Nature Rev. Cancer

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Fasting in oncology: a word of caution

16 January 2019 - 12:00am

Fasting in oncology: a word of caution

Fasting in oncology: a word of caution, Published online: 16 January 2019; doi:10.1038/s41568-018-0098-0

Fasting in oncology: a word of caution
Categories: Cancer

Reply to ‘Fasting in oncology: a word of caution’

16 January 2019 - 12:00am

Reply to ‘Fasting in oncology: a word of caution’

Reply to ‘Fasting in oncology: a word of caution’, Published online: 16 January 2019; doi:10.1038/s41568-018-0100-x

Reply to ‘Fasting in oncology: a word of caution’
Categories: Cancer

Modelling cancer in microfluidic human organs-on-chips

15 January 2019 - 12:00am

Modelling cancer in microfluidic human organs-on-chips

Modelling cancer in microfluidic human organs-on-chips, Published online: 15 January 2019; doi:10.1038/s41568-018-0104-6

In vitro cancer models often fail to faithfully recapitulate the local tissue and organ microenvironment. Organs-on-chips can overcome this limitation and better mimic in vivo cancer phenotypes. This Review outlines the advances that have been made with this technology and explains the challenges that must be overcome to see its implementation into drug development pipelines and clinical cancer care.
Categories: Cancer

Get to know your epigenetic target

7 January 2019 - 12:00am

Get to know your epigenetic target

Get to know your epigenetic target, Published online: 07 January 2019; doi:10.1038/s41568-018-0103-7

Two studies suggest that caution is warranted in attempts to inhibit the histone methyltransferase G9a for cancer therapy, as its loss can promote tumour development and evolution.
Categories: Cancer

Expanding the search

7 January 2019 - 12:00am

Expanding the search

Expanding the search, Published online: 07 January 2019; doi:10.1038/s41568-018-0101-9

Laumont, Vincent et al. have developed a proteogenomic strategy for high-throughput mass spectrometry-based discovery of aberrantly expressed tumour-specific antigens from non-coding sequences as well as mutated tumour-specific antigens encoded by all genomic regions, thereby expanding the number of targetable antigens that can be used for cancer vaccine development.
Categories: Cancer

Maintaining the tumour’s diet

4 January 2019 - 12:00am

Maintaining the tumour’s diet

Maintaining the tumour’s diet, Published online: 04 January 2019; doi:10.1038/s41568-018-0097-1

Poillet-Perez et al. show that autophagy in non-tumour tissues in tumour-bearing mice inhibits release of the arginine-degrading enzyme arginase 1 (ARG1) from the liver into circulation, thereby maintaining the levels of arginine in the circulation and contributing to tumour growth.
Categories: Cancer

Your genomic inheritance matters

21 December 2018 - 12:00am

Your genomic inheritance matters

Your genomic inheritance matters, Published online: 21 December 2018; doi:10.1038/s41568-018-0099-z

Lim et al. show that there is an association between germline genetic variants and the immune features of a tumour, and that genetic background might affect responses to immunotherapy.
Categories: Cancer

Genomic evolution of cancer models: perils and opportunities

21 December 2018 - 12:00am

Genomic evolution of cancer models: perils and opportunities

Genomic evolution of cancer models: perils and opportunities, Published online: 21 December 2018; doi:10.1038/s41568-018-0095-3

Genomic instability in cancer models presents a major challenge in the design and reproducibility of research and its clinical translation. This Opinion article discusses the causes and consequences of intra-tumour genomic heterogeneity and instability in commonly used models and implications thereof.
Categories: Cancer

Therapeutically exploiting STAT3 activity in cancer — using tissue repair as a road map

21 December 2018 - 12:00am

Therapeutically exploiting STAT3 activity in cancer — using tissue repair as a road map

Therapeutically exploiting STAT3 activity in cancer — using tissue repair as a road map, Published online: 21 December 2018; doi:10.1038/s41568-018-0090-8

This Review discusses how excessive signal transducer and activator of transcription 3 (STAT3) activation within cancer cells and cells of the tumour microenvironment can be viewed as a neoplastic mimic of an inflammation-driven repair response that promotes tumour progression.
Categories: Cancer

Checkpoint ahead — be prepared to stop!

12 December 2018 - 12:00am

Checkpoint ahead — be prepared to stop!

