Nature Rev. Cancer

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Fasting and cancer: molecular mechanisms and clinical application

16 October 2018 - 12:00am

Fasting and cancer: molecular mechanisms and clinical application

Fasting and cancer: molecular mechanisms and clinical application, Published online: 16 October 2018; doi:10.1038/s41568-018-0061-0

This Opinion discusses the potential of fasting and fasting-mimicking diets to help overcome toxicities induced by anticancer therapy. The differential response of normal and cancer cells undergoing starvation is argued to make normal cells less sensitive to therapy-induced toxicity, while cancer cells become more sensitive to therapy-induced cell death.
Categories: Cancer

Back to the beginning to understand metastasis

15 October 2018 - 12:00am

Back to the beginning to understand metastasis

Back to the beginning to understand metastasis, Published online: 15 October 2018; doi:10.1038/s41568-018-0069-5

Yang et al. have used genetically engineered mouse models of small cell lung cancer to show that the same genomic alterations in different cells of origin lead to the formation of tumours that follow distinct evolutionary paths to metastasis.
Categories: Cancer

SPOP mutations disrupt phase separation

11 October 2018 - 12:00am

SPOP mutations disrupt phase separation

SPOP mutations disrupt phase separation, Published online: 11 October 2018; doi:10.1038/s41568-018-0066-8

SPOP mutations disrupt phase separation
Categories: Cancer

New targets for cancer immunotherapy

11 October 2018 - 12:00am

New targets for cancer immunotherapy

New targets for cancer immunotherapy, Published online: 11 October 2018; doi:10.1038/s41568-018-0067-7

New targets for cancer immunotherapy
Categories: Cancer

Oncogenic mRNA modification explained

11 October 2018 - 12:00am

Oncogenic mRNA modification explained

Oncogenic mRNA modification explained, Published online: 11 October 2018; doi:10.1038/s41568-018-0068-6

Oncogenic mRNA modification explained
Categories: Cancer

BETting on YAP–TAZ

9 October 2018 - 12:00am

BETting on YAP–TAZ

BETting on YAP–TAZ, Published online: 09 October 2018; doi:10.1038/s41568-018-0065-9

Two papers recently published in Nature Medicine and Science Signaling highlight the various interdependent or independent ways by which YAP and TAZ can affect tumour growth.
Categories: Cancer

Neighbourly deaths dictate fate

9 October 2018 - 12:00am

Neighbourly deaths dictate fate

Neighbourly deaths dictate fate, Published online: 09 October 2018; doi:10.1038/s41568-018-0064-x

Seehawer, Heinzmann et al. show that lineage commitment in liver cancer is independent of oncogenic driver expression and is instead dictated by the type of cell death occurring in the nearby liver microenvironment.
Categories: Cancer

The COSMIC Cancer Gene Census: describing genetic dysfunction across all human cancers

6 October 2018 - 12:00am

The COSMIC Cancer Gene Census: describing genetic dysfunction across all human cancers

The COSMIC Cancer Gene Census: describing genetic dysfunction across all human cancers, Published online: 06 October 2018; doi:10.1038/s41568-018-0060-1

This Review discusses the 2018 Catalogue of Somatic Mutations in Cancer (COSMIC) Cancer Gene Census (CGC), an expert-curated description of human cancer genes, which has recently been expanded to include functional descriptions of how each gene contributes to cancer.
Categories: Cancer

A multiplexed view of immune infiltration

4 October 2018 - 12:00am

A multiplexed view of immune infiltration

A multiplexed view of immune infiltration, Published online: 04 October 2018; doi:10.1038/s41568-018-0063-y

Keren et al. have used multiplexed imaging in intact samples from breast cancer patients to gain insights into the architecture of the tumour immune microenvironment.
Categories: Cancer

STAT3’s true colours

3 October 2018 - 12:00am

STAT3’s true colours

STAT3’s true colours, Published online: 03 October 2018; doi:10.1038/s41568-018-0062-z

D’Amico et al. show that, in the presence of oncogenic RAS mutations, STAT3 acts as a tumour modifier by regulating the epithelial differentiation of pancreatic and lung cancer cells via p63.
Categories: Cancer

mRNA alterations mimic genetic mutations

21 September 2018 - 12:00am

mRNA alterations mimic genetic mutations

mRNA alterations mimic genetic mutations, Published online: 21 September 2018; doi:10.1038/s41568-018-0059-7

