 2018; doi:10.1038/s41577-018-0030-6Two papers show that combining IL-1 blockade with chimeric antigen receptor T cell therapy for cancer can prevent the induction of a potentially lethal ‘cytokine storm’.
Immunological mechanisms of human resistance to persistent <i>Mycobacterium tuberculosis</i> infection
Immunological mechanisms of human resistance to persistent Mycobacterium tuberculosis infection
Immunological mechanisms of human resistance to persistent <i>Mycobacterium tuberculosis</i> infection, Published online: 12 June 2018; doi:10.1038/s41577-018-0025-3Resisters are individuals who show resistance to infection despite long-term, high exposure to Mycobacterium tuberculosis. In this Review, Simmons and colleagues discuss potential mechanisms underlying this resistance, such as those mediated by macrophages, T cells and B cells, and how an understanding of these mechanisms might aid in the development of therapies for tuberculosis.
Antibodies and tuberculosis: finally coming of age?
Antibodies and tuberculosis: finally coming of age?, Published online: 05 June 2018; doi:10.1038/s41577-018-0028-0Most candidate vaccines for tuberculosis are designed to boost cell-mediated immunity to Mycobacterium tuberculosis, the intracellular bacterium that causes the disease. This Opinion article considers the rationale for also harnessing antibody-mediated immunity in future tuberculosis vaccines.
The inflammasome starts rolling
The inflammasome starts rolling, Published online: 01 June 2018; doi:10.1038/s41577-018-0027-1Thirumala-Devi Kanneganti describes a 2002 study by Jürg Tschopp and colleagues that first described the multiprotein, caspase-activating inflammasome complex that drives the maturation and secretion of IL-1β.
High-fibre diet beats flu
High-fibre diet beats flu, Published online: 25 May 2018; doi:10.1038/s41577-018-0024-4A high-fibre diet protects against influenza virus infection by limiting lung immunopathology and enhancing antiviral T cell responses.
Cheating cell death
Cheating cell death, Published online: 25 May 2018; doi:10.1038/s41577-018-0026-2The long-term survival of HIV-1-infected CD4+ T cells is shown to be controlled by the anti-apoptotic protein BIRC5 and its upstream regulator OX40, which suggests new therapeutic targets to reduce the size of the viral reservoir.
T cell balancing act in TB
T cell balancing act in TB, Published online: 24 May 2018; doi:10.1038/s41577-018-0023-5CYPD regulates the host response to tuberculosis infection through modulating T cell metabolism.