Checkpoint ahead — be prepared to stop!, Published online: 12 December 2018; doi:10.1038/s41568-018-0096-2

Two studies published in Cell have characterized the inhibitory immune receptor NKG2A expressed on cytotoxic lymphocytes, such as natural killer cells and CD8+ T cells, as a novel checkpoint for cancer immunotherapy.
Categories: Cancer

Radiation promotes systemic responses

12 December 2018 - 12:00am

Radiation promotes systemic responses

Radiation promotes systemic responses, Published online: 12 December 2018; doi:10.1038/s41568-018-0094-4

New findings published in Nature Medicine highlight a role for the anti-CTLA4 antibody ipilimumab when combined with radiotherapy in treating metastatic NSCLC.
Categories: Cancer

Post-GWAS in prostate cancer: from genetic association to biological contribution

11 December 2018 - 12:00am

Post-GWAS in prostate cancer: from genetic association to biological contribution

Post-GWAS in prostate cancer: from genetic association to biological contribution, Published online: 11 December 2018; doi:10.1038/s41568-018-0087-3

This Review discusses causal germline variants in prostate cancer identified through genome-wide association studies (GWAS) and post-GWAS analyses. The latter are vital to identify causal variants and molecular mechanisms by which these variants promote prostate tumorigenesis, with potential clinical applications.
Categories: Cancer

A year of ups and downs

10 December 2018 - 12:00am

A year of ups and downs

A year of ups and downs, Published online: 10 December 2018; doi:10.1038/s41568-018-0093-5

Cancer research and Nature Reviews Cancer have both experienced many highs and lows in 2018, and we look forward to what 2019 has in store.
Categories: Cancer

The lung microenvironment: an important regulator of tumour growth and metastasis

10 December 2018 - 12:00am

The lung microenvironment: an important regulator of tumour growth and metastasis

The lung microenvironment: an important regulator of tumour growth and metastasis, Published online: 10 December 2018; doi:10.1038/s41568-018-0081-9

In this Review, Altorki et al. discuss how the tumour-reprogrammed lung microenvironment can contribute to primary lung tumour progression as well as lung metastasis from extrapulmonary neoplasms by promoting inflammation, angiogenesis, immune modulation and therapeutic responses.
Categories: Cancer

Regulatory networks in AML

6 December 2018 - 12:00am

Regulatory networks in AML

Regulatory networks in AML, Published online: 06 December 2018; doi:10.1038/s41568-018-0092-6

Assi et al. have generated multi-omics data on leukaemic blasts from acute myeloid leukaemia (AML) patients with defined genetic alterations. These data provide a comprehensive overview of the specific transcriptional and signalling networks in certain AML subtypes.
Categories: Cancer

Cytokinesis defects and cancer

6 December 2018 - 12:00am

Cytokinesis defects and cancer

Cytokinesis defects and cancer, Published online: 06 December 2018; doi:10.1038/s41568-018-0084-6

This Review discusses the evidence that whole-genome duplication as a consequence of cytokinesis failure can contribute to tumorigenesis.
Categories: Cancer

Immunosuppressive lymphatics

6 December 2018 - 12:00am

Immunosuppressive lymphatics

Immunosuppressive lymphatics, Published online: 06 December 2018; doi:10.1038/s41568-018-0091-7

Lane et al. have shown that interferon-γ (IFNγ)-mediated activation of the lymphatic vasculature, as a non-haematopoietic component of the tumour stroma, serves to limit local CD8+ T cell accumulation in melanoma in mice as a mechanism of immune suppression.
Categories: Cancer

A source of calcium

3 December 2018 - 12:00am

A source of calcium

A source of calcium, Published online: 03 December 2018; doi:10.1038/s41568-018-0089-1

Wang et al. demonstrate that increased flux of calcium derived from osteogenic cells into cancer cells promotes early-stage bone colonization. Calcium signalling in cancer cells can be targeted by arsenic trioxide, thereby reducing bone metastasis progression.
Categories: Cancer

Cancer chromatin accessed

28 November 2018 - 12:00am

Cancer chromatin accessed

Cancer chromatin accessed, Published online: 28 November 2018; doi:10.1038/s41568-018-0088-2

A study in Science reports the genome-wide chromatin accessibility profiles across 23 cancer types from The Cancer Genome Atlas and notably increases the number of known gene regulatory elements.
Categories: Cancer

Cooperation among cancer cells: applying game theory to cancer

23 November 2018 - 12:00am

Cooperation among cancer cells: applying game theory to cancer

Cooperation among cancer cells: applying game theory to cancer, Published online: 23 November 2018; doi:10.1038/s41568-018-0083-7

This Opinion argues that understanding the interactions between cells that occur in tumours requires concepts from evolutionary game theory. Game theory can provide insights into the stability of cooperation among cells in a tumour and how this might be used therapeutically.
Categories: Cancer

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