Nature Rev. Cancer

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Clinical tumour sequencing for precision oncology: time for a universal strategy

20 July 2018 - 12:00am

Clinical tumour sequencing for precision oncology: time for a universal strategy

Clinical tumour sequencing for precision oncology: time for a universal strategy, Published online: 20 July 2018; doi:10.1038/s41568-018-0043-2

Comprehensive genomic characterization of patient tumours has the potential to advance therapies and inform basic cancer research. In this Comment, David B. Solit and colleagues provide their personal perspective on the implementation of an enterprise-wide, prospective clinical sequencing strategy and make a call for a universal approach to next-generation sequencing-based tumour profiling.
Categories: Cancer

Second chances

18 July 2018 - 12:00am

Second chances

Second chances, Published online: 18 July 2018; doi:10.1038/s41568-018-0044-1

Mutant KRAS has so far proven to be an undruggable target for lung adenocarcinoma and a widely held assumption is that KRAS mutations confer independence from upstream signalling. Two groups have now independently shown this might not be the case and suggest pan-ERBB inhibitors could be used to treat patients with KRAS-driven lung cancer
Categories: Cancer

Extracellular ATP and P2 purinergic signalling in the tumour microenvironment

13 July 2018 - 12:00am

Extracellular ATP and P2 purinergic signalling in the tumour microenvironment

Extracellular ATP and P2 purinergic signalling in the tumour microenvironment, Published online: 13 July 2018; doi:10.1038/s41568-018-0037-0

In this Review, Di Virgilio et al. describe how extracellular ATP and P2 purinergic signalling can shape the tumour microenvironment to both promote and restrain tumour progression and outline the opportunities to harness nucleotide receptor signalling as an anticancer strategy.
Categories: Cancer

Every step of the way: integrins in cancer progression and metastasis

12 July 2018 - 12:00am

Every step of the way: integrins in cancer progression and metastasis

Every step of the way: integrins in cancer progression and metastasis, Published online: 12 July 2018; doi:10.1038/s41568-018-0038-z

In this Review, Hamidi and Ivaska discuss the contribution of integrins to the different steps of cancer progression, highlighting some of the recently identified unconventional roles of integrins and novel opportunities to target integrin signalling.
Categories: Cancer

STAT3 on the brain

9 July 2018 - 12:00am

STAT3 on the brain

STAT3 on the brain, Published online: 09 July 2018; doi:10.1038/s41568-018-0042-3

Priego et al. show that a subpopulation of reactive astrocytes expressing signal transducer and activator of transcription 3 (STAT3) is crucial for the development of brain metastases and report positive initial clinical data that inhibiting STAT3 can reduce metastasis.
Categories: Cancer

From rock ‘n’ roll to heavy metal

28 June 2018 - 12:00am

From rock ‘n’ roll to heavy metal

From rock ‘n’ roll to heavy metal, Published online: 28 June 2018; doi:10.1038/s41568-018-0041-4

Three studies published in Developmental Cell, Nature and Nature Medicine shed new light on mechanisms of cancer-associated cachexia in early and advanced disease.
Categories: Cancer

Success stories

22 June 2018 - 12:00am

Success stories

Success stories, Published online: 22 June 2018; doi:10.1038/s41568-018-0039-y

Analyses of clinical trial patients with exceptional responses show that adoptive T cell therapy can be optimised to improve effectiveness in patients of chronic lymphocytic leukaemia and breast cancer.
Categories: Cancer

Tumours trigger systemic disruption

21 June 2018 - 12:00am

Tumours trigger systemic disruption

Tumours trigger systemic disruption, Published online: 21 June 2018; doi:10.1038/s41568-018-0040-5

Breast tumours in mice promote metabolic changes in the liver and sleep disruption through increasing activity of hypocretin (also known as orexin) neurons (HO neurons).
Categories: Cancer

Falling short to compete

19 June 2018 - 12:00am

Falling short to compete

Falling short to compete, Published online: 19 June 2018; doi:10.1038/s41568-018-0036-1

Increased shortening of RNA 3′ untranslated regions associated with tumorigenic transformation interferes with competing endogenous RNA (eRNA) networks, which results in trans-repression of tumour suppressors through microRNA-mediated silencing.
Categories: Cancer

Metabolizing microbes in control

18 June 2018 - 12:00am

Metabolizing microbes in control

Metabolizing microbes in control, Published online: 18 June 2018; doi:10.1038/s41568-018-0035-2

The gut microbiota can metabolize bile acids to affect immunosurveillance in the liver of mice and indirectly control the growth of primary liver tumours and liver metastases.
Categories: Cancer

