Nature Rev. Cancer

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Known and novel roles of the <i>MET</i> oncogene in cancer: a coherent approach to targeted therapy

19 April 2018 - 12:00am

Known and novel roles of the MET oncogene in cancer: a coherent approach to targeted therapy

Known and novel roles of the <i>MET</i> oncogene in cancer: a coherent approach to targeted therapy, Published online: 19 April 2018; doi:10.1038/s41568-018-0002-y

The MET oncogene encodes a receptor tyrosine kinase with pleiotropic functions. In this Review, Comoglio et al. describe the known and novel MET-mediated biological responses in cancer and discuss how clinical trials testing anti-MET therapies should be designed with careful consideration of these oncogenic functions of MET.
Categories: Cancer

Stop the shedding

17 April 2018 - 12:00am

Stop the shedding

Stop the shedding, Published online: 17 April 2018; doi:10.1038/s41568-018-0012-9

Ferrari de Andrade et al. find that monoclonal antibodies that prevent shedding of MICA and MICB from tumour cells can restore antitumour immunity by natural killer cells.
Categories: Cancer

Structural underpinnings of oestrogen receptor mutations in endocrine therapy resistance

16 April 2018 - 12:00am

Structural underpinnings of oestrogen receptor mutations in endocrine therapy resistance

Structural underpinnings of oestrogen receptor mutations in endocrine therapy resistance, Published online: 16 April 2018; doi:10.1038/s41568-018-0001-z

This Opinion article highlights how activating mutations in the gene encoding oestrogen receptor-α (ERα), a major driver in breast cancer, undermine structural features of wild-type ERα that maintain the ‘off-state’ in the absence of oestrogens, thus making ERα constitutively active and endocrine-therapy resistant.
Categories: Cancer

Take a left here

16 April 2018 - 12:00am

Take a left here

Take a left here, Published online: 16 April 2018; doi:10.1038/s41568-018-0011-x

Whether lymph node metastases can be a source of cancer cells for distant metastases has been debated. Now, two studies have used mouse models to show that tumour cells can colonize distant organs by invading lymph node blood vessels.
Categories: Cancer

Revisiting the role of ABC transporters in multidrug-resistant cancer

11 April 2018 - 12:00am

Revisiting the role of ABC transporters in multidrug-resistant cancer

Revisiting the role of ABC transporters in multidrug-resistant cancer, Published online: 11 April 2018; doi:10.1038/s41568-018-0005-8

This Opinion argues for a new look at the role of ABC transporters in cancer multidrug resistance to push forward their clinical application as biomarkers and as targets in combination therapies in order to improve anticancer drug efficiency.
Categories: Cancer

Too many targets, not enough patients: rethinking neuroblastoma clinical trials

9 April 2018 - 12:00am

Too many targets, not enough patients: rethinking neuroblastoma clinical trials

Too many targets, not enough patients: rethinking neuroblastoma clinical trials, Published online: 09 April 2018; doi:10.1038/s41568-018-0003-x

This Perspective provides an update on targeted therapy development for neuroblastoma and proposes that clinical trial design needs to be rethought in order to provide rigorous, evidence-based assessment of these new therapies in this rare and often deadly paediatric tumour.
Categories: Cancer

Breast cancer: Obesity — tipping the scales of resistance

6 April 2018 - 12:00am

Breast cancer: Obesity — tipping the scales of resistance

Breast cancer: Obesity — tipping the scales of resistance, Published online: 06 April 2018; doi:10.1038/nrc.2018.31

Using clinical tissue specimens and mouse models of breast cancer, Incio et al. show that obesity promotes the upregulation of interleukin-6 and fibroblast growth factor 2 in the tumour microenvironment, which confer resistance to anti-vascular endothelial growth factor therapy.
Categories: Cancer

Mechanisms of cancer resistance in long-lived mammals

5 April 2018 - 12:00am

Mechanisms of cancer resistance in long-lived mammals

Mechanisms of cancer resistance in long-lived mammals, Published online: 05 April 2018; doi:10.1038/s41568-018-0004-9

In this Opinion article, Seluanov et al. discuss the diverse mechanisms of cancer resistance found in long-lived mammals and argue that studies of unconventional long-lived and cancer-resistant animal species could provide breakthroughs in cancer therapy and prevention.
Categories: Cancer

Breast cancer: External communication

3 April 2018 - 12:00am

Breast cancer: External communication

Breast cancer: External communication, Published online: 03 April 2018; doi:10.1038/nrc.2018.30

In a new study, researchers show that basal-like breast cancer can be converted into the luminal subtype by inhibiting platelet-derived growth factor (PDGF)-CC signalling in the tumour microenvironment, thereby potentially broadening treatment options for oestrogen receptor-negative breast cancer patients.
Categories: Cancer