Lee, Singh et al. find that cancer-specific intronic polyadenylation events occur frequently in tumour suppressor genes in chronic lymphocytic leukaemia (CLL) and generate truncated proteins that could act as CLL drivers.
Categories: Cancer

Stem cell fate in cancer growth, progression and therapy resistance

18 September 2018 - 12:00am

Stem cell fate in cancer growth, progression and therapy resistance

Stem cell fate in cancer growth, progression and therapy resistance, Published online: 18 September 2018; doi:10.1038/s41568-018-0056-x

This Review discusses how cells with stem cell characteristics often serve as the tumour cell of origin, as they are preferentially primed for transformation. Furthermore, the activation of stem cell programmes can be crucial for promoting cancer progression and therapy resistance.
Categories: Cancer

Publisher Correction: The molecular landscape of head and neck cancer

12 September 2018 - 12:00am

Publisher Correction: The molecular landscape of head and neck cancer

Publisher Correction: The molecular landscape of head and neck cancer, Published online: 12 September 2018; doi:10.1038/s41568-018-0057-9

Publisher Correction: The molecular landscape of head and neck cancer
Categories: Cancer

Changing mutational patterns

12 September 2018 - 12:00am

Changing mutational patterns

Changing mutational patterns, Published online: 12 September 2018; doi:10.1038/s41568-018-0058-8

Lee, Adler et al. show that urea cycle dysregulation is common in cancer and leads to a purine to pyrimidine mutational bias that is associated with a better response to immune checkpoint inhibitors.
Categories: Cancer

Rewiring urea cycle metabolism in cancer to support anabolism

7 September 2018 - 12:00am

Rewiring urea cycle metabolism in cancer to support anabolism

Rewiring urea cycle metabolism in cancer to support anabolism, Published online: 07 September 2018; doi:10.1038/s41568-018-0054-z

This Review discusses the reprogramming of the urea cycle, the main metabolic liver pathway for nitrogen disposal, in cancer cells. The authors provide insight into the metabolic advantages and therapeutic opportunities stemming from urea cycle enzyme perturbations in cancer.
Categories: Cancer

Publisher Correction: Structural underpinnings of oestrogen receptor mutations in endocrine therapy resistance

5 September 2018 - 12:00am

Publisher Correction: Structural underpinnings of oestrogen receptor mutations in endocrine therapy resistance

Publisher Correction: Structural underpinnings of oestrogen receptor mutations in endocrine therapy resistance, Published online: 05 September 2018; doi:10.1038/s41568-018-0053-0

Publisher Correction: Structural underpinnings of oestrogen receptor mutations in endocrine therapy resistance
Categories: Cancer

Polyamine metabolism and cancer: treatments, challenges and opportunities

4 September 2018 - 12:00am

Polyamine metabolism and cancer: treatments, challenges and opportunities

Polyamine metabolism and cancer: treatments, challenges and opportunities, Published online: 04 September 2018; doi:10.1038/s41568-018-0050-3

This Review discusses new insights into molecular mechanisms that link the dysregulation of polyamine metabolism with carcinogenesis and strategies for targeting this pathway for cancer therapy.
Categories: Cancer

In search of missing T cells

31 August 2018 - 12:00am

In search of missing T cells

In search of missing T cells, Published online: 31 August 2018; doi:10.1038/s41568-018-0055-y

In search of missing T cells
Categories: Cancer

Leukaemic escape routes

29 August 2018 - 12:00am

Leukaemic escape routes

Leukaemic escape routes, Published online: 29 August 2018; doi:10.1038/s41568-018-0051-2

Yao et al. have established that acute lymphoblastic leukaemia cells bypass the need to metastasize via the circulation to the CNS and instead use a direct route migrating along the vascular channels that bridge the bone marrow to the meninges in an α6 integrin-dependent manner.
Categories: Cancer

Epigenetic control by sugar

29 August 2018 - 12:00am

Epigenetic control by sugar

Epigenetic control by sugar, Published online: 29 August 2018; doi:10.1038/s41568-018-0052-1

A recent study, published in Nature, identifies the methylcytosine dioxygenase 2 (TET2) as an epigenetic modifier that is regulated in response to glucose availability and mechanistically links higher cancer susceptibility in patients with diabetes to high blood glucose levels.
Categories: Cancer

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