Targeting ATR in cancer

13 June 2018 - 12:00am

Targeting ATR in cancer

Targeting ATR in cancer, Published online: 13 June 2018; doi:10.1038/s41568-018-0034-3

This Opinion provides insight into the potential of targeting the replication stress response in cancer and discusses the strategy of inhibiting ataxia telangiectasia and Rad3-related protein (ATR) and the need for reliable biomarkers to enable patient stratification.
Categories: Cancer

Eco-evolutionary causes and consequences of temporal changes in intratumoural blood flow

11 June 2018 - 12:00am

Eco-evolutionary causes and consequences of temporal changes in intratumoural blood flow

Eco-evolutionary causes and consequences of temporal changes in intratumoural blood flow, Published online: 11 June 2018; doi:10.1038/s41568-018-0030-7

This Opinion proposes that temporal variations in intratumoural blood flow are the result of eco-evolutionary dynamics. It describes adaptive strategies to stochastically varying environments that may strongly affect observed cancer phenotypes and clinical outcomes including formation of metastases and response to treatment.
Categories: Cancer

Insights on cancer resistance in vertebrates: reptiles as a parallel system to mammals

11 June 2018 - 12:00am

Insights on cancer resistance in vertebrates: reptiles as a parallel system to mammals

Insights on cancer resistance in vertebrates: reptiles as a parallel system to mammals, Published online: 11 June 2018; doi:10.1038/s41568-018-0033-4

Insights on cancer resistance in vertebrates: reptiles as a parallel system to mammals
Categories: Cancer

It’s all Greek to me

6 June 2018 - 12:00am

It’s all Greek to me

It’s all Greek to me, Published online: 06 June 2018; doi:10.1038/s41568-018-0032-5

Tumour-associated neutrophils can inhibit the proliferation of pro-tumoural interleukin-17 (IL-17)+ γδ T cells via production of reactive oxygen species.
Categories: Cancer

Lethally high ROS levels thwart resistance

5 June 2018 - 12:00am

Lethally high ROS levels thwart resistance

Lethally high ROS levels thwart resistance, Published online: 05 June 2018; doi:10.1038/s41568-018-0031-6

Wang, Leite de Oliveira et al. show that BRAFV600E-mutant melanomas that are resistant to BRAF and MEK inhibitors are vulnerable to increased levels of reactive oxygen species and that this can be exploited therapeutically using a histone deacetylase inhibitor.
Categories: Cancer

Author Correction: A causal mechanism for childhood acute lymphoblastic leukaemia

30 May 2018 - 12:00am

Author Correction: A causal mechanism for childhood acute lymphoblastic leukaemia

Author Correction: A causal mechanism for childhood acute lymphoblastic leukaemia, Published online: 30 May 2018; doi:10.1038/s41568-018-0029-0

Author Correction: A causal mechanism for childhood acute lymphoblastic leukaemia
Categories: Cancer

Deciphering the cells of origin of squamous cell carcinomas

30 May 2018 - 12:00am

Deciphering the cells of origin of squamous cell carcinomas

Deciphering the cells of origin of squamous cell carcinomas, Published online: 30 May 2018; doi:10.1038/s41568-018-0024-5

This Review discusses the origins of squamous cell carcinoma (SCC), with a focus on skin, lung, oesophageal and head and neck cancer, and describes how oncogenic mutations and the cell of origin cooperate in determining the rise of SCC.
Categories: Cancer

Inverted architecture

25 May 2018 - 12:00am

Inverted architecture

Inverted architecture, Published online: 25 May 2018; doi:10.1038/s41568-018-0025-4

Single-cell RNA sequencing analysis in paediatric diffuse midline gliomas with histone H3 lysine 27 to methionine mutations indicates that these aggressive tumours contain many stem-like cells and that lineage-based therapeutic targeting might be beneficial.
Categories: Cancer

Ciliary signalling in cancer

25 May 2018 - 12:00am

Ciliary signalling in cancer

Ciliary signalling in cancer, Published online: 25 May 2018; doi:10.1038/s41568-018-0023-6

This Opinion discusses the role of the primary cilium as a platform for pathways implicated in cancer and how changes in the ciliation of cells in the tumour microenvironment can affect cancer progression.
Categories: Cancer

Adapting to stress — chaperome networks in cancer

23 May 2018 - 12:00am

Adapting to stress — chaperome networks in cancer

Adapting to stress — chaperome networks in cancer, Published online: 23 May 2018; doi:10.1038/s41568-018-0020-9

In this Opinion, Joshi et al. argue that in cancer cells, a state of chaperome hyperconnectivity is obtained by increasing the interaction strength among chaperome machinery members. These chaperome scaffolding platforms act to increase the functional diversity of oncogenic processes and have implications for the development of chaperome inhibitors.
Categories: Cancer

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