Leukaemia: Powers of prediction

3 April 2018 - 12:00am

Leukaemia: Powers of prediction

Leukaemia: Powers of prediction, Published online: 03 April 2018; doi:10.1038/nrc.2018.28

Good et al. use deep phenotypic single-cell analyses and machine learning to identify developmentally dependent cell signalling states in B cell precursor acute lymphoblastic leukaemia that are predictive of relapse.
Categories: Cancer

Pancreatic cancer: The COMPASS shows the way

3 April 2018 - 12:00am

Pancreatic cancer: The COMPASS shows the way

Pancreatic cancer: The COMPASS shows the way, Published online: 03 April 2018; doi:10.1038/nrc.2018.29

Deregulation of the COMPASS-like complex, via loss of KDM6A in females and loss of both KDM6A and its Y chromosome homologue UTY in males, is important for activation of oncogene-associated super-enhancers and the development of pancreatic adenocarcinoma of the squamous subtype.
Categories: Cancer

Immunosurveillance: Presentation skills

22 March 2018 - 12:00am

Immunosurveillance: Presentation skills

Immunosurveillance: Presentation skills, Published online: 22 March 2018; doi:10.1038/nrc.2018.24

Immunosurveillance: Presentation skills
Categories: Cancer

Immunotherapy: iPSC-based vaccines provoke a response

22 March 2018 - 12:00am

Immunotherapy: iPSC-based vaccines provoke a response

Immunotherapy: iPSC-based vaccines provoke a response, Published online: 22 March 2018; doi:10.1038/nrc.2018.26

Immunotherapy: iPSC-based vaccines provoke a response
Categories: Cancer

Immunotherapy: A therapeutic reservoir

22 March 2018 - 12:00am

Immunotherapy: A therapeutic reservoir

Immunotherapy: A therapeutic reservoir, Published online: 22 March 2018; doi:10.1038/nrc.2018.23

Wang, C., Wang, J. et al. show that local injection of a hydrogel scaffold degraded by reactive oxygen species in the tumour microenvironment releases chemotherapy and an immune checkpoint inhibitor with kinetics that increase antitumour responses.
Categories: Cancer

Metastasis: Go with the flow

22 March 2018 - 12:00am

Metastasis: Go with the flow

Metastasis: Go with the flow, Published online: 22 March 2018; doi:10.1038/nrc.2018.25

Metastasis: Go with the flow
Categories: Cancer

Targeted therapy: Tipping the splicing balance to kill cancer cells

22 March 2018 - 12:00am

Targeted therapy: Tipping the splicing balance to kill cancer cells

Targeted therapy: Tipping the splicing balance to kill cancer cells, Published online: 22 March 2018; doi:10.1038/nrc.2018.27

A paper in Nature Medicine describes a novel, orally available splicing modulator that preferentially kills cancer cells with mutations in splicing factors in culture and in mouse models.
Categories: Cancer

Cell motility in cancer invasion and metastasis: insights from simple model organisms

16 March 2018 - 12:00am

Cell motility in cancer invasion and metastasis: insights from simple model organisms

Cell motility in cancer invasion and metastasis: insights from simple model organisms, Published online: 16 March 2018; doi:10.1038/nrc.2018.15

In this Review, Stuelten et al. outline insights with relevance to human cancer invasion and metastasis that have come from the study of cell motility in non-mammalian model organisms.
Categories: Cancer

Non-angiogenic tumours and their influence on cancer biology

9 March 2018 - 12:00am

Non-angiogenic tumours and their influence on cancer biology

Non-angiogenic tumours and their influence on cancer biology, Published online: 09 March 2018; doi:10.1038/nrc.2018.14

In this Opinion article, Donnem et al. outline the evidence for non-angiogenic tumours, which use pre-existing blood vessels to support tumour growth, and discuss the studies that are beginning to define their unique biology.
Categories: Cancer

Immunotherapy: Tear down this wall

9 March 2018 - 12:00am

Immunotherapy: Tear down this wall

Immunotherapy: Tear down this wall, Published online: 09 March 2018; doi:10.1038/nrc.2018.22

Activation of TGFβ signalling in invasive margins of metastatic tumours can contribute to T cell exclusion and reduced immune checkpoint therapy response. Inhibition of TGFβ in non-responders can potentially help to improve outcomes in these patients.
Categories: Cancer

Epigenetics: Methylating patterns

9 March 2018 - 12:00am

Epigenetics: Methylating patterns

Epigenetics: Methylating patterns, Published online: 09 March 2018; doi:10.1038/nrc.2018.21

Xie et al. show that senescence-associated DNA methylation changes evolve independently of stochastic tumour-associated methylation changes and that a subset of commonly methylated genes with the highest gains are associated with early tumorigenesis and ageing.
Categories: Cancer

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